LOCUS       NM_007797                856 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus cytotoxic T lymphocyte-associated protein 2 beta
            (Ctla2b), transcript variant 1, mRNA.
ACCESSION   NM_007797 XM_001477566
VERSION     NM_007797.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 856)
  AUTHORS   Silva-Vilches,C., Pletinckx,K., Lohnert,M., Pavlovic,V., Ashour,D.,
            John,V., Vendelova,E., Kneitz,S., Zhou,J., Chen,R., Reinheckel,T.,
            Mueller,T.D., Bodem,J. and Lutz,M.B.
  TITLE     Low doses of cholera toxin and its mediator cAMP induce CTLA-2
            secretion by dendritic cells to enhance regulatory T cell
            conversion
  JOURNAL   PLoS One 12 (7), e0178114 (2017)
   PUBMED   28759565
  REMARK    GeneRIF: CTLA-2 secretion is induced by dendritic cells to enhance
            regulatory T cell conversion after administration of cholera toxin
            and cAMP
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 856)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 856)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   4  (bases 1 to 856)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   5  (bases 1 to 856)
  AUTHORS   Cheon,Y.P., DeMayo,F.J., Bagchi,M.K. and Bagchi,I.C.
  TITLE     Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine
            protease inhibitor in decidua: a potential regulator of embryo
            implantation
  JOURNAL   J Biol Chem 279 (11), 10357-10363 (2004)
   PUBMED   14681235
  REMARK    GeneRIF: expression of CTLA-2beta in the decidua may regulate
            implantation of the embryo by neutralizing the activities of one or
            more proteases generated by the proliferating trophoblast
REFERENCE   6  (bases 1 to 856)
  AUTHORS   Deussing,J., Kouadio,M., Rehman,S., Werber,I., Schwinde,A. and
            Peters,C.
  TITLE     Identification and characterization of a dense cluster of
            placenta-specific cysteine peptidase genes and related genes on
            mouse chromosome 13
  JOURNAL   Genomics 79 (2), 225-240 (2002)
   PUBMED   11829493
REFERENCE   7  (bases 1 to 856)
  AUTHORS   Peterfy,M., Phan,J., Oswell,G.M., Xu,P. and Reue,K.
  TITLE     Genetic, physical, and transcript map of the fld region on mouse
            chromosome 12
  JOURNAL   Genomics 62 (3), 436-444 (1999)
   PUBMED   10644441
REFERENCE   8  (bases 1 to 856)
  AUTHORS   Denizot,F., Brunet,J.F., Roustan,P., Harper,K., Suzan,M.,
            Luciani,M.F., Mattei,M.G. and Golstein,P.
  TITLE     Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse
            activated T cells and mast cells and homologous to cysteine
            proteinase proregions
  JOURNAL   Eur J Immunol 19 (4), 631-635 (1989)
   PUBMED   2786470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE448128.1, AY034578.1 and DT925153.1.
            
            [WARNING] On Mar 13, 2024 this sequence was replaced by
            NM_007797.2.
            
            On Mar 12, 2009 this sequence version replaced XM_001477566.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY034578.1, X15592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BE448128.1         1-60
            61-834              AY034578.1         1-774
            835-856             DT925153.1         597-618
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.53 cM"
     gene            1..856
                     /gene="Ctla2b"
                     /gene_synonym="Ctla-2b"
                     /note="cytotoxic T lymphocyte-associated protein 2 beta"
                     /db_xref="GeneID:13025"
                     /db_xref="MGI:MGI:88555"
     exon            1..113
                     /gene="Ctla2b"
                     /gene_synonym="Ctla-2b"
                     /inference="alignment:Splign:2.1.0"
     exon            114..231
                     /gene="Ctla2b"
                     /gene_synonym="Ctla-2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..486
                     /gene="Ctla2b"
                     /gene_synonym="Ctla-2b"
                     /note="isoform a is encoded by transcript variant 1;
                     protein CTLA-2-beta"
                     /codon_start=1
                     /product="protein CTLA-2-beta isoform a"
                     /protein_id="NP_031823.1"
                     /db_xref="CCDS:CCDS49289.1"
                     /db_xref="GeneID:13025"
                     /db_xref="MGI:MGI:88555"
                     /translation="MMSAAPSPDPSLDNEWKEWKTTFAKAYSLDEERHRRLMWEENKK
                     KIEAHNADYERGKTSFYMGLNQFSDLTPEEFRTNCCGSSMCRGEMAPDLPEYEDLGKN
                     SYLTPGRAQPE"
     exon            232..354
                     /gene="Ctla2b"
                     /gene_synonym="Ctla-2b"
                     /inference="alignment:Splign:2.1.0"
     exon            355..477
                     /gene="Ctla2b"
                     /gene_synonym="Ctla-2b"
                     /inference="alignment:Splign:2.1.0"
     exon            478..846
                     /gene="Ctla2b"
                     /gene_synonym="Ctla-2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccacaggct gctctcctca tgcaccacta gcctcctctg tcagttgctc ttcagaggcc
       61 ctggacaaca aagttctggt ttctatctgt gaacagaagc tgcagcactt cagtgctgtc
      121 ttcctgctca tcctctgctt gggaatgatg tcagctgctc catcccctga tccaagtttg
      181 gataatgagt ggaaagaatg gaagacaaca tttgcaaaag cctacagtct ggatgaagaa
      241 agacacagaa gactcatgtg ggaggagaat aagaagaaaa ttgaggcaca caatgcagac
      301 tatgagcggg gcaagaccag cttctacatg ggcctgaatc aatttagtga cttgactcca
      361 gaagaattca ggacaaattg ctgtggaagc tcaatgtgta gaggagaaat ggctcctgat
      421 ttgcctgaat atgaagattt gggaaagaac agctatctga cacctggaag ggctcagcca
      481 gagtaacagt tgtggcttga ctggtaacaa tatcatagtc taggagtgaa gcaagcactc
      541 tgcattgtct tgggagtctt ctgtctcctg gtatgggagg aatgatgctg tagaggctca
      601 acagcaggaa gcagcccatc acagtgtcca gcatgtgctg tgtgatatgc aaaactgaac
      661 tcatataaga tcaacactgt ggtgtgaact ctgaggcaca gtcatactga gaaatcattg
      721 ccaattttta gctctgaagt tccttaaatg attctcacaa ggatctttag ttttcacttt
      781 aataagatga atatatgcca tgatgtcttc aaattaaagc tagatattaa attagtactc
      841 tgcttcaaaa aaaaaa
//
