LOCUS       NM_019541               2493 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus cathepsin 8 (Cts8), mRNA.
ACCESSION   NM_019541
VERSION     NM_019541.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2493)
  AUTHORS   Torregrosa-Carrion,R., Pineiro-Sabaris,R., Siguero-Alvarez,M.,
            Grego-Bessa,J., Luna-Zurita,L., Fernandes,V.S., MacGrogan,D.,
            Stainier,D.Y.R. and de la Pompa,J.L.
  TITLE     Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for
            placental development
  JOURNAL   Sci Adv 7 (46), eabj5445 (2021)
   PUBMED   34767447
REFERENCE   2  (bases 1 to 2493)
  AUTHORS   Blake,G.E.T., Zhao,X., Yung,H.W., Burton,G.J., Ferguson-Smith,A.C.,
            Hamilton,R.S. and Watson,E.D.
  TITLE     Defective folate metabolism causes germline epigenetic instability
            and distinguishes Hira as a phenotype inheritance biomarker
  JOURNAL   Nat Commun 12 (1), 3714 (2021)
   PUBMED   34140513
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2493)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   4  (bases 1 to 2493)
  AUTHORS   Mould,A., Morgan,M.A., Li,L., Bikoff,E.K. and Robertson,E.J.
  TITLE     Blimp1/Prdm1 governs terminal differentiation of endovascular
            trophoblast giant cells and defines multipotent progenitors in the
            developing placenta
  JOURNAL   Genes Dev 26 (18), 2063-2074 (2012)
   PUBMED   22987638
REFERENCE   5  (bases 1 to 2493)
  AUTHORS   Labied,S., Blacher,S., Carmeliet,P., Noel,A., Frankenne,F.,
            Foidart,J.M. and Munaut,C.
  TITLE     Transient reduction of placental angiogenesis in PAI-1-deficient
            mice
  JOURNAL   Physiol Genomics 43 (4), 188-198 (2011)
   PUBMED   21119013
REFERENCE   6  (bases 1 to 2493)
  AUTHORS   Screen,M., Dean,W., Cross,J.C. and Hemberger,M.
  TITLE     Cathepsin proteases have distinct roles in trophoblast function and
            vascular remodelling
  JOURNAL   Development 135 (19), 3311-3320 (2008)
   PUBMED   18776147
REFERENCE   7  (bases 1 to 2493)
  AUTHORS   Deussing,J., Kouadio,M., Rehman,S., Werber,I., Schwinde,A. and
            Peters,C.
  TITLE     Identification and characterization of a dense cluster of
            placenta-specific cysteine peptidase genes and related genes on
            mouse chromosome 13
  JOURNAL   Genomics 79 (2), 225-240 (2002)
   PUBMED   11829493
REFERENCE   8  (bases 1 to 2493)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049474.1 and BC068241.1.
            
            On May 13, 2008 this sequence version replaced NM_019541.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049474.1, BC068241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AK049474.1         2-55
            55-76               BC068241.1         45-66
            77-1553             AK049474.1         78-1554
            1554-1599           BC068241.1         1544-1589
            1600-2493           AK049474.1         1600-2493
FEATURES             Location/Qualifiers
     source          1..2493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.68 cM"
     gene            1..2493
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /note="cathepsin 8"
                     /db_xref="GeneID:56094"
                     /db_xref="MGI:MGI:1860275"
     exon            1..73
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /inference="alignment:Splign:2.1.0"
     exon            74..210
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1086
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /note="ectoplacental cone, invasive trophoblast giant
                     cells, extraembryonic ectoderm and chorion sequence 68;
                     cathepsin 2"
                     /codon_start=1
                     /product="cathepsin 8 precursor"
                     /protein_id="NP_062414.3"
                     /db_xref="CCDS:CCDS26587.1"
                     /db_xref="GeneID:56094"
                     /db_xref="MGI:MGI:1860275"
                     /translation="MGPAVLLAILCLGVAEVTQSSDPSLDSEWQEWKRKFNKNYSMEE
                     EGQKRAVWEENMKLVKQHNIEYDQGKKNFTMDVNAFGDMTGEEYRKMLTDIPVPNFRK
                     KKSIHQPIAGYLPKFVDWRKRGCVTPVKNQGTCNSCWAFSAAGAIEGQMFRKTGKLVP
                     LSTQNLVDCSRLEGNFGCFKGSTFLALKYVWKNRGLEAESTYPYKGTDGHCRYHPERS
                     AARITSFSFVSNSEKDLMRAVATIGPISVGIDARHKSFRLYREGIYYEPKCSSNIINH
                     SVLVVGYGYEGKESDGNKYWLIKNSHGEQWGMNGYMKLARGRNNHCGIASYAVYPRV"
     exon            211..333
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /inference="alignment:Splign:2.1.0"
     exon            334..480
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /inference="alignment:Splign:2.1.0"
     exon            481..705
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /inference="alignment:Splign:2.1.0"
     exon            706..868
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /inference="alignment:Splign:2.1.0"
     exon            869..986
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /inference="alignment:Splign:2.1.0"
     exon            987..2493
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2475..2480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /note="putative"
     polyA_site      2493
                     /gene="Cts8"
                     /gene_synonym="CTS2; Epcs68; Epcs70"
                     /note="putative"
ORIGIN      
        1 cagatcctag gatctcagcc acatctgaag atctgagttt gtggagtgca taaagacatt
       61 agaagtcttc ccggtgcttg aggcatgggt cctgctgtct tgctggccat cctatgcttg
      121 ggagtggctg aagttactca atcatctgat cccagtttgg attctgaatg gcaggagtgg
      181 aagagaaaat ttaacaaaaa ctacagcatg gaggaagaag gacagaagag agcagtgtgg
      241 gaagaaaaca tgaaactggt caaacagcat aatattgaat atgatcaggg aaagaaaaac
      301 ttcaccatgg atgtcaatgc ctttggtgac atgactggtg aggaatacag gaaaatgctg
      361 actgatattc cagtcccaaa ttttaggaag aagaaaagta tccaccaacc tattgctggt
      421 tatctcccca aatttgtgga ctggagaaaa agaggctgtg tgactcctgt gaagaatcag
      481 ggcacgtgta attcttgttg ggctttttct gcggctggtg ccatagaagg acagatgttc
      541 aggaaaacag gcaaactggt cccactgagc acacaaaatc tagtggactg ttctagactt
      601 gaagggaatt tcggctgttt taagggcagc acattccttg ctttaaagta cgtgtggaaa
      661 aatagaggtc tagaggctga gtcaacctat ccatacaaag gaacggacgg acactgcagg
      721 taccaccctg aacgttctgc tgctagaatc actagctttt cgtttgtttc aaacagtgag
      781 aaagacttaa tgcgtgctgt agcaactatc ggacccatct ctgttggaat tgatgctaga
      841 cataaatctt tcaggttgta tagggaaggt atttattatg agccaaagtg cagcagtaat
      901 attatcaacc attctgttct ggtagttggc tatggttatg aaggaaagga gtcagatggc
      961 aacaaatatt ggctgataaa gaacagtcat ggtgagcaat ggggcatgaa tggctacatg
     1021 aagcttgcca gaggcaggaa caaccactgt ggaattgctt catatgccgt ctaccccaga
     1081 gtgtaaactg cctgatggta agaaggaagg gttggaatgg agacagcctg tgaagtggag
     1141 gcactttctg tttaccatga ccagcctctg ctgcatggat agagttcatg agttactgca
     1201 gaacgtgatg taatgtgaat tctgttatgt ttttatccag taagacatga tggatactgt
     1261 aacttaagca cttcacttat ttgtatttga ttcccataac ttgattttgt gtttgtttaa
     1321 tgattgtata aaacaatatc tttaaagaat atttaagttc aaatgaagtg tctgtcttct
     1381 ttttgttttg aaagtagtga cttttaaatt gtatgtagtt catttcattt aatatatgtt
     1441 ttagttaaaa tataattata ttaacccatt tatttctttc ctccaacaac ttttcctccc
     1501 tacctcctca catattcccc actctcatct agtctcaaat tgattggttt ttttgttgtt
     1561 gttgttttgt ttgtttgttt tggttttggt tttttttttt gttttttgag acagggtttc
     1621 tctgtatagc cctggctgtc ctggaactca ctctgtagac caggctggcc tcaaattcag
     1681 aaatccacct acctctgcct cccaagtgct gggattgaag acatgcacca ccaccgccag
     1741 gctaaattga ttgtttctta ttctctggtg attttcatta tatatacgta tatgtgtata
     1801 tgtatatatt tgtgaatata taatgaaacc agctgaaggc tgaatcaatt tttgttcctt
     1861 ctatgttcaa gactttagga ctaatcacat tgtttaggta gttgatcagg ggttcacccc
     1921 tgggagtgct cattctcctt ttagtattca taactcctgc atgtaaggct cagggaatat
     1981 tgtggaagat agggcagaat gacttagaga caaaggatca tgaaatatac aaggagactg
     2041 tatgtccaaa aaattgttgc ttaaacaata tatgtacaat gacaacatca atagccttat
     2101 cagctgggaa taaggaacaa ctttagagtt cccactgcca ggtaatgagc tacaggatat
     2161 taattttgtt gtcacattaa taactcagta taaagacata catttgtgtt ctgttgatgt
     2221 tcttagagaa agaagggtgg ctcttttgtt attgtcaatt ttccatcttt agtaatgtgt
     2281 gtgttaaatt agattttgtg tatcgactat cactgtgaat cccccttgcc ttacttccat
     2341 cctgtgtagc atcttcattg tgaatgtact gaagacatcg gcaaaactgg atctgcagtt
     2401 acagattttt attcaaatga cactttcaga agttttagtg tctcagaggc aagagagctg
     2461 aaacatgcct tttaaataaa acctcctaga atc
//
