LOCUS       NM_026778               1182 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus collagen triple helix repeat containing 1 (Cthrc1),
            transcript variant 1, mRNA.
ACCESSION   NM_026778 XM_128002 XM_912539 XM_982785
VERSION     NM_026778.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1182)
  AUTHORS   Islam,M., Yang,Y., Simmons,A.J., Shah,V.M., Musale,K.P., Xu,Y.,
            Tasneem,N., Chen,Z., Trinh,L.T., Molina,P., Ramirez-Solano,M.A.,
            Sadien,I.D., Dou,J., Rolong,A., Chen,K., Magnuson,M.A.,
            Rathmell,J.C., Macara,I.G., Winton,D.J., Liu,Q., Zafar,H.,
            Kalhor,R., Church,G.M., Shrubsole,M.J., Coffey,R.J. and Lau,K.S.
  TITLE     Temporal recording of mammalian development and precancer
  JOURNAL   Nature 634 (8036), 1187-1195 (2024)
   PUBMED   39478207
REFERENCE   2  (bases 1 to 1182)
  AUTHORS   Tsukui,T., Wolters,P.J. and Sheppard,D.
  TITLE     Alveolar fibroblast lineage orchestrates lung inflammation and
            fibrosis
  JOURNAL   Nature 631 (8021), 627-634 (2024)
   PUBMED   38987592
REFERENCE   3  (bases 1 to 1182)
  AUTHORS   Janbandhu,V., Tallapragada,V., Li,J.V., Shewale,B., Ghazanfar,S.,
            Patrick,R., Cox,C.D. and Harvey,R.P.
  TITLE     Novel Mouse Model for Selective Tagging, Purification, and
            Manipulation of Cardiac Myofibroblasts
  JOURNAL   Circulation 149 (24), 1931-1934 (2024)
   PUBMED   38857329
REFERENCE   4  (bases 1 to 1182)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1182)
  AUTHORS   Toomey,B.H., Mitrovic,S.A., Lindner-Liaw,M., Leon Vazquez,R.G.,
            Kacer,D., Ryzhov,S., Prudovsky,I. and Lindner,V.
  TITLE     Activated CTHRC1 promotes glycolysis in endothelial cells:
            Implications for metabolism and angiogenesis
  JOURNAL   Vascul Pharmacol 153, 107246 (2023)
   PUBMED   38040222
  REMARK    GeneRIF: Activated CTHRC1 promotes glycolysis in endothelial cells:
            Implications for metabolism and angiogenesis.
REFERENCE   6  (bases 1 to 1182)
  AUTHORS   Yamamoto,S., Nishimura,O., Misaki,K., Nishita,M., Minami,Y.,
            Yonemura,S., Tarui,H. and Sasaki,H.
  TITLE     Cthrc1 selectively activates the planar cell polarity pathway of
            Wnt signaling by stabilizing the Wnt-receptor complex
  JOURNAL   Dev Cell 15 (1), 23-36 (2008)
   PUBMED   18606138
  REMARK    GeneRIF: Cthrc1 selectively activates the planar cell polarity
            pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
REFERENCE   7  (bases 1 to 1182)
  AUTHORS   Leclair,R.J., Wang,Q., Benson,M.A., Prudovsky,I. and Lindner,V.
  TITLE     Intracellular localization of Cthrc1 characterizes differentiated
            smooth muscle
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (7), 1332-1338 (2008)
   PUBMED   18467647
REFERENCE   8  (bases 1 to 1182)
  AUTHORS   Durmus,T., LeClair,R.J., Park,K.S., Terzic,A., Yoon,J.K. and
            Lindner,V.
  TITLE     Expression analysis of the novel gene collagen triple helix repeat
            containing-1 (Cthrc1)
  JOURNAL   Gene Expr Patterns 6 (8), 935-940 (2006)
   PUBMED   16678498
  REMARK    GeneRIF: Cthrc1 expression overlaps considerably with those
            reported for TGF-beta family members and interstitial collagens.
REFERENCE   9  (bases 1 to 1182)
  AUTHORS   MacLaren,E.J., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     Expression profiling identifies novel candidate genes for ethanol
            sensitivity QTLs
  JOURNAL   Mamm Genome 17 (2), 147-156 (2006)
   PUBMED   16465594
REFERENCE   10 (bases 1 to 1182)
  AUTHORS   Pyagay,P., Heroult,M., Wang,Q., Lehnert,W., Belden,J., Liaw,L.,
            Friesel,R.E. and Lindner,V.
  TITLE     Collagen triple helix repeat containing 1, a novel secreted protein
            in injured and diseased arteries, inhibits collagen expression and
            promotes cell migration
  JOURNAL   Circ Res 96 (2), 261-268 (2005)
   PUBMED   15618538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151282.1 and CD741549.1.
            
            On Jul 12, 2018 this sequence version replaced NM_026778.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076498.1, AK151282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1164              AK151282.1         2-1165
            1165-1182           CD741549.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.35 cM"
     gene            1..1182
                     /gene="Cthrc1"
                     /gene_synonym="1110014B07Rik"
                     /note="collagen triple helix repeat containing 1"
                     /db_xref="GeneID:68588"
                     /db_xref="MGI:MGI:1915838"
     exon            1..228
                     /gene="Cthrc1"
                     /gene_synonym="1110014B07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..810
                     /gene="Cthrc1"
                     /gene_synonym="1110014B07Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; collagen triple helix repeat-containing protein
                     1"
                     /codon_start=1
                     /product="collagen triple helix repeat-containing protein
                     1 isoform 1 precursor"
                     /protein_id="NP_081054.1"
                     /db_xref="CCDS:CCDS27442.1"
                     /db_xref="GeneID:68588"
                     /db_xref="MGI:MGI:1915838"
                     /translation="MHPQGRAAPPQLLLGLFLVLLLLLQLSAPISASENPKVKQKALI
                     RQREVVDLYNGMCLQGPAGVPGRDGSPGANGIPGTPGIPGRDGFKGEKGECLRESFEE
                     SWTPNYKQCSWSSLNYGIDLGKIAECTFTKMRSNSALRVLFSGSLRLKCRNACCQRWY
                     FTFNGAECSGPLPIEAIIYLDQGSPELNSTINIHRTSSVEGLCEGIGAGLVDVAIWVG
                     TCSDYPKGDASTGWNSVSRIIIEELPK"
     exon            229..450
                     /gene="Cthrc1"
                     /gene_synonym="1110014B07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            451..667
                     /gene="Cthrc1"
                     /gene_synonym="1110014B07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1166
                     /gene="Cthrc1"
                     /gene_synonym="1110014B07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cthrc1"
                     /gene_synonym="1110014B07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1166
                     /gene="Cthrc1"
                     /gene_synonym="1110014B07Rik"
                     /note="major polyA site"
ORIGIN      
        1 agacgctgag cagggtcagg ctcctgccga cccctttacc tcctgctccg cgcttcgcag
       61 ccaccgcaca ccatgcaccc ccaaggccgc gcggcccccc cgcagctgct gctcggtctc
      121 ttccttgtgc tgctgctgct gctacagttg tccgcaccga tcagcgcctc tgagaacccc
      181 aaggtgaagc aaaaagcgct gatccggcag agggaggtgg tagacctgta taatggaatg
      241 tgtctacaag gaccagcagg agttcccggt cgtgatggga gccctggggc caacggcatt
      301 cctggcacac ctggcatccc aggtcgggat ggattcaaag gggaaaaggg agaatgctta
      361 agggaaagct ttgaggagtc ctggacccca aactataagc agtgttcgtg gagttcgctg
      421 aactatggca tagatcttgg gaaaattgcg gagtgtacat tcacgaagat gcgctccaac
      481 agtgctctgc gagttctgtt cagtggctcg cttcggctca aatgcaggaa tgcatgctgt
      541 cagcgctggt attttacatt taatggagct gaatgttcag gacctcttcc catcgaagcc
      601 atcatctatc tggaccaagg aagccctgag ttaaattcaa ctattaatat tcatcgtact
      661 tcctctgtgg aaggactctg tgaagggatt ggtgctggat tggtagatgt ggccatctgg
      721 gtcggcacct gttcagatta ccccaaagga gacgcttcta ctggatggaa ttccgtgtct
      781 cgcatcatca ttgaagaact accgaaataa agcctctgac gatttcagtc cctgcctcgt
      841 tggcttttta aatcaagccc ttgaatggtt catttaaatg acatttaaga aatcacttaa
      901 atgaagtgct cagctgaatg aaaaagcaaa gttaaatatg tttacagacc aaagtgtgat
      961 ctcacactta aaaatcaagt attaaccatt ttatttcagc caaagatggt ttcaagattt
     1021 tttttcatta ttatttttta agcctatata ttggaatgcc attacagtat ttagtatttc
     1081 cttctataac atataaatgt tatttctttg taaggactgt atagaattat tttatatctg
     1141 ttaaataaaa tgcttctaaa acctaaaaaa aaaaaaaaaa aa
//
