LOCUS       NM_001411453            5334 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus catenin delta 2 (Ctnnd2), transcript variant 4, mRNA.
ACCESSION   NM_001411453 XM_030248380
VERSION     NM_001411453.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5334)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5334)
  AUTHORS   Xu,M., Wang,X., Wang,L., Wang,S., Deng,J., Wang,Y., Li,Y., Pan,S.,
            Liao,A., Tao,Y. and Tan,S.
  TITLE     Effects of chronic sleep restriction on the neuro-phenotypes of
            Ctnnd2 knockout mice
  JOURNAL   Brain Behav 13 (7), e3075 (2023)
   PUBMED   37226399
  REMARK    GeneRIF: Effects of chronic sleep restriction on the
            neuro-phenotypes of Ctnnd2 knockout mice.
REFERENCE   3  (bases 1 to 5334)
  AUTHORS   Mendez-Vazquez,H., Roach,R.L., Nip,K., Chanda,S., Sathler,M.F.,
            Garver,T., Danzman,R.A., Moseley,M.C., Roberts,J.P., Koch,O.N.,
            Steger,A.A., Lee,R., Arikkath,J. and Kim,S.
  TITLE     The autism-associated loss of delta-catenin functions disrupts
            social behavior
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2300773120 (2023)
   PUBMED   37216537
REFERENCE   4  (bases 1 to 5334)
  AUTHORS   Martin,J.B., Herman,K., Houssin,N.S., Rich,W., Reilly,M.A. and
            Plageman,T.F. Jr.
  TITLE     Arvcf Dependent Adherens Junction Stability is Required to Prevent
            Age-Related Cortical Cataracts
  JOURNAL   Front Cell Dev Biol 10, 840129 (2022)
   PUBMED   35874813
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5334)
  AUTHORS   Wang,X., Xu,M., Xu,Q., Yang,F., Tang,H., Shao,C., Wang,L., Wang,Y.,
            Deng,J. and Wang,S.
  TITLE     Rictor is involved in Ctnnd2 deletion-induced impairment of spatial
            learning and memory but not autism-like behaviors
  JOURNAL   Front Biosci (Landmark Ed) 26 (8), 335-346 (2021)
   PUBMED   34455763
  REMARK    GeneRIF: Rictor is involved in Ctnnd2 deletion-induced impairment
            of spatial learning and memory but not autism-like behaviors.
REFERENCE   6  (bases 1 to 5334)
  AUTHORS   Ho,C., Zhou,J., Medina,M., Goto,T., Jacobson,M., Bhide,P.G. and
            Kosik,K.S.
  TITLE     delta-catenin is a nervous system-specific adherens junction
            protein which undergoes dynamic relocalization during development
  JOURNAL   J Comp Neurol 420 (2), 261-276 (2000)
   PUBMED   10753311
REFERENCE   7  (bases 1 to 5334)
  AUTHORS   Kawamura,Y., Fan,Q.W., Hayashi,H., Michikawa,M., Yanagisawa,K. and
            Komano,H.
  TITLE     Expression of the mRNA for two isoforms of neural
            plakophilin-related arm-repeat protein/delta-catenin in rodent
            neurons and glial cells
  JOURNAL   Neurosci Lett 277 (3), 185-188 (1999)
   PUBMED   10626844
REFERENCE   8  (bases 1 to 5334)
  AUTHORS   Paffenholz,R., Kuhn,C., Grund,C., Stehr,S. and Franke,W.W.
  TITLE     The arm-repeat protein NPRAP (neurojungin) is a constituent of the
            plaques of the outer limiting zone in the retina, defining a novel
            type of adhering junction
  JOURNAL   Exp Cell Res 250 (2), 452-464 (1999)
   PUBMED   10413599
REFERENCE   9  (bases 1 to 5334)
  AUTHORS   Lu,Q., Paredes,M., Medina,M., Zhou,J., Cavallo,R., Peifer,M.,
            Orecchio,L. and Kosik,K.S.
  TITLE     delta-catenin, an adhesive junction-associated protein which
            promotes cell scattering
  JOURNAL   J Cell Biol 144 (3), 519-532 (1999)
   PUBMED   9971746
REFERENCE   10 (bases 1 to 5334)
  AUTHORS   Paffenholz,R. and Franke,W.W.
  TITLE     Identification and localization of a neurally expressed member of
            the plakoglobin/armadillo multigene family
  JOURNAL   Differentiation 61 (5), 293-304 (1997)
   PUBMED   9342840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124675.9, AC134414.12, AC110569.8, AC139197.10 and AC105408.5.
            
            On Aug 25, 2022 this sequence version replaced XM_030248380.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.575364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AC124675.9         44953-45122         c
            171-283             AC124675.9         21901-22013         c
            284-315             AC134414.12        89725-89756         c
            316-432             AC134414.12        89039-89155         c
            433-605             AC134414.12        74162-74334         c
            606-1161            AC134414.12        61654-62209         c
            1162-1356           AC134414.12        39372-39566         c
            1357-1612           AC134414.12        25508-25763         c
            1613-1745           AC110569.8         110808-110940
            1746-1959           AC110569.8         142395-142608
            1960-2143           AC110569.8         182937-183120
            2144-2261           AC139197.10        68991-69108
            2262-2447           AC139197.10        74962-75147
            2448-2621           AC139197.10        93528-93701
            2622-2772           AC139197.10        109723-109873
            2773-2983           AC139197.10        154624-154834
            2984-3068           AC139197.10        160661-160745
            3069-3195           AC105408.5         115705-115831       c
            3196-3327           AC105408.5         111616-111747       c
            3328-3401           AC105408.5         100006-100079       c
            3402-5334           AC105408.5         91436-93368         c
FEATURES             Location/Qualifiers
     source          1..5334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 12.02 cM"
     gene            1..5334
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="catenin delta 2"
                     /db_xref="GeneID:18163"
                     /db_xref="MGI:MGI:1195966"
     exon            1..170
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            171..283
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..3662
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="isoform 3 is encoded by transcript variant 4;
                     neural plakophilin-related arm-repeat protein; catenin
                     (cadherin-associated protein), delta 2 (neural
                     plakophilin-related arm-repeat protein); neurojungin;
                     catenin (cadherin associated protein), delta 2"
                     /codon_start=1
                     /product="catenin delta-2 isoform 3"
                     /protein_id="NP_001398382.1"
                     /db_xref="GeneID:18163"
                     /db_xref="MGI:MGI:1195966"
                     /translation="MSSISSAEQFHWQTQDGQKDIEDELTTGLELVDSCIRSLQESGI
                     LDPQDYSTSERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGDTAPSQLPARSTQ
                     ARAAGQSFSQGTTGRAGHLAGSEPAPPPPPPREPFAPSLGSAFHLPDAPPAAAALYYS
                     SSTLPAPPRGGSPLTTTQGGSPTKLQRGGSAPEGAAYAAPRGSSPKQSPSRLAKSYST
                     SSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQ
                     YSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLAPELRALQSPEHHIDPIYEDRVY
                     QKPPMRSLSQSQGDPLPPAHTGTFRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQ
                     RASYAAGPASNYADPYRQLQYCASVDSPYSKSGPALPPEGTLARSPSIDSIQKDPREF
                     GWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDH
                     RMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVL
                     WNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCL
                     RNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAA
                     ETSQGQHMGTDELDGLLCGETNGKDTESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPP
                     KGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKG
                     LPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNSG
                     SKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAA
                     SQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPN
                     NRSASAPASPREMISLKERKTDYESAGNNATYHGTKGEHTSRKDTMTAQNTGVSTLYR
                     NSYGAPAEDIKQNQVSTQPVPQEPSRKDYETYQPFPNSTRNYDESFFEDQVHHRPPAS
                     EYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV"
     exon            284..315
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            316..432
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            433..605
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1161
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1356
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1612
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1745
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1959
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2143
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2261
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2447
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2621
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2772
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2983
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3068
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3195
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3327
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3401
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..5334
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4199..4204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: ATTAAA"
     polyA_site      4235
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     regulatory      4596..4601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     polyA_site      4622
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     regulatory      5307..5312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     regulatory      5317..5322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     polyA_site      5330
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     polyA_site      5334
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
ORIGIN      
        1 atctgatgca tcccgctttg ctttcgctga acactgtttg ctagtggaag cagaaattag
       61 agtgtggaaa ttgcgcatcc tgactttttt tctggaccac tcttctccgc cttcttggat
      121 tttgagctcc tccgcttgct tttagccttc tttccaggag ggaggagcag gaattacagt
      181 ttgaaaggct gacccgagag ctggaggctg aacgccagat cgtagccagc cagctggagc
      241 gatgcaagct tggctcggag acaggaagca tgagcagtat cagttcagca gagcagtttc
      301 actggcagac acaagatggc caaaaagata tcgaagatga acttacaacg ggccttgagc
      361 tggtggactc ctgtatccgc tctctgcagg agtcaggcat tctggaccca caggattact
      421 ccacaagtga aaggcctagc ctgctctccc agagtgcact tcagctcaat tctaaacctg
      481 aagggtcttt ccagtatccg gccagctacc atagcaacca gaccctggcc ctgggtgaca
      541 cagccccttc tcagctccca gcacgcagca cgcaagcccg agctgccggc cagagcttca
      601 gccagggcac gaccggccgc gcggggcacc tggcgggctc cgagcctgcg ccaccgcctc
      661 cgcctccgcg ggaaccgttc gcgcccagcc tgggcagcgc cttccacctg cccgacgcgc
      721 cgcccgccgc cgcggcgctc tactactcca gctccacgct gcccgcgccg ccgcgcgggg
      781 gctccccgct gaccaccacg cagggcggct cacccaccaa gctgcagcgc ggaggctcgg
      841 cccccgaggg tgccgcctac gccgcgccgc gcggctcctc gcccaagcag tcgcccagcc
      901 gcctggctaa gtcctacagc accagctcgc ccatcaacat cgtcgtgtcc tcggccggcc
      961 tgtccccgat ccgcgtgacc tcgcccccca ccgtgcagtc caccatctcc tcttcgccca
     1021 tccaccagct gagctccacc atcggcacct acgccaccct gtcgcccacc aagcgcctgg
     1081 tccacgcgtc tgagcagtac agcaagcatt cgcaggagct gtatgccacc gccaccctcc
     1141 agaggccggg cagcctggca gctggatccc gagcctcgta tagcagccag catgggcacc
     1201 tggcccctga gctgcgggcc ctgcagtccc cagagcacca catagacccc atctatgaag
     1261 accgtgtcta tcagaagccc cctatgagga gtctcagcca gagccagggg gatcctctgc
     1321 cgccagcaca taccggcacc ttccgcacga gcacagcccc gtcctcccct ggtgtcgact
     1381 ccgtcccctt gcagcgcaca ggcagccaac acgggccaca gaatgccgcc gcagccacct
     1441 tccagagggc cagctatgct gccggcccag cctccaacta cgcagacccc taccgacagc
     1501 tgcagtattg tgcctccgtt gactctccgt acagcaaatc tggccctgcc ctcccacccg
     1561 aaggcacctt ggccagatcc ccatccatcg acagcattca gaaagacccc agggagtttg
     1621 gatggagaga cccggagctg cctgaagtga tacagatgtt acagcaccag ttcccttcag
     1681 tccagtccaa tgctgcagct tacctgcaac acctctgttt tggagacaat aaaattaagg
     1741 cagagataag gagacaagga gggatacagc tcctggtgga cctgctggat caccgaatga
     1801 cagaagtcca ccgtagtgcc tgtggggctc tgaggaacct ggtgtatggg aaggccaatg
     1861 atgataacaa aatcgccctg aaaaactgtg gtggtatccc agcgctggtg agactccttc
     1921 gcaagaccac agacctggag atccgggagc tggtcacagg agtcctttgg aacctctcat
     1981 catgtgatgc actcaaaatg ccaatcatcc aggacgccct ggcagtgctg accaatgcgg
     2041 tgattatccc tcactcgggc tgggagaatt cacctcttca ggatgatcgg aaaatacagc
     2101 tgcattcatc acaggtgctg cgcaacgcca ctgggtgcct aaggaatgta agttcagctg
     2161 gagaggaggc ccgccgaagg atgcgggagt gtgatgggct cacggatgcc ttgctgtacg
     2221 tgatccagtc tgcactgggg agcagtgaga tcgatagcaa gaccgttgaa aactgtgtgt
     2281 gcatcttgag gaacctctcc taccggctag cagcagaaac gtctcaggga cagcacatgg
     2341 gcacagacga gctggacggg ctgctctgcg gggagaccaa cggcaaagac acagagagtt
     2401 ctgggtgctg gggcaagaag aagaagaaaa agaaatccca ggaccagtgg gatggagtag
     2461 gacctcttcc agactgtgca gagccaccaa aagggatcca gatgctgtgg cacccgtcca
     2521 tagtcaaacc ctacctcaca ctgctctctg agtgctcaaa cccagacacg ctggaagggg
     2581 cagcgggcgc cctgcagaac ttggctgcag ggagctggaa gtggtccgtg tatatccgag
     2641 ctgctgtccg gaaagagaaa ggcctgccca ttcttgtgga gctcctccga atagacaatg
     2701 accgtgtagt gtgtgcagtg gccacagcac ttcggaacat ggccctcgat gtcagaaaca
     2761 aggaactcat tggcaagtat gccatgcgag acctggtcca ccggcttcct ggtgggaaca
     2821 acagcaacaa ctcggggagc aaggccatgt cagatgacac cgtgacggcc gtgtgctgca
     2881 ccctgcatga agtgatcacc aagaacatgg agaatgccaa ggccttacgg gatgctggtg
     2941 gcatcgagaa gttggtcggc atctctaaaa gcaaaggaga caagcactct ccaaaggtgg
     3001 tcaaggctgc ttctcaggtc ctaaacagca tgtggcagta tcgcgatctg aggagtctct
     3061 acaagaagga tggatggtca caatatcact ttgtagcctc atcttcaacc atcgagaggg
     3121 atcgacaaag gccctactcc tcctcccgca caccctccat ctctcccgtg cgtgtgtctc
     3181 ccaacaaccg ctcagcaagt gccccagctt cacctcggga aatgatcagc ctcaaagaaa
     3241 ggaagacgga ctacgagtcc gctggcaaca acgccactta ccacggaact aaaggagaac
     3301 acacctccag aaaagacacc atgacagctc aaaacactgg agtttcaact ttgtacagga
     3361 attcatacgg tgcgcccgct gaagacatca aacagaacca ggtttccaca cagcctgtcc
     3421 ctcaggagcc cagcaggaaa gactacgaga cctaccagcc ctttccgaat tccacacgaa
     3481 attatgatga gtccttcttt gaggaccagg tccaccaccg ccctccagcc agcgagtaca
     3541 ccatgcacct gggcctcaag tccactggca actatgtcga cttctactct gcagcccgtc
     3601 cttacagtga actgaactat gaaacgagcc actacccggc ctcgcccgac tcctgggtgt
     3661 aaggagccag gacacgaggc actccgggga cagtgcatgt gcatgcatac accacaggac
     3721 attttgtttc tttttttctt ttcttttctt ttgttttttt ttttctttcc ctgcaaattt
     3781 agtttgttaa agcctgttcc gtaggaaggc tgtgataacc aggaagaaat actcagagct
     3841 attttagaaa gctaaaatga atcaagagtt aactgggaaa tcgataggaa gctaaacgca
     3901 atcctaattg tgaccgcatt caacaccttt ctagtttgaa ctatagcatt ttgaaagtgc
     3961 tttatagtcc ggtgaggctg aaggtaggag agaggagaca gtcagggtgg tgggcgtggt
     4021 tatcgctaag cacaagacag actagtttac acactgtggg gacggcttct cacgctttgt
     4081 ttactctctt catccgtgtg actctaggct tcaagttgca ttggggttcc tctgtacagc
     4141 aagacgtctc ttgccttttg ttaatgcatt gttgtaaagt attcgatgta cattacagat
     4201 taaagacgaa gagtgcattg tgtatattac accaatgcca ctgtgtttcc tcatcaatgg
     4261 ttctaaatat tgcttcaatt tcaaactttt gaaagatgta tgggtttcca attttctttt
     4321 tttttttctt tctcccagta tgttttaaca aaaaaggaaa aaaaaaaaca ggaaaaaaaa
     4381 aaaaggaata tttagcagta ttgttcgttc tgatatgtga tttgtttgtg gcaactaaac
     4441 gcggcatcca gcagtctctc ccaagctaac aagtcattcc acacccctcg tcaacaaaat
     4501 gctttttcac tgcctaaaat tctagatgta gatatttgaa atagattttt ttcatttata
     4561 ccagttttct ttatgataat acagtgttaa aagaaaataa attacaattg atctgtcatc
     4621 catccttgct aagaatgtct atttccatgg accagtctta caaaatacac attcttgcac
     4681 gtgtgtctgt gcgtgtgtgg gtgcgtgtgg gtgtgtcggt gtatgtgcaa agctgacctg
     4741 tgtggggttg tatctggata gaagcagttt catccgctgt ccatcgtgtg tgccagcctt
     4801 cgttttccca gcatccgtgt gcatccgtct gtccctcttg taacgtatct atccgctctt
     4861 ctcaccatct agtggctcag gatattaggc cagctgagat aaagtaggat ttttcacgcg
     4921 atcacacatt cttggacgcc aactcttttc tacaggtcaa tcccttccat attttatgct
     4981 ctcagaacat gctaaaccat ggtcactcaa ctcggtagtt tccctttggg gccaattact
     5041 tgaagtatca atagaagatg taaactgctc accttattcc ctttcaaact gttcttttgt
     5101 ttatgtggca gggagcagta gacaattatg ggctagatga ttaaaactga actcaaagct
     5161 aacgttagac tagtggttaa cagagctaag aaataaggct aaccatttca gagaacgtgg
     5221 gctgttgggt aaattagctt tgctctttag atgcaagtga ctgaggccaa caggtgcctg
     5281 gcaaatgtta actgttcttg gaaaaaaata aaaaaaaata aataacaaaa gaaa
//
