LOCUS       NM_009431               4317 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CTR9 homolog, Paf1/RNA polymerase II complex component
            (Ctr9), mRNA.
ACCESSION   NM_009431
VERSION     NM_009431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4317)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4317)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4317)
  AUTHORS   Yu,S.E., Kim,M.S., Park,S.H., Yoo,B.C., Kim,K.H. and Jang,Y.K.
  TITLE     SET domain-containing protein 5 is required for expression of
            primordial germ cell specification-associated genes in murine
            embryonic stem cells
  JOURNAL   Cell Biochem Funct 35 (5), 247-253 (2017)
   PUBMED   28612505
  REMARK    GeneRIF: our data suggest that Setd5 is required for maintaining
            PGC-associated genes and Setd5-associated protein complexes
            containing Tbl1xr1 and Ctr9, which in turn are likely involved in
            regulating germ cell-related genes in mESCs
REFERENCE   4  (bases 1 to 4317)
  AUTHORS   Osipovich,A.B., Gangula,R., Vianna,P.G. and Magnuson,M.A.
  TITLE     Setd5 is essential for mammalian development and the
            co-transcriptional regulation of histone acetylation
  JOURNAL   Development 143 (24), 4595-4607 (2016)
   PUBMED   27864380
REFERENCE   5  (bases 1 to 4317)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4317)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   7  (bases 1 to 4317)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4317)
  AUTHORS   Kozak,C.A., Su,Y., Raj,N.B. and Pitha,P.M.
  TITLE     Identification and genetic mapping of differentially expressed
            genes in mice differing at the If1 interferon regulatory locus
  JOURNAL   Mamm Genome 10 (9), 853-857 (1999)
   PUBMED   10441734
REFERENCE   9  (bases 1 to 4317)
  AUTHORS   Burbelo,P.D., Kozak,C.A., Finegold,A.A., Hall,A. and Pirone,D.M.
  TITLE     Cloning, central nervous system expression and chromosomal mapping
            of the mouse PAK-1 and PAK-3 genes
  JOURNAL   Gene 232 (2), 209-215 (1999)
   PUBMED   10352232
REFERENCE   10 (bases 1 to 4317)
  AUTHORS   Malek,S.N., Yang,C.H., Earnshaw,W.C., Kozak,C.A. and Desiderio,S.
  TITLE     p150TSP, a conserved nuclear phosphoprotein that contains multiple
            tetratricopeptide repeats and binds specifically to SH2 domains
  JOURNAL   J Biol Chem 271 (12), 6952-6962 (1996)
   PUBMED   8636124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY012072.1, BC024749.1, L49502.1 and AI841408.1.
            
            On Jul 27, 2007 this sequence version replaced NM_009431.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.76864.1, L49502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY012072.1         1-37
            38-2987             BC024749.1         1-2950
            2988-4020           L49502.1           2936-3968
            4021-4317           AI841408.1         1-297               c
FEATURES             Location/Qualifiers
     source          1..4317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.98 cM"
     gene            1..4317
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /note="CTR9 homolog, Paf1/RNA polymerase II complex
                     component"
                     /db_xref="GeneID:22083"
                     /db_xref="MGI:MGI:109345"
     exon            1..231
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..3708
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /note="SH2 domain binding protein 1 (tetratricopeptide
                     repeat containing); p150TSP; SH2 domain-binding protein 1;
                     TPR-containing, SH2-binding phosphoprotein of 150 kDa;
                     Ctr9, Paf1/RNA polymerase II complex component, homolog;
                     tetratricopeptide repeat-containing, SH2-binding
                     phosphoprotein of 150 kDa"
                     /codon_start=1
                     /product="RNA polymerase-associated protein CTR9 homolog"
                     /protein_id="NP_033457.2"
                     /db_xref="CCDS:CCDS21750.1"
                     /db_xref="GeneID:22083"
                     /db_xref="MGI:MGI:109345"
                     /translation="MSRGSIEIPLRDTDEVIELDFDQLPEGDEVISILKQEHTQLHIW
                     IALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKN
                     KDNKKDLITQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFHFVLNQSP
                     NNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKAR
                     LAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLA
                     NHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQ
                     FASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQE
                     KRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVP
                     PEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYE
                     AMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPD
                     AWSLIGNLHLAKQEWGPGQKKFERILKQPATQSDTYSMLALGNVWLQTLHQPTRDREK
                     EKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISD
                     VWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTL
                     LKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLSK
                     VGDKMRFDLALAASEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKL
                     LKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKG
                     GEFDEFVNDDTDDDLPVSKKKKRRKGSGSEQEGEEEEGGERKKKRRRRPPKGEEGSEE
                     EETENGPKPKKRRPPRAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIAD
                     EGHPRNSNSDSDDDERPNRRASSESDSDDNQNKSGSEAGSPRRSGRQESDEDSDSDQP
                     SRKRRRSGSEQSDNESVQSGRSPSGASENENDSRPASPSAESDHESEQGSDNEGSGQG
                     SGNESEPEGSNNEASDRGSEHGSDDSD"
     exon            232..330
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            331..570
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            571..688
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            689..778
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            779..927
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1035
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1143
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1380
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1470
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1599
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1783
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1872
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2058
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2146
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2295
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2412
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2558
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2630
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2766
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2913
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3071
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3168
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3281
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..4300
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /note="hexamer: AATAAA"
     polyA_site      4300
                     /gene="Ctr9"
                     /gene_synonym="mKIAA0155; Sh2bp1; Tsbp; Tsp"
                     /note="major polyA site"
ORIGIN      
        1 gggcggggcc tccggaagtg gccggtcgcg gtctgaagct cgttgtttca gcggcggaca
       61 gcagaggaga agctggtctc cggcagctcc gctgggtgtg aggtgtggta acctctgtaa
      121 ggctggaagc cgggactgcg atctgccgag cggcggggtg agaagcgcct gctttcagag
      181 ctcaccatgt cgcggggctc catcgagatt cccctccggg atactgacga ggtcattgaa
      241 cttgacttcg atcagttacc ggagggagac gaagtcatca gcattctgaa gcaggagcac
      301 acacaactgc acatatggat tgccttggcg ctggaatact acaagcaagg gaaaacagaa
      361 gagtttgtga agctgctgga ggcagcacgg atagatggca atttggacta tcgagatcac
      421 gagaaagacc agatgacttg cttggataca ttggcagcct actatgtaca acaggctcgg
      481 aaagaaaaga acaaggacaa taagaaggac cttattacgc aggcaacttt gttatataca
      541 atggctgata aaattattat gtatgatcag aaccatttgt tgggaagagc ctgcttctgt
      601 ctgctcgagg gcgacaaaat ggaccaagct gacgcacagt ttcactttgt acttaaccag
      661 tctccaaaca atattccagc ccttcttggg aaagcttgta tttcattcaa caagaaggat
      721 tacagaggag ctctggctta ctataaaaaa gcattgcgca ctaacccggg atgtccagct
      781 gaagttcgtt taggaatggg ccattgcttt gtcaaactta acaaactgga aaaagctcga
      841 ctggcattca gcagagccct ggaactcaac tcgaagtgtg tgggagcact ggttggactg
      901 gctgttctag aactcaacaa taaagaggct gattccatca aaaatggcgt gcagcttctt
      961 tccagagcct atactattga tcctagcaac ccgatggtac tgaaccattt ggcaaaccac
     1021 tttttcttca agaaggatta tagtaaagtg cagcacctgg ctctccacgc attccacaac
     1081 accgaggtgg aggctatgca agcagaaagc tgttaccagc tggctcggtc cttccatgtt
     1141 caggaagatt atgaccaagc ctttcagtac tactatcaag ccacacagtt tgcttcatct
     1201 tcctttgtcc taccattttt tggtttggga caaatgtata tttatcgagg tgacaaagag
     1261 aatgcatctc agtgctttga gaaagttttg aaagcttatc cgaacaatta tgaaactatg
     1321 aaaattcttg gctctctcta tgctgcttca gaagatcagg agaaacgaga catagccaag
     1381 ggccatttga agaaggtcac agaacagtat cctgatgacg tggaagcttg gattgagttg
     1441 gcccagatct tagaacagac tgacatacag ggtgcccttt cagcttatgg aacagccaca
     1501 cgcatcctgc aggagaaagt gcaggccgat gtccctcccg agattttgaa taatgttggg
     1561 gccctccatt ttagactcgg aaacctgggg gaagcaaaga aatacttcct ggcctcactg
     1621 gaccgcgcaa aggcagaggc cgagcatgat gaacactact acaatgccat ctctgtcacc
     1681 acatcctaca atttagccag gctctatgag gccatgtgtg aatttcacga agcagagaaa
     1741 ctgtacaaaa acattttacg agagcatcct aactacgttg attgctatct acgcctagga
     1801 gccatggcca gagataaagg aaacttctat gaagcttcag actggtttaa ggaagccctt
     1861 cagatcaatc aggatcatcc ggatgcctgg tctttgattg gtaacctcca tctggcaaaa
     1921 caagaatggg gcccaggtca gaagaagttt gagaggatat taaaacagcc agccacacag
     1981 agtgacacct actctatgct ggcccttggc aatgtgtggc tccagacttt gcatcagcca
     2041 acccgagacc gagaaaagga aaagcgccat caagaccgtg ccctggccat ctacaaacaa
     2101 gtcctcagaa atgatgccaa gaacctgtat gctgccaatg gcataggagc tgtcttggcc
     2161 cacaaaggat acttccgtga agctcgtgat gttttcgccc aagtgagaga agcaacagca
     2221 gatatcagtg atgtgtggtt gaacctagca cacatctacg tggagcagaa gcagtatatc
     2281 agcgccgttc agatgtatga gaactgcctc agaaagttct ataagcacca aaacactgag
     2341 gttgtgctct acctggcccg cgccctcttc aagtgcggca agctgcagga gtgcaagcag
     2401 actctgctga aggccagaca cgtggcaccc agtgacacag ttctgatgtt taatgtggcc
     2461 ttggtcttgc aaagattagc tacctctgtc ctgaaagatg aaaaaagtaa tctgaaggaa
     2521 gtccttaatg ctgtgaaaga gctggagctc gcacacaggt acttcagtta cttgagcaaa
     2581 gttggagata aaatgagatt tgatttggcc cttgctgcct ctgaagccag gcagtgctct
     2641 gacttactga gccaggccca gtaccatgtg gcccgggcac gcaagcagga tgaggaagaa
     2701 cgggagctgc gggccaagca ggagcaggaa aaggagctct taagacagaa gcttctcaaa
     2761 gagcaggaag agaaacgtct cagagaaaag gaagaacaaa agaaactttt ggaacagcgt
     2821 gcccagtatg tggagaagac caaaaatatc cttatgttca ctggcgagac tgaagcaaca
     2881 aaggagaaga aaagaggtgg aggtggaggg cggcgttcca agaaaggagg cgagtttgat
     2941 gaatttgtca acgatgacac cgacgatgac ctccctgtat ccaaaaagaa gaagagaagg
     3001 aagggcagtg gcagtgaaca ggaaggcgaa gaagaggaag gtggagagag gaagaagaag
     3061 aggaggagaa gacctccaaa gggagaagag ggatctgagg aggaggagac agaaaatggc
     3121 cccaaaccaa agaagcgccg cccaccgaga gcagagaaaa agaaggctcc caagccagaa
     3181 cgcctgcctc cttcaatgaa gggaaaaata aaatccaaag ccattatatc atcaagtgat
     3241 gattcttcag atgaggataa actgaaaatt gctgatgaag gacatcccag gaatagcaac
     3301 agcgattctg atgacgacga gaggcccaac agacgcgcct catctgagag cgactcagat
     3361 gacaaccaga acaagtctgg cagcgaggca ggcagccctc ggaggtcggg tagacaggag
     3421 tcggatgagg attccgacag tgaccagccg tccagaaaga gaaggcgctc cggctctgag
     3481 cagtcggaca atgagtctgt gcagtcaggg agaagcccct ccggagcttc tgagaacgag
     3541 aacgattctc gcccggcttc tccaagtgca gaatcggacc acgaatcaga gcagggctct
     3601 gacaacgagg gctctggcca aggctctgga aatgaatcag aaccagaggg ctcaaacaac
     3661 gaggcctcag accgaggctc agaacatggg tcagatgata gcgactaggt ttatttcatc
     3721 aaagactcca tgggttggga ggagctttat aatatataaa agctgtgata agaaaccttt
     3781 caggtggtta gtcacttgta aactttttct taaggcaatt ttttttctac ttgtatattt
     3841 actaacttcc aagagacatt tcctgtgctg gagagtccag tgtcccaagc tggagcagtg
     3901 agactcctgc attgtggtgc agctccacct gccatatgtg aaaactgcag tgataacaca
     3961 gatgctaaag cattcccaag gcttgcaagc caggctagcc cctcccctct cctctcctct
     4021 cctctcctct cctctcctct cctctccggt aggcagcatg ctgctatgta caaacttgta
     4081 ccaaatgttg cagaagcaga gataaaagcc tttgttccct tttgagttga gactgagttt
     4141 tatctccaga ggaagagatg tccctgtact gaactctgtt ggaaggggtt gcagccatga
     4201 gcagagtgca aacacgggag ggtaaggtgt ggaaagtgct ttcctggtgt cagagtggga
     4261 agacctcccc agtcacttaa taaacccttt accaaccatg aaaaaaaaaa aaaaaaa
//
