LOCUS       NM_026017               1615 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CTD nuclear envelope phosphatase 1 (Ctdnep1), mRNA.
ACCESSION   NM_026017 XM_903213 XM_903227 XM_903228 XM_909184
VERSION     NM_026017.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Konno,T., Murachi,H., Otsuka,K., Kimura,Y., Sampei,C., Arasaki,Y.,
            Kohara,Y. and Hayata,T.
  TITLE     Ctdnep1 phosphatase is required for negative regulation of
            RANKL-induced osteoclast differentiation in RAW264.7 cells
  JOURNAL   Biochem Biophys Res Commun 719, 150063 (2024)
   PUBMED   38749090
  REMARK    GeneRIF: Ctdnep1 phosphatase is required for negative regulation of
            RANKL-induced osteoclast differentiation in RAW264.7 cells.
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Luo,Z., Xin,D., Liao,Y., Berry,K., Ogurek,S., Zhang,F., Zhang,L.,
            Zhao,C., Rao,R., Dong,X., Li,H., Yu,J., Lin,Y., Huang,G., Xu,L.,
            Xin,M., Nishinakamura,R., Yu,J., Kool,M., Pfister,S.M.,
            Roussel,M.F., Zhou,W., Weiss,W.A., Andreassen,P. and Lu,Q.R.
  TITLE     Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma
            by triggering MYC amplification and genomic instability
  JOURNAL   Nat Commun 14 (1), 762 (2023)
   PUBMED   36765089
  REMARK    GeneRIF: Loss of phosphatase CTDNEP1 potentiates aggressive
            medulloblastoma by triggering MYC amplification and genomic
            instability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Darrigrand,J.F., Valente,M., Comai,G., Martinez,P., Petit,M.,
            Nishinakamura,R., Osorio,D.S., Renault,G., Marchiol,C., Ribes,V.
            and Cadot,B.
  TITLE     Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural
            crest cells condensation and outflow tract septation
  JOURNAL   Elife 9, e50325 (2020)
   PUBMED   32105214
  REMARK    GeneRIF: Dullard-mediated Smad1/5/8 inhibition controls mouse
            cardiac neural crest cells condensation and outflow tract
            septation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Hayata,T., Chiga,M., Ezura,Y., Asashima,M., Katabuchi,H.,
            Nishinakamura,R. and Noda,M.
  TITLE     Dullard deficiency causes hemorrhage in the adult ovarian follicles
  JOURNAL   Genes Cells 23 (5), 345-356 (2018)
   PUBMED   29521016
  REMARK    GeneRIF: Dullard deficiency results in hemorrhagic ovarian cysts
            and infertility.
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Hayata,T., Ezura,Y., Asashima,M., Nishinakamura,R. and Noda,M.
  TITLE     Dullard/Ctdnep1 regulates endochondral ossification via suppression
            of TGF-beta signaling
  JOURNAL   J Bone Miner Res 30 (2), 318-329 (2015)
   PUBMED   25155999
  REMARK    GeneRIF: Dullard is involved in suppression of TGF-beta signaling
            during endochondral ossification.
            Erratum:[J Bone Miner Res. 2015 May;30(5):947. doi:
            10.1002/jbmr.2479.. Yoichi, Ezura [corrected to Ezura, Yoichi].
            PMID: 25879424]
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Tanaka,S.S., Nakane,A., Yamaguchi,Y.L., Terabayashi,T., Abe,T.,
            Nakao,K., Asashima,M., Steiner,K.A., Tam,P.P. and Nishinakamura,R.
  TITLE     Dullard/Ctdnep1 modulates WNT signalling activity for the formation
            of primordial germ cells in the mouse embryo
  JOURNAL   PLoS One 8 (3), e57428 (2013)
   PUBMED   23469192
  REMARK    GeneRIF: Dullard may play a role in the fine-tuning of WNT
            signalling activity by modulating the expression of
            ligands/antagonists and the availability of Dvl2 protein during
            specification of the germ cell lineage.
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Sakaguchi,M., Sharmin,S., Taguchi,A., Ohmori,T., Fujimura,S.,
            Abe,T., Kiyonari,H., Komatsu,Y., Mishina,Y., Asashima,M., Araki,E.
            and Nishinakamura,R.
  TITLE     The phosphatase Dullard negatively regulates BMP signalling and is
            essential for nephron maintenance after birth
  JOURNAL   Nat Commun 4, 1398 (2013)
   PUBMED   23360989
  REMARK    GeneRIF: Dullard keeps BMP signalling at an appropriate level,
            which is required for nephron maintenance in the postnatal period.
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Satow,R., Chan,T.C. and Asashima,M.
  TITLE     Molecular cloning and characterization of dullard: a novel gene
            required for neural development
  JOURNAL   Biochem Biophys Res Commun 295 (1), 85-91 (2002)
   PUBMED   12083771
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL596185.12.
            
            On Nov 17, 2006 this sequence version replaced NM_026017.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018265.1, AK164602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               AL596185.12        92813-93230
            419-485             AL596185.12        95899-95965
            486-604             AL596185.12        96061-96179
            605-676             AL596185.12        96379-96450
            677-793             AL596185.12        100258-100374
            794-905             AL596185.12        100473-100584
            906-990             AL596185.12        101127-101211
            991-1615            AL596185.12        101622-102246
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.95 cM"
     gene            1..1615
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /note="CTD nuclear envelope phosphatase 1"
                     /db_xref="GeneID:67181"
                     /db_xref="MGI:MGI:1914431"
     exon            1..418
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1051
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /EC_number="3.1.3.16"
                     /note="serine/threonine-protein phosphatase dullard"
                     /codon_start=1
                     /product="CTD nuclear envelope phosphatase 1"
                     /protein_id="NP_080293.1"
                     /db_xref="CCDS:CCDS24927.1"
                     /db_xref="GeneID:67181"
                     /db_xref="MGI:MGI:1914431"
                     /translation="MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYD
                     ILPLSPLSRNRLAQVKRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKH
                     PVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQH
                     CTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLL
                     PMLDALRFTADVRSVLSRNLHQHRLW"
     exon            419..485
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /inference="alignment:Splign:2.1.0"
     exon            486..604
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /inference="alignment:Splign:2.1.0"
     exon            605..676
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /inference="alignment:Splign:2.1.0"
     exon            677..793
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /inference="alignment:Splign:2.1.0"
     exon            794..905
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /inference="alignment:Splign:2.1.0"
     exon            906..990
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1615
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1420
                     /gene="Ctdnep1"
                     /gene_synonym="2610507E10Rik; Dullard"
                     /note="major polyA site"
ORIGIN      
        1 cttccctcct ggtctcagag gaccctgtcc tagcccgacc tgtttcggcc tgcagcccac
       61 gcgaagtcgt cggtgccact tcccgctcat gtgggccccc gcgggctgcc cacgccagtc
      121 ccccagttcc cggttccgct gggctttccc ttcgctgggg gtggctttct aagccaccca
      181 ctccgtgctc atctctgcag cctctcctgc cgctcggggc ccccgttccc cctccctgcg
      241 gcggggggct gcccccgggg ggctggcgga gctgggccgc gggggccccg gggccggcgg
      301 tgccggggtc atcgggatga tgcggacgca gtgtctgctg gggctgcgca cgttcgtggc
      361 cttcgccgcc aagctctgga gcttctttat ttaccttttg cggaggcaga tccgcacggt
      421 aattcagtat cagactgttc gatatgatat cctgccctta tctcctttgt cccggaatcg
      481 cctagcccag gtgaagagga agatcctggt gctggatctg gacgaaaccc tgattcactc
      541 tcaccacgat ggggtgctga ggcctacagt gagacctggg acacctcccg acttcatcct
      601 caaggtggta atagacaaac acccagtccg gttttttgta cataagaggc cccatgtgga
      661 tttcttctta gaagtggtaa gccagtggta tgagcttgtg gtgttcacag caagcatgga
      721 aatttatggc tctgctgtgg cagataaact ggacaacagc agaagcattc ttaagaggag
      781 atactacaga cagcactgca ctttggagtt gggcagctac atcaaagacc tctccgtggt
      841 ccacagcgac ctgtccagca tcgtgatcct ggacaactcc cccggggctt acaggagcca
      901 cccagacaat gccatcccca tcaaatcctg gttcagtgac cccagtgaca cagcccttct
      961 caaccttctc ccaatgctgg atgccctcag gttcactgct gatgtccgat cggtgctgag
     1021 ccgaaacctt caccaacata ggctctggtg acagctgctc cccctccacc tgagttgggg
     1081 tggaggggaa agggagggag agttcttggg acaccgtctg ttgccctgtc caatgtgagg
     1141 actgcctggg cagagtctgc ccctcccacc cctctgccct gggagcccta cactccactt
     1201 atggagtctg gatggacaca tgggccagac cgtgaagcag cctcactctg ggttcacact
     1261 ccgtggaaat gccagactgg gacaggcgaa ggcctagagg agccgaaaca gtctggtgaa
     1321 gaggcaggac tggccagagt gacagacata tcccagaggc tcaaaagaag ccaattcaac
     1381 tttgttgtga tttgattttt ttaaaaactc ttatacaaaa ctgatctaat tcttcactcc
     1441 tgctccaagg gctgggctgt gggtggggac tggggtttcg ggccactgga tcctcctcag
     1501 acttgtcccc cccttacttt tcctcatttt ttttctttcc ccaatccccc atacctgtaa
     1561 tcggctcctt tcttctttcc tcttttaaac catgcattat aactttgaaa ccaaa
//
