LOCUS       NM_007796               1373 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus cytotoxic T lymphocyte-associated protein 2 alpha
            (Ctla2a), transcript variant 1, mRNA.
ACCESSION   NM_007796
VERSION     NM_007796.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Li,H., Kurtzeborn,K., Kupari,J., Gui,Y., Siefker,E., Lu,B.,
            Matlik,K., Olfat,S., Montano-Rodriguez,A.R., Huh,S.H.,
            Costantini,F., Andressoo,J.O. and Kuure,S.
  TITLE     Postnatal prolongation of mammalian nephrogenesis by excess fetal
            GDNF
  JOURNAL   Development 148 (10) (2021)
   PUBMED   34032268
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Silva-Vilches,C., Pletinckx,K., Lohnert,M., Pavlovic,V., Ashour,D.,
            John,V., Vendelova,E., Kneitz,S., Zhou,J., Chen,R., Reinheckel,T.,
            Mueller,T.D., Bodem,J. and Lutz,M.B.
  TITLE     Low doses of cholera toxin and its mediator cAMP induce CTLA-2
            secretion by dendritic cells to enhance regulatory T cell
            conversion
  JOURNAL   PLoS One 12 (7), e0178114 (2017)
   PUBMED   28759565
  REMARK    GeneRIF: CTLA-2 secretion is induced by dendritic cells to enhance
            regulatory T cell conversion after administration of cholera toxin
            and cAMP
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Luziga,C., Nga,B.T., Mbassa,G. and Yamamoto,Y.
  TITLE     Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in
            distinct regions of the mouse brain
  JOURNAL   Acta Histochem 118 (7), 704-710 (2016)
   PUBMED   27586811
  REMARK    GeneRIF: that the fine equilibrium between synthesis and secretion
            of cathespin L and CTLA-2alpha is part of the brain processes to
            maintain normal growth and development
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Nga,B.T., Luziga,C., Yamamoto,M., Kusakabe,K.T. and Yamamoto,Y.
  TITLE     Identification and characterization of the interactive proteins
            with cytotoxic T-lymphocyte antigen-2alpha
  JOURNAL   Biosci Biotechnol Biochem 79 (4), 587-597 (2015)
   PUBMED   25514977
  REMARK    GeneRIF: Double immunofluorescence analysis showed that CTLA-2alpha
            was co-localized with cathepsin L, cathepsin C, and TINAGL1 in
            placenta.
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Zhou,P., Zhang,Y., Ma,Q., Gu,F., Day,D.S., He,A., Zhou,B., Li,J.,
            Stevens,S.M., Romo,D. and Pu,W.T.
  TITLE     Interrogating translational efficiency and lineage-specific
            transcriptomes using ribosome affinity purification
  JOURNAL   Proc Natl Acad Sci U S A 110 (38), 15395-15400 (2013)
   PUBMED   24003143
REFERENCE   6  (bases 1 to 1373)
  AUTHORS   Frankfort,B.J. and Gelman,I.H.
  TITLE     Identification of novel cellular genes transcriptionally suppressed
            by v-src
  JOURNAL   Biochem Biophys Res Commun 206 (3), 916-926 (1995)
   PUBMED   7832805
REFERENCE   7  (bases 1 to 1373)
  AUTHORS   Ko,M.S., Wang,X., Horton,J.H., Hagen,M.D., Takahashi,N., Maezaki,Y.
            and Nadeau,J.H.
  TITLE     Genetic mapping of 40 cDNA clones on the mouse genome by PCR
  JOURNAL   Mamm Genome 5 (6), 349-355 (1994)
   PUBMED   8043949
REFERENCE   8  (bases 1 to 1373)
  AUTHORS   Rowe,L.B., Nadeau,J.H., Turner,R., Frankel,W.N., Letts,V.A.,
            Eppig,J.T., Ko,M.S., Thurston,S.J. and Birkenmeier,E.H.
  TITLE     Maps from two interspecific backcross DNA panels available as a
            community genetic mapping resource
  JOURNAL   Mamm Genome 5 (5), 253-274 (1994)
   PUBMED   8075499
  REMARK    Erratum:[Mamm Genome 1994 Jul;5(7):463]
REFERENCE   9  (bases 1 to 1373)
  AUTHORS   Denizot,F., Brunet,J.F., Roustan,P., Harper,K., Suzan,M.,
            Luciani,M.F., Mattei,M.G. and Golstein,P.
  TITLE     Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse
            activated T cells and mast cells and homologous to cysteine
            proteinase proregions
  JOURNAL   Eur J Immunol 19 (4), 631-635 (1989)
   PUBMED   2786470
REFERENCE   10 (bases 1 to 1373)
  AUTHORS   Brunet,J.F., Dosseto,M., Denizot,F., Mattei,M.G., Clark,W.R.,
            Haqqi,T.M., Ferrier,P., Nabholz,M., Schmitt-Verhulst,A.M.,
            Luciani,M.F. and Golstein,P.
  TITLE     The inducible cytotoxic T-lymphocyte-associated gene transcript
            CTLA-1 sequence and gene localization to mouse chromosome 14
  JOURNAL   Nature 322 (6076), 268-271 (1986)
   PUBMED   3090449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB574774.1, AK167433.1 and AK132290.1.
            
            On Mar 11, 2009 this sequence version replaced NM_007796.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132290.1, CF618454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN02415136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BB574774.1         2-69
            69-751              AK167433.1         2-684
            752-1373            AK132290.1         683-1304
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.56 cM"
     gene            1..1373
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /note="cytotoxic T lymphocyte-associated protein 2 alpha"
                     /db_xref="GeneID:13024"
                     /db_xref="MGI:MGI:88554"
     exon            1..135
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..508
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; protein CTLA-2-alpha"
                     /codon_start=1
                     /product="protein CTLA-2-alpha isoform a precursor"
                     /protein_id="NP_031822.2"
                     /db_xref="CCDS:CCDS49290.1"
                     /db_xref="GeneID:13024"
                     /db_xref="MGI:MGI:88554"
                     /translation="MMVSICEQKLQHFSAVFLLILCLGMMSAAPPPDPSLDNEWKEWK
                     TKFAKAYNLNEERHRRLVWEENKKKIEAHNADYEQGKTSFYMGLNQFSDLTPEEFKTN
                     CYGNSLNRGEMAPDLPEYEDLGKNSYLTPGRAQPE"
     exon            136..253
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            254..376
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            377..499
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1373
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      731..736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /note="hexamer: AATAAA"
     polyA_site      755
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /note="major polyA site"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
                     /note="hexamer: AATAAA"
     polyA_site      1363
                     /gene="Ctla2a"
                     /gene_synonym="Ctla-2a"
ORIGIN      
        1 gctccaggaa ggaaaaggcg gagccacagg ctgctctcct caagtaccac cagcctcctc
       61 tgtcagttgc tcttcagaga ccgtggacaa caaaatgatg gtttctatct gtgaacagaa
      121 gctgcagcac ttcagtgctg tcttcctgct catcctctgc ttgggaatga tgtcagctgc
      181 tccaccccct gatccaagtt tggataatga gtggaaagaa tggaagacga aatttgcaaa
      241 agcctacaat ctgaatgaag aaagacacag aagactcgtg tgggaggaga ataagaagaa
      301 aattgaggca cacaatgcag actatgagca gggcaagacc agcttctaca tgggcctgaa
      361 tcaatttagt gacttgactc cagaagaatt caagacaaat tgctatggaa actcactgaa
      421 tagaggagaa atggctcctg atttgcctga atatgaagat ttgggaaaga acagctatct
      481 gacacctgga agggctcagc cagagtaaca gctgtggctt gactggtaac aatagcatag
      541 gctagaagtg aagcaagcac tctgccattg ccttggaagt cttctgtctc ctggtatgag
      601 aggaatgatg ctggagaggc tcaacagcag gaggcatccc atcacagctt ccagcacctg
      661 ctttgtgtag tgtaacattg aattcatgta agattaacac tgtggtgtaa actctgaggc
      721 acattcatgc aataaaacta ctagttttgg cagtctctag atggtccatc ctttcgtctc
      781 agctccaaac tttgtctctg aaactccttc catggatgtt ttgttcccaa ttctaagaag
      841 gggcatagtg ttcacatttt gttcttcgtt cttcttgagt ttcatatgtt ttgcaaattg
      901 tatcttgtat cttgggtagt ctaagtttct gggctaatat cctcttatca gtgagtacat
      961 atcatgtgag ttctttggcc tggcaaacac agaagtggat gctcacagtt aggtattgga
     1021 tggaacacag ggcccccaat ggaggagcta gagaaagtac ccaaggagct aaaggggtct
     1081 gcaaccctat aggtggaaca acaatatgaa ctaaccagta cccccggagc tcatgtctct
     1141 agctgcatat ctatcagaag atggcctagt cggccatcat tgagaagaga ggtcccttgg
     1201 tcttacaaac tttatatgcc tcagtacagg gggatgccag ggccaagaag tgggactggg
     1261 tgggtagggg agtcgcgggg gagggcctgg ggaacttttg ggatagcatt tgtaatgtaa
     1321 atgaagaaaa tacctaattt aaaaataaat aaataaacta ccagtttttg ccc
//
