LOCUS       NM_009982               2430 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus cathepsin C (Ctsc), transcript variant 1, mRNA.
ACCESSION   NM_009982
VERSION     NM_009982.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2430)
  AUTHORS   Zierke,L., John,D., Gischke,M., Tran,Q.T., Sendler,M., Weiss,F.U.,
            Bornscheuer,U.T., Ritter,C., Lerch,M.M. and Aghdassi,A.A.
  TITLE     Initiation of acute pancreatitis in mice is independent of fusion
            between lysosomes and zymogen granules
  JOURNAL   Cell Mol Life Sci 81 (1), 207 (2024)
   PUBMED   38709385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2430)
  AUTHORS   Liu,J., Qi,Y., Chao,J., Sathuvalli,P., Y Lee,L. and Li,S.
  TITLE     CREG1 promotes lysosomal biogenesis and function
  JOURNAL   Autophagy 17 (12), 4249-4265 (2021)
   PUBMED   33966596
REFERENCE   3  (bases 1 to 2430)
  AUTHORS   Zhao,X., Liu,S., Yang,X., Liu,Y., Liu,G., Fan,K. and Ma,J.
  TITLE     Cathepsin C aggravates neuroinflammation via promoting production
            of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain
            lesion
  JOURNAL   Neurochem Int 148, 105107 (2021)
   PUBMED   34171415
  REMARK    GeneRIF: Cathepsin C aggravates neuroinflammation via promoting
            production of CCL2 and CXCL2 in glial cells and neurons in a
            cryogenic brain lesion.
REFERENCE   4  (bases 1 to 2430)
  AUTHORS   Alam,S., Liu,Q., Liu,S., Liu,Y., Zhang,Y., Yang,X., Liu,G., Fan,K.
            and Ma,J.
  TITLE     Up-regulated cathepsin C induces macrophage M1 polarization through
            FAK-triggered p38 MAPK/NF-kappaB pathway
  JOURNAL   Exp Cell Res 382 (2), 111472 (2019)
   PUBMED   31229505
  REMARK    GeneRIF: CTSC may promote macrophage towards M1 activation status
            through FAK-induced p38MAPK/NF-kappaB signaling pathway activation.
REFERENCE   5  (bases 1 to 2430)
  AUTHORS   Liu,Q., Zhang,Y., Liu,S., Liu,Y., Yang,X., Liu,G., Shimizu,T.,
            Ikenaka,K., Fan,K. and Ma,J.
  TITLE     Cathepsin C promotes microglia M1 polarization and aggravates
            neuroinflammation via activation of Ca2+-dependent
            PKC/p38MAPK/NF-kappaB pathway
  JOURNAL   J Neuroinflammation 16 (1), 10 (2019)
   PUBMED   30651105
  REMARK    GeneRIF: The data suggest that CatC promotes microglia M1
            polarization and aggravates neuroinflammation via activation of
            Ca(2+)-dependent PKC/p38MAPK/NF-kappaB pathway.
            Erratum:[J Neuroinflammation. 2022 Jan 11;19(1):14. doi:
            10.1186/s12974-021-02346-1.. PMID: 35016688]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2430)
  AUTHORS   Wolters,P.J., Pham,C.T., Muilenburg,D.J., Ley,T.J. and Caughey,G.H.
  TITLE     Dipeptidyl peptidase I is essential for activation of mast cell
            chymases, but not tryptases, in mice
  JOURNAL   J Biol Chem 276 (21), 18551-18556 (2001)
   PUBMED   11279033
REFERENCE   7  (bases 1 to 2430)
  AUTHORS   Hart,T.C., Hart,P.S., Michalec,M.D., Zhang,Y., Firatli,E., Van
            Dyke,T.E., Stabholz,A., Zlotogorski,A., Shapira,L. and
            Soskolne,W.A.
  TITLE     Haim-Munk syndrome and Papillon-Lefevre syndrome are allelic
            mutations in cathepsin C
  JOURNAL   J Med Genet 37 (2), 88-94 (2000)
   PUBMED   10662807
  REMARK    Erratum:[J Med Genet 2001 Jan;38(1):79. Zlorogorski, A [corrected
            to Zlotogorski, A]]
REFERENCE   8  (bases 1 to 2430)
  AUTHORS   Pham,C.T. and Ley,T.J.
  TITLE     Dipeptidyl peptidase I is required for the processing and
            activation of granzymes A and B in vivo
  JOURNAL   Proc Natl Acad Sci U S A 96 (15), 8627-8632 (1999)
   PUBMED   10411926
REFERENCE   9  (bases 1 to 2430)
  AUTHORS   Rao,N.V., Rao,G.V. and Hoidal,J.R.
  TITLE     Human dipeptidyl-peptidase I. Gene characterization, localization,
            and expression
  JOURNAL   J Biol Chem 272 (15), 10260-10265 (1997)
   PUBMED   9092576
REFERENCE   10 (bases 1 to 2430)
  AUTHORS   Paris,A., Strukelj,B., Pungercar,J., Renko,M., Dolenc,I. and
            Turk,V.
  TITLE     Molecular cloning and sequence analysis of human preprocathepsin C
  JOURNAL   FEBS Lett 369 (2-3), 326-330 (1995)
   PUBMED   7649281
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124322.7.
            
            On Sep 28, 2022 this sequence version replaced NM_009982.5.
            
            Summary: This gene encodes a member of the peptidase C1 (papain)
            family of cysteine proteases. Alternative splicing results in
            multiple transcript variants, at least one of which encodes a
            preproprotein that is proteolytically processed to generate
            multiple protein products. These products include the dipeptidyl
            peptidase 1 light, heavy, and exclusion domain chains, which
            together comprise one subunit of the homotetrameric enzyme. This
            enzyme has amino dipeptidase activity and may play a role in the
            activation of granzymes during inflammation. Homozygous knockout
            mice for this gene exhibit impaired granzyme activation and
            enhanced survival in a sepsis model. [provided by RefSeq, Aug
            2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049406.1, AK167882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC124322.7         104362-104601
            241-386             AC124322.7         107614-107759
            387-553             AC124322.7         123310-123476
            554-706             AC124322.7         125672-125824
            707-822             AC124322.7         128412-128527
            823-954             AC124322.7         134240-134371
            955-2430            AC124322.7         135627-137102
FEATURES             Location/Qualifiers
     source          1..2430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 49.11 cM"
     gene            1..2430
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /note="cathepsin C"
                     /db_xref="GeneID:13032"
                     /db_xref="MGI:MGI:109553"
     exon            1..240
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1457
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /EC_number="3.4.14.1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; dipeptidyl peptidase 1; cathepsin J; dipeptidyl
                     transferase; dipeptidyl peptidase I"
                     /codon_start=1
                     /product="dipeptidyl peptidase 1 isoform 1 preproprotein"
                     /protein_id="NP_034112.3"
                     /db_xref="CCDS:CCDS21438.1"
                     /db_xref="GeneID:13032"
                     /db_xref="MGI:MGI:109553"
                     /translation="MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVG
                     PRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWF
                     AFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQ
                     ERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAP
                     MTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNN
                     SQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRE
                     NCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGL
                     SDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIE
                     SIAVAAIPIPKL"
     exon            241..386
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            387..553
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            554..706
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            707..822
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            823..954
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            955..2430
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /note="major polyA site"
     regulatory      2405..2410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
                     /note="hexamer: AATAAA"
     polyA_site      2430
                     /gene="Ctsc"
                     /gene_synonym="CatC; DPP1; DPPI"
ORIGIN      
        1 gactgccatc gagtggtgtt ccagttgaac ttgctttctc tgccatctgc tccgcgggcg
       61 ccgtcagcat gggtccctgg acccactcct tgcgcgccgt cctgctgctg gtgcttttgg
      121 gagtctgcac cgtgcgctcc gacactcctg ccaactgcac ctaccctgat ctgctgggca
      181 cctgggtgtt ccaggtgggc cctagaagtt cccgaagcga cattaactgc tcggtgatgg
      241 aagcaacaga agaaaaggta gtggtacacc ttaagaagtt ggatactgcc tacgacgagc
      301 tgggcaattc cgggcatttt accctcattt acaaccaagg cttcgagatt gtgttgaatg
      361 actacaaatg gtttgcgttt ttcaagtatg aagtcagagg ccacacagct atcagttact
      421 gccatgagac catgactggg tgggtccatg atgtgctggg ccggaactgg gcttgctttg
      481 ttggcaagaa ggtggaaagt cacattgaga aggttaatat gaatgcagca catcttggag
      541 gtctccagga aagatattct gaaagactct acactcacaa ccacaacttt gtgaaggcca
      601 tcaataccgt tcagaagtct tggactgcaa ctgcatataa ggaatatgag aaaatgagcc
      661 tgcgagatct gataaggaga agtggccaca gccaaaggat cccaaggccc aaacctgccc
      721 cgatgactga tgaaatacag caacaaattt taaatttgcc agaatcttgg gactggagaa
      781 acgtccaagg cgtcaattat gttagccctg ttcgaaacca agaatcttgt ggaagctgct
      841 actcatttgc ctctatgggt atgctagaag caagaattcg tatattaacc aacaattctc
      901 agacaccaat cctgagtcct caggaggttg tatcttgcag cccctatgcc caaggttgtg
      961 atggtggatt cccatacctc attgcaggga agtatgccca agattttggg gtggtggaag
     1021 aaagctgctt tccctacaca gccaaagatt ctccatgcaa accaagggag aattgcctcc
     1081 gttactattc ttctgactac tactatgtgg gtggtttcta tggtggctgc aatgaagccc
     1141 tgatgaagct tgagctggtc aaacatggac ccatggcagt tgcctttgaa gtccacgatg
     1201 acttcctaca ctaccacagt ggaatctatc accacactgg gctgagtgac cctttcaacc
     1261 ccttcgagct gacaaatcat gctgttttgc ttgtgggcta tggaagagat ccagttactg
     1321 ggatagaata ctggattata aagaacagct ggggctctaa ctggggggag agtggctact
     1381 tccgtatccg cagaggaact gatgaatgtg caattgagag tatagccgtg gcggccatac
     1441 cgattcctaa attataggac atagctccca gtgttacata cgggtcttta tcactcacag
     1501 agtgatttag tcacatgctg aagacttttt cagagcaata tcagaagctt accactaagc
     1561 atctttaaag aattttgtct ttgaacttaa aaccatcctt gatttttttc ttttaatatc
     1621 ttccccatca actactgaac tacttttctt tttaaagtac ttggttaagt aatactttta
     1681 tgagcagtgg ttcagttgtc caatattttt tgcaggtcat ctacaatgca accagatgtt
     1741 tcagttctaa aaatctatgt aaaagtacaa gctcgttttt aaattatgta agtcacatga
     1801 aaacatggca aaaaaattag ttaaattttt tacaaagagt tttaaataaa tgtttatgta
     1861 atcagtacca tagtctttct atgtgtgttt acaagaattt ttgtcaccta cttcttccct
     1921 tagaagcatt tatgctccat ggacgtactt ctttatggag aaaaaaaaaa tcaatgaaaa
     1981 tatttcatgt ataaatcagt cgagggagtg tgaagattca tcacctgcca attgcttgct
     2041 gtgcaagcaa gaggacctga ggccagactt caggatctgt gtcagaaaaa caagacagat
     2101 atgctgacac acttgtaatt ctagtgctag agagacagag acaggtggaa ccctagagcc
     2161 tactggttaa ccaacatagt tcagtgaaca agtatctgtc aatgagtgag ctgtgtcaaa
     2221 atcaagttat atgttcctaa gaagcgatag ccatggttga cctctgatcc ctgacttctg
     2281 tatatgcttg ggcttccata cacacatgag cgcacaccta aataactaaa taaaacaaga
     2341 acatttaacc ttgtcaaaga ggatcttctg acaataccta gtgaacccta aaattcagac
     2401 aggaaataaa gaggagtttt tacaatgtca
//
