LOCUS       NM_018761               3712 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus catenin alpha like 1 (Ctnnal1), mRNA.
ACCESSION   NM_018761 XM_980596
VERSION     NM_018761.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3712)
  AUTHORS   Liu,C., Wang,J., Tan,Y., Liu,C., Qu,X., Liu,H., Tan,M., Deng,C.,
            Qin,X. and Xiang,Y.
  TITLE     CTNNAL1 promotes the structural integrity of bronchial epithelial
            cells through the RhoA/ROCK1 pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (5), 753-762 (2024)
   PUBMED   38602002
  REMARK    GeneRIF: CTNNAL1 promotes the structural integrity of bronchial
            epithelial cells through the RhoA/ROCK1 pathway.
REFERENCE   2  (bases 1 to 3712)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3712)
  AUTHORS   Cao,J., Yao,Q.J., Wu,J., Chen,X., Huang,L., Liu,W., Qian,K.,
            Wan,J.J. and Zhou,B.O.
  TITLE     Deciphering the metabolic heterogeneity of hematopoietic stem cells
            with single-cell resolution
  JOURNAL   Cell Metab 36 (1), 209-221 (2024)
   PUBMED   38171334
REFERENCE   4  (bases 1 to 3712)
  AUTHORS   Wu,D., Zhu,J., Yang,F., Li,R., Liu,L., Liu,D., Liu,C., Qu,X.,
            Liu,H., Ji,M., Qin,X., Hua,L. and Xiang,Y.
  TITLE     CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma
            mouse model through ROCK1-CAL signaling pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1618-1629 (2023)
   PUBMED   37715489
  REMARK    GeneRIF: CTNNAL1 deficiency suppresses CFTR expression in
            HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.
REFERENCE   5  (bases 1 to 3712)
  AUTHORS   Kara,N., Xue,Y., Zhao,Z., Murphy,M.M., Comazzetto,S., Lesser,A.,
            Du,L. and Morrison,S.J.
  TITLE     Endothelial and Leptin Receptor+ cells promote the maintenance of
            stem cells and hematopoiesis in early postnatal murine bone marrow
  JOURNAL   Dev Cell 58 (5), 348-360 (2023)
   PUBMED   36868235
REFERENCE   6  (bases 1 to 3712)
  AUTHORS   Van den Bossche,J., Bogaert,P., van Hengel,J., Guerin,C.J.,
            Berx,G., Movahedi,K., Van den Bergh,R., Pereira-Fernandes,A.,
            Geuns,J.M., Pircher,H., Dorny,P., Grooten,J., De Baetselier,P. and
            Van Ginderachter,J.A.
  TITLE     Alternatively activated macrophages engage in homotypic and
            heterotypic interactions through IL-4 and polyamine-induced
            E-cadherin/catenin complexes
  JOURNAL   Blood 114 (21), 4664-4674 (2009)
   PUBMED   19726720
  REMARK    GeneRIF: This study identifies the E-cadherin/catenin complex as a
            discriminative, partly polyamine-regulated feature of
            IL-4/IL-13-exposed alternatively activated macrophages
REFERENCE   7  (bases 1 to 3712)
  AUTHORS   Xiang,Y., Tan,Y.R., Zhang,J.S., Qin,X.Q., Hu,B.B., Wang,Y., Qu,F.
            and Liu,H.J.
  TITLE     Wound repair and proliferation of bronchial epithelial cells
            regulated by CTNNAL1
  JOURNAL   J Cell Biochem 103 (3), 920-930 (2008)
   PUBMED   17647259
  REMARK    GeneRIF: We observed the temporal and spatial distribution of
            CTNNAL1 expression in mouse lung tissue with the OVA-sensitized
            asthma model and found that the level of CTNNAL1 mRNA showed a
            prominent negative correlation with pulmonary resistance.
REFERENCE   8  (bases 1 to 3712)
  AUTHORS   Heanue,T.A. and Pachnis,V.
  TITLE     Expression profiling the developing mammalian enteric nervous
            system identifies marker and candidate Hirschsprung disease genes
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 6919-6924 (2006)
   PUBMED   16632597
REFERENCE   9  (bases 1 to 3712)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3712)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ094037.1, CF896873.1, BC050070.1, CK794820.1, BG064548.2 and
            AW536536.1.
            
            On Apr 22, 2009 this sequence version replaced NM_018761.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050070.1, AK082755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                CJ094037.1         1-73
            74-699              CF896873.1         1-626
            700-2278            BC050070.1         677-2255
            2279-2775           CK794820.1         138-634
            2776-3129           BG064548.2         1-354               c
            3130-3398           AW536536.1         288-556             c
            3399-3712           BC050070.1         3376-3689
FEATURES             Location/Qualifiers
     source          1..3712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.66 cM"
     gene            1..3712
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /note="catenin alpha like 1"
                     /db_xref="GeneID:54366"
                     /db_xref="MGI:MGI:1859649"
     exon            1..235
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2293
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /note="alpha-catenin related protein; catenin alpha-like
                     protein 1; catenin (cadherin associated protein),
                     alpha-like 1"
                     /codon_start=1
                     /product="alpha-catulin"
                     /protein_id="NP_061231.3"
                     /db_xref="CCDS:CCDS18200.1"
                     /db_xref="GeneID:54366"
                     /db_xref="MGI:MGI:1859649"
                     /translation="MAASPVPGGGGAGAVHSSNAAGFTFDSGLEIRTRSVEQTLLPLV
                     SQITTLINHKDNTKKSDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEINIA
                     CIEAKQAGETIASLTDVTKRSHLESDGQVTILTDKTGVVQAARLLLSSVTKVLLLADR
                     VVIKQIVTSRNKILATMERLEKVNSFQEFVQIFSQFGNEMVEFAHLTGDRQNDLKDEK
                     KKARMAVARAVLEKGTMMLLTASKTCLRHPSCESAHTNKEGVFDRMRVALEKVTEIVT
                     DCRLSGETDSSSVSIFTGIKELKVNIEALRENVCFESKENLSAALEAVLEHVEDFTDS
                     AYTSHEHRERILELSSQARTELQQLLSVWMQTQSRKTKSAAEELELTVLKISHSLDEL
                     RRELHCTAMQLAADLLKFHADHVVLKALKVTGVEGNLEALAEYACKLSEQKEQLVETC
                     RLLRHISGTEPLEITCIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAWE
                     SQMSDMATLLREISDVFEGRRGERCDHLSLPKPTKNSANLKSLKPDKPDSEEQAKIAK
                     LGLKLGLLSSDADCEIEKWEDEENEIVRHGRNMSRMAYSLYLFTRGEGPLKTSQDLIH
                     FLEVFAAEGLKLTSSVQSFSKQLKDDDKLMLLLEINKLIPLCHQLQTITKTSLQSKVF
                     LKVDKCITKIRSMMTLVVQLLSLCYKLLKKMENNRWGSATNKDTMDGQN"
     exon            236..425
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..613
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..733
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..823
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..994
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1195
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1282
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1441
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1534
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1685
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1723
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1774
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1929
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..1978
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2035
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2149
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2233
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..3687
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3109..3114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /note="hexamer: AATAAA"
     polyA_site      3132
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /note="major polyA site"
     regulatory      3662..3667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /note="hexamer: AATAAA"
     polyA_site      3687
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /note="major polyA site"
ORIGIN      
        1 ggtggggcct cggtgcggcg aggcggcggg caacccggag gctggttggc gggcaggcag
       61 aggtgcggat agcgcgctgt gctatcggtg gagggccatg gccgcttctc cagtcccggg
      121 cggtggcggt gcgggagctg tccactcctc caacgcggct ggcttcacct tcgactcggg
      181 actggagatc aggacgcgct cggtggaaca gactcttctg cccctggttt ctcagatcac
      241 cacacttata aaccataaag ataataccaa aaagtctgat aaaaccctgc aagcgattca
      301 gcgtgtggga caagcggtca acttggcagt tggaagattt gttaaagtag gggaagctat
      361 agccaacgaa aactgggatt tgaaagaaga aattaacatc gcctgcatcg aagccaagca
      421 agcaggtgaa acaatcgcct cactcacaga tgtgactaaa cggagccatt tggaatcaga
      481 tggtcaggtc acgattctga cagacaaaac aggcgtcgtg caggccgccc ggctgctgct
      541 ctcctcagtg acaaaagtgc tgctgctggc agatcgtgta gtcatcaagc agatagtgac
      601 atcgagaaac aagattctcg caaccatgga aaggctagag aaagtaaaca gctttcagga
      661 atttgttcag atattcagcc agtttggaaa cgaaatggtg gagtttgcac atctaacggg
      721 agaccgacaa aatgatttga aagatgagaa gaaaaaggcc agaatggctg tggcgagggc
      781 tgtgcttgaa aagggtacga tgatgctcct tacagcctca aagacatgtc tcaggcatcc
      841 cagctgtgag tcagcccaca caaacaaaga aggagtgttt gaccggatga gagtggccct
      901 ggagaaggtc acggagatcg tgactgactg cagactcagc ggagagaccg acagctcatc
      961 tgtcagcatt tttactggga ttaaagagtt gaaggtgaat attgaagctc ttcgggagaa
     1021 tgtttgcttt gagtccaaag agaacctttc tgccgcattg gaggccgtct tggagcatgt
     1081 ggaggacttc actgattctg cctacaccag ccacgagcac agggaacgga tcttggagct
     1141 gtcttctcag gcgaggacag agctgcagca gctcctttcc gtgtggatgc aaacccaaag
     1201 caggaagaca aagagcgccg ccgaggagct ggaactcaca gttctgaaga tcagccacag
     1261 cctggacgag ctgaggagag aactccattg tacagccatg cagctggcag ccgacctgtt
     1321 aaaattccat gctgatcatg tggttttaaa agcattaaaa gttactggag tagaaggaaa
     1381 tttggaagct ttggctgagt atgcctgtaa actctctgag cagaaagaac agcttgtgga
     1441 gacatgtcga ttgttgcggc atatatccgg cacagaaccc cttgagataa cgtgcataca
     1501 tgcagaggag acatttcagg tgactggcca acagatcatt tctgctgctg aaacgttgac
     1561 gttgcatccg tctagcaaaa tcgctaagga aaacctggat gtgttttgtg aagcttggga
     1621 gtctcagatg agtgacatgg cgacgctgct aagggaaatc agtgatgtgt ttgaaggaag
     1681 acgaggagag aggtgcgacc atctttcact tccaaagccc acgaagaata gtgcaaacct
     1741 gaagtcacta aagcccgaca aacctgactc ggaggagcaa gccaagatag caaagctcgg
     1801 gctgaagctg ggattgctct cctctgatgc tgactgtgaa atcgagaaat gggaagatga
     1861 agagaacgag atcgttcggc atggacgcaa tatgtccagg atggcctatt ctctgtattt
     1921 atttactaga ggagaggggc cactgaaaac ttcccaggac ttaattcact tcctagaggt
     1981 ttttgctgca gagggattaa agcttacttc aagtgtacag tcattttcaa aacagctaaa
     2041 agatgatgac aaacttatgc ttctcctgga aataaacaaa cttattcctc tatgccacca
     2101 gcttcagaca ataactaaga catctttgca gagtaaagtc tttctaaagg ttgacaagtg
     2161 tattacaaag ataagatcca tgatgactct tgtggtccag ctcctctcac tttgctataa
     2221 actactgaag aagatggaaa ataacagatg gggctctgcg acgaacaaag ataccatgga
     2281 tggtcaaaac tgagcagcct ggggttcatc tcagggatac catgtggcac agctgacatt
     2341 ttaaaacgca aatgatcctt tgtactttca taagttcatc agtcttttaa agaggatgct
     2401 gaaatctttt tttctgatct tcagattaga cagtcatgtt gctatggtgg ttgctaagat
     2461 tctaacagca gtgcaatttg aaaacaaaca ctgtgctcag ggtgtttttc agcacacacc
     2521 aaatatccca actgtcttaa tggcggctga atcccaaaga agcaattgca aatgcacatt
     2581 ctccttggca ttcttaactg gtttttaagc ggattattta caacactaat ttcagcagaa
     2641 agtatacagt ggccttgttg aatgcagctt tttttttgag gcctgtggac tcttcttcat
     2701 ttcttgttga agcaggataa ggggccgtca gtgcctggtc ccagatcaca cctgttagca
     2761 ctgctgcttc taataagtat ctcactggta aggctgtgag gctgcacctg tcccttccct
     2821 acttctggaa ggaaaaacca caggagtcac tccaaagaag cctggagcaa cttcagaaga
     2881 ggagatggtt tttgttagct gtagtaagca cagctgacca ggcagccctg aataatggat
     2941 ggaatcctaa gtatttctta ctgggttaaa gacacgtttg aagtaccctt ctcagtattg
     3001 aggaaatgac agctgcagaa gacagaacat cggaaccaag aggctgttta gatcgcagac
     3061 acctgtacac tgtattttat gtatgtggaa ttggaatgct cattttaaaa taaatatttt
     3121 tagtcttttt aactttagga tttaaacctt ttcttgggct gggaagatga ctctgctgga
     3181 aacctgtgta ccttgtaagc tgtgtaatga agcaaggcaa aggttgccca ggagatggcc
     3241 cagctatctg ctgtactgca gactatcaga acgagggccg agagagggag catgtgcagt
     3301 cccagcgtgt gctatacaga aatctcacct ttagctactg tcacagctgc caacataacc
     3361 aggctttcaa aagcctagtc ttgcaggcag ctgttacagg gaatgattga atggaaccag
     3421 cgtctgtgaa aagtcaggat tggtaccaac acgtgtgagt gaaaactctg ggatttcttt
     3481 ttaaactgag aagcagaatg ctaacttcac tgggttctca gtgttgctat ctcagtgaca
     3541 aagcagctcc ctcaacaaaa ctgtaaaaga ccatcaaata tgtggcaaca ataccattat
     3601 ctctgacgac aaaatagggt ttattagtta gtattaaaga tcatgtgata atataagctt
     3661 caataaaaat cgtacattca aactgaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
