LOCUS       NM_008729               6006 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus catenin delta 2 (Ctnnd2), transcript variant 1, mRNA.
ACCESSION   NM_008729 XM_907776 XM_920546
VERSION     NM_008729.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6006)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6006)
  AUTHORS   Xu,M., Wang,X., Wang,L., Wang,S., Deng,J., Wang,Y., Li,Y., Pan,S.,
            Liao,A., Tao,Y. and Tan,S.
  TITLE     Effects of chronic sleep restriction on the neuro-phenotypes of
            Ctnnd2 knockout mice
  JOURNAL   Brain Behav 13 (7), e3075 (2023)
   PUBMED   37226399
  REMARK    GeneRIF: Effects of chronic sleep restriction on the
            neuro-phenotypes of Ctnnd2 knockout mice.
REFERENCE   3  (bases 1 to 6006)
  AUTHORS   Mendez-Vazquez,H., Roach,R.L., Nip,K., Chanda,S., Sathler,M.F.,
            Garver,T., Danzman,R.A., Moseley,M.C., Roberts,J.P., Koch,O.N.,
            Steger,A.A., Lee,R., Arikkath,J. and Kim,S.
  TITLE     The autism-associated loss of delta-catenin functions disrupts
            social behavior
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2300773120 (2023)
   PUBMED   37216537
REFERENCE   4  (bases 1 to 6006)
  AUTHORS   Martin,J.B., Herman,K., Houssin,N.S., Rich,W., Reilly,M.A. and
            Plageman,T.F. Jr.
  TITLE     Arvcf Dependent Adherens Junction Stability is Required to Prevent
            Age-Related Cortical Cataracts
  JOURNAL   Front Cell Dev Biol 10, 840129 (2022)
   PUBMED   35874813
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6006)
  AUTHORS   Wang,X., Xu,M., Xu,Q., Yang,F., Tang,H., Shao,C., Wang,L., Wang,Y.,
            Deng,J. and Wang,S.
  TITLE     Rictor is involved in Ctnnd2 deletion-induced impairment of spatial
            learning and memory but not autism-like behaviors
  JOURNAL   Front Biosci (Landmark Ed) 26 (8), 335-346 (2021)
   PUBMED   34455763
  REMARK    GeneRIF: Rictor is involved in Ctnnd2 deletion-induced impairment
            of spatial learning and memory but not autism-like behaviors.
REFERENCE   6  (bases 1 to 6006)
  AUTHORS   Ho,C., Zhou,J., Medina,M., Goto,T., Jacobson,M., Bhide,P.G. and
            Kosik,K.S.
  TITLE     delta-catenin is a nervous system-specific adherens junction
            protein which undergoes dynamic relocalization during development
  JOURNAL   J Comp Neurol 420 (2), 261-276 (2000)
   PUBMED   10753311
REFERENCE   7  (bases 1 to 6006)
  AUTHORS   Kawamura,Y., Fan,Q.W., Hayashi,H., Michikawa,M., Yanagisawa,K. and
            Komano,H.
  TITLE     Expression of the mRNA for two isoforms of neural
            plakophilin-related arm-repeat protein/delta-catenin in rodent
            neurons and glial cells
  JOURNAL   Neurosci Lett 277 (3), 185-188 (1999)
   PUBMED   10626844
REFERENCE   8  (bases 1 to 6006)
  AUTHORS   Paffenholz,R., Kuhn,C., Grund,C., Stehr,S. and Franke,W.W.
  TITLE     The arm-repeat protein NPRAP (neurojungin) is a constituent of the
            plaques of the outer limiting zone in the retina, defining a novel
            type of adhering junction
  JOURNAL   Exp Cell Res 250 (2), 452-464 (1999)
   PUBMED   10413599
REFERENCE   9  (bases 1 to 6006)
  AUTHORS   Lu,Q., Paredes,M., Medina,M., Zhou,J., Cavallo,R., Peifer,M.,
            Orecchio,L. and Kosik,K.S.
  TITLE     delta-catenin, an adhesive junction-associated protein which
            promotes cell scattering
  JOURNAL   J Cell Biol 144 (3), 519-532 (1999)
   PUBMED   9971746
REFERENCE   10 (bases 1 to 6006)
  AUTHORS   Paffenholz,R. and Franke,W.W.
  TITLE     Identification and localization of a neurally expressed member of
            the plakoglobin/armadillo multigene family
  JOURNAL   Differentiation 61 (5), 293-304 (1997)
   PUBMED   9342840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124993.19, AC124675.9, AC134414.12, AC110569.8, AC139197.10 and
            AC105408.5.
            
            On Feb 25, 2019 this sequence version replaced NM_008729.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U90331.1, BC138261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-630               AC124993.19        159979-160608       c
            631-767             AC124993.19        996-1132            c
            768-880             AC124675.9         21901-22013         c
            881-912             AC134414.12        89725-89756         c
            913-1029            AC134414.12        89039-89155         c
            1030-1202           AC134414.12        74162-74334         c
            1203-1758           AC134414.12        61654-62209         c
            1759-1953           AC134414.12        39372-39566         c
            1954-2209           AC134414.12        25508-25763         c
            2210-2342           AC110569.8         110808-110940
            2343-2556           AC110569.8         142395-142608
            2557-2740           AC110569.8         182937-183120
            2741-2858           AC139197.10        68991-69108
            2859-3044           AC139197.10        74962-75147
            3045-3218           AC139197.10        93528-93701
            3219-3293           AC139197.10        108580-108654
            3294-3444           AC139197.10        109723-109873
            3445-3655           AC139197.10        154624-154834
            3656-3740           AC139197.10        160661-160745
            3741-3867           AC105408.5         115705-115831       c
            3868-3999           AC105408.5         111616-111747       c
            4000-4073           AC105408.5         100006-100079       c
            4074-6006           AC105408.5         91436-93368         c
FEATURES             Location/Qualifiers
     source          1..6006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 12.02 cM"
     gene            1..6006
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="catenin delta 2"
                     /db_xref="GeneID:18163"
                     /db_xref="MGI:MGI:1195966"
     exon            1..630
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..4334
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neural plakophilin-related arm-repeat protein; catenin
                     (cadherin-associated protein), delta 2 (neural
                     plakophilin-related arm-repeat protein); neurojungin;
                     catenin (cadherin associated protein), delta 2"
                     /codon_start=1
                     /product="catenin delta-2 isoform 1"
                     /protein_id="NP_032755.2"
                     /db_xref="CCDS:CCDS27405.1"
                     /db_xref="GeneID:18163"
                     /db_xref="MGI:MGI:1195966"
                     /translation="MFARKQSGAAPFGAMPVPDQPPSASEKNSSLSPGLNTSNGDGSE
                     TETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSISSAEQFH
                     WQTQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTSERPSLLSQSALQLNSK
                     PEGSFQYPASYHSNQTLALGDTAPSQLPARSTQARAAGQSFSQGTTGRAGHLAGSEPA
                     PPPPPPREPFAPSLGSAFHLPDAPPAAAALYYSSSTLPAPPRGGSPLTTTQGGSPTKL
                     QRGGSAPEGAAYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQ
                     STISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSR
                     ASYSSQHGHLAPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTFR
                     TSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCASV
                     DSPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNA
                     AAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDN
                     KIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAV
                     IIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALL
                     YVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGETNGKD
                     TESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNP
                     DTLEGAAGALQNLAAGSWKGWAEDVAGMAYALRSLPEGAPCLPQWSVYIRAAVRKEKG
                     LPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNSG
                     SKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAA
                     SQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPN
                     NRSASAPASPREMISLKERKTDYESAGNNATYHGTKGEHTSRKDTMTAQNTGVSTLYR
                     NSYGAPAEDIKQNQVSTQPVPQEPSRKDYETYQPFPNSTRNYDESFFEDQVHHRPPAS
                     EYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV"
     exon            631..767
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            768..880
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            881..912
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1029
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1202
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1758
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1953
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2209
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2342
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2556
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2740
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2858
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3044
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3218
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3293
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3444
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3655
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3740
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3867
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..3999
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4073
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..6006
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4871..4876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: ATTAAA"
     polyA_site      4907
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     regulatory      5268..5273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     polyA_site      5294
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     regulatory      5979..5984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     regulatory      5989..5994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     polyA_site      6002
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     polyA_site      6006
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
ORIGIN      
        1 atgctccgca cccggggcag gtttcggtgg tggggcggac gctcgctcgc tcactagcca
       61 agcgccggag ccggccgccg cggctgagcc ggaggctgag ctgcggcgcg cggcgggagg
      121 agcctcgctc tcggcggcgg cggcggcggc ggcgacacag gtggcgcggg cggcgcgcag
      181 ggcgcagctc gagagcgctc ggcgccgggc gccagggcgg cccaggctcg cgcccgcggc
      241 ggcaaccggc cgagcggagc ggcgggcgcg gcggctcggt agcccggccc gagcccgggg
      301 agccccgcgg aaccctgagc atcccgcggc gcccgccgag tcgggcaggg ggcgctacgc
      361 tcgccgcgct cggaggggcg gccgggccgg gcgctgcgca ctcgcgtcgg gagccgcctc
      421 tcgcctgccg cgctcgcccc tgctccccgc cagcatcact tgtcccgcgg ccgcgctccg
      481 acaacaaaag cggaggatgc tgcagctggg caaggtcagg accttgctct gaagccgggc
      541 ggcggcgcgc acgcctttcc cccgactgag gagctgtctt tggcggcggg tgcatgttcg
      601 ccaggaagca gtcgggcgcc gcgccgttcg gagctatgcc tgtcccagac cagcctccat
      661 cagcctcaga gaagaacagc tccttgagcc caggcttaaa cacctccaat ggtgatggct
      721 ctgagacgga aaccacctct gctatccttg cctccgtcaa agaacaggaa ttacagtttg
      781 aaaggctgac ccgagagctg gaggctgaac gccagatcgt agccagccag ctggagcgat
      841 gcaagcttgg ctcggagaca ggaagcatga gcagtatcag ttcagcagag cagtttcact
      901 ggcagacaca agatggccaa aaagatatcg aagatgaact tacaacgggc cttgagctgg
      961 tggactcctg tatccgctct ctgcaggagt caggcattct ggacccacag gattactcca
     1021 caagtgaaag gcctagcctg ctctcccaga gtgcacttca gctcaattct aaacctgaag
     1081 ggtctttcca gtatccggcc agctaccata gcaaccagac cctggccctg ggtgacacag
     1141 ccccttctca gctcccagca cgcagcacgc aagcccgagc tgccggccag agcttcagcc
     1201 agggcacgac cggccgcgcg gggcacctgg cgggctccga gcctgcgcca ccgcctccgc
     1261 ctccgcggga accgttcgcg cccagcctgg gcagcgcctt ccacctgccc gacgcgccgc
     1321 ccgccgccgc ggcgctctac tactccagct ccacgctgcc cgcgccgccg cgcgggggct
     1381 ccccgctgac caccacgcag ggcggctcac ccaccaagct gcagcgcgga ggctcggccc
     1441 ccgagggtgc cgcctacgcc gcgccgcgcg gctcctcgcc caagcagtcg cccagccgcc
     1501 tggctaagtc ctacagcacc agctcgccca tcaacatcgt cgtgtcctcg gccggcctgt
     1561 ccccgatccg cgtgacctcg ccccccaccg tgcagtccac catctcctct tcgcccatcc
     1621 accagctgag ctccaccatc ggcacctacg ccaccctgtc gcccaccaag cgcctggtcc
     1681 acgcgtctga gcagtacagc aagcattcgc aggagctgta tgccaccgcc accctccaga
     1741 ggccgggcag cctggcagct ggatcccgag cctcgtatag cagccagcat gggcacctgg
     1801 cccctgagct gcgggccctg cagtccccag agcaccacat agaccccatc tatgaagacc
     1861 gtgtctatca gaagccccct atgaggagtc tcagccagag ccagggggat cctctgccgc
     1921 cagcacatac cggcaccttc cgcacgagca cagccccgtc ctcccctggt gtcgactccg
     1981 tccccttgca gcgcacaggc agccaacacg ggccacagaa tgccgccgca gccaccttcc
     2041 agagggccag ctatgctgcc ggcccagcct ccaactacgc agacccctac cgacagctgc
     2101 agtattgtgc ctccgttgac tctccgtaca gcaaatctgg ccctgccctc ccacccgaag
     2161 gcaccttggc cagatcccca tccatcgaca gcattcagaa agaccccagg gagtttggat
     2221 ggagagaccc ggagctgcct gaagtgatac agatgttaca gcaccagttc ccttcagtcc
     2281 agtccaatgc tgcagcttac ctgcaacacc tctgttttgg agacaataaa attaaggcag
     2341 agataaggag acaaggaggg atacagctcc tggtggacct gctggatcac cgaatgacag
     2401 aagtccaccg tagtgcctgt ggggctctga ggaacctggt gtatgggaag gccaatgatg
     2461 ataacaaaat cgccctgaaa aactgtggtg gtatcccagc gctggtgaga ctccttcgca
     2521 agaccacaga cctggagatc cgggagctgg tcacaggagt cctttggaac ctctcatcat
     2581 gtgatgcact caaaatgcca atcatccagg acgccctggc agtgctgacc aatgcggtga
     2641 ttatccctca ctcgggctgg gagaattcac ctcttcagga tgatcggaaa atacagctgc
     2701 attcatcaca ggtgctgcgc aacgccactg ggtgcctaag gaatgtaagt tcagctggag
     2761 aggaggcccg ccgaaggatg cgggagtgtg atgggctcac ggatgccttg ctgtacgtga
     2821 tccagtctgc actggggagc agtgagatcg atagcaagac cgttgaaaac tgtgtgtgca
     2881 tcttgaggaa cctctcctac cggctagcag cagaaacgtc tcagggacag cacatgggca
     2941 cagacgagct ggacgggctg ctctgcgggg agaccaacgg caaagacaca gagagttctg
     3001 ggtgctgggg caagaagaag aagaaaaaga aatcccagga ccagtgggat ggagtaggac
     3061 ctcttccaga ctgtgcagag ccaccaaaag ggatccagat gctgtggcac ccgtccatag
     3121 tcaaacccta cctcacactg ctctctgagt gctcaaaccc agacacgctg gaaggggcag
     3181 cgggcgccct gcagaacttg gctgcaggga gctggaaggg ctgggctgag gatgtggcag
     3241 gcatggcgta tgccctacgt tcactgccag agggggctcc ctgcctgcca cagtggtccg
     3301 tgtatatccg agctgctgtc cggaaagaga aaggcctgcc cattcttgtg gagctcctcc
     3361 gaatagacaa tgaccgtgta gtgtgtgcag tggccacagc acttcggaac atggccctcg
     3421 atgtcagaaa caaggaactc attggcaagt atgccatgcg agacctggtc caccggcttc
     3481 ctggtgggaa caacagcaac aactcgggga gcaaggccat gtcagatgac accgtgacgg
     3541 ccgtgtgctg caccctgcat gaagtgatca ccaagaacat ggagaatgcc aaggccttac
     3601 gggatgctgg tggcatcgag aagttggtcg gcatctctaa aagcaaagga gacaagcact
     3661 ctccaaaggt ggtcaaggct gcttctcagg tcctaaacag catgtggcag tatcgcgatc
     3721 tgaggagtct ctacaagaag gatggatggt cacaatatca ctttgtagcc tcatcttcaa
     3781 ccatcgagag ggatcgacaa aggccctact cctcctcccg cacaccctcc atctctcccg
     3841 tgcgtgtgtc tcccaacaac cgctcagcaa gtgccccagc ttcacctcgg gaaatgatca
     3901 gcctcaaaga aaggaagacg gactacgagt ccgctggcaa caacgccact taccacggaa
     3961 ctaaaggaga acacacctcc agaaaagaca ccatgacagc tcaaaacact ggagtttcaa
     4021 ctttgtacag gaattcatac ggtgcgcccg ctgaagacat caaacagaac caggtttcca
     4081 cacagcctgt ccctcaggag cccagcagga aagactacga gacctaccag ccctttccga
     4141 attccacacg aaattatgat gagtccttct ttgaggacca ggtccaccac cgccctccag
     4201 ccagcgagta caccatgcac ctgggcctca agtccactgg caactatgtc gacttctact
     4261 ctgcagcccg tccttacagt gaactgaact atgaaacgag ccactacccg gcctcgcccg
     4321 actcctgggt gtaaggagcc aggacacgag gcactccggg gacagtgcat gtgcatgcat
     4381 acaccacagg acattttgtt tctttttttc ttttcttttc ttttgttttt ttttttcttt
     4441 ccctgcaaat ttagtttgtt aaagcctgtt ccgtaggaag gctgtgataa ccaggaagaa
     4501 atactcagag ctattttaga aagctaaaat gaatcaagag ttaactggga aatcgatagg
     4561 aagctaaacg caatcctaat tgtgaccgca ttcaacacct ttctagtttg aactatagca
     4621 ttttgaaagt gctttatagt ccggtgaggc tgaaggtagg agagaggaga cagtcagggt
     4681 ggtgggcgtg gttatcgcta agcacaagac agactagttt acacactgtg gggacggctt
     4741 ctcacgcttt gtttactctc ttcatccgtg tgactctagg cttcaagttg cattggggtt
     4801 cctctgtaca gcaagacgtc tcttgccttt tgttaatgca ttgttgtaaa gtattcgatg
     4861 tacattacag attaaagacg aagagtgcat tgtgtatatt acaccaatgc cactgtgttt
     4921 cctcatcaat ggttctaaat attgcttcaa tttcaaactt ttgaaagatg tatgggtttc
     4981 caattttctt tttttttttc tttctcccag tatgttttaa caaaaaagga aaaaaaaaaa
     5041 caggaaaaaa aaaaaaggaa tatttagcag tattgttcgt tctgatatgt gatttgtttg
     5101 tggcaactaa acgcggcatc cagcagtctc tcccaagcta acaagtcatt ccacacccct
     5161 cgtcaacaaa atgctttttc actgcctaaa attctagatg tagatatttg aaatagattt
     5221 ttttcattta taccagtttt ctttatgata atacagtgtt aaaagaaaat aaattacaat
     5281 tgatctgtca tccatccttg ctaagaatgt ctatttccat ggaccagtct tacaaaatac
     5341 acattcttgc acgtgtgtct gtgcgtgtgt gggtgcgtgt gggtgtgtcg gtgtatgtgc
     5401 aaagctgacc tgtgtggggt tgtatctgga tagaagcagt ttcatccgct gtccatcgtg
     5461 tgtgccagcc ttcgttttcc cagcatccgt gtgcatccgt ctgtccctct tgtaacgtat
     5521 ctatccgctc ttctcaccat ctagtggctc aggatattag gccagctgag ataaagtagg
     5581 atttttcacg cgatcacaca ttcttggacg ccaactcttt tctacaggtc aatcccttcc
     5641 atattttatg ctctcagaac atgctaaacc atggtcactc aactcggtag tttccctttg
     5701 gggccaatta cttgaagtat caatagaaga tgtaaactgc tcaccttatt ccctttcaaa
     5761 ctgttctttt gtttatgtgg cagggagcag tagacaatta tgggctagat gattaaaact
     5821 gaactcaaag ctaacgttag actagtggtt aacagagcta agaaataagg ctaaccattt
     5881 cagagaacgt gggctgttgg gtaaattagc tttgctcttt agatgcaagt gactgaggcc
     5941 aacaggtgcc tggcaaatgt taactgttct tggaaaaaaa taaaaaaaaa taaataacaa
     6001 aagaaa
//
