LOCUS       NM_153088               2790 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus CTD (carboxy-terminal domain, RNA polymerase II,
            polypeptide A) small phosphatase 1 (Ctdsp1), mRNA.
ACCESSION   NM_153088 XM_913453 XM_922770
VERSION     NM_153088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Liao P, Wang W, Li Y, Wang R, Jin J, Pang W, Chen Y, Shen M, Wang
            X, Jiang D, Pang J, Liu M, Lin X, Feng XH, Wang P and Ge X.
  TITLE     Palmitoylated SCP1 is targeted to the plasma membrane and
            negatively regulates angiogenesis
  JOURNAL   Elife 6, e22058 (2017)
   PUBMED   28440748
  REMARK    GeneRIF: Consistently, the authors observed increased AKT
            phosphorylation and angiogenesis followed by enhanced tumorigenesis
            in Ctdsp1 (which encodes SCP1) gene - knockout mice. Importantly,
            they discovered that the membrane localization of SCP1 is crucial
            for impeding angiogenesis and tumor growth, and this localization
            depends on palmitoylation of a conserved cysteine motif within its
            NH2 terminus.
            Erratum:[Elife. 2017 Oct 17;6:. PMID: 29039735]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Jaramillo-Tatis S, Vassall KA, Bamm VV and Harauz G.
  TITLE     Regulatory effect of the glial Golli-BG21 protein on the
            full-length murine small C-terminal domain phosphatase (SCP1, or
            Golli-interacting protein)
  JOURNAL   Biochem Biophys Res Commun 447 (4), 633-637 (2014)
   PUBMED   24751520
  REMARK    GeneRIF: Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas
            PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a
            potential role of BG21 as a molecular switch ('quick-brake
            mechanism') on SCP1/GIP.
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Zhu Y, Lu Y, Zhang Q, Liu JJ, Li TJ, Yang JR, Zeng C and Zhuang SM.
  TITLE     MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S
            transition by activating the pRb protein
  JOURNAL   Nucleic Acids Res 40 (10), 4615-4625 (2012)
   PUBMED   22210897
REFERENCE   6  (bases 1 to 2790)
  AUTHORS   Bamm VV and Harauz G.
  TITLE     Expression and purification of the active variant of recombinant
            murine Golli-interacting protein (GIP)--characterization of its
            phosphatase activity and interaction with Golli-BG21
  JOURNAL   Protein Expr Purif 62 (1), 36-43 (2008)
   PUBMED   18625321
  REMARK    GeneRIF: Expression and purification of the active variant of
            recombinant murine Golli-interacting protein (GIP) and its
            characterization
REFERENCE   7  (bases 1 to 2790)
  AUTHORS   Visvanathan J, Lee S, Lee B, Lee JW and Lee SK.
  TITLE     The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway
            during embryonic CNS development
  JOURNAL   Genes Dev 21 (7), 744-749 (2007)
   PUBMED   17403776
REFERENCE   8  (bases 1 to 2790)
  AUTHORS   Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J,
            Ohara O and Seino S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 2790)
  AUTHORS   Fernandes AO, Campagnoni CW, Kampf K, Feng JM, Handley VW,
            Schonmann V, Bongarzone ER, Reyes S and Campagnoni AT.
  TITLE     Identification of a protein that interacts with the golli-myelin
            basic protein and with nuclear LIM interactor in the nervous system
  JOURNAL   J Neurosci Res 75 (4), 461-471 (2004)
   PUBMED   14743429
REFERENCE   10 (bases 1 to 2790)
  AUTHORS   Amson RB, Nemani M, Roperch JP, Israeli D, Bougueleret L, Le Gall
            I, Medhioub M, Linares-Cruz G, Lethrosne F, Pasturaud P, Piouffre
            L, Prieur S, Susini L, Alvaro V, Millasseau P, Guidicelli C, Bui H,
            Massart C, Cazes L, Dufour F, Bruzzoni-Giovanelli H, Owadi H,
            Hennion C, Charpak G, Telerman A et al.
  TITLE     Isolation of 10 differentially expressed cDNAs in p53-induced
            apoptosis: activation of the vertebrate homologue of the drosophila
            seven in absentia gene
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 3953-3957 (1996)
   PUBMED   8632996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP765657.1, AK167390.1 and BE948438.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_153088.3.
            
            On May 16, 2009 this sequence version replaced NM_153088.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028804.1, BC065158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               BP765657.1         29-206
            179-243             BP765657.1         208-272
            244-2483            AK167390.1         2-2241
            2484-2790           BE948438.1         3-309               c
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2790
                     /gene="Ctdsp1"
                     /gene_synonym="GIP; Nif3; NLIIF; SCP1"
                     /note="CTD (carboxy-terminal domain, RNA polymerase II,
                     polypeptide A) small phosphatase 1"
                     /db_xref="GeneID:227292"
                     /db_xref="MGI:MGI:2654470"
     exon            1..356
                     /gene="Ctdsp1"
                     /gene_synonym="GIP; Nif3; NLIIF; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..505
                     /gene="Ctdsp1"
                     /gene_synonym="GIP; Nif3; NLIIF; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..610
                     /gene="Ctdsp1"
                     /gene_synonym="GIP; Nif3; NLIIF; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..667
                     /gene="Ctdsp1"
                     /gene_synonym="GIP; Nif3; NLIIF; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..760
                     /gene="Ctdsp1"
                     /gene_synonym="GIP; Nif3; NLIIF; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..946
                     /gene="Ctdsp1"
                     /gene_synonym="GIP; Nif3; NLIIF; SCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..2776
                     /gene="Ctdsp1"
                     /gene_synonym="GIP; Nif3; NLIIF; SCP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggcgcg ccgaagccgt tgccctttta aggggaagcc ttgaaacggc gcccgggttc
       61 catgtttgca tccgcctcgc ggggaggaaa ctccatgttg taacaaagtt tcctccgcgc
      121 cccctccctc cccctccccc cgagaacctg gctcccctcc cctccgaagc tcgcggggat
      181 ccctccctcc caccctcccc tcccccccgc gccccgattc cggcccgagc cgggggggag
      241 gccgggcgcc ggggccagag tccggccgga gcggagcgcg ccgggcccca tggacagctc
      301 ggccgtcatt actcagatca gcaaggagga ggcgcggggc ccgctgcggg gcaaaggtga
      361 ccagaagtca gcagtttccc agaagccccg gagtcggggc atcctccact ccctcttctg
      421 ctgtgtctgc cgggatgatg gggagcccct acctgcccac agtggggctc ccctgctggt
      481 ggaggaaaat ggcgccatcc ctaagcacac cccagtccag tacctgcttc ccgaggccaa
      541 ggcccaggac tcagacaaga tctgcgtcgt catcgacctg gacgagaccc tggtgcacag
      601 ctccttcaag ccagtgaaca atgcggactt catcatcccg gtggagatag atggagtggt
      661 ccaccaggtc tatgtgctga agcggcccca cgtagatgag ttcctacagc gaatgggcga
      721 gctctttgaa tgtgtgctgt tcactgccag ccttgccaag tacgcagacc ctgtagctga
      781 tctgctggac aagtggggag ccttccgtgc caggctgttt cgagagtcgt gtgtcttcca
      841 ccgggggaac tacgtaaagg acctgagcag gctgggccga gacctgcggc gagtgctcat
      901 tctagacaac tcacccgcct cctatgtctt ccatccagac aatgccgtac cagtggcctc
      961 gtggtttgac aacatgagtg acactgagct acacgatctc ttacccttct ttgagcaact
     1021 cagccgcgtg gacgacgtat actcagtgct cagacagcct aggcccggga gctagtgagg
     1081 tgtcctgggg ccaggacctg cctctcatca aggcccaagc ctctccccag cagactgtgg
     1141 gcgcctgcct ttgctgttaa cacccccggc tgtgtcatgg tcacggccct ggggaagagg
     1201 tgtctcccct gccatgttgc atggaggaca gtgagccctt gggcccctgt gtcagtgcct
     1261 tcaaacttct tcccctcttc tcaggggacc tggggggccc tgcctgctgc tccccacttc
     1321 tgtcttatcc acgctgccat gtttctctgt tgccaaattg ggccttttcg ccccagttct
     1381 gctctggggg tagggacagg gtttttgctg ccccgtgcct tggattcccc acccacccac
     1441 ccacccccgt ctgagaacag tggacaccca agtgcctttc atagaaccct ctttactggt
     1501 cagcttttcc cagatctagg ctgacctgag aggaaccaat ttctcccctt tccctcctcc
     1561 ctcctgggat gacggtgccc caccagtttg tacgtgggca ggagaggaag aaagtctatt
     1621 ataatacact tgtaaaagag ctggggacct tcctcgggag gaacgctccc tgtccagctt
     1681 gtccaaggct gaaggctgct ccatatctca cttaagcccc aagtctcccc aaagccctgg
     1741 ggctcggcag gatgcccccg tggtgccata taaatatgta tatgtgtata tagattttga
     1801 agggaaggag aaaggaaagg gtgagaacaa gacactcttc cttaaccctt ccctgggccc
     1861 agaaattggg ggagggaggg aaaggatttt tacattttta aaactactat ttttctgaat
     1921 ggaacaagct gggctgaggg gtcaggtcgg gtcttctgtc tgtcccaacc ctttttactc
     1981 ttcattcaaa agacatttat tgagtacctt cagtgcccag cagtgagcta gtcccaccag
     2041 cttagtggga gggggttgtc tctgcttcat ttttaggtgc ctctaaaccc cagatgtcac
     2101 gtgccttcag agtatcaaca gggggtggaa ccttcttgtg gggttaggga gtctccaaac
     2161 cttaaccaag ctggctcctc ctgtgccaac tcctccttcc ctgttccgtg cagcctcctc
     2221 catggccccc cgctggctgg gggcagctcc tgggtttctg ccttctgttt ttaaagcccc
     2281 tccccatacc tgcagagtct gcagttcaag cccttaggct ctctccccag attatgaggg
     2341 ttaagtgaac ccacaaacaa gtgccaaggg ggttggtgaa gggagagaag atggccggaa
     2401 tcagatgacc ttcccaatta agtgccttct ctgtgacctg agcacctcag agtgataact
     2461 aaagagaaag ctagaccccc tcctattccg cctctgtggt ttttggggaa gggacctgaa
     2521 gtgcgagaat gtctcacatc tgtgactgca gttttgacta tttttcataa ccctgctgga
     2581 caggaggaag ttagccaaga gggactgcct gggcactcga tctgagttcg attgctagag
     2641 cccacgtgat ggaaagagaa aacgaactcc cacaagttgt cctctgacct cctcacatgc
     2701 accatggcac gagctctacc caccccccac ccccagatac acgcactcta aacaaataaa
     2761 aaatacacaa aaagcaaaaa aaaaaaaaaa
//
