LOCUS       NM_009818               3713 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus catenin alpha 1 (Ctnna1), mRNA.
ACCESSION   NM_009818
VERSION     NM_009818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3713)
  AUTHORS   Hung,M., Lo,H.F., Beckmann,A.G., Demircioglu,D., Damle,G.,
            Hasson,D., Radice,G.L. and Krauss,R.S.
  TITLE     Cadherin-dependent adhesion is required for muscle stem cell niche
            anchorage and maintenance
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38456551
REFERENCE   2  (bases 1 to 3713)
  AUTHORS   Yang,Y., Li,S., Li,Y., Lv,L., Ye,D., Kang,J., Yu,T., Wang,Y. and
            Wu,H.
  TITLE     alpha-Catenin acetylation is essential for its stability and blocks
            its tumor suppressor effects in breast cancer through Yap1
  JOURNAL   Cancer Gene Ther 30 (12), 1624-1635 (2023)
   PUBMED   37679528
  REMARK    GeneRIF: alpha-Catenin acetylation is essential for its stability
            and blocks its tumor suppressor effects in breast cancer through
            Yap1.
            Erratum:[Cancer Gene Ther. 2023 Nov;30(11):1581. doi:
            10.1038/s41417-023-00668-1.. PMID: 37737279]
REFERENCE   3  (bases 1 to 3713)
  AUTHORS   Dehn,A.S., Duhaime,L., Gogna,N., Nishina,P.M., Kelley,K. and
            Losick,V.P.
  TITLE     Epithelial mechanics are maintained by inhibiting cell fusion with
            age in Drosophila
  JOURNAL   J Cell Sci 136 (20) (2023)
   PUBMED   37732459
REFERENCE   4  (bases 1 to 3713)
  AUTHORS   Tixi,W., Maldonado,M., Chang,Y.T., Chiu,A., Yeung,W., Parveen,N.,
            Nelson,M.S., Hart,R., Wang,S., Hsu,W.J., Fueger,P., Kopp,J.L.,
            Huising,M.O., Dhawan,S. and Shih,H.P.
  TITLE     Coordination between ECM and cell-cell adhesion regulates the
            development of islet aggregation, architecture, and functional
            maturation
  JOURNAL   Elife 12, e90006 (2023)
   PUBMED   37610090
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3713)
  AUTHORS   Dominguez,M.H., Krup,A.L., Muncie,J.M. and Bruneau,B.G.
  TITLE     Graded mesoderm assembly governs cell fate and morphogenesis of the
            early mammalian heart
  JOURNAL   Cell 186 (3), 479-496 (2023)
   PUBMED   36736300
REFERENCE   6  (bases 1 to 3713)
  AUTHORS   Guenet,J.L., Simon-Chazottes,D., Ringwald,M. and Kemler,R.
  TITLE     The genes coding for alpha and beta catenin (Catna1 and Catnb) and
            plakoglobin (Jup) map to mouse chromosomes 18, 9, and 11,
            respectively
  JOURNAL   Mamm Genome 6 (5), 363-366 (1995)
   PUBMED   7626889
REFERENCE   7  (bases 1 to 3713)
  AUTHORS   Herrenknecht,K., Ozawa,M., Eckerskorn,C., Lottspeich,F., Lenter,M.
            and Kemler,R.
  TITLE     The uvomorulin-anchorage protein alpha catenin is a vinculin
            homologue
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9156-9160 (1991)
   PUBMED   1924379
REFERENCE   8  (bases 1 to 3713)
  AUTHORS   Nagafuchi,A., Takeichi,M. and Tsukita,S.
  TITLE     The 102 kd cadherin-associated protein: similarity to vinculin and
            posttranscriptional regulation of expression
  JOURNAL   Cell 65 (5), 849-857 (1991)
   PUBMED   1904011
REFERENCE   9  (bases 1 to 3713)
  AUTHORS   Ozawa,M., Ringwald,M. and Kemler,R.
  TITLE     Uvomorulin-catenin complex formation is regulated by a specific
            domain in the cytoplasmic region of the cell adhesion molecule
  JOURNAL   Proc Natl Acad Sci U S A 87 (11), 4246-4250 (1990)
   PUBMED   2349235
REFERENCE   10 (bases 1 to 3713)
  AUTHORS   Ozawa,M., Baribault,H. and Kemler,R.
  TITLE     The cytoplasmic domain of the cell adhesion molecule uvomorulin
            associates with three independent proteins structurally related in
            different species
  JOURNAL   EMBO J 8 (6), 1711-1717 (1989)
   PUBMED   2788574
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X59990.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59990.1, AK159339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.89 cM"
     gene            1..3713
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /note="catenin alpha 1"
                     /db_xref="GeneID:12385"
                     /db_xref="MGI:MGI:88274"
     exon            1..70
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..177
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..2793
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /note="cadherin associated protein; CAP102; alpha
                     E-catenin; 102 kDa cadherin-associated protein; catenin
                     (cadherin associated protein), alpha 1"
                     /codon_start=1
                     /product="catenin alpha-1"
                     /protein_id="NP_033948.1"
                     /db_xref="CCDS:CCDS29139.1"
                     /db_xref="GeneID:12385"
                     /db_xref="MGI:MGI:88274"
                     /translation="MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNS
                     KGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVVAVEDVRKQGD
                     LMKSAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDG
                     ILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGNRDQMAAARGILQKNV
                     PILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDAAQHQGGSGG
                     ELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIV
                     AECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSD
                     SFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLV
                     RMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSI
                     DDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPG
                     VYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRD
                     IRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKA
                     KIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
                     DVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKA
                     EVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPA
                     VSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI"
     exon            178..373
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..540
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..660
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..930
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1134
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1215
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1368
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1461
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1618
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1819
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1971
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2082
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2264
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2370
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2505
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..3676
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3655..3660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /note="hexamer: AATAAA"
     polyA_site      3676
                     /gene="Ctnna1"
                     /gene_synonym="2010010M04Rik; Catna1"
                     /note="major polyA site"
ORIGIN      
        1 cgggagacaa agcggcggcc gtcggcttgg cgcctcagga gtcgtcccgt gctcgcccag
       61 ttcgctgcag aaatgactgc cgtccacgca ggcaacataa acttcaaatg ggaccccaaa
      121 agtctggaga ttaggactct ggctgttgaa agactgttgg agcctcttgt tacacaggtt
      181 acaaccctgg taaacaccaa tagtaaaggg ccgtctaata aaaagagagg ccgttctaag
      241 aaggcccatg ttttggctgc atctgttgaa caagcaactg agaatttctt ggaaaagggg
      301 gataaaattg caaaagagag ccagtttctc aaggaggagc ttgtggttgc tgtagaagat
      361 gttcgaaaac aaggagattt gatgaagagc gctgctgggg agtttgcaga tgatccatgc
      421 tcttctgtga agcgaggcaa catggtccgg gcagctcgag ctttgctctc tgccgtcacc
      481 cggctgctga ttctggctga catggcagat gtctacaaat tacttgttca gctgaaagtt
      541 gtggaagatg gtatattgaa actgaggaat gctggcaatg aacaagactt agggatacag
      601 tacaaagctc tgaaaccaga agtagataag ctgaacatca tggcagcaaa aagacaacag
      661 gaactaaaag atgtgggcaa tcgtgatcag atggctgcag ctagaggaat cctgcagaaa
      721 aatgttccaa tcctctatac tgcatcccag gcatgtctac aacaccctga tgttgcagcc
      781 tataaggcca accgggactt gatatacaag cagctgcagc aggccgtcac aggaatttct
      841 aatgcagccc aggctactgc atcagatgat gctgcccagc accagggtgg cagtggcgga
      901 gagctggcat acgctctcaa caactttgat aaacaaatca ttgtggaccc cttgagcttc
      961 agcgaggagc gctttaggcc gtccctggag gagcgcctgg aaagcattat tagtggggct
     1021 gccctgatgg ctgactcatc ctgcacacgt gatgaccgtc gggagcgcat tgtggcagag
     1081 tgtaatgctg tccgccaggc tctacaggac ctgctctcag aatacatggg caacgctgga
     1141 cgtaaagaaa gaagtgatgc actcaactct gcaatagata aaatgaccaa gaagaccagg
     1201 gacttgcgta gacagcttcg caaagctgtc atggaccacg tatcagattc tttcctggag
     1261 accaatgtcc ctctattagt actgattgaa gctgcaaaga atggaaatga gaaagaagtt
     1321 aaggaatatg cccaagtttt tcgtgaacat gccaacaaac tgattgaggt tgccaacctg
     1381 gcctgttcaa tctccaacaa tgaagaaggc gtgaagcttg tccgaatgtc tgcaagccag
     1441 ttagaagcgc tgtgtcctca ggttatcaat gctgcattgg cgttggcagc aaagccgcag
     1501 agtaaactgg cccaagagaa catggatctt tttaaagagc aatgggaaaa gcaagtccgt
     1561 gttctcacag atgctgttga tgacattact tccatcgatg acttcttggc tgtctcagag
     1621 aaccacattt tagaagatgt gaacaagtgt gttattgctc tccaagagaa agacgtggat
     1681 gggctggatc gcactgccgg tgccatccga ggccgggcag cccgagtcat tcatgtagtc
     1741 acctcagaga tggacaacta cgagccagga gtttacacag agaaggttct ggaagccacc
     1801 aagctcctct ccaacacagt catgccgcgc ttcactgagc aggtggaagc agctgtggaa
     1861 gccctcagct cggacccggc ccagcccatg gatgagaatg agttcatcga cgcctcccgt
     1921 ctggtgtacg acggcatccg ggacatccgg aaagcagtgc tgatgatcag gacccccgag
     1981 gagttggacg actctgactt cgagactgaa gactttgatg tcagaagcag gaccagtgtc
     2041 cagacagaag atgaccagct gatagctggc cagagcgccc gggcgatcat ggctcagctt
     2101 cctcaggagc aaaaagcaaa gattgcagaa caggtggcca gtttccagga agagaagagc
     2161 aagctggatg ctgaagtgtc caagtgggat gacagtggca atgacatcat tgtgctggcc
     2221 aagcagatgt gcatgatcat gatggagatg accgacttca cccgaggcaa aggtccactc
     2281 aaaaacacct ctgacgtgat cagtgctgcc aagaaaattg cggaggcggg atccaggatg
     2341 gacaagctcg gccggaccat cgcagaccat tgcccagact cggcatgcaa gcaggacctg
     2401 ctggcctacc ttcagcgcat cgctctctac tgccaccagc tcaacatctg cagcaaagtc
     2461 aaggctgaag tacagaacct tggtggagag ctggtcgtct ctggggtgga cagcgccatg
     2521 tccctgatcc aggcggccaa gaacttgatg aatgctgttg tgcagacagt gaaggcgtcc
     2581 tacgtggctt ccaccaaata ccagaagtca caggggatgg cttccttgaa ccttcctgct
     2641 gtgtcatgga agatgaaggc ccctgagaag aagccgttgg tgaagagaga gaagcaggat
     2701 gagacgcaga ccaagattaa acgagcttct cagaagaaac acgtgaaccc agtgcaggcc
     2761 ctgagcgagt tcaaagccat ggacagcatc tgagcctgca cagcccatgg ggttctgaaa
     2821 aaaaccagtc acatgcttca ctcaaatgta tttgctaagt agagaacact gtcttattcc
     2881 acagggaggt agcagatttc agactcaacc aggtggtgaa ttttgcaagg acatgtttgt
     2941 gttaaagctg gttagaaaaa aaaagctttt agaattcaaa aatatatttc tagctatatt
     3001 tttataagtt taatgaaaat aacagttctg taaccaaaga gtaccacatt aacttcttgg
     3061 tcacatttct gagtaggctg aagtgcctgc tttctaggta ggggtgagcg cctgagggga
     3121 gaggttgctt tttagcccta ctgttgggca gatggaatta aatgaccaag ggtggcccag
     3181 tgtaaatcac agggcacctt agacggtctg gagaaggaag gtaccagaaa cctcttctga
     3241 ggaataaact ataggagaca ataaaatata acacagtacc caggaagttg attgctttct
     3301 ttatgaagca gaaggggaat tatgacgcat ggctacagtt actaatggac tctgctgcag
     3361 aacattaatg gagttgcttt attcgggctc gtgtgttgtg atgctgtaat cagaacatgc
     3421 ttccctgtta ttccagcttg aaatgcaaat tcaccatcgg gctcatttct aatcgtcgca
     3481 gtgtttcctg ctttgggcca gcaaagaagc ctgatgactg catagggttt gcttaggcaa
     3541 tacttagacg caccgtgttt gtgactacta cagcaatcac catagctacg agatgagatt
     3601 ttactgtctt atttaaattt tatgaatctg tctgtttttt acactaattt tcccaataaa
     3661 gtccattaag aaccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
