LOCUS       NM_019539               1533 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cathepsin 7 (Cts7), transcript variant 1, mRNA.
ACCESSION   NM_019539
VERSION     NM_019539.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1533)
  AUTHORS   Torregrosa-Carrion,R., Pineiro-Sabaris,R., Siguero-Alvarez,M.,
            Grego-Bessa,J., Luna-Zurita,L., Fernandes,V.S., MacGrogan,D.,
            Stainier,D.Y.R. and de la Pompa,J.L.
  TITLE     Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for
            placental development
  JOURNAL   Sci Adv 7 (46), eabj5445 (2021)
   PUBMED   34767447
REFERENCE   2  (bases 1 to 1533)
  AUTHORS   Oikawa,D. and Iwawaki,T.
  TITLE     Positive contribution of IRE1alpha-XBP1 pathway to the expression
            of placental cathepsins
  JOURNAL   Biochem Biophys Res Commun 433 (4), 426-431 (2013)
   PUBMED   23541586
  REMARK    GeneRIF: Disruption of IRE1alpha and XBP1 drastically attenuated
            the expression of Cts7 and Cts8, which are essential cathepsins for
            placenta formation.
REFERENCE   3  (bases 1 to 1533)
  AUTHORS   Screen,M., Dean,W., Cross,J.C. and Hemberger,M.
  TITLE     Cathepsin proteases have distinct roles in trophoblast function and
            vascular remodelling
  JOURNAL   Development 135 (19), 3311-3320 (2008)
   PUBMED   18776147
REFERENCE   4  (bases 1 to 1533)
  AUTHORS   Deussing,J., Kouadio,M., Rehman,S., Werber,I., Schwinde,A. and
            Peters,C.
  TITLE     Identification and characterization of a dense cluster of
            placenta-specific cysteine peptidase genes and related genes on
            mouse chromosome 13
  JOURNAL   Genomics 79 (2), 225-240 (2002)
   PUBMED   11829493
REFERENCE   5  (bases 1 to 1533)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030645.4, CA536242.1 and BC064740.1.
            
            On Jan 4, 2018 this sequence version replaced NM_019539.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064740.1, AK017466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CT030645.4         82435-82445         c
            12-497              CA536242.1         1-486
            498-649             BC064740.1         472-623
            650-650             CT030645.4         79996-79996         c
            651-1451            BC064740.1         625-1425
            1452-1452           CT030645.4         76777-76777         c
            1453-1533           BC064740.1         1427-1507
FEATURES             Location/Qualifiers
     source          1..1533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.71 cM"
     gene            1..1533
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /note="cathepsin 7"
                     /db_xref="GeneID:56092"
                     /db_xref="MGI:MGI:1860262"
     exon            1..237
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /inference="alignment:Splign:2.1.0"
     exon            238..374
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1244
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /note="cathepsin 1"
                     /codon_start=1
                     /product="cathepsin 7 preproprotein"
                     /protein_id="NP_062412.1"
                     /db_xref="CCDS:CCDS26588.1"
                     /db_xref="GeneID:56092"
                     /db_xref="MGI:MGI:1860262"
                     /translation="MTPTVFLSILCLGVALAAPAPDYNLDAEWEEWKRSNDRTYSPEE
                     EKQRRAVWEGNVKWIKQHIMENGLWMNNFTIEMNEFGDMTGEEMKMLTESSSYPLRNG
                     KHIQKRNPKIPPTLDWRKEGYVTPVRRQGSCGACWAFSVTACIEGQLFKKTGKLIPLS
                     VQNLMDCSVSYGTKGCDGGRPYDAFQYVKNNGGLEAEATYPYEAKAKHCRYRPERSVV
                     KVNRFFVVPRNEEALLQALVTHGPIAVAIDGSHASFHSYRGGIYHEPKCRKDTLDHGL
                     LLVGYGYEGHESENRKYWLLKNSHGERWGENGYMKLPRGQNNYCGIASYAMYPAL"
     exon            375..497
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /inference="alignment:Splign:2.1.0"
     exon            498..638
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /inference="alignment:Splign:2.1.0"
     exon            639..863
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1026
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1144
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1519
                     /gene="Cts7"
                     /gene_synonym="CTS1; Epcs24; Epcs71"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatcctgac agcccaacaa cctctgaaga gactgtggag tgcaccaaga tagcagcaat
       61 catcagaggt ggggccctga ctctactttt cctggaagga agccttgaga gactccttgg
      121 aaaatcagac aggccctcat aaataagaac atcttctaaa cgtcagcagc ccccattgtg
      181 tggaagtggg ggagggtaag gaagtcagag aggaatccaa gccacacctg gatccaggta
      241 cttggaacat gactcctact gtcttcctgt ccatcctgtg cttgggagtg gccttggctg
      301 ctccagcacc tgattacaat ttggatgccg agtgggagga gtggaagagg agcaatgaca
      361 gaacatacag cccagaggaa gaaaaacaga ggagagcagt gtgggaagga aatgtgaaat
      421 ggatcaaaca gcacattatg gagaatggcc tgtggatgaa caacttcacc atagaaatga
      481 atgaatttgg tgatatgact ggtgaagaaa tgaaaatgtt gacagaaagc tcatcttatc
      541 ctctaagaaa tgggaaacac atccagaaac gcaaccccaa aatcccccca actttggatt
      601 ggagaaagga aggctatgtg actccagtgc gaagacaggg aagttgtggt gcatgttggg
      661 ctttttctgt gactgcatgc atagaaggtc aactgttcaa gaaaactggc aaactgatcc
      721 cactgagtgt acagaattta atggactgct cagtatctta tggcaccaag ggctgtgatg
      781 gaggcagacc ttatgatgcc ttccaatatg tgaagaacaa tggaggtcta gaagctgagg
      841 caacctatcc atatgaagca aaggcaaaac actgcaggta ccgtcctgaa cgttctgttg
      901 ttaaggtcaa ccgctttttt gttgttccaa ggaatgaaga agctctactg caagctctag
      961 taacacatgg acccattgct gttgcaattg atggttcaca tgcatccttt cattcatatc
     1021 ggggaggtat atatcatgag ccaaagtgca gaaaggatac tctcgaccat ggtttactat
     1081 tggttggcta tggctatgaa ggccatgagt cagagaacag gaaatattgg ctgctaaaga
     1141 acagccatgg tgaaagatgg ggagaaaatg gctacatgaa gcttcccaga ggtcagaaca
     1201 actactgtgg aattgcttct tatgccatgt accctgcatt gtgagctgcc tatgtgtatg
     1261 aaggaaggaa agatattaag gcaacacata cagaagaatt ttatcctatt caaaatggcc
     1321 agcctctgct gtataaaaac atttgtgtca ccgaacaaca gggaaaaagg tgaaatctgt
     1381 tttatgtttg gtttagtaag tcataaccat tgatgatgtt ctgaagtgac ttatataact
     1441 gaatcctgta atgactttat tttatttttt tcactgtacc aaatgctgtt cttaaaaata
     1501 aaagttaact acaaagttaa aaaaaaaaaa aaa
//
