LOCUS       NM_001355502            5931 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus catenin delta 2 (Ctnnd2), transcript variant 2, mRNA.
ACCESSION   NM_001355502 XM_006520032
VERSION     NM_001355502.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5931)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5931)
  AUTHORS   Xu,M., Wang,X., Wang,L., Wang,S., Deng,J., Wang,Y., Li,Y., Pan,S.,
            Liao,A., Tao,Y. and Tan,S.
  TITLE     Effects of chronic sleep restriction on the neuro-phenotypes of
            Ctnnd2 knockout mice
  JOURNAL   Brain Behav 13 (7), e3075 (2023)
   PUBMED   37226399
  REMARK    GeneRIF: Effects of chronic sleep restriction on the
            neuro-phenotypes of Ctnnd2 knockout mice.
REFERENCE   3  (bases 1 to 5931)
  AUTHORS   Mendez-Vazquez,H., Roach,R.L., Nip,K., Chanda,S., Sathler,M.F.,
            Garver,T., Danzman,R.A., Moseley,M.C., Roberts,J.P., Koch,O.N.,
            Steger,A.A., Lee,R., Arikkath,J. and Kim,S.
  TITLE     The autism-associated loss of delta-catenin functions disrupts
            social behavior
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2300773120 (2023)
   PUBMED   37216537
REFERENCE   4  (bases 1 to 5931)
  AUTHORS   Martin,J.B., Herman,K., Houssin,N.S., Rich,W., Reilly,M.A. and
            Plageman,T.F. Jr.
  TITLE     Arvcf Dependent Adherens Junction Stability is Required to Prevent
            Age-Related Cortical Cataracts
  JOURNAL   Front Cell Dev Biol 10, 840129 (2022)
   PUBMED   35874813
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5931)
  AUTHORS   Wang,X., Xu,M., Xu,Q., Yang,F., Tang,H., Shao,C., Wang,L., Wang,Y.,
            Deng,J. and Wang,S.
  TITLE     Rictor is involved in Ctnnd2 deletion-induced impairment of spatial
            learning and memory but not autism-like behaviors
  JOURNAL   Front Biosci (Landmark Ed) 26 (8), 335-346 (2021)
   PUBMED   34455763
  REMARK    GeneRIF: Rictor is involved in Ctnnd2 deletion-induced impairment
            of spatial learning and memory but not autism-like behaviors.
REFERENCE   6  (bases 1 to 5931)
  AUTHORS   Ho,C., Zhou,J., Medina,M., Goto,T., Jacobson,M., Bhide,P.G. and
            Kosik,K.S.
  TITLE     delta-catenin is a nervous system-specific adherens junction
            protein which undergoes dynamic relocalization during development
  JOURNAL   J Comp Neurol 420 (2), 261-276 (2000)
   PUBMED   10753311
REFERENCE   7  (bases 1 to 5931)
  AUTHORS   Kawamura,Y., Fan,Q.W., Hayashi,H., Michikawa,M., Yanagisawa,K. and
            Komano,H.
  TITLE     Expression of the mRNA for two isoforms of neural
            plakophilin-related arm-repeat protein/delta-catenin in rodent
            neurons and glial cells
  JOURNAL   Neurosci Lett 277 (3), 185-188 (1999)
   PUBMED   10626844
REFERENCE   8  (bases 1 to 5931)
  AUTHORS   Paffenholz,R., Kuhn,C., Grund,C., Stehr,S. and Franke,W.W.
  TITLE     The arm-repeat protein NPRAP (neurojungin) is a constituent of the
            plaques of the outer limiting zone in the retina, defining a novel
            type of adhering junction
  JOURNAL   Exp Cell Res 250 (2), 452-464 (1999)
   PUBMED   10413599
REFERENCE   9  (bases 1 to 5931)
  AUTHORS   Lu,Q., Paredes,M., Medina,M., Zhou,J., Cavallo,R., Peifer,M.,
            Orecchio,L. and Kosik,K.S.
  TITLE     delta-catenin, an adhesive junction-associated protein which
            promotes cell scattering
  JOURNAL   J Cell Biol 144 (3), 519-532 (1999)
   PUBMED   9971746
REFERENCE   10 (bases 1 to 5931)
  AUTHORS   Paffenholz,R. and Franke,W.W.
  TITLE     Identification and localization of a neurally expressed member of
            the plakoglobin/armadillo multigene family
  JOURNAL   Differentiation 61 (5), 293-304 (1997)
   PUBMED   9342840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124993.19, AC124675.9, AC134414.12, AC110569.8, AC139197.10 and
            AC105408.5.
            
            On Feb 25, 2019 this sequence version replaced NM_001355502.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145217.1, SRR7652917.492464.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-630               AC124993.19        159979-160608       c
            631-767             AC124993.19        996-1132            c
            768-880             AC124675.9         21901-22013         c
            881-912             AC134414.12        89725-89756         c
            913-1029            AC134414.12        89039-89155         c
            1030-1202           AC134414.12        74162-74334         c
            1203-1758           AC134414.12        61654-62209         c
            1759-1953           AC134414.12        39372-39566         c
            1954-2209           AC134414.12        25508-25763         c
            2210-2342           AC110569.8         110808-110940
            2343-2556           AC110569.8         142395-142608
            2557-2740           AC110569.8         182937-183120
            2741-2858           AC139197.10        68991-69108
            2859-3044           AC139197.10        74962-75147
            3045-3218           AC139197.10        93528-93701
            3219-3369           AC139197.10        109723-109873
            3370-3580           AC139197.10        154624-154834
            3581-3665           AC139197.10        160661-160745
            3666-3792           AC105408.5         115705-115831       c
            3793-3924           AC105408.5         111616-111747       c
            3925-3998           AC105408.5         100006-100079       c
            3999-5931           AC105408.5         91436-93368         c
FEATURES             Location/Qualifiers
     source          1..5931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 12.02 cM"
     gene            1..5931
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="catenin delta 2"
                     /db_xref="GeneID:18163"
                     /db_xref="MGI:MGI:1195966"
     exon            1..630
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..4259
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="isoform 2 is encoded by transcript variant 2;
                     neural plakophilin-related arm-repeat protein; catenin
                     (cadherin-associated protein), delta 2 (neural
                     plakophilin-related arm-repeat protein); neurojungin;
                     catenin (cadherin associated protein), delta 2"
                     /codon_start=1
                     /product="catenin delta-2 isoform 2"
                     /protein_id="NP_001342431.1"
                     /db_xref="CCDS:CCDS88745.1"
                     /db_xref="GeneID:18163"
                     /db_xref="MGI:MGI:1195966"
                     /translation="MFARKQSGAAPFGAMPVPDQPPSASEKNSSLSPGLNTSNGDGSE
                     TETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSISSAEQFH
                     WQTQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTSERPSLLSQSALQLNSK
                     PEGSFQYPASYHSNQTLALGDTAPSQLPARSTQARAAGQSFSQGTTGRAGHLAGSEPA
                     PPPPPPREPFAPSLGSAFHLPDAPPAAAALYYSSSTLPAPPRGGSPLTTTQGGSPTKL
                     QRGGSAPEGAAYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQ
                     STISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSR
                     ASYSSQHGHLAPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTFR
                     TSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCASV
                     DSPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNA
                     AAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDN
                     KIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAV
                     IIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALL
                     YVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGETNGKD
                     TESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNP
                     DTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRN
                     MALDVRNKELIGKYAMRDLVHRLPGGNNSNNSGSKAMSDDTVTAVCCTLHEVITKNME
                     NAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQY
                     HFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYES
                     AGNNATYHGTKGEHTSRKDTMTAQNTGVSTLYRNSYGAPAEDIKQNQVSTQPVPQEPS
                     RKDYETYQPFPNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYS
                     ELNYETSHYPASPDSWV"
     exon            631..767
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            768..880
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            881..912
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1029
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1202
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1758
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1953
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2209
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2342
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2556
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2740
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2858
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3044
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3218
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3369
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3580
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3665
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3792
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3924
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..3998
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..5931
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4796..4801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: ATTAAA"
     polyA_site      4832
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     regulatory      5193..5198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     polyA_site      5219
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     regulatory      5904..5909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     regulatory      5914..5919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="hexamer: AATAAA"
     polyA_site      5927
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
                     /note="major polyA site"
     polyA_site      5931
                     /gene="Ctnnd2"
                     /gene_synonym="Catnd2; neurojugin; Nprap"
ORIGIN      
        1 atgctccgca cccggggcag gtttcggtgg tggggcggac gctcgctcgc tcactagcca
       61 agcgccggag ccggccgccg cggctgagcc ggaggctgag ctgcggcgcg cggcgggagg
      121 agcctcgctc tcggcggcgg cggcggcggc ggcgacacag gtggcgcggg cggcgcgcag
      181 ggcgcagctc gagagcgctc ggcgccgggc gccagggcgg cccaggctcg cgcccgcggc
      241 ggcaaccggc cgagcggagc ggcgggcgcg gcggctcggt agcccggccc gagcccgggg
      301 agccccgcgg aaccctgagc atcccgcggc gcccgccgag tcgggcaggg ggcgctacgc
      361 tcgccgcgct cggaggggcg gccgggccgg gcgctgcgca ctcgcgtcgg gagccgcctc
      421 tcgcctgccg cgctcgcccc tgctccccgc cagcatcact tgtcccgcgg ccgcgctccg
      481 acaacaaaag cggaggatgc tgcagctggg caaggtcagg accttgctct gaagccgggc
      541 ggcggcgcgc acgcctttcc cccgactgag gagctgtctt tggcggcggg tgcatgttcg
      601 ccaggaagca gtcgggcgcc gcgccgttcg gagctatgcc tgtcccagac cagcctccat
      661 cagcctcaga gaagaacagc tccttgagcc caggcttaaa cacctccaat ggtgatggct
      721 ctgagacgga aaccacctct gctatccttg cctccgtcaa agaacaggaa ttacagtttg
      781 aaaggctgac ccgagagctg gaggctgaac gccagatcgt agccagccag ctggagcgat
      841 gcaagcttgg ctcggagaca ggaagcatga gcagtatcag ttcagcagag cagtttcact
      901 ggcagacaca agatggccaa aaagatatcg aagatgaact tacaacgggc cttgagctgg
      961 tggactcctg tatccgctct ctgcaggagt caggcattct ggacccacag gattactcca
     1021 caagtgaaag gcctagcctg ctctcccaga gtgcacttca gctcaattct aaacctgaag
     1081 ggtctttcca gtatccggcc agctaccata gcaaccagac cctggccctg ggtgacacag
     1141 ccccttctca gctcccagca cgcagcacgc aagcccgagc tgccggccag agcttcagcc
     1201 agggcacgac cggccgcgcg gggcacctgg cgggctccga gcctgcgcca ccgcctccgc
     1261 ctccgcggga accgttcgcg cccagcctgg gcagcgcctt ccacctgccc gacgcgccgc
     1321 ccgccgccgc ggcgctctac tactccagct ccacgctgcc cgcgccgccg cgcgggggct
     1381 ccccgctgac caccacgcag ggcggctcac ccaccaagct gcagcgcgga ggctcggccc
     1441 ccgagggtgc cgcctacgcc gcgccgcgcg gctcctcgcc caagcagtcg cccagccgcc
     1501 tggctaagtc ctacagcacc agctcgccca tcaacatcgt cgtgtcctcg gccggcctgt
     1561 ccccgatccg cgtgacctcg ccccccaccg tgcagtccac catctcctct tcgcccatcc
     1621 accagctgag ctccaccatc ggcacctacg ccaccctgtc gcccaccaag cgcctggtcc
     1681 acgcgtctga gcagtacagc aagcattcgc aggagctgta tgccaccgcc accctccaga
     1741 ggccgggcag cctggcagct ggatcccgag cctcgtatag cagccagcat gggcacctgg
     1801 cccctgagct gcgggccctg cagtccccag agcaccacat agaccccatc tatgaagacc
     1861 gtgtctatca gaagccccct atgaggagtc tcagccagag ccagggggat cctctgccgc
     1921 cagcacatac cggcaccttc cgcacgagca cagccccgtc ctcccctggt gtcgactccg
     1981 tccccttgca gcgcacaggc agccaacacg ggccacagaa tgccgccgca gccaccttcc
     2041 agagggccag ctatgctgcc ggcccagcct ccaactacgc agacccctac cgacagctgc
     2101 agtattgtgc ctccgttgac tctccgtaca gcaaatctgg ccctgccctc ccacccgaag
     2161 gcaccttggc cagatcccca tccatcgaca gcattcagaa agaccccagg gagtttggat
     2221 ggagagaccc ggagctgcct gaagtgatac agatgttaca gcaccagttc ccttcagtcc
     2281 agtccaatgc tgcagcttac ctgcaacacc tctgttttgg agacaataaa attaaggcag
     2341 agataaggag acaaggaggg atacagctcc tggtggacct gctggatcac cgaatgacag
     2401 aagtccaccg tagtgcctgt ggggctctga ggaacctggt gtatgggaag gccaatgatg
     2461 ataacaaaat cgccctgaaa aactgtggtg gtatcccagc gctggtgaga ctccttcgca
     2521 agaccacaga cctggagatc cgggagctgg tcacaggagt cctttggaac ctctcatcat
     2581 gtgatgcact caaaatgcca atcatccagg acgccctggc agtgctgacc aatgcggtga
     2641 ttatccctca ctcgggctgg gagaattcac ctcttcagga tgatcggaaa atacagctgc
     2701 attcatcaca ggtgctgcgc aacgccactg ggtgcctaag gaatgtaagt tcagctggag
     2761 aggaggcccg ccgaaggatg cgggagtgtg atgggctcac ggatgccttg ctgtacgtga
     2821 tccagtctgc actggggagc agtgagatcg atagcaagac cgttgaaaac tgtgtgtgca
     2881 tcttgaggaa cctctcctac cggctagcag cagaaacgtc tcagggacag cacatgggca
     2941 cagacgagct ggacgggctg ctctgcgggg agaccaacgg caaagacaca gagagttctg
     3001 ggtgctgggg caagaagaag aagaaaaaga aatcccagga ccagtgggat ggagtaggac
     3061 ctcttccaga ctgtgcagag ccaccaaaag ggatccagat gctgtggcac ccgtccatag
     3121 tcaaacccta cctcacactg ctctctgagt gctcaaaccc agacacgctg gaaggggcag
     3181 cgggcgccct gcagaacttg gctgcaggga gctggaagtg gtccgtgtat atccgagctg
     3241 ctgtccggaa agagaaaggc ctgcccattc ttgtggagct cctccgaata gacaatgacc
     3301 gtgtagtgtg tgcagtggcc acagcacttc ggaacatggc cctcgatgtc agaaacaagg
     3361 aactcattgg caagtatgcc atgcgagacc tggtccaccg gcttcctggt gggaacaaca
     3421 gcaacaactc ggggagcaag gccatgtcag atgacaccgt gacggccgtg tgctgcaccc
     3481 tgcatgaagt gatcaccaag aacatggaga atgccaaggc cttacgggat gctggtggca
     3541 tcgagaagtt ggtcggcatc tctaaaagca aaggagacaa gcactctcca aaggtggtca
     3601 aggctgcttc tcaggtccta aacagcatgt ggcagtatcg cgatctgagg agtctctaca
     3661 agaaggatgg atggtcacaa tatcactttg tagcctcatc ttcaaccatc gagagggatc
     3721 gacaaaggcc ctactcctcc tcccgcacac cctccatctc tcccgtgcgt gtgtctccca
     3781 acaaccgctc agcaagtgcc ccagcttcac ctcgggaaat gatcagcctc aaagaaagga
     3841 agacggacta cgagtccgct ggcaacaacg ccacttacca cggaactaaa ggagaacaca
     3901 cctccagaaa agacaccatg acagctcaaa acactggagt ttcaactttg tacaggaatt
     3961 catacggtgc gcccgctgaa gacatcaaac agaaccaggt ttccacacag cctgtccctc
     4021 aggagcccag caggaaagac tacgagacct accagccctt tccgaattcc acacgaaatt
     4081 atgatgagtc cttctttgag gaccaggtcc accaccgccc tccagccagc gagtacacca
     4141 tgcacctggg cctcaagtcc actggcaact atgtcgactt ctactctgca gcccgtcctt
     4201 acagtgaact gaactatgaa acgagccact acccggcctc gcccgactcc tgggtgtaag
     4261 gagccaggac acgaggcact ccggggacag tgcatgtgca tgcatacacc acaggacatt
     4321 ttgtttcttt ttttcttttc ttttcttttg tttttttttt tctttccctg caaatttagt
     4381 ttgttaaagc ctgttccgta ggaaggctgt gataaccagg aagaaatact cagagctatt
     4441 ttagaaagct aaaatgaatc aagagttaac tgggaaatcg ataggaagct aaacgcaatc
     4501 ctaattgtga ccgcattcaa cacctttcta gtttgaacta tagcattttg aaagtgcttt
     4561 atagtccggt gaggctgaag gtaggagaga ggagacagtc agggtggtgg gcgtggttat
     4621 cgctaagcac aagacagact agtttacaca ctgtggggac ggcttctcac gctttgttta
     4681 ctctcttcat ccgtgtgact ctaggcttca agttgcattg gggttcctct gtacagcaag
     4741 acgtctcttg ccttttgtta atgcattgtt gtaaagtatt cgatgtacat tacagattaa
     4801 agacgaagag tgcattgtgt atattacacc aatgccactg tgtttcctca tcaatggttc
     4861 taaatattgc ttcaatttca aacttttgaa agatgtatgg gtttccaatt ttcttttttt
     4921 ttttctttct cccagtatgt tttaacaaaa aaggaaaaaa aaaaacagga aaaaaaaaaa
     4981 aggaatattt agcagtattg ttcgttctga tatgtgattt gtttgtggca actaaacgcg
     5041 gcatccagca gtctctccca agctaacaag tcattccaca cccctcgtca acaaaatgct
     5101 ttttcactgc ctaaaattct agatgtagat atttgaaata gatttttttc atttatacca
     5161 gttttcttta tgataataca gtgttaaaag aaaataaatt acaattgatc tgtcatccat
     5221 ccttgctaag aatgtctatt tccatggacc agtcttacaa aatacacatt cttgcacgtg
     5281 tgtctgtgcg tgtgtgggtg cgtgtgggtg tgtcggtgta tgtgcaaagc tgacctgtgt
     5341 ggggttgtat ctggatagaa gcagtttcat ccgctgtcca tcgtgtgtgc cagccttcgt
     5401 tttcccagca tccgtgtgca tccgtctgtc cctcttgtaa cgtatctatc cgctcttctc
     5461 accatctagt ggctcaggat attaggccag ctgagataaa gtaggatttt tcacgcgatc
     5521 acacattctt ggacgccaac tcttttctac aggtcaatcc cttccatatt ttatgctctc
     5581 agaacatgct aaaccatggt cactcaactc ggtagtttcc ctttggggcc aattacttga
     5641 agtatcaata gaagatgtaa actgctcacc ttattccctt tcaaactgtt cttttgttta
     5701 tgtggcaggg agcagtagac aattatgggc tagatgatta aaactgaact caaagctaac
     5761 gttagactag tggttaacag agctaagaaa taaggctaac catttcagag aacgtgggct
     5821 gttgggtaaa ttagctttgc tctttagatg caagtgactg aggccaacag gtgcctggca
     5881 aatgttaact gttcttggaa aaaaataaaa aaaaataaat aacaaaagaa a
//
