LOCUS       NP_061231                731 aa            linear   ROD 29-JUL-2024
DEFINITION  alpha-catulin [Mus musculus].
ACCESSION   NP_061231 XP_985690
VERSION     NP_061231.3
DBSOURCE    REFSEQ: accession NM_018761.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 731)
  AUTHORS   Liu,C., Wang,J., Tan,Y., Liu,C., Qu,X., Liu,H., Tan,M., Deng,C.,
            Qin,X. and Xiang,Y.
  TITLE     CTNNAL1 promotes the structural integrity of bronchial epithelial
            cells through the RhoA/ROCK1 pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (5), 753-762 (2024)
   PUBMED   38602002
  REMARK    GeneRIF: CTNNAL1 promotes the structural integrity of bronchial
            epithelial cells through the RhoA/ROCK1 pathway.
REFERENCE   2  (residues 1 to 731)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 731)
  AUTHORS   Cao,J., Yao,Q.J., Wu,J., Chen,X., Huang,L., Liu,W., Qian,K.,
            Wan,J.J. and Zhou,B.O.
  TITLE     Deciphering the metabolic heterogeneity of hematopoietic stem cells
            with single-cell resolution
  JOURNAL   Cell Metab 36 (1), 209-221 (2024)
   PUBMED   38171334
REFERENCE   4  (residues 1 to 731)
  AUTHORS   Wu,D., Zhu,J., Yang,F., Li,R., Liu,L., Liu,D., Liu,C., Qu,X.,
            Liu,H., Ji,M., Qin,X., Hua,L. and Xiang,Y.
  TITLE     CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma
            mouse model through ROCK1-CAL signaling pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1618-1629 (2023)
   PUBMED   37715489
  REMARK    GeneRIF: CTNNAL1 deficiency suppresses CFTR expression in
            HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.
REFERENCE   5  (residues 1 to 731)
  AUTHORS   Kara,N., Xue,Y., Zhao,Z., Murphy,M.M., Comazzetto,S., Lesser,A.,
            Du,L. and Morrison,S.J.
  TITLE     Endothelial and Leptin Receptor+ cells promote the maintenance of
            stem cells and hematopoiesis in early postnatal murine bone marrow
  JOURNAL   Dev Cell 58 (5), 348-360 (2023)
   PUBMED   36868235
REFERENCE   6  (residues 1 to 731)
  AUTHORS   Van den Bossche,J., Bogaert,P., van Hengel,J., Guerin,C.J.,
            Berx,G., Movahedi,K., Van den Bergh,R., Pereira-Fernandes,A.,
            Geuns,J.M., Pircher,H., Dorny,P., Grooten,J., De Baetselier,P. and
            Van Ginderachter,J.A.
  TITLE     Alternatively activated macrophages engage in homotypic and
            heterotypic interactions through IL-4 and polyamine-induced
            E-cadherin/catenin complexes
  JOURNAL   Blood 114 (21), 4664-4674 (2009)
   PUBMED   19726720
  REMARK    GeneRIF: This study identifies the E-cadherin/catenin complex as a
            discriminative, partly polyamine-regulated feature of
            IL-4/IL-13-exposed alternatively activated macrophages
REFERENCE   7  (residues 1 to 731)
  AUTHORS   Xiang,Y., Tan,Y.R., Zhang,J.S., Qin,X.Q., Hu,B.B., Wang,Y., Qu,F.
            and Liu,H.J.
  TITLE     Wound repair and proliferation of bronchial epithelial cells
            regulated by CTNNAL1
  JOURNAL   J Cell Biochem 103 (3), 920-930 (2008)
   PUBMED   17647259
  REMARK    GeneRIF: We observed the temporal and spatial distribution of
            CTNNAL1 expression in mouse lung tissue with the OVA-sensitized
            asthma model and found that the level of CTNNAL1 mRNA showed a
            prominent negative correlation with pulmonary resistance.
REFERENCE   8  (residues 1 to 731)
  AUTHORS   Heanue,T.A. and Pachnis,V.
  TITLE     Expression profiling the developing mammalian enteric nervous
            system identifies marker and candidate Hirschsprung disease genes
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 6919-6924 (2006)
   PUBMED   16632597
REFERENCE   9  (residues 1 to 731)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 731)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ094037.1, CF896873.1, BC050070.1, CK794820.1, BG064548.2 and
            AW536536.1.
            
            On Apr 22, 2009 this sequence version replaced NP_061231.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050070.1, AK082755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.66 cM"
     Protein         1..731
                     /product="alpha-catulin"
                     /note="alpha-catenin related protein; catenin alpha-like
                     protein 1; catenin (cadherin associated protein),
                     alpha-like 1"
                     /calculated_mol_wt=81332
     Region          30..674
                     /region_name="Vinculin"
                     /note="Vinculin family; pfam01044"
                     /db_xref="CDD:460040"
     Site            373
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88327.1)"
     Region          535..559
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88327.1)"
     Site            537
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBT7; propagated from
                     UniProtKB/Swiss-Prot (O88327.1)"
     CDS             1..731
                     /gene="Ctnnal1"
                     /gene_synonym="ACRP; Catnal1"
                     /coded_by="NM_018761.3:98..2293"
                     /db_xref="CCDS:CCDS18200.1"
                     /db_xref="GeneID:54366"
                     /db_xref="MGI:MGI:1859649"
ORIGIN      
        1 maaspvpggg gagavhssna agftfdsgle irtrsveqtl lplvsqittl inhkdntkks
       61 dktlqaiqrv gqavnlavgr fvkvgeaian enwdlkeein iacieakqag etiasltdvt
      121 krshlesdgq vtiltdktgv vqaarlllss vtkvllladr vvikqivtsr nkilatmerl
      181 ekvnsfqefv qifsqfgnem vefahltgdr qndlkdekkk armavaravl ekgtmmllta
      241 sktclrhpsc esahtnkegv fdrmrvalek vteivtdcrl sgetdsssvs iftgikelkv
      301 niealrenvc feskenlsaa leavlehved ftdsaytshe hrerilelss qartelqqll
      361 svwmqtqsrk tksaaeelel tvlkishsld elrrelhcta mqlaadllkf hadhvvlkal
      421 kvtgvegnle alaeyackls eqkeqlvetc rllrhisgte pleitcihae etfqvtgqqi
      481 isaaetltlh psskiakenl dvfceawesq msdmatllre isdvfegrrg ercdhlslpk
      541 ptknsanlks lkpdkpdsee qakiaklglk lgllssdadc eiekwedeen eivrhgrnms
      601 rmayslylft rgegplktsq dlihflevfa aeglkltssv qsfskqlkdd dklmlllein
      661 kliplchqlq titktslqsk vflkvdkcit kirsmmtlvv qllslcykll kkmennrwgs
      721 atnkdtmdgq n
//
