LOCUS       NM_001412290            1358 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus cardiotrophin 1 (Ctf1), transcript variant 6, mRNA.
ACCESSION   NM_001412290 XM_006507316
VERSION     NM_001412290.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1358)
  AUTHORS   Akkoc,Y., Dalci,K., Karakas,H.E., Erbil-Bilir,S., Yalav,O.,
            Sakman,G., Celik,F., Arikan,S., Zeybek,U., Ergin,M., Akkiz,H.,
            Dilege,E., Dengjel,J., Dogan-Ekici,A.I. and Gozuacik,D.
  TITLE     Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of
            stroma-assisted and autophagy-dependent breast cancer cell
            migration, invasion and metastasis
  JOURNAL   Autophagy 19 (1), 306-323 (2023)
   PUBMED   35722965
  REMARK    GeneRIF: Tumor-derived CTF1 (cardiotrophin 1) is a critical
            mediator of stroma-assisted and autophagy-dependent breast cancer
            cell migration, invasion and metastasis.
REFERENCE   2  (bases 1 to 1358)
  AUTHORS   Gadomski,S., Fielding,C., Garcia-Garcia,A., Korn,C., Kapeni,C.,
            Ashraf,S., Villadiego,J., Toro,R.D., Domingues,O., Skepper,J.N.,
            Michel,T., Zimmer,J., Sendtner,R., Dillon,S., Poole,K.E.S.,
            Holdsworth,G., Sendtner,M., Toledo-Aral,J.J., De Bari,C.,
            McCaskie,A.W., Robey,P.G. and Mendez-Ferrer,S.
  TITLE     A cholinergic neuroskeletal interface promotes bone formation
            during postnatal growth and exercise
  JOURNAL   Cell Stem Cell 29 (4), 528-544 (2022)
   PUBMED   35276096
REFERENCE   3  (bases 1 to 1358)
  AUTHORS   Robbe,Z.L., Shi,W., Wasson,L.K., Scialdone,A.P., Wilczewski,C.M.,
            Sheng,X., Hepperla,A.J., Akerberg,B.N., Pu,W.T., Cristea,I.M.,
            Davis,I.J. and Conlon,F.L.
  TITLE     CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene
            programs in the developing heart
  JOURNAL   Genes Dev 36 (7-8), 468-482 (2022)
   PUBMED   35450884
REFERENCE   4  (bases 1 to 1358)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1358)
  AUTHORS   Carneros,D., Medina-Gomez,G., Giralt,M., Leon-Camacho,M.,
            Campbell,M., Moreno-Aliaga,M.J., Villarroya,F. and Bustos,M.
  TITLE     Cardiotrophin-1 contributes to metabolic adaptations through the
            regulation of lipid metabolism and to the fasting-induced fatty
            acid mobilization
  JOURNAL   FASEB J 34 (12), 15875-15887 (2020)
   PUBMED   33047392
  REMARK    GeneRIF: Cardiotrophin-1 contributes to metabolic adaptations
            through the regulation of lipid metabolism and to the
            fasting-induced fatty acid mobilization.
REFERENCE   6  (bases 1 to 1358)
  AUTHORS   Pennica,D., Arce,V., Swanson,T.A., Vejsada,R., Pollock,R.A.,
            Armanini,M., Dudley,K., Phillips,H.S., Rosenthal,A., Kato,A.C. and
            Henderson,C.E.
  TITLE     Cardiotrophin-1, a cytokine present in embryonic muscle, supports
            long-term survival of spinal motoneurons
  JOURNAL   Neuron 17 (1), 63-74 (1996)
   PUBMED   8755479
REFERENCE   7  (bases 1 to 1358)
  AUTHORS   Pennica,D., Swanson,T.A., Shaw,K.J., Kuang,W.J., Gray,C.L.,
            Beatty,B.G. and Wood,W.I.
  TITLE     Human cardiotrophin-1: protein and gene structure, biological and
            binding activities, and chromosomal localization
  JOURNAL   Cytokine 8 (3), 183-189 (1996)
   PUBMED   8833032
REFERENCE   8  (bases 1 to 1358)
  AUTHORS   Ishikawa,M., Saito,Y., Miyamoto,Y., Kuwahara,K., Ogawa,E.,
            Nakagawa,O., Harada,M., Masuda,I. and Nakao,K.
  TITLE     cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of
            CT-1 gene in ventricle of genetically hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 219 (2), 377-381 (1996)
   PUBMED   8604995
REFERENCE   9  (bases 1 to 1358)
  AUTHORS   Sheng,Z., Pennica,D., Wood,W.I. and Chien,K.R.
  TITLE     Cardiotrophin-1 displays early expression in the murine heart tube
            and promotes cardiac myocyte survival
  JOURNAL   Development 122 (2), 419-428 (1996)
   PUBMED   8625793
REFERENCE   10 (bases 1 to 1358)
  AUTHORS   Pennica,D., King,K.L., Shaw,K.J., Luis,E., Rullamas,J., Luoh,S.M.,
            Darbonne,W.C., Knutzon,D.S., Yen,R., Chien,K.R. et al.
  TITLE     Expression cloning of cardiotrophin 1, a cytokine that induces
            cardiac myocyte hypertrophy
  JOURNAL   Proc Natl Acad Sci U S A 92 (4), 1142-1146 (1995)
   PUBMED   7862649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124507.4.
            
            On Sep 27, 2022 this sequence version replaced XM_006507316.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4162655.1,
                                           SRR13422586.548783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC124507.4         173343-173399
            58-173              AC124507.4         174548-174663
            174-1358            AC124507.4         177624-178808
FEATURES             Location/Qualifiers
     source          1..1358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.69 cM"
     gene            1..1358
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /note="cardiotrophin 1"
                     /db_xref="GeneID:13019"
                     /db_xref="MGI:MGI:105115"
     exon            1..57
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..641
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="cardiotrophin-1 isoform 6"
                     /protein_id="NP_001399219.1"
                     /db_xref="GeneID:13019"
                     /db_xref="MGI:MGI:105115"
                     /translation="MSQREGSLDHQTDSSISFLPHLEAKIRQTHNLARLLTKYAEQLL
                     EEYVQQQGEPFGLPGFSPPRLPLAGLSGPAPSHAGLPVSERLRQDAAALSVLPALLDA
                     VRRRQAELNPRAPRLLRSLEDAARQVRALGAAVETVLAALGAAARGPGPEPVTVATLF
                     TANSTAGIFSAKVLGFHVCGLYGEWVSRTEGDLGQLVPGGVA"
     exon            58..173
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..1358
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /note="hexamer: ACTAAA"
     polyA_site      1358
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /note="major polyA site"
ORIGIN      
        1 gttgagggaa cctggataag cctggggcca gcatgagcca gagggaggga agtctggacc
       61 accagactga ctcctcaatc tcattcctac cccatttgga ggccaagatc cgccagacac
      121 acaaccttgc ccgcctcctg accaaatatg cagaacaact tctggaggaa tacgtgcagc
      181 aacagggaga gccctttggg ctgccgggct tctcaccacc gcggctgccg ctggccggcc
      241 tgagtggccc ggctccgagc catgcagggc taccggtgtc cgagcggctg cggcaggatg
      301 cagccgccct gagtgtgctg cccgcgctgt tggatgccgt ccgccgccgc caggcggagc
      361 tgaacccgcg cgccccgcgc ctgctgcgga gcctggagga cgcagcccgc caggttcggg
      421 ccctgggcgc cgcggtggag acagtgctgg ccgcgctggg cgctgcagcc cgcgggcccg
      481 ggccagagcc cgtcaccgtc gccaccctct tcacggccaa cagcactgca ggcatcttct
      541 cagccaaggt gctggggttc cacgtgtgcg gcctctatgg cgagtgggtg agccgcacag
      601 agggcgacct gggccagctg gtgccagggg gcgtcgcctg agagtgaata ctttttcttg
      661 taagctcgct ctgtctcgcc tctttggctt caaattttct gtctctccat ctgtgtcctg
      721 tgtgttcttg ggctgtccct atctttctgc atttgtgtgg tctctctctt ctgctctcct
      781 ctctgcaggg agcttctttt ttccaacagt ttctcgtttt gtctctctcc agtcttgaac
      841 acttttgtct ccgagaggtc tctttttgtt tccttgtctc ttggttcttt ctttgcttgc
      901 ttgcttgctt gcttgcttgt tgttgagaca gggtctcacc atatagctct ggatggcctg
      961 gaacttgcta tgtaggccag gctggcctcc agctcataga gatccacttg cctccgactc
     1021 ccaatttccc catctgtctc cctgtgatcc atatgggtat gtgtaaccct tactttgtct
     1081 catggaggtg acaatttttc tcccttcagt ttctttgttc tttactgacc agaaaagtgc
     1141 ctacttgtcc cctggtggca aggccattca ccttaggacc ttcccaccag ttcctttgta
     1201 ggcaaatccc tccccctttg aggtccttcc ctttcatacc gccctaggct ggtcaatgga
     1261 gagagaaagg cagaaaaaca tctttaaaga gttttatttg agaataaatt aatttttgta
     1321 aataaaatgt ttaacaataa aactaaactt ttatgaaa
//
