LOCUS       NM_001412288            1365 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus cardiotrophin 1 (Ctf1), transcript variant 4, mRNA.
ACCESSION   NM_001412288 XM_030242071
VERSION     NM_001412288.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Akkoc,Y., Dalci,K., Karakas,H.E., Erbil-Bilir,S., Yalav,O.,
            Sakman,G., Celik,F., Arikan,S., Zeybek,U., Ergin,M., Akkiz,H.,
            Dilege,E., Dengjel,J., Dogan-Ekici,A.I. and Gozuacik,D.
  TITLE     Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of
            stroma-assisted and autophagy-dependent breast cancer cell
            migration, invasion and metastasis
  JOURNAL   Autophagy 19 (1), 306-323 (2023)
   PUBMED   35722965
  REMARK    GeneRIF: Tumor-derived CTF1 (cardiotrophin 1) is a critical
            mediator of stroma-assisted and autophagy-dependent breast cancer
            cell migration, invasion and metastasis.
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Gadomski,S., Fielding,C., Garcia-Garcia,A., Korn,C., Kapeni,C.,
            Ashraf,S., Villadiego,J., Toro,R.D., Domingues,O., Skepper,J.N.,
            Michel,T., Zimmer,J., Sendtner,R., Dillon,S., Poole,K.E.S.,
            Holdsworth,G., Sendtner,M., Toledo-Aral,J.J., De Bari,C.,
            McCaskie,A.W., Robey,P.G. and Mendez-Ferrer,S.
  TITLE     A cholinergic neuroskeletal interface promotes bone formation
            during postnatal growth and exercise
  JOURNAL   Cell Stem Cell 29 (4), 528-544 (2022)
   PUBMED   35276096
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Robbe,Z.L., Shi,W., Wasson,L.K., Scialdone,A.P., Wilczewski,C.M.,
            Sheng,X., Hepperla,A.J., Akerberg,B.N., Pu,W.T., Cristea,I.M.,
            Davis,I.J. and Conlon,F.L.
  TITLE     CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene
            programs in the developing heart
  JOURNAL   Genes Dev 36 (7-8), 468-482 (2022)
   PUBMED   35450884
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Carneros,D., Medina-Gomez,G., Giralt,M., Leon-Camacho,M.,
            Campbell,M., Moreno-Aliaga,M.J., Villarroya,F. and Bustos,M.
  TITLE     Cardiotrophin-1 contributes to metabolic adaptations through the
            regulation of lipid metabolism and to the fasting-induced fatty
            acid mobilization
  JOURNAL   FASEB J 34 (12), 15875-15887 (2020)
   PUBMED   33047392
  REMARK    GeneRIF: Cardiotrophin-1 contributes to metabolic adaptations
            through the regulation of lipid metabolism and to the
            fasting-induced fatty acid mobilization.
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Pennica,D., Arce,V., Swanson,T.A., Vejsada,R., Pollock,R.A.,
            Armanini,M., Dudley,K., Phillips,H.S., Rosenthal,A., Kato,A.C. and
            Henderson,C.E.
  TITLE     Cardiotrophin-1, a cytokine present in embryonic muscle, supports
            long-term survival of spinal motoneurons
  JOURNAL   Neuron 17 (1), 63-74 (1996)
   PUBMED   8755479
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Pennica,D., Swanson,T.A., Shaw,K.J., Kuang,W.J., Gray,C.L.,
            Beatty,B.G. and Wood,W.I.
  TITLE     Human cardiotrophin-1: protein and gene structure, biological and
            binding activities, and chromosomal localization
  JOURNAL   Cytokine 8 (3), 183-189 (1996)
   PUBMED   8833032
REFERENCE   8  (bases 1 to 1365)
  AUTHORS   Ishikawa,M., Saito,Y., Miyamoto,Y., Kuwahara,K., Ogawa,E.,
            Nakagawa,O., Harada,M., Masuda,I. and Nakao,K.
  TITLE     cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of
            CT-1 gene in ventricle of genetically hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 219 (2), 377-381 (1996)
   PUBMED   8604995
REFERENCE   9  (bases 1 to 1365)
  AUTHORS   Sheng,Z., Pennica,D., Wood,W.I. and Chien,K.R.
  TITLE     Cardiotrophin-1 displays early expression in the murine heart tube
            and promotes cardiac myocyte survival
  JOURNAL   Development 122 (2), 419-428 (1996)
   PUBMED   8625793
REFERENCE   10 (bases 1 to 1365)
  AUTHORS   Pennica,D., King,K.L., Shaw,K.J., Luis,E., Rullamas,J., Luoh,S.M.,
            Darbonne,W.C., Knutzon,D.S., Yen,R., Chien,K.R. et al.
  TITLE     Expression cloning of cardiotrophin 1, a cytokine that induces
            cardiac myocyte hypertrophy
  JOURNAL   Proc Natl Acad Sci U S A 92 (4), 1142-1146 (1995)
   PUBMED   7862649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124507.4.
            
            On Sep 27, 2022 this sequence version replaced XM_030242071.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.438311.1,
                                           SRR7345562.4118721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC124507.4         173343-173399
            58-180              AC124507.4         174545-174667
            181-1365            AC124507.4         177624-178808
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.69 cM"
     gene            1..1365
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /note="cardiotrophin 1"
                     /db_xref="GeneID:13019"
                     /db_xref="MGI:MGI:105115"
     exon            1..57
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..845
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="cardiotrophin-1 isoform 4"
                     /protein_id="NP_001399217.1"
                     /db_xref="GeneID:13019"
                     /db_xref="MGI:MGI:105115"
                     /translation="MSQREGSLEDHQTDSSISFLPHLEAKIRQTHNLARLLTKYAEQL
                     LEEYVSAATGRALWAAGLLTTAAAAGRPEWPGSEPCRATGVRAAAAGCSRPECAARAV
                     GCRPPPPGGAEPARPAPAAEPGGRSPPGSGPGRRGGDSAGRAGRCSPRARARARHRRH
                     PLHGQQHCRHLLSQGAGVPRVRPLWRVGEPHRGRPGPAGARGRRLRVNTFSCKLALSR
                     LFGFKFSVSPSVSCVFLGCPYLSAFVWSLSSALLSAGSFFFPTVSRFVSLQS"
     exon            58..180
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..1365
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /note="hexamer: ACTAAA"
     polyA_site      1365
                     /gene="Ctf1"
                     /gene_synonym="CT-1"
                     /note="major polyA site"
ORIGIN      
        1 gttgagggaa cctggataag cctggggcca gcatgagcca gagggaggga agtctggaag
       61 accaccagac tgactcctca atctcattcc taccccattt ggaggccaag atccgccaga
      121 cacacaacct tgcccgcctc ctgaccaaat atgcagaaca acttctggag gaatacgtga
      181 gtgcagcaac agggagagcc ctttgggctg ccgggcttct caccaccgcg gctgccgctg
      241 gccggcctga gtggcccggc tccgagccat gcagggctac cggtgtccga gcggctgcgg
      301 caggatgcag ccgccctgag tgtgctgccc gcgctgttgg atgccgtccg ccgccgccag
      361 gcggagctga acccgcgcgc cccgcgcctg ctgcggagcc tggaggacgc agcccgccag
      421 gttcgggccc tgggcgccgc ggtggagaca gtgctggccg cgctgggcgc tgcagcccgc
      481 gggcccgggc cagagcccgt caccgtcgcc accctcttca cggccaacag cactgcaggc
      541 atcttctcag ccaaggtgct ggggttccac gtgtgcggcc tctatggcga gtgggtgagc
      601 cgcacagagg gcgacctggg ccagctggtg ccagggggcg tcgcctgaga gtgaatactt
      661 tttcttgtaa gctcgctctg tctcgcctct ttggcttcaa attttctgtc tctccatctg
      721 tgtcctgtgt gttcttgggc tgtccctatc tttctgcatt tgtgtggtct ctctcttctg
      781 ctctcctctc tgcagggagc ttcttttttc caacagtttc tcgttttgtc tctctccagt
      841 cttgaacact tttgtctccg agaggtctct ttttgtttcc ttgtctcttg gttctttctt
      901 tgcttgcttg cttgcttgct tgcttgttgt tgagacaggg tctcaccata tagctctgga
      961 tggcctggaa cttgctatgt aggccaggct ggcctccagc tcatagagat ccacttgcct
     1021 ccgactccca atttccccat ctgtctccct gtgatccata tgggtatgtg taacccttac
     1081 tttgtctcat ggaggtgaca atttttctcc cttcagtttc tttgttcttt actgaccaga
     1141 aaagtgccta cttgtcccct ggtggcaagg ccattcacct taggaccttc ccaccagttc
     1201 ctttgtaggc aaatccctcc ccctttgagg tccttccctt tcataccgcc ctaggctggt
     1261 caatggagag agaaaggcag aaaaacatct ttaaagagtt ttatttgaga ataaattaat
     1321 ttttgtaaat aaaatgttta acaataaaac taaactttta tgaaa
//
