LOCUS       NM_023182                919 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus chymotrypsin-like (Ctrl), mRNA.
ACCESSION   NM_023182
VERSION     NM_023182.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 919)
  AUTHORS   Demcsak,A., Shariatzadeh,S. and Sahin-Toth,M.
  TITLE     Secretagogue-induced pancreatitis in mice devoid of chymotrypsin
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (3), G333-G344 (2024)
   PUBMED   38981616
  REMARK    GeneRIF: Secretagogue-induced pancreatitis in mice devoid of
            chymotrypsin.
REFERENCE   2  (bases 1 to 919)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 919)
  AUTHORS   Mosztbacher,D., Jancso,Z. and Sahin-Toth,M.
  TITLE     Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic
            protease activation but not pancreatitis severity in mice
  JOURNAL   Sci Rep 10 (1), 11731 (2020)
   PUBMED   32678161
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 919)
  AUTHORS   Hale,M.A., Swift,G.H., Hoang,C.Q., Deering,T.G., Masui,T.,
            Lee,Y.K., Xue,J. and MacDonald,R.J.
  TITLE     The nuclear hormone receptor family member NR5A2 controls aspects
            of multipotent progenitor cell formation and acinar differentiation
            during pancreatic organogenesis
  JOURNAL   Development 141 (16), 3123-3133 (2014)
   PUBMED   25063451
REFERENCE   5  (bases 1 to 919)
  AUTHORS   Azhar,M., Brown,K., Gard,C., Chen,H., Rajan,S., Elliott,D.A.,
            Stevens,M.V., Camenisch,T.D., Conway,S.J. and Doetschman,T.
  TITLE     Transforming growth factor Beta2 is required for valve remodeling
            during heart development
  JOURNAL   Dev Dyn 240 (9), 2127-2141 (2011)
   PUBMED   21780244
REFERENCE   6  (bases 1 to 919)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   7  (bases 1 to 919)
  AUTHORS   Czipri,M., Otto,J.M., Cs-Szabo,G., Kamath,R.V., Vermes,C.,
            Firneisz,G., Kolman,K.J., Watanabe,H., Li,Y., Roughley,P.J.,
            Yamada,Y., Olsen,B.R. and Glant,T.T.
  TITLE     Genetic rescue of chondrodysplasia and the perinatal lethal effect
            of cartilage link protein deficiency
  JOURNAL   J Biol Chem 278 (40), 39214-39223 (2003)
   PUBMED   12732630
REFERENCE   8  (bases 1 to 919)
  AUTHORS   Barbour,K.W., Goodwin,R.L., Guillonneau,F., Wang,Y., Baumann,H. and
            Berger,F.G.
  TITLE     Functional diversification during evolution of the murine
            alpha(1)-proteinase inhibitor family: role of the hypervariable
            reactive center loop
  JOURNAL   Mol Biol Evol 19 (5), 718-727 (2002)
   PUBMED   11961105
REFERENCE   9  (bases 1 to 919)
  AUTHORS   Becker-Follmann,J., Gaa,A., Bausch,E., Natt,E., Scherer,G. and von
            Deimling,O.
  TITLE     High-resolution mapping of a linkage group on mouse chromosome 8
            conserved on human chromosome 16Q
  JOURNAL   Mamm Genome 8 (3), 172-177 (1997)
   PUBMED   9069116
REFERENCE   10 (bases 1 to 919)
  AUTHORS   von Deimling,O.H., Groning,J. and Gaa,A.
  TITLE     Genetic and biochemical characterization of a new chymotrypsin
            isozyme of the house mouse, CTRA-1
  JOURNAL   Biochem Genet 29 (11-12), 545-557 (1991)
   PUBMED   1820020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB016228.1 and CF582693.1.
            
            On Apr 8, 2006 this sequence version replaced NM_023182.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016228.1, BC087918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-878               AB016228.1         1-878
            879-919             CF582693.1         2-42                c
FEATURES             Location/Qualifiers
     source          1..919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.06 cM"
     gene            1..919
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /note="chymotrypsin-like"
                     /db_xref="GeneID:109660"
                     /db_xref="MGI:MGI:88558"
     exon            1..84
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..827
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /EC_number="3.4.21.-"
                     /note="chymotrypsin A CTRA-1"
                     /codon_start=1
                     /product="chymotrypsin-like protease CTRL-1 precursor"
                     /protein_id="NP_075671.1"
                     /db_xref="CCDS:CCDS22620.1"
                     /db_xref="GeneID:109660"
                     /db_xref="MGI:MGI:88558"
                     /translation="MLLLSLTLSLVLLGSSWGCGVPAITPALSYNQRIVNGENAVPGS
                     WPWQVSLQDNTGFHFCGGSLISPNWVVTAAHCQVTPGRHFVVLGEYDRSSNAEPVQVL
                     SIARAITHPNWNANTMNNDLTLLKLASPARYTAQVSPVCLASTNEALPSGLTCVTTGW
                     GRISGVGNVTPARLQQVVLPLVTVNQCRQYWGARITDAMICAGGSGASSCQGDSGGPL
                     VCQKGNTWVLIGIVSWGTKNCNIQAPAMYTRVSKFSTWINQVMAYN"
     exon            85..188
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /inference="alignment:Splign:2.1.0"
     exon            189..268
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /inference="alignment:Splign:2.1.0"
     exon            269..350
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /inference="alignment:Splign:2.1.0"
     exon            351..531
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /inference="alignment:Splign:2.1.0"
     exon            532..665
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /inference="alignment:Splign:2.1.0"
     exon            666..888
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /inference="alignment:Splign:2.1.0"
     regulatory      860..865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /note="hexamer: AATAAA"
     polyA_site      882
                     /gene="Ctrl"
                     /gene_synonym="0910001G08Rik; 1810004D15Rik; chymopasin;
                     Ctra-1; Ctra1; mFLJ00366"
                     /note="major polyA site"
ORIGIN      
        1 gaccatctca acaccattcc ttatttgtca caatgctact gctcagccta acccttagcc
       61 tggtcctcct tggctcctcc tggggctgtg gtgttcctgc catcacgcct gcactgagct
      121 acaatcagag aattgtcaac ggggagaatg cagtgccagg ctcctggccc tggcaggtgt
      181 ctctccagga taacaccggc ttccacttct gcggtggttc tctcatcagt ccgaactggg
      241 tggtcacggc tgcccactgc caagtcacgc ctggacgcca ctttgtcgtt ttgggagaat
      301 atgaccgatc ttccaatgct gaacctgtgc aggtcctctc gatcgcaagg gccatcacac
      361 accctaactg gaacgccaac accatgaaca atgacctgac tctcctgaag cttgcctcgc
      421 cagcccggta cacagcacaa gtctcaccag tctgcctggc ttccacaaac gaggcactgc
      481 cttcggggct cacctgtgtc accactggct ggggccgaat cagtggtgtg ggcaatgtga
      541 caccagctcg cctgcagcaa gttgttctac ccctggtcac tgtgaatcag tgtcggcagt
      601 actggggtgc acgcattacc gatgccatga tatgtgcagg tggctcaggc gcctcctcat
      661 gtcagggtga ctcaggaggc cctcttgtct gccagaaggg aaacacctgg gtgcttattg
      721 ggattgtctc ctggggcact aagaactgca acatacaagc accggccatg tacactcggg
      781 tcagcaagtt cagtacctgg atcaaccaag tcatggccta caactaaact gtccacagat
      841 ccgttcccca tctcaatcta ataaacatac tcgtctcagt ttctcttgaa aaaaaaaaaa
      901 aaaaaaaaaa aaaaaaaaa
//
