LOCUS       NM_001168568            5474 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus cytidine 5'-triphosphate synthase 2 (Ctps2),
            transcript variant 2, mRNA.
ACCESSION   NM_001168568
VERSION     NM_001168568.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5474)
  AUTHORS   Soudais,C., Schaus,R., Bachelet,C., Minet,N., Mouasni,S.,
            Garcin,C., Souza,C.L., David,P., Cousu,C., Asnagli,H., Parker,A.,
            Palmquist-Gomes,P., Sepulveda,F.E., Storck,S., Meilhac,S.M.,
            Fischer,A., Martin,E. and Latour,S.
  TITLE     Inactivation of cytidine triphosphate synthase 1 prevents fatal
            auto-immunity in mice
  JOURNAL   Nat Commun 15 (1), 1982 (2024)
   PUBMED   38438357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5474)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5474)
  AUTHORS   Peng,M., Chang,C.C., Liu,J.L. and Sung,L.Y.
  TITLE     CTPS and IMPDH form cytoophidia in developmental thymocytes
  JOURNAL   Exp Cell Res 405 (1), 112662 (2021)
   PUBMED   34022203
REFERENCE   4  (bases 1 to 5474)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY288253.1, AK084595.1, AL671975.12 and AW048867.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.132939.1, AK084595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                BY288253.1         3-74
            73-2469             AK084595.1         2-2398
            2470-4952           AL671975.12        83651-86133
            4953-5474           AW048867.1         1-522               c
FEATURES             Location/Qualifiers
     source          1..5474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 75.09 cM"
     gene            1..5474
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /note="cytidine 5'-triphosphate synthase 2"
                     /db_xref="GeneID:55936"
                     /db_xref="MGI:MGI:1933185"
     exon            1..188
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            189..393
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1988
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /EC_number="6.3.4.2"
                     /note="isoform a is encoded by transcript variant 2; CTP
                     synthetase homolog; CTP synthase 2; cytidine triphosphate
                     synthase II; CTP synthetase 2; UTP--ammonia ligase 2"
                     /codon_start=1
                     /product="CTP synthase 2 isoform a"
                     /protein_id="NP_001162040.1"
                     /db_xref="CCDS:CCDS41202.1"
                     /db_xref="GeneID:55936"
                     /db_xref="MGI:MGI:1933185"
                     /translation="MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYIN
                     IDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKER
                     RGDYLGKTVQVVPHITDAIQEWVMNQAKVSVDGNKEDPQICVIELGGTIGDIEGMAFV
                     EAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKTKPTQNSVRALRGLGLSPDLIVCRS
                     STPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVPLLLEEQGVVKYFQERLGLPIND
                     CSSNLLFKWKAMADRYERLQKICSIALVGKYTKLRDCYASVFKALEHSALAINHKLNL
                     MYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFGIRGTLGKLQAISWARTKK
                     IPFLGICLGMQLAVIEFARNCLNLKDANSTEFEPNTPVPLVIDMPEHNPGDLGGTMRL
                     GLRRTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDVDGKR
                     MEIVELTSHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAHLQQMNKLPYSDG
                     YSDASDDSFPEAKLAELDLN"
     exon            394..564
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            565..665
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            666..782
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            783..866
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            867..947
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1099
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1232
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1321
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1416
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1479
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1523
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1620
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1676
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1773
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1918
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2030
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..5458
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /note="hexamer: ATTAAA"
     polyA_site      2236
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /note="major polyA site"
     regulatory      3404..3409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /note="hexamer: AAGAAA"
     polyA_site      3426
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
     regulatory      5439..5444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
                     /note="hexamer: ATTAAA"
     polyA_site      5458
                     /gene="Ctps2"
                     /gene_synonym="A830031M15Rik; Ctpsh"
ORIGIN      
        1 ggggccggcc catactgtgg cctggggcca aggacgtcta gagcagaggg tgatgggagc
       61 tgcctgtgct ataggaaaca ctttttaggc gcttgttttg tactgtccct ggaacccaac
      121 gctgcagcac tcgcaatttc acaaccagcg tgagtcagct gggccggctg ccggactgcg
      181 aggggaagat tgcatctggg tattggcagt cacctattcg cccgccaatg aagtatatcc
      241 tggttactgg tggggtcatc tcaggcattg gtaaagggat tatcgccagc agcattggga
      301 ctattctcaa gtcatgtgga ctccgagtta ctgccatcaa aattgacccc tatattaaca
      361 tcgatgctgg aactttctca ccttatgaac atggtgaagt atttgtttta aatgatggtg
      421 gagaagttga tttggacctt ggaaactatg aaagattctt ggacattaat ctctataaag
      481 acaacaacat caccactggg aagatatatc agcatgtgat caacaaagag aggcgcggtg
      541 attacctggg gaaaactgtt caagttgtcc cccatattac tgatgctatc caggagtggg
      601 ttatgaatca agccaaggtg tctgtggatg gcaataagga agatccccag atatgtgtta
      661 ttgagctggg aggcaccatt ggagacattg aaggaatggc atttgtggaa gcattccgac
      721 agttccagtt taaagccaag aaagagaatt tctataatat tcatgtcagc cttgtgccac
      781 agcccagtgc tactggagaa caaaaaacca agcccacgca aaacagtgtc cgtgcgctga
      841 gagggttggg cttgtctccg gatctgatcg tctgccgtag ttcaaccccc attgagatgg
      901 ctgtgaagga gaagatttct atgttttgtc acgtgaaccc tgaacaggtc atctgtatcc
      961 atgatgtttc ttccatctac cgagtgcctc tccttttgga ggagcaaggt gtggttaaat
     1021 attttcaaga gagattgggc ctgcccatca atgattgttc aagtaatttg cttttcaagt
     1081 ggaaagccat ggctgacagg tatgagagat tgcagaaaat atgttccata gccctggttg
     1141 gtaaatacac caaactcagg gactgctacg cctctgtgtt caaagcactg gaacactcag
     1201 ccttggccat caaccacaag ttgaacctga tgtacataga ctccattgat ctggagccag
     1261 tcaccaaagc cgaggatcct gtgaaattcc atgaagcttg gcagaagctg tgcttagctg
     1321 atgggattct tgtgcccgga gggtttggaa tccgaggaac attgggaaaa ctccaggcaa
     1381 tttcgtgggc aaggacaaag aagattccat ttctgggaat ttgccttggg atgcaactgg
     1441 cagtgattga gtttgcaaga aactgcctga acttgaaaga tgctaattct acagaatttg
     1501 agccaaacac tccagtccca ttggtaattg acatgcctga acacaaccct ggcgatttgg
     1561 gaggaacaat gagactgggg ttaagacgaa ctgttttcac aactgaaaac tccatactga
     1621 agaagcttta tggtgacgtt ccttacatag aagaaagaca ccgacatcgc tatgaggtga
     1681 accctaacct gatcaaccaa tttgagaata aagacctttg ttttgtcggt gaggatgtag
     1741 atgggaagag gatggaaatt gttgagttga caagtcatcc atatttcatt ggtgtccagt
     1801 tccatcctga gttttcctct aggccaatga agccttcccc tccgtacctg gggctcttac
     1861 ttgcagcaac ggggaatctg aatgcccatc tgcagcagat gaacaagctg ccatacagtg
     1921 atggatacag tgatgccagc gatgacagct ttccagaggc aaagcttgct gaactggatc
     1981 tcaactgaag ctctttcttg cctcaggaat agcagaagct acctaagagg cctctgaagt
     2041 cattatacgg aagatgaagg aattgtctga agaaaccacc acactgttcc ctagacatgg
     2101 gctgtgaaga ttcaaagaga atctgacaat gtttacttca tgcaacagaa ccaaaggggt
     2161 ccttttcttt tccctccaga ggcagcctgt agtagtcaca catttctatc cttaattaaa
     2221 cgcaattcag cagcaagccc gggcccggca gaaagtggtt ttgtgttttc tccaggacat
     2281 agtgagttca aagtggtgag caggaagggg gtggggagaa ctttgccttc acagtattac
     2341 acgggtaagg ggcatgtgct gtaaccaagg ttgggtctgt aggttaatgt gggagttaag
     2401 attatttcac gttctcgttc tgtttatttc caatacatcc attttctcaa atatgaaagg
     2461 gaaagaggat ctgaaaattc aggaatcagg ataagttggg ccgagtttca tctcttcaac
     2521 ccacgcagag gagcaaattg gctccatgag tcttctgacc ccagcatgca cacacataga
     2581 cacgtagaca ctaaaaaacc taaggagcat taaaaacaaa acaaaaaatt tcctttttaa
     2641 ttcaaattac tttttactat tcttttgaca acttcataca tatatagaat cattttagtc
     2701 attttaatct tttcagagca ccttatttat ttctttgttt atttgtttat ttattatttt
     2761 tcatatccca gtcactgccc catcttttta ttacactctc atcctgttct cactgaaacc
     2821 cttcttctca aataagtccc tcttttattt tcatgtcttt tttgttgctt tgtctttttc
     2881 ttattgagac agcatctcac agcatagtgc aagctgacgt ggaactaact gtgcagtcca
     2941 ctataatctt gacttactgt catcctccgg cctcgaccgc ccatgagtta ggattatagg
     3001 tgtgacctgg tctcctctgc tcaagatcag catttttgtt tgtttgtgtg tttttttttt
     3061 ttgagacatg ttttcgatac atagatctgg ctatcctgga actcactatg tagaccaggc
     3121 tggcctcaaa ctcacaaagt tatgccagct tctgcctctc aagtgctgga gttaaaggcg
     3181 ttgtatacaa acacgcttgg ctaacatttt ttttaattgg aaaaaataac aattttaaag
     3241 tgaagtatgc agtgtcattt attgatagtg cacagctctc agttttatga aattattcca
     3301 ggaataacct ctgttcccat cagccgtcac tccggaggca ttcttctatg cgcatcccct
     3361 ggcaacagtt acagccagat tgatcagggc aacttggaaa taaaagaaat cacagaccaa
     3421 cctctacatg ggcagacttg tactttaacc aaaacagctg aaggacacct gtctcccctt
     3481 gggagtgaac acttgtgcgc acgtggcacg gaagggttgg ggacttcata gaacagaaaa
     3541 gaggactttg ggcatggaag attccacctg caagctcaaa gctcagtttc ccgaaggctc
     3601 aaagtggcag atagcagggg aggttggtat gctgatcctc ttatcaggag catcctgact
     3661 cctgaccccc accctcagga tgtttatcag taaagtcaac tttccagtcc agagtttctc
     3721 agcccactgg agactttttt ttttttaaag atcattaacc cttctttcca gtccttgagg
     3781 actgattaga agtagggagt tgacatattc tgtcattggc tgttttcttc aagaagaggg
     3841 acaacaggga caggagggag tgtggatagg ctctgtgccc aggacctaag ggggcatagg
     3901 caggattgac tttttgtagc aggaggaaca ttttaacttc attggctaca gtggattctg
     3961 tggttgcctt tcctagaaga ctcttgggaa acaattagct ggggtgaggg tgagggcgta
     4021 tagtaagatg agacatcaga ctggggaccc agtaggcaat cttagccagg ggagctattt
     4081 gccctaatgc taacctagta aaggcagtga cttaatccag gacgaagttc tgtggaaagt
     4141 ttgaaagtta gggtaaaacc taagtatgag gattattaga gttaggaggg aagaagtgac
     4201 caaggggaga acctgagtgg gagggaccca aaggccctcc atggtagggc cgttgtttta
     4261 ggattactac tgctatgatg aaaccccatg atgaaaggca agttggagag gaaagagttt
     4321 catagtacac tgagggaagc caaggtaagg actccgtggg gaacttggag gaaggaactg
     4381 atgatgcaga acctatgaag gattgttctt tactgacttg ctcctcatat cttgctcagc
     4441 ctgctttctt agagaagcta ggaccactag cccaggtggg ataccaccta caataggctg
     4501 gaccctccgc gtgaatcatt aagaaaatgg ctaatgggct gatcttacgg aggcattttt
     4561 ttttcttcaa ttgaggttcc ctcctctcag atgactctag cttgtatcaa gttgatagaa
     4621 aactagtcag cacactcatc attgaatctt ttctggtccc tatgcctttg agccctatcc
     4681 tctaaggagt tttggtttgt tactgcggaa gcaacattgt tcctggagaa ggatgcagat
     4741 accatcttca gcagtgggca ggattcctag tctgctagca ttttgaaata ctgaagcagc
     4801 caaagaagcg agctagtcct gaaggatgtg aagatgatct gaaattgctt taaggtttcc
     4861 tgagagctgg tgagacagct taactgatgc acggaagcct ccagtctact gttttagttc
     4921 agagtcctga aaaaagggcc cagagtggca agaagaggga tgagttgaat ggctcattag
     4981 tccctctttc agaggtcacc cgaactgctt ttaggaggtt gggtgcacag aactcttaac
     5041 tgcttagagc tgacaaaggg gtgatgtagg aagggcagct taatcaagtg cctcagagga
     5101 gggtccatct aaggggccac cgtaaactta acagatggca aagatacaga acataagaca
     5161 gccatttgat gacaacgttt tatctcagtt agaggaaact gggcctagag atttcagcag
     5221 aaatagtagg catcgggacc ccgcttctca ctgacagcag cctgcctagc acttggctga
     5281 ttatcctttg agtctctgtt gggacctgta aatctcaaag tgttagctcc tttggttagc
     5341 atgccagtgt gggaggcatg tggctgggaa catctttatg tcctctttga agccagtaaa
     5401 tgtatcatgc aaagactgta tcaaagtgaa aacaaaacat taaaatcaca aaataacaaa
     5461 aaaaaaaaaa aaaa
//
