LOCUS       NM_001085450            5357 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus catenin delta 1 (Ctnnd1), transcript variant 2, mRNA.
ACCESSION   NM_001085450
VERSION     NM_001085450.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5357)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   2  (bases 1 to 5357)
  AUTHORS   Caetano da Silva,C., Macias Trevino,C., Mitchell,J., Murali,H.,
            Tsimbal,C., Dalessandro,E., Carroll,S.H., Kochhar,S., Curtis,S.W.,
            Cheng,C.H.E., Wang,F., Kutschera,E., Carstens,R.P., Xing,Y.,
            Wang,K., Leslie,E.J. and Liao,E.C.
  TITLE     Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in
            orofacial cleft pathogenesis
  JOURNAL   Commun Biol 7 (1), 1040 (2024)
   PUBMED   39179789
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5357)
  AUTHORS   Darrigrand,J.F., Salowka,A., Torres-Cano,A., Tapia-Rojo,R., Zhu,T.,
            Garcia-Manyes,S. and Spagnoli,F.M.
  TITLE     Acinar-ductal cell rearrangement drives branching morphogenesis of
            the murine pancreas in an IGF/PI3K-dependent manner
  JOURNAL   Dev Cell 59 (3), 326-338 (2024)
   PUBMED   38237591
REFERENCE   4  (bases 1 to 5357)
  AUTHORS   Tan,C.X., Bindu,D.S., Hardin,E.J., Sakers,K., Baumert,R.,
            Ramirez,J.J., Savage,J.T. and Eroglu,C.
  TITLE     delta-Catenin controls astrocyte morphogenesis via layer-specific
            astrocyte-neuron cadherin interactions
  JOURNAL   J Cell Biol 222 (11) (2023)
   PUBMED   37707499
  REMARK    GeneRIF: delta-Catenin controls astrocyte morphogenesis via
            layer-specific astrocyte-neuron cadherin interactions.
REFERENCE   5  (bases 1 to 5357)
  AUTHORS   Wu,H., Yan,X., Zhao,L., Li,X., Li,X., Zhang,Y., Gu,C., Yang,F.,
            Yan,J., Lou,Y., Li,Y., Yang,L., Qin,X. and Wang,Y.
  TITLE     p120-catenin promotes innate antiviral immunity through stabilizing
            TBK1-IRF3 complex
  JOURNAL   Mol Immunol 157, 8-17 (2023)
   PUBMED   36958140
  REMARK    GeneRIF: p120-catenin promotes innate antiviral immunity through
            stabilizing TBK1-IRF3 complex.
REFERENCE   6  (bases 1 to 5357)
  AUTHORS   Semb,H. and Christofori,G.
  TITLE     The tumor-suppressor function of E-cadherin
  JOURNAL   Am J Hum Genet 63 (6), 1588-1593 (1998)
   PUBMED   9837810
  REMARK    Review article
REFERENCE   7  (bases 1 to 5357)
  AUTHORS   Nakamura,K. and Cambier,J.C.
  TITLE     B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120
            complex and its inhibition by Fc gamma RIIB1-BCR coligation
  JOURNAL   J Immunol 161 (2), 684-691 (1998)
   PUBMED   9670943
REFERENCE   8  (bases 1 to 5357)
  AUTHORS   Mo,Y.Y. and Reynolds,A.B.
  TITLE     Identification of murine p120 isoforms and heterogeneous expression
            of p120cas isoforms in human tumor cell lines
  JOURNAL   Cancer Res 56 (11), 2633-2640 (1996)
   PUBMED   8653709
REFERENCE   9  (bases 1 to 5357)
  AUTHORS   Reynolds,A.B., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Shapiro,D.N., Wu,J. and Daniel,J.M.
  TITLE     The gene encoding p120cas, a novel catenin, localizes on human
            chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)
  JOURNAL   Genomics 31 (1), 127-129 (1996)
   PUBMED   8808291
REFERENCE   10 (bases 1 to 5357)
  AUTHORS   Reynolds,A.B., Herbert,L., Cleveland,J.L., Berg,S.T. and Gaut,J.R.
  TITLE     p120, a novel substrate of protein tyrosine kinase receptors and of
            p60v-src, is related to cadherin-binding factors beta-catenin,
            plakoglobin and armadillo
  JOURNAL   Oncogene 7 (12), 2439-2445 (1992)
   PUBMED   1334250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ174738.1, BC043108.1 and BY422861.1.
            
            Transcript Variant: This variant (2) lacks a segment in the 5' UTR
            compared to variant 1. Variants 1, 2, and 6 all encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043108.1, SRR1660817.270504.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                CJ174738.1         1-65
            66-5353             BC043108.1         1-5288
            5354-5357           BY422861.1         378-381
FEATURES             Location/Qualifiers
     source          1..5357
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..5357
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /note="catenin delta 1"
                     /db_xref="GeneID:12388"
                     /db_xref="MGI:MGI:105100"
     exon            1..335
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            336..624
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..3246
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /note="isoform 1 is encoded by transcript variant 2;
                     catenin src; CAS; p120(cas); p120(ctn); p120 catenin;
                     cadherin-associated Src substrate; catenin (cadherin
                     associated protein), delta 1"
                     /codon_start=1
                     /product="catenin delta-1 isoform 1"
                     /protein_id="NP_001078919.1"
                     /db_xref="CCDS:CCDS16186.1"
                     /db_xref="GeneID:12388"
                     /db_xref="MGI:MGI:105100"
                     /translation="MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERV
                     RVSPQDANSLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHNHLLYSTIPRM
                     QEPGQIVETYTEEDPEGAMSVVSVETTDDGTTRRTETTVKKVVKTMTTRTVQPVPMGP
                     DGLPVDASAVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYGRHYE
                     DGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFH
                     PEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPPDQY
                     YWAPLAQHERGSLASLDSLRKGMPPPSNWRQPELPEVIAMLGFRLDAVKSNAAAYLQH
                     LCYRNDKVKTDVRKLKGIPILVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNC
                     DGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGW
                     EREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEI
                     GQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEALPTVANSTGPHAASCFGAKKG
                     KDEWFSRGKKPTEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILE
                     ASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIAELLTSEHERVVKAASGALRNLAVD
                     ARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVVSILNTINEVIAENLEAAKKLRE
                     TQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNA
                     SRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIPMSNMGSNTKSLDNNYSTLNERGDHN
                     RTLDRSGDLGDMEPLKGAPLMQKI"
     exon            625..696
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            697..849
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1385
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1849
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2033
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2151
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2305
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2323
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2392
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2520
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2671
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2864
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2979
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3067
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3130
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3234
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..5357
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5335..5340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /note="hexamer: AATAAA"
     polyA_site      5355
                     /gene="Ctnnd1"
                     /gene_synonym="Catns; Ctnnd; mKIAA0384; P120"
                     /note="major polyA site"
ORIGIN      
        1 agatcagttt gtcaccaccc aggctgcctt gcctttggct gggtgcaact tccattttag
       61 gtgttggatc tgaggggaaa aggagagagg gagagagagg gagagaggga gagagggaaa
      121 gggagagaga gagagagaga aagaggacga tcaagaggga gggagggaga gccagcgagc
      181 gagacagaca cggagggaga ggagaaaggc aggaaagatc ctggaacgag gaagaggaag
      241 aggcggcgaa cctcgctgga tttgtctttc tcagcacatt ggtgaagctt tgggtttgtt
      301 tcttaaagga ctggctttag aagtccacat ttgagtgtga agtgagggga cctactccct
      361 cctttctact ccctctgtgg tccaccttac tttttatcct gccctgcggc ggctcctccc
      421 cttaccttca tggacgactc agaggtggag tcgaccgcca gcatcttggc ctctgtgaaa
      481 gaacaagagg cccagtttga gaagctgacc cgggcgctgg aagaggagcg gcgccatgtc
      541 tcggcgcaac tggaacgcgt ccgggtctca ccacaagatg ccaactcact catggccaat
      601 ggcaccctca ctcgtcggca tcagaacggc cggtttgtgg gcgatgctga ccttgagaga
      661 cagaaatttt cagatctgaa actcaacgga ccccaggatc acaaccacct tctgtacagc
      721 actatcccca ggatgcagga gccaggacag attgtggaaa cctacaccga ggaggaccct
      781 gaaggagcca tgtctgttgt ttctgtggag accacagatg atgggaccac tagacgcacg
      841 gagaccacag tcaaaaaagt tgtgaagaca atgacaactc ggacagtaca gcctgtcccc
      901 atggggccag acgggctgcc cgtggacgcc tcagcagtct ccaataacta tatccagacc
      961 ttgggccgtg attttcgcaa gaatggcaat gggggccctg gtccctatgt ggggcaagcg
     1021 ggcactgcca ctcttcctag gaacttccac tatcctccag atgggtatgg ccgacactat
     1081 gaagatggtt atccaggtgg cagtgacaac tacggcagtc tgtcccgggt gacccgaatt
     1141 gaggagcggt ataggcccag catggaaggc taccgggcac ccagtagaca agatgtctat
     1201 gggccccagc cccaggttcg agtaggtgga agcagtgtgg acctgcatcg ttttcatcct
     1261 gagccttacg ggctagagga tgaccagcgc agcatgggct atgatgacct cgattacggc
     1321 atgatgtctg attatggtac tgcccgtcgg acaggaacac cctctgaccc tcgacgacgc
     1381 ctcaggagct atgaagacat gattggtgaa gaggtgccgc ctgatcagta ctattgggct
     1441 cctttagctc agcatgagcg gggcagttta gcaagcttgg atagtttgcg aaagggaatg
     1501 cccccacctt caaactggag acagcctgag ctgccagagg tgattgccat gttaggcttc
     1561 cgcttggatg ctgttaagtc caatgcagct gcatacctgc agcacttatg ctaccgcaat
     1621 gacaaggtga agactgacgt gcggaagctc aagggtatcc cgatattggt aggattgtta
     1681 gaccatccca aaaaggaagt gcacctcgga gcctgtggag ctctcaagaa tatctctttt
     1741 ggacgtgacc aagataacaa gatcgccata aaaaactgtg atggtgttcc tgctctggtc
     1801 cgattgctcc gaaaggctcg tgatatggac ctgactgaag tgattactgg aaccctgtgg
     1861 aatctctcat cccatgattc aatcaaaatg gagattgtgg accatgcgct acatgccttg
     1921 acagatgaag ttatcattcc acattctggt tgggagagag aacctaatga agactgtaag
     1981 ccacggcata ttgaatggga gtcagtgctt accaacactg ctggctgcct tcggaacgta
     2041 agctcagaga ggagtgaagc ccggaggaaa cttcgggaat gtgacggctt agttgatgcc
     2101 ctcattttca tcgttcaggc agaaattggg cagaaggatt cagacagtaa gcttgtggag
     2161 aattgtgttt gcctcctccg gaacttatca taccaagttc atcgtgaaat cccacaggca
     2221 gagcgttacc aggaggccct tcctactgtg gctaacagta ctgggccaca cgctgccagt
     2281 tgctttggag ccaagaaggg caaagatgag tggttctcca gagggaaaaa gcctacagag
     2341 gatccagcaa atgatacagt ggatttccct aaaagaacta gtcctgctcg aggctatgaa
     2401 ctcttatttc agccagaagt ggtgcgaata tacatttcac tccttaagga gagcaagacg
     2461 cctgccatct tagaagcctc ggccggagct atccagaact tgtgtgctgg gcgttggaca
     2521 tatggcagat acatccgctc tgctcttcgt caggagaagg ctctctctgc catagctgag
     2581 ctccttacga gtgagcatga gcgagtagta aaagctgctt ctggggcact gagaaatctg
     2641 gctgtggatg ctcggaacaa agagttaatt ggcaagcatg ctattcctaa cttggtaaag
     2701 aatctgccag gaggtcaaca gaactcctcc tggaattttt ctgaagatac tgtggtctcc
     2761 atattgaaca ccatcaacga agttatcgct gagaacttag aagctgccaa aaagcttcga
     2821 gagacgcagg gtattgagaa gctggtgttg atcaacaaat cagggaatcg ttcagaaaaa
     2881 gaagtccggg cagcagctct tgtcctgcag acaatctggg gctataagga gcttcggaag
     2941 ccactggaaa aagaaggatg gaagaaatca gacttccagg tgaatctaaa caatgcatct
     3001 agaagccaga gcagccattc atatgatgat agcactctcc ccctcattga ccggaatcaa
     3061 aaatcagata agaaacctga ccgggaagaa attccaatga gcaatatggg gtcaaacaca
     3121 aaatcattag ataacaacta ttccacactg aatgagagag gagaccacaa cagaacactg
     3181 gaccgatctg gggatctggg tgatatggaa ccattgaagg gagcaccctt gatgcagaag
     3241 atttagcgcc actctacctg ctccatatgg gcttataata tattactttt attttttggt
     3301 ggtgaaatgg actgatgatt tttttccttt cttcgctgga ctattgtgcc aactgccagg
     3361 ctgactccta cccttgtagc ccaaattggc tgccgtcatc cgtgaattac ctacatcttc
     3421 cactgaagtt taattgtcct atcctcccag accctacttc cagttttccc ccaagaaacc
     3481 tgactctgtt atttgcatat cttgagaaac tgctgcagat tagctctttt tgccagcctt
     3541 ccctggaact cttggccttg catagaggga gggagagtgg aactctctac tggaagcaat
     3601 gggaagaact gaaaattaca cactgtctgt tcagcagtca gcattctgac aaactgatga
     3661 cttttaatca agactatttt ttctggtgtg gggggaactt tttattttgt tttggatggg
     3721 gaagtgtgag ttcttccctt atccagtggc gatttttgaa gccaagaagg ctggaaacat
     3781 tggcacattc cacctggcaa gggccctcaa gtaagtgaag tactccccaa cctcagagtg
     3841 agaactcttg ttcctcctgt tcaaggcagg gaccacaaag gacctacaga ctccatctct
     3901 ctgtcagctt caggataacc ttggggtgct gtcctgacca aggctgtcct taaccctcct
     3961 ctcctaccct gtgataaacc tgctaacttg acctggctgt tttgcaagat gctttgtaaa
     4021 aaggagaatg ccatggaacc ccctggttga gaagaaacag aaagattgtc tattgagaag
     4081 atgaacctct aggaggaatg tacatgaagt ggttagtctg aaactggcag gaagcttcag
     4141 agctggcttt cctcagcccc ctcaccccat ctctcttcgt cctttataag cttgtcctcc
     4201 ctctcctccc cttccctgga tttgttggcc aacttacaag acttgtacat agctcctccc
     4261 cctttgccct tgtaaggtag gagttgccct ggctttgcct cttctttgtg cctttggcct
     4321 ggggtgcatc tcctccctct cttccaggtg cctttctttg cctctgcagt ctcatttctc
     4381 atgattttgc aagttagacc ttgttatttt cttacccact gttgaccccc agtagctgaa
     4441 gcaaagaaga ggagtggtaa cttagggaac ttcacgtccc tactgggtgt tgttaaagcc
     4501 tctgacatag ccacaacagg cttctgctta acagtgtgca gttgggattg gtgaaaatcc
     4561 atcccgataa gtctcaaagt gaggctgtta ggagggagtg ctgtgactct gactccttag
     4621 tcgtccccag ttcccatcat ctctgaaagg ctacagggaa tcaggccatg cctccattac
     4681 acccttttct gttgtagtga gtgttacagc ttggctagag aagcagctac tatgtgggtg
     4741 caattttttt taaacatttt tccttatttt ctttccttaa tctaaaagct ctattcaatg
     4801 caactggaat tctttatccc tcttgtcctg ttccttaata tattgaggct atggggtagg
     4861 agaaaagtgc acagcccacc aactcctttt cttatacatt gcagtcaccc cctcccccca
     4921 acctttgctt ccttcccatt tcttcctagt cccgtttccc ttttctggca aaaaggagct
     4981 ctgtgctctc tgtgaccctc agagtacact gcacagggga gcctccccca cccacatcta
     5041 tctgcctctg gttttgggtt ctcttgtcct cttctgctct tcctggtgct ctttcttctc
     5101 ggtggggtgt gggtaataga atagccatgg gctttgggga cctttaactg tttttttgtt
     5161 tgtttgtttt gtttttcctt tttcatttat aaaaacacta aacattcaat ttcagcaaac
     5221 caaaaatcct accctcccac cgaatactac taaggggcat atcttctgct ctgtatcttt
     5281 tctctctttc tttctcttgt taatgctttt aaaaacaaat gagtttttta tataaataaa
     5341 agtttttaaa gtgtgtg
//
