LOCUS       NM_007614               3640 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus catenin beta 1 (Ctnnb1), transcript variant 1, mRNA.
ACCESSION   NM_007614
VERSION     NM_007614.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3640)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   2  (bases 1 to 3640)
  AUTHORS   Kaplan,M.M., Zeidler,M., Knapp,A., Holzl,M., Kress,M., Fritsch,H.,
            Krogsdam,A. and Flucher,B.E.
  TITLE     Spatial transcriptomics in embryonic mouse diaphragm muscle reveals
            regional gradients and subdomains of developmental gene expression
  JOURNAL   iScience 27 (6), 110018 (2024)
   PUBMED   38883818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3640)
  AUTHORS   Stansak,K.L., Baum,L.D., Ghosh,S., Thapa,P., Vanga,V. and
            Walters,B.J.
  TITLE     PCP auto count: a novel Fiji/ImageJ plug-in for automated
            quantification of planar cell polarity and cell counting
  JOURNAL   Front Cell Dev Biol 12, 1394031 (2024)
   PUBMED   38827526
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3640)
  AUTHORS   Nie,X., Abbasi,Y. and Chung,M.K.
  TITLE     Piezo1 and Piezo2 collectively regulate jawbone development
  JOURNAL   Development 151 (9) (2024)
   PUBMED   38619396
REFERENCE   5  (bases 1 to 3640)
  AUTHORS   Lv,Y., Wang,Q., Lin,C., Zheng,X., Zhang,Y. and Hu,X.
  TITLE     Overexpression of Fgf18 in cranial neural crest cells recapitulates
            Pierre Robin sequence in mice
  JOURNAL   Front Cell Dev Biol 12, 1376814 (2024)
   PUBMED   38694818
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3640)
  AUTHORS   Butz,S., Stappert,J., Weissig,H. and Kemler,R.
  TITLE     Plakoglobin and beta-catenin: distinct but closely related
  JOURNAL   Science 257 (5073), 1142-1144 (1992)
   PUBMED   1509266
REFERENCE   7  (bases 1 to 3640)
  AUTHORS   Peifer,M., McCrea,P.D., Green,K.J., Wieschaus,E. and Gumbiner,B.M.
  TITLE     The vertebrate adhesive junction proteins beta-catenin and
            plakoglobin and the Drosophila segment polarity gene armadillo form
            a multigene family with similar properties
  JOURNAL   J Cell Biol 118 (3), 681-691 (1992)
   PUBMED   1639851
REFERENCE   8  (bases 1 to 3640)
  AUTHORS   Ozawa,M., Ringwald,M. and Kemler,R.
  TITLE     Uvomorulin-catenin complex formation is regulated by a specific
            domain in the cytoplasmic region of the cell adhesion molecule
  JOURNAL   Proc Natl Acad Sci U S A 87 (11), 4246-4250 (1990)
   PUBMED   2349235
REFERENCE   9  (bases 1 to 3640)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
REFERENCE   10 (bases 1 to 3640)
  AUTHORS   Ozawa,M., Baribault,H. and Kemler,R.
  TITLE     The cytoplasmic domain of the cell adhesion molecule uvomorulin
            associates with three independent proteins structurally related in
            different species
  JOURNAL   EMBO J 8 (6), 1711-1717 (1989)
   PUBMED   2788574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY766878.1 and BC053065.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_007614.4.
            
            On Oct 1, 2009 this sequence version replaced NM_007614.2.
            
            Summary: This gene encodes not only an important cytoplasmic
            component of the classical cadherin adhesion complex that forms the
            adherens junction in epithelia and mediates cell-cell adhesion in
            many other tissues but also a key signaling molecule in the
            canonical Wnt signaling pathway that controls cell growth and
            differentiation during both normal development and tumorigenesis.
            The gene product contains a central armadillo-repeat containing
            domain through which it binds the cytoplasmic tail of classical
            cadherins; meanwhile, it also binds alpha-catenin, which further
            links the cadherin complex to the actin cytoskeleton either
            directly or indirectly. Beta-catenin is therefore necessary for the
            adhesive function of classical cadherins. Another key function of
            this protein is to mediate the canonical Wnt signaling pathway and
            regulate gene transcription. Without Wnt signal, cytoplasmic
            beta-catenin that is not associated with the cadherin complex is
            quickly phosphorylated at the N-terminal Ser/Thr residues by the so
            called degradation complex containing axin, adenomatous polyposis
            coli (APC), casein kinase I, and GSK3B, then ubiquitylated by
            beta-TrCP, and degraded by the proteasome. However, in the presence
            of Wnt signal, the degradation complex is disrupted and the
            stabilized cytoplasmic beta-catenin translocates into the nucleus,
            where it binds various transcription factors and, together with
            these factors, regulates the transcription of many downstream
            genes. Mutations of this gene have been linked with various types
            of tumors. Alternatively spliced variants have been found for this
            gene. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048153.1, AK132398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY766878.1         1-75
            76-3640             BC053065.1         1-3565
FEATURES             Location/Qualifiers
     source          1..3640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.19 cM"
     gene            1..3640
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /note="catenin beta 1"
                     /db_xref="GeneID:12387"
                     /db_xref="MGI:MGI:88276"
     exon            1..239
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            240..300
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            301..528
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            529..782
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1021
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1223
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1368
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1472
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1811
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1970
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2090
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2241
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2363
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2424
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..3623
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3603..3608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /note="hexamer: ATTAAA"
     polyA_site      3623
                     /gene="Ctnnb1"
                     /gene_synonym="Bfc; Catnb; Mesc"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggcgga acgctccgcg cggagcggca gcggcaggat acacggtgcc gcgccgctta
       61 taaatcgctc cttgtgcggc gccatcttaa gccctcgctc ggtggcggcc gcgtcagctc
      121 gtgtcctgtg aagcccgcgg cccggggagg cggagacgga gcacggtggg cgccgagccg
      181 tcagtgcagg aggccgaggc cgagcgggcg gccgcgagtg agcagcgcgc gggcctgagg
      241 gtacctgaag ctcagcgcac agctgctgtg acaccgctgc gtggacaatg gctactcaag
      301 ctgacctgat ggagttggac atggccatgg agccggacag aaaagctgct gtcagccact
      361 ggcagcagca gtcttacttg gattctggaa tccattctgg tgccaccacc acagctcctt
      421 ccctgagtgg caagggcaac cctgaggaag aagatgttga cacctcccaa gtcctttatg
      481 aatgggagca aggcttttcc cagtccttca cgcaagagca agtagctgat attgacgggc
      541 agtatgcaat gactagggct cagagggtcc gagctgccat gttccctgag acgctagatg
      601 agggcatgca gatcccatcc acgcagtttg acgctgctca tcccactaat gtccagcgct
      661 tggctgaacc atcacagatg ttgaaacatg cagttgtcaa tttgattaac tatcaggatg
      721 acgcggaact tgccacacgt gcaattcctg agctgacaaa actgctaaac gatgaggacc
      781 aggtggtagt taataaagct gctgttatgg tccatcagct ttccaaaaag gaagcttcca
      841 gacatgccat catgcgctcc cctcagatgg tgtctgccat tgtacgcacc atgcagaata
      901 caaatgatgt agagacagct cgttgtactg ctgggactct gcacaacctt tctcaccacc
      961 gcgagggctt gctggccatc tttaagtctg gtggcatccc agcgctggtg aaaatgcttg
     1021 ggtcaccagt ggattctgta ctgttctacg ccatcacgac actgcataat ctcctgctcc
     1081 atcaggaagg agctaaaatg gcagtgcgcc tagctggtgg actgcagaaa atggttgctt
     1141 tgctcaacaa aacaaacgtg aaattcttgg ctattacaac agactgcctt cagatcttag
     1201 cttatggcaa tcaagagagc aagctcatca ttctggccag tggtggaccc caagccttag
     1261 taaacataat gaggacctac acttatgaga agcttctgtg gaccacaagc agagtgctga
     1321 aggtgctgtc tgtctgctct agcaacaagc cggccattgt agaagctggt gggatgcagg
     1381 cactggggct tcatctgaca gacccaagtc agcgacttgt tcaaaactgt ctttggactc
     1441 tcagaaacct ttcagatgca gcgactaagc aggaagggat ggaaggcctc cttgggactc
     1501 tagtgcagct tctgggttcc gatgatataa atgtggtcac ctgtgcagct ggaattctct
     1561 ctaacctcac ttgcaataat tacaaaaaca agatgatggt gtgccaagtg ggtggcatag
     1621 aggctcttgt acgcaccgtc cttcgtgctg gtgacaggga agacatcact gagcctgcca
     1681 tctgtgctct tcgtcatctg accagccggc atcaggaagc cgagatggcc cagaatgccg
     1741 ttcgccttca ttatggactg cctgttgtgg ttaaactcct gcacccacca tcccactggc
     1801 ctctgataaa ggcaactgtt ggattgattc gaaaccttgc cctttgccca gcaaatcatg
     1861 cgcctttgcg ggaacagggt gctattccac gactagttca gctgcttgta cgagcacatc
     1921 aggacaccca acggcgcacc tccatgggtg gaacgcagca gcagtttgtg gagggcgtgc
     1981 gcatggagga gatagtagaa gggtgtactg gagctctcca catccttgct cgggacgttc
     2041 acaaccggat tgtaatccga ggactcaata ccattccatt gtttgtgcag ttgctttatt
     2101 ctcccattga aaatatccaa agagtagctg caggggtcct ctgtgaactt gctcaggaca
     2161 aggaggctgc agaggccatt gaagctgagg gagccacagc tcccctgaca gagttactcc
     2221 actccaggaa tgaaggcgtg gcaacatacg cagctgctgt cctattccga atgtctgagg
     2281 acaagccaca ggattacaag aagcggcttt cagtcgagct gaccagttcc ctcttcagga
     2341 cagagccaat ggcttggaat gagactgcag atcttggact ggacattggt gcccagggag
     2401 aagcccttgg atatcgccag gatgatccca gctaccgttc ttttcactct ggtggatacg
     2461 gccaggatgc cttggggatg gaccctatga tggagcatga gatgggtggc caccaccctg
     2521 gtgctgacta tccagttgat gggctgcctg atctgggaca cgcccaggac ctcatggatg
     2581 ggctgccccc aggtgatagc aatcagctgg cctggtttga tactgacctg taaatcgtcc
     2641 tttaggtaag aaagcttata aaagccagtg tgggtgaata ctttactctg cctgcagaac
     2701 tccagaaaga cttggtaggg tgggaatggt tttaggcctg tttgtaaatc tgccaccaaa
     2761 cagatacata ccttggaagg agatgttcat gtgtggaagt ttctcacgtt gatgtttttg
     2821 ccacagcttt tgcagcgtta tactcagatg agtaacattt gctgttttca acattaatag
     2881 cagcctttct ctctatacag ctgtagtgtc tgaacgtgca ttgtgattgg cctgtagagt
     2941 tgctgagagg gctcgagggg tgggctggta tctcagaaag tgcctgacac actaaccaag
     3001 ctgagtttcc tatgggaaca gtcgaagtac gctttttgtt ctggtccttt ttggtcgagg
     3061 agtaacaata caaatggatt tggggagtga ctcacgcagt gaagaatgca cacgaatgga
     3121 tcacaagatg gcgttatcaa accctagcct tgcttgttct ttgttttaat atctgtagtg
     3181 gtgctgactt tgcttgcttt tattttttgc agtaactgtt agtttttaag tagtgttatg
     3241 ttctagtgaa cctgctacag caatttctga tttctaagaa ccgagtaatg gtgtagaaca
     3301 ctaattcata atcacgctaa ttgtaatctg gagacgtgta acattgtgta gccttttgta
     3361 taaatagaca gatagaaatg gtccgattag tttccttttt aatatgctta aaataagcag
     3421 gtggatctat ttcatgtttt tgaacaaaaa ctttatcggg gatacgtgcg gtagggtaaa
     3481 tcagtaagag gtgttatttg agccttgttt tggacagtat accagttgcc ttttatccca
     3541 aagttgttgt aacctgctgt gatacaatgc ttcaacagat gcggttatag aaatggttca
     3601 gaattaaact tttaattcat tcaaaaaaaa aaaaaaaaaa
//
