LOCUS       NM_001164376            3681 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus catenin alpha 3 (Ctnna3), transcript variant 1, mRNA.
ACCESSION   NM_001164376
VERSION     NM_001164376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3681)
  AUTHORS   Zhang,J., Li,J., Hou,Y., Lin,Y., Zhao,H., Shi,Y., Chen,K., Nian,C.,
            Tang,J., Pan,L., Xing,Y., Gao,H., Yang,B., Song,Z., Cheng,Y.,
            Liu,Y., Sun,M., Linghu,Y., Li,J., Huang,H., Lai,Z., Zhou,Z., Li,Z.,
            Sun,X., Chen,Q., Su,D., Li,W., Peng,Z., Liu,P., Chen,W., Huang,H.,
            Chen,Y., Xiao,B., Ye,L., Chen,L. and Zhou,D.
  TITLE     Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T
            cell exhaustion in tumor
  JOURNAL   Cell 187 (13), 3409-3426 (2024)
   PUBMED   38744281
REFERENCE   2  (bases 1 to 3681)
  AUTHORS   Hung,M., Lo,H.F., Beckmann,A.G., Demircioglu,D., Damle,G.,
            Hasson,D., Radice,G.L. and Krauss,R.S.
  TITLE     Cadherin-dependent adhesion is required for muscle stem cell niche
            anchorage and maintenance
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38456551
REFERENCE   3  (bases 1 to 3681)
  AUTHORS   Weng,A., Rabin,E.E., Flozak,A.S., Chiarella,S.E., Aillon,R.P. and
            Gottardi,C.J.
  TITLE     Alpha-T-catenin is expressed in peripheral nerves as a constituent
            of Schwann cell adherens junctions
  JOURNAL   Biol Open 11 (12) (2022)
   PUBMED   36420826
  REMARK    GeneRIF: Alpha-T-catenin is expressed in peripheral nerves as a
            constituent of Schwann cell adherens junctions.
REFERENCE   4  (bases 1 to 3681)
  AUTHORS   Zhang,Y.
  TITLE     SPATA33 affects the formation of cell adhesion complex by
            interacting with CTNNA3 in TM4 cells
  JOURNAL   Cell Tissue Res 389 (1), 145-157 (2022)
   PUBMED   35536443
  REMARK    GeneRIF: SPATA33 affects the formation of cell adhesion complex by
            interacting with CTNNA3 in TM4 cells.
REFERENCE   5  (bases 1 to 3681)
  AUTHORS   Sokpor,G., Kerimoglu,C., Nguyen,H., Pham,L., Rosenbusch,J.,
            Wagener,R., Nguyen,H.P., Fischer,A., Staiger,J.F. and Tuoc,T.
  TITLE     Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal
            Migration in a WNT Signaling-Dependent Manner
  JOURNAL   Front Mol Neurosci 14, 687581 (2021)
   PUBMED   34220450
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3681)
  AUTHORS   Goossens,S., Janssens,B., Bonne,S., De Rycke,R., Braet,F., van
            Hengel,J. and van Roy,F.
  TITLE     A unique and specific interaction between alphaT-catenin and
            plakophilin-2 in the area composita, the mixed-type junctional
            structure of cardiac intercalated discs
  JOURNAL   J Cell Sci 120 (Pt 12), 2126-2136 (2007)
   PUBMED   17535849
  REMARK    GeneRIF: By providing an extra link between the cadherin-catenin
            complex and intermediate filaments, the binding of alphaT-catenin
            to plakophilin-2 is proposed to be a means of modulating and
            strengthening cell-cell adhesion between cardiac muscle cells.
REFERENCE   7  (bases 1 to 3681)
  AUTHORS   Goossens,S., Janssens,B., Vanpoucke,G., De Rycke,R., van Hengel,J.
            and van Roy,F.
  TITLE     Truncated isoform of mouse alphaT-catenin is testis-restricted in
            expression and function
  JOURNAL   FASEB J 21 (3), 647-655 (2007)
   PUBMED   17185752
REFERENCE   8  (bases 1 to 3681)
  AUTHORS   Gavard,J., Lambert,M., Grosheva,I., Marthiens,V., Irinopoulou,T.,
            Riou,J.F., Bershadsky,A. and Mege,R.M.
  TITLE     Lamellipodium extension and cadherin adhesion: two cell responses
            to cadherin activation relying on distinct signalling pathways
  JOURNAL   J Cell Sci 117 (Pt 2), 257-270 (2004)
   PUBMED   14657280
REFERENCE   9  (bases 1 to 3681)
  AUTHORS   Janssens,B., Mohapatra,B., Vatta,M., Goossens,S., Vanpoucke,G.,
            Kools,P., Montoye,T., van Hengel,J., Bowles,N.E., van Roy,F. and
            Towbin,J.A.
  TITLE     Assessment of the CTNNA3 gene encoding human alpha T-catenin
            regarding its involvement in dilated cardiomyopathy
  JOURNAL   Hum Genet 112 (3), 227-236 (2003)
   PUBMED   12596047
REFERENCE   10 (bases 1 to 3681)
  AUTHORS   Janssens,B., Goossens,S., Staes,K., Gilbert,B., van Hengel,J.,
            Colpaert,C., Bruyneel,E., Mareel,M. and van Roy,F.
  TITLE     alphaT-catenin: a novel tissue-specific beta-catenin-binding
            protein mediating strong cell-cell adhesion
  JOURNAL   J Cell Sci 114 (Pt 17), 3177-3188 (2001)
   PUBMED   11590244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142745.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142745.1, AF344871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3681              AK142745.1         2-3682
FEATURES             Location/Qualifiers
     source          1..3681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     gene            1..3681
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /note="catenin alpha 3"
                     /db_xref="GeneID:216033"
                     /db_xref="MGI:MGI:2661445"
     exon            1..154
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            155..258
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2847
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-catenin-like protein; alpha T-catenin; catenin
                     (cadherin associated protein), alpha 3;
                     cadherin-associated protein; alphaT-catenin"
                     /codon_start=1
                     /product="catenin alpha-3 isoform 1"
                     /protein_id="NP_001157848.1"
                     /db_xref="CCDS:CCDS23901.1"
                     /db_xref="GeneID:216033"
                     /db_xref="MGI:MGI:2661445"
                     /translation="MSAETPITLNMDTQDLQIQTFTVEKLLEPLIIQVTTLVNCPQNP
                     SNRKKGRSKRARVLLASVEEATWNLLDKGEMIAKEATVLKEELAAALQEVRKESKALK
                     VSAERFTDDPCYLPKREAVVQAARALLAAVTRLLVLADMIDVMCLLQHVSSFQRTFES
                     LKNVSNKSDLQRTYQKLGKELESLDYLAFKRQQDLKSPSQRDEIAGARATLKENSPLL
                     HSICSACLEHSDVASLKASKDTVCEEIQNALDVISNASQGIQNAPAPPEPQAATLGSA
                     FDELENLIVLNPLTVTEEDVRPSLEKRLEAIISGAALLADSSCTRDLHRERIIAECNA
                     IRQALQDLLTEYMSNTGKTERSNTLNTAIVNMSKKTRDLRRQLRKAIIDHISDSFLDT
                     TVPLLVLIEAAKNGRVKEIKDYAAIFHEHTGRLVEVANLACSMSTNEDGIKIVRIAAN
                     HLETLCPQIINAALALASRPKSQVVKNTMEMYKRTWEHYIHVLTEAVDDITSIDDFLA
                     VSESHILEDVNKCIIALRDQDADNLDRAAGAIRGRAARVAHIVAGEMDSYEPGAYTEG
                     VMRNVNFLTSTVIPEFVTQVNVALDALSKNSLTALDDNQFVDISKKIYDTIHDIRCSV
                     MMIRTPEELEDVSDLEDDHEVRSHTSIQTEGKTDRAKMTQLPEAEKEKIAEQVADFKK
                     VKSKLDAEIEIWDDTSNDIIVLAKKMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISE
                     SGSRMDVLARQIANQCPDPPCKQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIV
                     SALDSVTSLIQAAKNLMNAVVQTVKMSYIASTKIIRIQSSAGPRHPVVMWRMKAPAKK
                     PLIKREKPEETWAAVRRGSAKKKIHPVQVMSEFRGRQVY"
     exon            259..451
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            452..618
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            619..738
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1002
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1206
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1287
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1440
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1533
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1690
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1891
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2043
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2136
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2318
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2424
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2559
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..3681
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2963..2968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /note="hexamer: CATAAA"
     polyA_site      2982
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /note="major polyA site"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /note="hexamer: AATAAA"
     polyA_site      3101
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
ORIGIN      
        1 cccctttctc tcttatcctg agtgaatggt gctcagctaa agggactgcc ccaccagctc
       61 tgtctctttc ctcccaccct tcgagctctc tttggaaaaa ttccctccaa aagctgaacc
      121 caaagctcat ttacttgtag gaagcatcag aaaggcaaca tgtcggcaga aacgccaata
      181 accctgaata tggacactca ggatctgcag atccaaacgt tcactgtgga gaaactgctg
      241 gagcctctga taatccaggt tactaccctg gtgaattgtc cgcagaatcc ttccaacagg
      301 aagaaaggac gttcaaagag agccagagtt cttctagctt ccgtggagga agcaacttgg
      361 aatttgttag acaaggggga gatgattgct aaggaagcca cggttttaaa ggaagagctg
      421 gcagctgcac tccaggaagt tcgaaaagag agcaaagctc tgaaggtatc agctgagaga
      481 tttacagacg acccctgtta cctcccgaaa agggaggccg tggttcaagc cgcccgcgcc
      541 ctgttggcag cagttacaag actccttgtt cttgccgaca tgattgatgt catgtgcctc
      601 ttgcagcatg tgtcatcttt ccaaagaaca ttcgagtctc tcaaaaatgt ttccaacaag
      661 tccgacctcc agagaaccta ccagaagctc gggaaggagc tggaaagcct ggattatttg
      721 gccttcaaac gccagcagga cctaaaatct ccaagccaga gggatgaaat tgcaggggcc
      781 cgggccacct tgaaggagaa ctccccactc ctgcattcta tttgttcagc atgcttggaa
      841 cattccgatg ttgcttcgct caaagccagt aaggacaccg tctgtgaaga gatccagaac
      901 gctcttgatg taatttcaaa tgcttcccaa ggcatccaga atgcgccagc gccccctgaa
      961 cctcaggcag caacactggg aagtgctttt gatgagctgg agaacttaat tgtcctgaac
     1021 ccactcacag tgacagagga agatgtaaga ccatcactag agaaacgcct agaagccatc
     1081 atcagtgggg ccgcactgtt ggccgactcg tcctgcacca gggacctcca ccgggagcgg
     1141 attatcgccg agtgcaatgc catccgccag gctctccagg acctgctgac ggagtacatg
     1201 agtaatactg gaaaaacaga aaggagtaat accctgaata ctgccattgt caacatgagc
     1261 aagaagacaa gagacctccg cagacagctc cgcaaagcta tcatagatca catatcagat
     1321 tctttcttgg atacaacagt tccactcctg gtcctcattg aagctgcgaa gaatggccga
     1381 gtcaaggaaa tcaaagacta tgctgccata tttcatgagc acactggcag gctcgtggag
     1441 gtggcaaatc tggcttgttc catgtcaacg aatgaagatg ggattaaaat cgtcagaatt
     1501 gcagccaatc acctggagac cctgtgtcca cagatcataa atgctgcact tgctttggca
     1561 tcaagaccca agagtcaagt ggtcaaaaac accatggaaa tgtacaagcg cacatgggaa
     1621 cactacatcc acgtcctcac tgaagctgta gatgacatca ccagcattga cgactttctg
     1681 gctgtatctg aaagccacat cctggaagat gtcaacaaat gcattatagc cttgagagat
     1741 caggatgctg ataatttaga ccgagctgcc ggtgccatca gaggacgggc cgcaagagta
     1801 gctcacatcg ttgcgggtga aatggatagt tacgaacccg gcgcttacac cgaaggtgtg
     1861 atgagaaatg tcaacttcct tacaagcact gtgatcccgg agttcgtgac acaagtgaat
     1921 gtggccctag atgctttaag caagaactct ctgactgcgc ttgatgataa tcagtttgtg
     1981 gacatctcca agaagatcta tgacacaatc catgatatca ggtgttcggt catgatgatt
     2041 cggacaccag aggaactaga ggatgtttct gaccttgaag atgaccatga ggtccgtagc
     2101 cacaccagca ttcagacaga agggaaaact gatcgggcca agatgactca actgcctgag
     2161 gcagaaaagg aaaagattgc tgagcaagtc gccgacttca agaaggtgaa gagcaagctg
     2221 gacgctgaga ttgagatatg ggatgacaca agcaatgaca tcattgttct tgccaagaag
     2281 atgtgcatga tcatgatgga gatgaccgac ttcacgaggg ggaaaggacc actaaagcat
     2341 accactgatg taatctatgc agctaaaatg atatcagagt caggatcaag gatggatgtt
     2401 cttgctcggc agattgctaa ccagtgtcca gatccaccgt gcaaacagga cttgctggct
     2461 tacctggaac agattaaatt ctactcccac cagctgaaaa tctgcagtca agttaaagca
     2521 gagatccaaa atctgggggg agaactcatc gtatcagctt tggacagtgt cacctccctg
     2581 atccaggcag ccaagaattt aatgaatgct gtagtgcaaa cagtgaaaat gtcatacatt
     2641 gcctccacca agatcatccg catccagagt tctgcaggac cccggcaccc agtagtcatg
     2701 tggaggatga aggctccggc taagaagccc ttgattaaaa gagagaagcc agaagaaaca
     2761 tgggcagctg tcagaagagg ctctgccaag aaaaagatcc acccagttca agtcatgagt
     2821 gaattcagag ggagacaagt ctactgaata ccctcatcca ctctagtgcc catttctaca
     2881 ccccaggcta accacactgc tttatttcat ggttcattgg ttctttaatt tcaccaagtt
     2941 tcagagttaa gctcacaaat aacataaaac attggggtta aacaagtgtg taagatgtgt
     3001 gtttgggatc ttgtcattgt gtactctata cggccagcac aacctagtta actggttggt
     3061 agtacctagg aaataaaact cacgggtgtt gcttaccact acccttcaga gggaagactt
     3121 atgttcatta caaaatgagc gtaagtgata atgtgagttc ctattaccca gaaatgtctg
     3181 cacccatgca ttctatatcc ctgggaagga aaaccctgac atacgctttg cacttgcatt
     3241 ttgctagaca taaaagagtt tatcaactat tttcccaatt agcatccata ctttctttaa
     3301 cccacctaac cttgcatcta acctgccaaa aatgtgtcac cctagccctg ggaaatttta
     3361 atcactgttc atcatgaata ggttagatac ctgtaaccga gtgggtgtgg ccaaccttct
     3421 tcctagaatt taaaagtcag gcatgttatt caagaagtgc tttgatgacc ctctgtaggc
     3481 tgccatcttg gaacataatg cttgaacctt gtatttctat agtgatcaga agttctggac
     3541 tcttagtatt gggcttatca gagcatacct gtagagtcat cacccactgg agaagtgaat
     3601 ttttgtttgt tgttggtgtg gggttttttt tgtttatttg tttgtttgtt tttggtattg
     3661 gaaataaaac atttcacatt c
//
