LOCUS       NM_001013256            4183 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CTS telomere maintenance complex component 1 (Ctc1),
            transcript variant 1, mRNA.
ACCESSION   NM_001013256 NM_026889
VERSION     NM_001013256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4183)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4183)
  AUTHORS   Gu,P., Min,J.N., Wang,Y., Huang,C., Peng,T., Chai,W. and Chang,S.
  TITLE     CTC1 deletion results in defective telomere replication, leading to
            catastrophic telomere loss and stem cell exhaustion
  JOURNAL   EMBO J 31 (10), 2309-2321 (2012)
   PUBMED   22531781
  REMARK    GeneRIF: These data demonstrate an essential role for CTC1 in
            promoting efficient replication and length maintenance of
            telomeres.
REFERENCE   3  (bases 1 to 4183)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   4  (bases 1 to 4183)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
REFERENCE   5  (bases 1 to 4183)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   6  (bases 1 to 4183)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4183)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB854410.1, CA327858.1, BC066078.1, BC147495.1 and AW047236.1.
            
            On or before Jan 7, 2009 this sequence version replaced
            NM_026889.2, NM_001013256.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145919.1, AK165906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BB854410.1         3-72
            71-185              CA327858.1         28-142
            186-202             BC066078.1         1-17
            203-4108            BC147495.1         1-3906
            4109-4183           AW047236.1         1-75                c
FEATURES             Location/Qualifiers
     source          1..4183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.29 cM"
     gene            1..4183
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /note="CTS telomere maintenance complex component 1"
                     /db_xref="GeneID:68964"
                     /db_xref="MGI:MGI:1916214"
     exon            1..255
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..3861
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /note="isoform a is encoded by transcript variant 1; CST
                     complex subunit CTC1; alpha accessory factor 132;
                     alpha-accessory factor of 132 kDa; conserved telomere
                     maintenance component 1"
                     /codon_start=1
                     /product="CST complex subunit CTC1 isoform a"
                     /protein_id="NP_001013274.2"
                     /db_xref="CCDS:CCDS36189.2"
                     /db_xref="GeneID:68964"
                     /db_xref="MGI:MGI:1916214"
                     /translation="MAACRAQPPTSEQAWLEAAQTFIQETLCPAGKEVDKELTRSVIA
                     CVKETWLSQGENQDLTLPFSYSFVSVQSLKTHQRLPCCSHLSWSQSAYQAWTRGGRPG
                     DGVLPREQLILLGTLVDLLGDSEQECRSGSLYVRDNTGTLDCELIDLDLSWLGHLFLF
                     PSWSYLPSAKRNSLGEGHLELWGTPVPVFPLTVSPGPLIPIPVLYPEKASHLLRYRKK
                     SSIKEINLAGKLVHLSALIITQNKRYFIMTLGELAQAGSQVSIIVQIPAQMVWHRVLR
                     PGRAYVLTKLQVTKTRIHLSCIWTTIPSSTLKPLRPGYVQELELDLEFSKADLKPPPQ
                     PTSSKDSRGQEGLVRASKVLHYLGTVTAVLHESAGLYILDGQLILCLAYQKIHGLRRV
                     IRPGVCLELRDVHLLQAVGGATTKPVLALCLHGTVRLQGFSCLKPLTLPSSKVYGASL
                     YEQLVWKCQLGLPLYLWAAKTLEDLIYKLCPHVLRCHQFLKQPSPGKPSLGLQLLAPS
                     WDVLIPPGSPMRHAYSEILEEPHNCPLQKYTPLQTPYSFPTMLALAEEGQHRAWATFD
                     PKAMLPLPEASHLTSCQLNRHLAWSWVCLPSCVFQPAQVLLGVLVASSRKGCLELRDL
                     RGSLPCIPLTESSQPLIDPNLVGCLVRVEKFQLVVEREVRSSFPSWEEMGMARFIQKK
                     QARVYVQFYLADALILPVPRPTFGSEPSQTASSCPEGPHLGQSRLFLLSHKEALMKRN
                     FCLLPGDSSQPAKPTLSFHVSGTWLCGTQRKEGSGWSPPESLAVESKDQKVFLIFLGS
                     SVRWFPFLYPNQVYRLVASGPSQTPVFETEGSAGTSRRPLELADCGSCLTVQEEWTLE
                     LGSSQDIPNVLEVPRTLPESSLAQLLGDNSPDSLVSFSAEILSRILCEPPLALRRMKP
                     GNAGAIKTGVKLTVALEMDDCEYPPHLDIYIEDPQLPPQIGLLPGARVHFSQLEKRIS
                     RSNIVYCCFRSSTSVQVLSFPPETKASAPLPHIYLAELLQGDRPPFQATTSCHIVYVL
                     SLQILWVCAHCTSICPQGKCSRRDPSCPSQRAVSQANIRLLVEDGTAEATVICRNHLV
                     ARALGLSPSEWSSILEHARGPGRVALQFTGLGGQTESASKTHEPLTLLLRTLCTSPFV
                     LRPVKLSFALERRPTDISPREPSRLQQFQCGELPLLTRVNPRLRLVCLSLQEPELPNP
                     PQASAASS"
     exon            256..419
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            420..657
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            658..869
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1014
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1293
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1422
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1655
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1833
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2034
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2161
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2276
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2592
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2682
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2876
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2965
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3140
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3218
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3363
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3428
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3594
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3721
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..4167
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4142..4147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /note="hexamer: AATAAA"
     polyA_site      4164
                     /gene="Ctc1"
                     /gene_synonym="1500010J02Rik; AAF-132; AAF132"
                     /note="major polyA site"
ORIGIN      
        1 tctgtaattc ccgcctttag gagtcagaag cggaagggtc gctgcaaatt taaggccagt
       61 aggctcctta cggcaagttc accgcaaaag gtccctgacg ccccagtacc ctggtggatg
      121 cagagggaag aggcagtgct gctccctgac gtcacaggtt ccctcccgtg agcacttgcg
      181 cccggagttc gcgcgttctt cagggtaggg gtttggctca tcatggctgc ttgccgagca
      241 caaccaccta cctccgagca agcctggctt gaggctgccc agaccttcat ccaagagacc
      301 ctctgtccag ctggcaagga ggtggacaaa gagttgactc ggtcagtaat tgcttgtgtg
      361 aaggagacgt ggctgtccca gggggagaac caggatttaa ctctgccctt cagctacagc
      421 tttgtctcgg tacagagtct gaagacccat cagcgcctcc catgctgcag ccacctgtcc
      481 tggagtcaga gtgcttacca ggcgtggacc cgcggaggcc ggccggggga cggcgtcctg
      541 ccccgggagc agctgatact tttagggaca ctagtagacc tattgggaga ttcggaacaa
      601 gaatgtagga gtggaagcct gtatgtgagg gataacactg ggaccttgga ctgtgagctc
      661 attgatctag acctttcttg gttgggccat ctcttcctat tccccagttg gagttacctt
      721 ccttctgcca agaggaattc cttgggggaa gggcacttgg aactatgggg tacaccggtg
      781 ccagtatttc ctttgactgt cagtcctggc cctctcatac ctatccctgt cctctaccca
      841 gaaaaggcgt cccacctgct cagatacaga aagaaatcca gtataaagga gataaacctc
      901 gctggaaaac tggtccatct gagtgccctg ataataactc agaacaaaag gtatttcatc
      961 atgacacttg gtgaattagc ccaagctggc agccaggtgt ccatcattgt acagatccct
     1021 gctcagatgg tgtggcaccg agtcctccgg cctggcaggg cctatgtact gacaaaattg
     1081 caagtaacca agacccggat tcacctttcc tgtatttgga caaccattcc atcttcaact
     1141 ctgaagcctc tgagaccagg ttatgtgcaa gagctggagc tggacttaga gttctcgaaa
     1201 gctgacctta aaccaccacc ccagcccacc agctccaaag acagcagagg gcaagaaggt
     1261 cttgtccggg cttccaaagt cttgcattat ttgggaacag tcactgctgt gttgcatgag
     1321 tctgccggcc tctacattct agatgggcag ctgattctct gcctcgcata ccagaagatc
     1381 catggcctca ggcgggttat tcgaccaggg gtctgtctgg agctccgaga tgttcatctc
     1441 ctccaggcag tgggtggagc aacaacaaaa cctgtcctgg cgctctgtct ccatggcact
     1501 gttcggcttc aaggcttttc ttgtcttaag cctctgactt tgccgtcctc caaagtttat
     1561 ggtgcctcct tgtatgagca actcgtgtgg aaatgtcagt taggacttcc cttatactta
     1621 tgggctgcca agaccctgga ggatctcatc tacaagctgt gtccccatgt gttgagatgt
     1681 caccagttcc tgaagcaacc ctctcctggg aagcccagct tgggcctgca gctcctggct
     1741 ccctcctggg atgttctgat tccacctggc agccccatgc ggcatgcgta cagcgagatc
     1801 ctggaagaac cacacaactg cccccttcag aaatacactc cactgcagac tccctactct
     1861 ttccctacta tgctcgccct ggcagaggaa gggcagcaca gggcttgggc tacttttgac
     1921 ccaaaggcca tgctgcctct cccagaagcc agtcacctga ccagctgcca actgaatcgc
     1981 cacctagcct ggtcctgggt ctgtctgcca tcctgtgtgt tccagccagc ccaggtttta
     2041 cttggggtcc tggtggcttc atctcgtaaa ggttgtctgg agcttcggga tctaagaggt
     2101 tcactgcctt gtatcccctt gactgagagt tcacagcccc tcattgaccc gaatctcgta
     2161 ggctgcctgg tgcgggtaga gaagttccag ttggtagtag agagagaagt caggagcagc
     2221 ttcccttcct gggaggagat gggcatggca cgcttcatcc agaagaagca ggccagagtc
     2281 tacgtccagt tctacctggc tgatgccctg atcctgcccg tgcccagacc cacctttggt
     2341 tcagaaccat ctcagacagc ctcctcctgc ccagagggac cccacctggg acagagccgg
     2401 ctgttcttac tgtcccacaa ggaggccctc atgaaacgta atttttgtct ccttccggga
     2461 gacagttcac aacctgcaaa gcccaccttg agtttccacg tgtcaggaac ttggctttgt
     2521 ggcacacaga ggaaggaagg ttctggatgg agcccacccg agtctctggc cgttgagagc
     2581 aaggatcaga aggtcttcct catctttctt ggctcttcag ttcgatggtt tccgttcttg
     2641 tacccaaacc aagtctaccg actcgtggct tccggcccct cacagacacc agtgttcgag
     2701 acagagggct cagctggcac ctctcgacgt cctctggaac tggctgactg tggatcttgc
     2761 ctcactgtcc aagaggagtg gaccctggag cttgggagct ctcaggacat acctaatgta
     2821 ctggaggtcc ctagaacact gcccgagtcc tcactggccc agctgctcgg tgacaactcc
     2881 cccgattcct tggtatcttt ctctgctgag attttgtctc ggatactgtg tgaaccacct
     2941 ctggcccttc gccggatgaa acctgggaat gctggggcta ttaaaacagg tgtgaagcta
     3001 acagtagctc tagaaatgga tgactgtgaa tatccccctc acctggacat atatatcgaa
     3061 gatccacagt tgcctcccca aataggactc cttccaggag cccgagtcca ctttagccag
     3121 ctggagaaaa ggatttccag atccaacatt gtttactgtt gtttccggtc atccacttct
     3181 gtgcaggtcc tgagcttccc cccagagacc aaagccagtg ctcctctgcc ccacatctat
     3241 ctggctgaac ttctccaagg tgaccggcct cccttccagg ccactacctc ttgccatatt
     3301 gtgtatgtcc tgagccttca gatcctgtgg gtgtgtgctc attgcaccag catctgcccc
     3361 cagggtaagt gtagtcgccg ggaccccagt tgtccatctc agagggctgt aagccaggcc
     3421 aacatcaggc tcctggtaga agatggcacc gcagaagcga cggtgatctg taggaatcat
     3481 cttgtggcaa gggcactagg gctgagtcct agtgagtggt cctccatcct cgagcatgcc
     3541 agggggccgg ggagagtggc cttgcagttt acagggctag gaggccaaac agagtctgca
     3601 agcaaaaccc atgagccctt gaccctgctc ctccggacac tttgtaccag cccctttgtc
     3661 ctccgacccg ttaagctttc ttttgcactt gaaaggagac ccactgatat ttccccacga
     3721 gaaccgtccc ggctgcagca gttccagtgt ggagagctcc ctctgctgac cagagtgaat
     3781 cccaggctcc gactggtctg cctttctctg caggagccgg agctccccaa ccctccacaa
     3841 gcatctgctg cttcgtcttg atgacactgc ctaaggtggc cccagagttt ccaggacccc
     3901 agacactgga gtgaggaact cctgccccac tgtgatttct agttattctg gtgtcagcat
     3961 gccttggaga cactgaaaac ggcagatcac agcatgataa tggtgtttcc tccaattggg
     4021 ttagaacacc tacactcaga ggtgaccctc cctgagtgct tgggttctgc cttgtggaga
     4081 aagcaggacg gagaccttgc cccttatgat tgattgtatt gtgataggcc ctttgggcta
     4141 caataaactt ctctgaggac tttctgaaaa aaaaaaaaaa aaa
//
