LOCUS       NM_198858                900 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cardiotrophin 2 (Ctf2), mRNA.
ACCESSION   NM_198858 XM_146055
VERSION     NM_198858.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 900)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 900)
  AUTHORS   Larsen,J.V., Hansen,M., Moller,B., Madsen,P., Scheller,J.,
            Nielsen,M. and Petersen,C.M.
  TITLE     Sortilin facilitates signaling of ciliary neurotrophic factor and
            related helical type 1 cytokines targeting the gp130/leukemia
            inhibitory factor receptor beta heterodimer
  JOURNAL   Mol Cell Biol 30 (17), 4175-4187 (2010)
   PUBMED   20584990
REFERENCE   3  (bases 1 to 900)
  AUTHORS   White,U.A. and Stephens,J.M.
  TITLE     Neuropoietin activates STAT3 independent of LIFR activation in
            adipocytes
  JOURNAL   Biochem Biophys Res Commun 395 (1), 48-50 (2010)
   PUBMED   20353755
  REMARK    GeneRIF: Neuropoietin induced activation of STAT3 tyrosine
            phosphorylation in adipocytes is independent of LIFR
            phosphorylation and degradation.
REFERENCE   4  (bases 1 to 900)
  AUTHORS   Rousseau,F., Chevalier,S., Guillet,C., Ravon,E., Diveu,C.,
            Froger,J., Barbier,F., Grimaud,L. and Gascan,H.
  TITLE     Ciliary neurotrophic factor, cardiotrophin-like cytokine, and
            neuropoietin share a conserved binding site on the ciliary
            neurotrophic factor receptor alpha chain
  JOURNAL   J Biol Chem 283 (44), 30341-30350 (2008)
   PUBMED   18728012
  REMARK    GeneRIF: Ciliary neurotrophic factor, cardiotrophin-like cytokine,
            and neuropoietin share a conserved binding site on the ciliary
            neurotrophic factor receptor alpha chain
REFERENCE   5  (bases 1 to 900)
  AUTHORS   Oberle,S., Schober,A., Meyer,V., Holtmann,B., Henderson,C.,
            Sendtner,M. and Unsicker,K.
  TITLE     Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1
            causes similar deficits in preganglionic sympathetic neurons and
            adrenal medulla
  JOURNAL   J Neurosci 26 (6), 1823-1832 (2006)
   PUBMED   16467531
REFERENCE   6  (bases 1 to 900)
  AUTHORS   Derouet,D., Rousseau,F., Alfonsi,F., Froger,J., Hermann,J.,
            Barbier,F., Perret,D., Diveu,C., Guillet,C., Preisser,L.,
            Dumont,A., Barbado,M., Morel,A., deLapeyriere,O., Gascan,H. and
            Chevalier,S.
  TITLE     Neuropoietin, a new IL-6-related cytokine signaling through the
            ciliary neurotrophic factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 101 (14), 4827-4832 (2004)
   PUBMED   15051883
  REMARK    GeneRIF: a new ligand for ciliary neurotrophic factor receptor
            alpha, with important implications for murine nervous system
            development
REFERENCE   7  (bases 1 to 900)
  AUTHORS   Amador,A.G., Mayerhofer,A., Parkening,T.A., Collins,T.J. and
            Bartke,A.
  TITLE     Differential effects of two alleles of the dy locus on the
            pituitary-testicular axis of mice
  JOURNAL   Rev Esp Fisiol 48 (3), 157-166 (1992)
   PUBMED   1301630
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB125661.1.
            
            On Dec 17, 2003 this sequence version replaced XM_146055.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB125661.1, BC120763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.69 cM"
     gene            1..900
                     /gene="Ctf2"
                     /gene_synonym="Gm494; NP"
                     /note="cardiotrophin 2"
                     /db_xref="GeneID:244218"
                     /db_xref="MGI:MGI:2684607"
     exon            1..50
                     /gene="Ctf2"
                     /gene_synonym="Gm494; NP"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..649
                     /gene="Ctf2"
                     /gene_synonym="Gm494; NP"
                     /note="neuropoietin; CT-2"
                     /codon_start=1
                     /product="cardiotrophin-2 precursor"
                     /protein_id="NP_942155.1"
                     /db_xref="CCDS:CCDS21876.1"
                     /db_xref="GeneID:244218"
                     /db_xref="MGI:MGI:2684607"
                     /translation="MYCLLATPLCLLSLLLPPLSPAAPISPSEPIGQAYSLALYMQKN
                     TSALLQTYLQHQGSPFSDPGFSAPELQLSTLPSAAVSFKTWHAMEDAERLSRAQGAFL
                     ALTQHLQLVGDDQSYLNPGSPILLAQLGAARLRAQGLLGNMAAIMTALGLPIPPEEDT
                     LGFVPFGASAFERKCRGYIVTREYGHWTDRAVRDLALLKAKYSA"
     exon            51..190
                     /gene="Ctf2"
                     /gene_synonym="Gm494; NP"
                     /inference="alignment:Splign:2.1.0"
     exon            191..900
                     /gene="Ctf2"
                     /gene_synonym="Gm494; NP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagactgc agaggaagga gccaaggagg gaggatgtac tgcctgctgg caactcccct
       61 atgcctactg agcctgctgt tgccacccct cagtcctgcg gcccccatct ccccatcaga
      121 gcccatcggt caagcctaca gcctggctct ctacatgcag aagaacacgt cagcactgct
      181 gcagacctat ctccaacacc agggcagccc cttcagtgac cccggcttct cagctcctga
      241 gctccagctc agcaccctgc cttctgcagc tgtctccttc aagacctggc atgccatgga
      301 agatgcagaa cggctaagcc gagcccaggg agccttcctg gccttgaccc agcacctcca
      361 gctcgtgggg gacgaccaga gttatctgaa tcctggcagt cctatcctgc tggcccagct
      421 aggagcagca agactcaggg cccaaggcct cttgggcaac atggctgcta tcatgactgc
      481 tctagggctg cccatccctc cagaagagga tactctgggg tttgtccctt ttggggcctc
      541 agcctttgag aggaaatgca gaggctacat agtgacccga gaatatggtc actggacaga
      601 ccgggctgtg agggacttgg ctctcctcaa ggctaagtac tcagcataga aggtcagcct
      661 tctatcagaa gtcccaagaa tttctctttc agaggactca ttactgcctt acttctgcat
      721 ttgggactat ttcctggaag ccaaacctct actccttatt gtctggatct tcctgccagg
      781 tcctacagac tcctttccag aaatggggga gaggggtatt ctggatctat ttgatggatc
      841 actaaaccaa cattgattta tttacttcct ggttggaaaa aagagccctt ctgaggaggc
//
