LOCUS       NM_009843               1933 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus cytotoxic T-lymphocyte-associated protein 4 (Ctla4),
            transcript variant 1, mRNA.
ACCESSION   NM_009843 XM_001479130 XM_001479137
VERSION     NM_009843.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1933)
  AUTHORS   Tey,P.Y., Dufner,A., Knobeloch,K.P., Pruneda,J.N., Clague,M.J. and
            Urbe,S.
  TITLE     Rapid turnover of CTLA4 is associated with a complex architecture
            of reversible ubiquitylation
  JOURNAL   J Cell Biol 224 (1) (2025)
   PUBMED   39404738
  REMARK    GeneRIF: Rapid turnover of CTLA4 is associated with a complex
            architecture of reversible ubiquitylation.
REFERENCE   2  (bases 1 to 1933)
  AUTHORS   Sun,T., Yang,Y., Qiu,Y., Wang,T., Yang,M., Shen,S. and Wang,W.
  TITLE     High PD-1 and CTLA-4 expression correlates with host immune
            suppression in patients and a mouse model infected with
            Echinococcus multilocularis
  JOURNAL   Parasit Vectors 17 (1), 437 (2024)
   PUBMED   39456030
  REMARK    GeneRIF: High PD-1 and CTLA-4 expression correlates with host
            immune suppression in patients and a mouse model infected with
            Echinococcus multilocularis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1933)
  AUTHORS   Ahmed,A., Joseph,A.M., Zhou,J., Horn,V., Uddin,J., Lyu,M., Goc,J.,
            Sockolow,R.E., Wing,J.B., Vivier,E., Sakaguchi,S. and
            Sonnenberg,G.F.
  CONSRTM   JRI Live Cell Bank
  TITLE     CTLA-4-expressing ILC3s restrain interleukin-23-mediated
            inflammation
  JOURNAL   Nature 630 (8018), 976-983 (2024)
   PUBMED   38867048
  REMARK    GeneRIF: CTLA-4-expressing ILC3s restrain interleukin-23-mediated
            inflammation.
REFERENCE   4  (bases 1 to 1933)
  AUTHORS   Xue,G., Li,X., Kalim,M., Fang,J., Jiang,Z., Zheng,N., Wang,Z.,
            Li,X., Abdelrahim,M., He,Z., Nikiforov,M., Jin,G. and Lu,Y.
  TITLE     Clinical drug screening reveals clofazimine potentiates the
            efficacy while reducing the toxicity of anti-PD-1 and CTLA-4
            immunotherapy
  JOURNAL   Cancer Cell 42 (5), 780-796 (2024)
   PUBMED   38518774
REFERENCE   5  (bases 1 to 1933)
  AUTHORS   Ward,F.J., Dahal,L.N., Wijesekera,S.K., Abdul-Jawad,S.K.,
            Kaewarpai,T., Xu,H., Vickers,M.A. and Barker,R.N.
  TITLE     The soluble isoform of CTLA-4 as a regulator of T-cell responses
  JOURNAL   Eur J Immunol 43 (5), 1274-1285 (2013)
   PUBMED   23400950
  REMARK    GeneRIF: The soluble isoform of CTLA-4 is a regulator of T-cell
            responses.
REFERENCE   6  (bases 1 to 1933)
  AUTHORS   Ostrov,D.A., Shi,W., Schwartz,J.C., Almo,S.C. and Nathenson,S.G.
  TITLE     Structure of murine CTLA-4 and its role in modulating T cell
            responsiveness
  JOURNAL   Science 290 (5492), 816-819 (2000)
   PUBMED   11052947
REFERENCE   7  (bases 1 to 1933)
  AUTHORS   Freeman,G.J., Lombard,D.B., Gimmi,C.D., Brod,S.A., Lee,K.,
            Laning,J.C., Hafler,D.A., Dorf,M.E., Gray,G.S., Reiser,H. et al.
  TITLE     CTLA-4 and CD28 mRNA are coexpressed in most T cells after
            activation. Expression of CTLA-4 and CD28 mRNA does not correlate
            with the pattern of lymphokine production
  JOURNAL   J Immunol 149 (12), 3795-3801 (1992)
   PUBMED   1281186
REFERENCE   8  (bases 1 to 1933)
  AUTHORS   Cole,T.J., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schutz,G. and
            Ruppert,S.
  TITLE     The mouse CREB (cAMP responsive element binding protein) gene:
            structure, promoter analysis, and chromosomal localization
  JOURNAL   Genomics 13 (4), 974-982 (1992)
   PUBMED   1387109
REFERENCE   9  (bases 1 to 1933)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (bases 1 to 1933)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL663047.15, AK138891.1 and
            AI323635.1.
            
            On Aug 13, 2013 this sequence version replaced NM_009843.3.
            
            Summary: This gene is a member of the immunoglobulin superfamily,
            and encodes a protein that functions as a negative regulator of
            T-cell responses. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) encodes the longer
            membrane-bound isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042741.1, AK138891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL663047.15        21678-21745
            69-675              AK138891.1         2-608
            676-1743            AK138891.1         610-1677
            1744-1933           AI323635.1         1-190               c
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.58 cM"
     gene            1..1933
                     /gene="Ctla4"
                     /gene_synonym="Cd152; Ctla-4; Ly-56"
                     /note="cytotoxic T-lymphocyte-associated protein 4"
                     /db_xref="GeneID:12477"
                     /db_xref="MGI:MGI:88556"
     exon            1..255
                     /gene="Ctla4"
                     /gene_synonym="Cd152; Ctla-4; Ly-56"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..818
                     /gene="Ctla4"
                     /gene_synonym="Cd152; Ctla-4; Ly-56"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytotoxic T-lymphocyte protein 4; cytotoxic
                     T-lymphocyte-associated antigen 4; CD152 antigen"
                     /codon_start=1
                     /product="cytotoxic T-lymphocyte protein 4 isoform 1
                     precursor"
                     /protein_id="NP_033973.2"
                     /db_xref="CCDS:CCDS14993.1"
                     /db_xref="GeneID:12477"
                     /db_xref="MGI:MGI:88556"
                     /translation="MACLGLRRYKAQLQLPSRTWPFVALLTLLFIPVFSEAIQVTQPS
                     VVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPF
                     CSGTFNESRVNLTIQGLRAVDTGLYLCKVELMYPPPYFVGMGNGTQIYVIDPEPCPDS
                     DFLLWILVAVSLGLFFYSFLVTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPY
                     FIPIN"
     exon            256..603
                     /gene="Ctla4"
                     /gene_synonym="Cd152; Ctla-4; Ly-56"
                     /inference="alignment:Splign:2.1.0"
     exon            604..713
                     /gene="Ctla4"
                     /gene_synonym="Cd152; Ctla-4; Ly-56"
                     /inference="alignment:Splign:2.1.0"
     exon            714..1933
                     /gene="Ctla4"
                     /gene_synonym="Cd152; Ctla-4; Ly-56"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctacacatat gtagcacgta ccttggatca aagctgtcta tataaagtcc ccgagtctgt
       61 gtgggttcaa acacatctca aggcttctgg atcctgttgg gttttactct gctccctgag
      121 gacctcagca catttgcccc ccagccatgg cttgtcttgg actccggagg tacaaagctc
      181 aactgcagct gccttctagg acttggcctt ttgtagccct gctcactctt cttttcatcc
      241 cagtcttctc tgaagccata caggtgaccc aaccttcagt ggtgttggct agcagccatg
      301 gtgtcgccag ctttccatgt gaatattcac catcacacaa cactgatgag gtccgggtga
      361 ctgtgctgcg gcagacaaat gaccaaatga ctgaggtctg tgccacgaca ttcacagaga
      421 agaatacagt gggcttccta gattacccct tctgcagtgg tacctttaat gaaagcagag
      481 tgaacctcac catccaagga ctgagagctg ttgacacggg actgtacctc tgcaaggtgg
      541 aactcatgta cccaccgcca tactttgtgg gcatgggcaa cgggacgcag atttatgtca
      601 ttgatccaga accatgcccg gattctgact tcctcctttg gatccttgtc gcagttagct
      661 tggggttgtt tttttacagt ttcctggtca ctgctgtttc tttgagcaag atgctaaaga
      721 aaagaagtcc tcttacaaca ggggtctatg tgaaaatgcc cccaacagag ccagaatgtg
      781 aaaagcaatt tcagccttat tttattccca tcaactgaaa ggccgtttat gaagaagaag
      841 gagcatactt cagtctctaa aagctgaggc aatttcaact ttccttttct ctccagctat
      901 ttttacctgt ttgtatattt taaggagagt atgcctctct ttaatagaaa gctggatgca
      961 aaattccaat taagcatact acaatttaaa gctaaggagc atgaacagag agctgggata
     1021 tttctgttgt gtcagaacca ttttactaaa agcatcactt ggaagcagca taaggatata
     1081 gcattatggt gtggggtcaa gggaacatta gggaatggca cagcccaaag aaaggaaggg
     1141 ggtgaaggaa gagattatat tgtacacatc ttgtatttac ctgagagatg tttatgactt
     1201 aaataatttt taaatttttc atgctgttat tttctttaac aatgtataat tacacgaagg
     1261 tttaaacatt tattcacaga gctatgtgac atagccagtg gttccaaagg ttgtagtgtt
     1321 ccaagatgta tttttaagta atattgtaca tgggtgtttc atgtgctgtt gtgtatttgc
     1381 tggtggtttg aatataaaca ctatgtatca gtgtcgtccc acagtgggtc ctggggaggt
     1441 ttggctgggg agcttaggac actaatccat caggttggac tcgaggtcct gcaccaactg
     1501 gcttggaaac tagatgaggc tgtcacaggg ctcagttgca taaaccgatg gtgatggagt
     1561 gtaaactggg tctttacact cattttattt tttgtttctg cttttgtttt cttcaatgat
     1621 ttgcaaggaa accaaaagct ggcagtgttt gtatgaacct gacagaacac tgtcttcaag
     1681 gaaatgcctc attcctgaga ccagtaggtt tgttttttta ggaagttcca atactaggac
     1741 cccctacaag tactatggct cctcgaaaac acaaagttaa tgccacagga agcagcagat
     1801 ggtaggatgg gatgcacaag agttcctgaa aactaacact gttagtgttt tttttttaac
     1861 tcaatatttt ccatgaaaat gcaaccacat gtataatatt tttaattaaa taaaagtttc
     1921 ttgtgattgt ttt
//
