LOCUS       NM_026295               3725 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CTD phosphatase subunit 1 (Ctdp1), mRNA.
ACCESSION   NM_026295
VERSION     NM_026295.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3725)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3725)
  AUTHORS   Qiao,F., Law,H.C., Krieger,K.L., Clement,E.J., Xiao,Y.,
            Buckley,S.M. and Woods,N.T.
  TITLE     Ctdp1 deficiency leads to early embryonic lethality in mice and
            defects in cell cycle progression in MEFs
  JOURNAL   Biol Open 10 (1) (2021)
   PUBMED   33408128
  REMARK    GeneRIF: Ctdp1 deficiency leads to early embryonic lethality in
            mice and defects in cell cycle progression in MEFs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3725)
  AUTHORS   Kaneko,S., Chu,C., Shatkin,A.J. and Manley,J.L.
  TITLE     Human capping enzyme promotes formation of transcriptional R loops
            in vitro
  JOURNAL   Proc Natl Acad Sci U S A 104 (45), 17620-17625 (2007)
   PUBMED   17978174
REFERENCE   4  (bases 1 to 3725)
  AUTHORS   Yamamoto,K., Yamamoto,M., Hanada,K., Nogi,Y., Matsuyama,T. and
            Muramatsu,M.
  TITLE     Multiple protein-protein interactions by RNA polymerase
            I-associated factor PAF49 and role of PAF49 in rRNA transcription
  JOURNAL   Mol Cell Biol 24 (14), 6338-6349 (2004)
   PUBMED   15226435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY239926.1 and BC053435.1.
            
            On Jul 18, 2018 this sequence version replaced NM_026295.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053435.1, AK156617.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY239926.1         2-26
            26-3725             BC053435.1         1-3700
FEATURES             Location/Qualifiers
     source          1..3725
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 53.48 cM"
     gene            1..3725
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /note="CTD phosphatase subunit 1"
                     /db_xref="GeneID:67655"
                     /db_xref="MGI:MGI:1926953"
     exon            1..460
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..3029
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /EC_number="3.1.3.16"
                     /note="TFIIF-associating CTD phosphatase; CTD
                     (carboxy-terminal domain, RNA polymerase II, polypeptide
                     A) phosphatase, subunit 1"
                     /codon_start=1
                     /product="RNA polymerase II subunit A C-terminal domain
                     phosphatase"
                     /protein_id="NP_080571.2"
                     /db_xref="CCDS:CCDS29368.1"
                     /db_xref="GeneID:67655"
                     /db_xref="MGI:MGI:1926953"
                     /translation="MEAPPAAGVPTECTPAVAGAEVRCPGPTPLRLLEWKVAAGATVR
                     IGSVLAVCETAASAQPAGPAPARAASGGCVRAARTERRLRSERAGVVRELCAQPGQVV
                     APGALLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGRQQVPLSTATVSMVHSVPELM
                     VSSEQAEKLGREDQQRLHRNRKLVLMVDLDQTLIHTTEQHCPQMSNKGIFHFQLGRGE
                     PMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDE
                     CIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFPGTGDVNAPPA
                     ARETQARRKVNHSSKGGDALEQALSVRDPEDGRPAPGVEHSNGLGKASRELNGGEAVP
                     GVFPSKADEKEAWPLTRASPASSSSGHEPTEAPELPVSCEWDGRTTPGVQPTQGDAAT
                     QDLDFDLSSDSESSESSSRSEGQRAPAPQERTKAAPEHSGPQDTSGGRAAASPLGESG
                     PSIHPHDKGSDLDTQEEGERDSLCGLGNGSVDRKEAETESQNSEQSGVTAGESLDQSV
                     GEEEEEDTDDDDHLIHLEEILVRVHTDYYTKYDRYLNKELEEAPDIRKIVPELKSKVL
                     ADVAVIFSGLHPTNFPVEKTREHYHATALGAKVLTQLVLSPDAPDRATHLIAARAGTE
                     KVRQAQECKHLHVVSPDWLWSCLERWDKVEEQLFPLIDDDTRTHRDNSPAVFPDRHSV
                     LPTALFHPTPIHSKAHPGPEVRIYDSNTGKLIRMGPQGSAPAPSSAPLNHGEPSSFRA
                     VQPHQQQMFGEELPESQDGEQPGPARRKRQPSMSEAMPLYTLCKEDLESMDKEVDDIL
                     GEGSDDSDIEKKKPEDQDNEQERAPKPRKPRAPGIRREQPVGLPSSGERSTPGMRGPR
                     GHKRKLNEEDAASESSGESSNDDEEGSSSEADEMAAALEAELNDLM"
     exon            461..544
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            545..638
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            639..767
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            768..918
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1009
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1176
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..2184
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2326
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2536
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2699
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2887
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3710
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3688..3693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3706
                     /gene="Ctdp1"
                     /gene_synonym="4930563P03Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgcag cgagcggcgg gtgaagccgg tgtcggagcg ggaacaccag tgtcgccgcc
       61 gcccgcggtg ggcgccgcgc cctgagcgcc ttgtgttttc gtctctcacc tctgttgtga
      121 ccgtccgtgc cgctctctgg gtcacgatgg aagcgccgcc cgcggccggc gtccccaccg
      181 agtgcactcc ggcggtggcc ggggcagagg tgcgctgccc cggccccacg ccgctgcgtc
      241 tgctggagtg gaaggtggcg gcgggcgcga ccgtgcgcat cggctcggtg ctggcagtgt
      301 gcgaaaccgc agcctccgcg cagcccgcag ggccggcacc ggctcgcgcg gcctctgggg
      361 gctgcgtgcg cgccgcgcgg accgagcgca ggctcaggtc ggagcgcgcc ggcgtggtcc
      421 gtgaactgtg tgcgcagcca ggccaggtgg tggcccctgg agcacttctg gtgagattgg
      481 aaggatgcag ccatcctgtt gtcatgaagg gcctgtgtgc cgagtgtggc caggacctga
      541 cccagctgca gagtaaaaat ggaaggcagc aggtccccct ttccacagcg acggtttcca
      601 tggtgcacag tgtgccggag ttgatggtga gctctgagca agctgagaaa ctaggaagag
      661 aggatcagca gcgactacat cgaaacagaa aactggttct catggttgac ttggaccaga
      721 ccctgattca tacgactgag cagcactgtc cccagatgtc caacaaaggc atcttccact
      781 tccagctggg ccggggggag cccatgctgc acacgcgcct gaggcctcac tgcaaggatt
      841 tcctggagaa aatcgccaag ctgtatgagc tgcacgtttt caccttcggc agccgtctgt
      901 atgcccacac catcgcaggc tttctggacc ccgagaagaa gcttttttct catcgaatat
      961 tgtctagaga tgaatgtatt gacccgtttt ctaaaacagg aaaccttaga aatcttttcc
     1021 cctgtggaga ctcaatggtt tgcatcatcg atgaccgaga agatgtgtgg aagttcgccc
     1081 ctaacctcat aactgtgaag aagtacgtct acttcccagg cacaggtgat gtgaatgcac
     1141 cccctgcagc ccgggaaact caggcaagga gaaaagtaaa tcattcttct aagggagggg
     1201 acgccttgga acaagctctc tccgtgaggg accctgagga cggcaggcct gctcccgggg
     1261 tggagcacag caatggcctt gggaaggcct cccgagagct caatggtggt gaggctgtgc
     1321 caggagtttt tcccagtaaa gcagatgaga aggaagcctg gcccctcact cgggcctctc
     1381 ctgccagcag ctctagtggc cacgagccaa ctgaagctcc agagctccct gtgtcttgtg
     1441 agtgggatgg tcggacaacg ccaggggtgc agcccactca gggtgatgcc gccacccagg
     1501 atttggactt tgacctgtcc agcgacagcg agagcagcga gagcagcagc aggtcagaag
     1561 gtcagagggc tccagccccc caggagagaa caaaagcagc tccagagcac agtgggcccc
     1621 aggacacgag tgggggcaga gctgcagcaa gccccctggg agagtctggg cctagcatcc
     1681 acccccatga caaagggtca gacctggaca ctcaggagga gggtgaacgg gacagcctct
     1741 gtggcctggg caatggcagt gtggaccgga aagaggctga aacggaatcc cagaacagtg
     1801 agcagtcagg tgtcactgca ggcgagtccc tagatcagag tgtcggggag gaagaggaag
     1861 aggacacaga cgacgatgac cacttgatac acctcgagga gatcctggtc cgagtacaca
     1921 ctgactatta cacaaagtat gacagatacc tcaacaagga gcttgaggaa gctccagata
     1981 tacggaaaat tgtgccagag ctcaagagca aggtgctcgc agatgtggct gtgatattca
     2041 gtgggctgca cccaacaaac tttcctgtgg aaaagactcg cgagcactat cacgccacgg
     2101 ccctgggagc caaggtcctt acccagctgg tgctgagccc tgatgctcca gacagggcca
     2161 ctcacctcat tgcagcacgg gctggtacag agaaggtgcg ccaggcacag gagtgcaaac
     2221 acctacatgt ggtcagccct gattggctgt ggagctgcct ggagcgctgg gacaaggtgg
     2281 aggagcagct cttcccactc atagatgacg atacccgcac acatagggat aacagccctg
     2341 cagtctttcc agacagacac agtgtgcttc caacagcctt gttccatcca acacccatcc
     2401 attccaaggc ccatcctggt cccgaggttc ggatctatga ctctaacaca ggcaagctga
     2461 tccggatggg cccccagggt tctgcaccag ctccctccag tgccccactt aaccatggag
     2521 agccttcctc cttcagagct gttcagccac atcagcagca aatgtttggt gaagagttgc
     2581 cagaatctca agatggagag cagcctggcc ctgctagaag aaagcgacaa cccagtatgt
     2641 ccgaggcaat gccgctgtac actctctgta aggaggactt agagagtatg gacaaagagg
     2701 tcgacgacat ccttggagag ggcagtgatg acagtgacat cgagaagaag aagccagaag
     2761 accaagacaa tgagcaggag agagccccga agcccaggaa gccccgggct ccagggatcc
     2821 gaagagagca gcctgtaggc ttgccctcat ctggcgagag gagcacccct ggcatgcgtg
     2881 ggcccagagg ccacaagagg aaactaaatg aggaagacgc tgccagcgag tccagcgggg
     2941 agtccagcaa cgatgatgag gagggcagca gttcagaagc agatgagatg gccgctgctc
     3001 tggaggcgga gcttaatgac ctcatgtgac ttggacccgc cccataccag cccttggctt
     3061 gggtcctttt tctccagaaa aacatatatt ttgcagagct ccacatacag aaacacatta
     3121 ttttgcagaa ataagtgttt gtaagaagtt ttactatagg aaagtctact tttttaagca
     3181 gcaaagtgtt ctgaggagtt ggtgtgtgat gccaaagagc tcaacggggc ctctcatggt
     3241 gagcgtggat agatacgtga tgtctggtca tgtagtgagg gccttggggg cttgcctttg
     3301 aatgctatag catatttagt gtgaggactg gggacccagt aagatttaga gagcaatata
     3361 gcaaaacctg tcatcttgga cctttttcac agctgatgct atcataattt tgaaggattt
     3421 ttaagtaaaa cagcagtgta catatgtgtg tacaggacac caagactcgc aggcaggcct
     3481 gagagcccca gccactcttc cggccctcgg cggacctgca gatgacctgg agttcctgat
     3541 tcaggtccct gtctgcagcc cgggctgcct gggccacagc ctgccagtgt gggcagtgtg
     3601 acgaaaggcg gcctgtactg ccctaagaaa tctgatgtaa agtttttgta tatttcatat
     3661 tccacccacc agattctgct tccatttaat aaaacccttt ttgtaagctg aaaaaaaaaa
     3721 aaaaa
//
