LOCUS       NM_016748               2726 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus cytidine 5'-triphosphate synthase 1 (Ctps1),
            transcript variant 1, mRNA.
ACCESSION   NM_016748
VERSION     NM_016748.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2726)
  AUTHORS   Soudais,C., Schaus,R., Bachelet,C., Minet,N., Mouasni,S.,
            Garcin,C., Souza,C.L., David,P., Cousu,C., Asnagli,H., Parker,A.,
            Palmquist-Gomes,P., Sepulveda,F.E., Storck,S., Meilhac,S.M.,
            Fischer,A., Martin,E. and Latour,S.
  TITLE     Inactivation of cytidine triphosphate synthase 1 prevents fatal
            auto-immunity in mice
  JOURNAL   Nat Commun 15 (1), 1982 (2024)
   PUBMED   38438357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2726)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2726)
  AUTHORS   Peng,M., Chang,C.C., Liu,J.L. and Sung,L.Y.
  TITLE     CTPS and IMPDH form cytoophidia in developmental thymocytes
  JOURNAL   Exp Cell Res 405 (1), 112662 (2021)
   PUBMED   34022203
REFERENCE   4  (bases 1 to 2726)
  AUTHORS   Tang,R., Cui,X.B., Wang,J.N. and Chen,S.Y.
  TITLE     CTP synthase 1, a smooth muscle-sensitive therapeutic target for
            effective vascular repair
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (10), 2336-2344 (2013)
   PUBMED   24008161
  REMARK    GeneRIF: CTPS1 inhibition selectively blocks smooth muscle cell
            proliferation without disturbing or even promoting
            re-endothelialization for effective vascular repair after injury.
REFERENCE   5  (bases 1 to 2726)
  AUTHORS   Balzarini,J., Gago,F., Kulik,W., van Kuilenburg,A.B., Karlsson,A.,
            Peterson,M.A. and Robins,M.J.
  TITLE     Introduction of a fluorine atom at C3 of 3-deazauridine shifts its
            antimetabolic activity from inhibition of CTP synthetase to
            inhibition of orotidylate decarboxylase, an early event in the de
            novo pyrimidine nucleotide biosynthesis pathway
  JOURNAL   J Biol Chem 287 (36), 30444-30454 (2012)
   PUBMED   22730407
  REMARK    GeneRIF: Introduction of a fluorine atom at C3 of 3-deazauridine
            shifts its antimetabolic activity from inhibition of CTP synthetase
            to inhibition of orotidylate decarboxylase, an early event in the
            de novo pyrimidine nucleotide biosynthesis pathway.
REFERENCE   6  (bases 1 to 2726)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146476.1, AK148259.1, AK161110.1 and CD363725.1.
            
            On Apr 4, 2008 this sequence version replaced NM_016748.1.
            
            Transcript Variant: This variant represents the shorter transcript.
            Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006698.1, AK146476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AK146476.1         2-53
            53-2102             AK148259.1         2-2051
            2103-2419           AK161110.1         2049-2365
            2420-2726           CD363725.1         113-419
FEATURES             Location/Qualifiers
     source          1..2726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 56.52 cM"
     gene            1..2726
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /note="cytidine 5'-triphosphate synthase 1"
                     /db_xref="GeneID:51797"
                     /db_xref="MGI:MGI:1858304"
     exon            1..126
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            127..304
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1914
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /EC_number="6.3.4.2"
                     /note="CTP synthetase 1; UTP--ammonia ligase 1"
                     /codon_start=1
                     /product="CTP synthase 1"
                     /protein_id="NP_058028.2"
                     /db_xref="CCDS:CCDS18591.1"
                     /db_xref="GeneID:51797"
                     /db_xref="MGI:MGI:1858304"
                     /translation="MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDPYIN
                     IDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKER
                     KGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFI
                     EAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRC
                     SNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIER
                     QSRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEI
                     KYIDSTDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARKQK
                     KPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPKTSHPVVIDMPEHNPGQMGGTMRL
                     GKRRTLFQTKNSVMRKLYGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGER
                     MEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPRDT
                     YSDRSGSSSPDSEITELKFPSISQD"
     exon            305..475
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            476..576
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            577..693
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            694..777
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            778..858
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1010
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1143
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1232
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1327
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1390
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1434
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1531
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1587
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1684
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1829
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1918
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2705
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2687..2692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /note="major polyA site"
ORIGIN      
        1 gcctagagcc cgcctctcag aaagacggct ggcgcatgcg gcccggccga gcactggctg
       61 cccgaggctc accacgcgcg cgccggcctt gctgtggctg acacgagact ccgaagccgg
      121 cctcaggtta aaagaaaaat gaagtacatt ctagttactg gtggtgttat atcaggaatt
      181 ggaaaaggag tcatcgccag cagtgtgggc acaatactta aatcatgtgg cttacatgta
      241 acatcaatta agattgaccc ctatattaac attgatgcag gaacattctc tccttatgaa
      301 catggagaag tctttgtgct ggatgatggt ggagaagttg accttgactt gggaaattat
      361 gagcgattcc ttgatatccg tctcaccaag gacaataatc tgaccacagg gaagatatac
      421 cagtacgtca ttaacaagga gcgcaaaggg gattacttag ggaagactgt ccaggttgtc
      481 cctcacatca ctgatgcaat ccaagagtgg gtgatgagac aggcattaat acccgtagac
      541 gaagatggct tagaacctca agtgtgtgtt attgagcttg gtggcacagt gggagacatt
      601 gaaagcatgc ccttcattga ggccttccgc cagttccagt tcaaggtcaa gagggaaaac
      661 ttttgtaata tccatgtcag tctggttcct cagccaagtt caacagggga acagaagaca
      721 aaacccaccc agaacagtgt tcgggaactt agaggactcg ggctttctcc agacttagtg
      781 gtgtgcaggt gctcaaatcc tcttgacaca tctgtgaaag agaaaatatc aatgttttgc
      841 catgtggaac ctgaacaagt gatctgtgtt catgatgttt catccatcta ccgggtaccc
      901 ttgttgttag aagagcaagg ggttgtagac tactttcttc ggagacttga ccttcctatt
      961 gagagacagt cacgaaagat gctgatgaaa tggaaagaga tggcagacag gtatgaccgc
     1021 ttgctggaga cctgctcgat cgctcttgtg ggcaaataca ccaaattctc agactcgtac
     1081 gcctctgtca ttaaagcgct agagcactct gcattggcca ttaaccacaa gctggagatc
     1141 aagtacatcg attccacaga cctggagcca agtaccctgc aggaagagcc tgtgcgctac
     1201 catgaggcat ggcagaagct ctgcagtgct catggagtgc tggttccagg aggatttggt
     1261 gttcggggaa cagaaggaaa aattcaagca attgcttggg ctcggaaaca gaagaagcct
     1321 tttttgggtg tgtgcttagg aatgcagcta gcagtggtag aattttcaag aaatgtgctg
     1381 ggatggcaag atgccaattc tacagagttt gaccccaaga ctagtcaccc tgtggttata
     1441 gacatgccag aacataaccc tgggcaaatg ggtggaacca tgaggctggg caagaggaga
     1501 accctgttcc agaccaagaa ctcagtcatg aggaaactct atggagacac agactacttg
     1561 gaagaaaggc accgccaccg atttgaggtg aacccagtcc tgaaaaagtg cttggaagag
     1621 caaggcttga agttcgttgg ccaagatgtg gaaggcgaga ggatggagat cgtggagttg
     1681 gaagatcatc cattttttgt tggagtgcag tatcaccccg agttcctgtc caggcctatc
     1741 aagccctccc caccctactt tggcctcctc ctggcctctg tggggcggct cccacattac
     1801 cttcagaaag gttgccggct ctcacccagg gacacttaca gtgacagaag cgggagcagc
     1861 tcccccgact cggaaatcac tgaactcaag tttccatcaa taagtcagga ctgatctgga
     1921 tgagtcttca acttcagctt tgacagttta caactatgat tttacatcct gcttttgaca
     1981 cttcttttaa attatgtttt tattaagatt attttattat gggggaaaag catttggaaa
     2041 actttgtcac ttgcatgtcc cgtcatttat acttgatcct gcaacacatg tatttgtgcg
     2101 acaataatac ctttgcagtt tttgtgcttc tgtgatggga aacaggactc tggatggaac
     2161 ctgatggtgg ctgctggctg tggttaaggg ccatcaacca ccttgttttc cagccactcg
     2221 agtcactgtc attggagtga attgctgttg tctccctggg gtgccaggac tcccggtgct
     2281 gggctgctaa ctgggtgttg ctgacatctc agtgctgctg agttacaggg gactaggtgc
     2341 cagctgtggt tgccctcgcc atccagaggg ttgtttggtt ctttggtaca tcaaactctg
     2401 tctgtataaa gtatcatata aaaaccccgg gtctctggct acactttcta ttcctggggc
     2461 tgagaaaact ccttgcatca aggggtcaag aaacacggaa ttttagggta accggttcta
     2521 aagccctctc ttgtgtgtgc accgttggct tgaaggtatt ttttttcttc cagaatggtg
     2581 ttattgcatt tgaaatgcaa tttgaagtta ttttcttaat gtgatatggc aatgggcatg
     2641 accatgtgcc tacagtatgg tggttagctt gatgcatatc taacttaata aataatgcag
     2701 aaccaaaaaa aaaaaaaaaa aaaaaa
//
