LOCUS       NM_001293672            2906 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus chitobiase (Ctbs), transcript variant 1, mRNA.
ACCESSION   NM_001293672 XM_006502151
VERSION     NM_001293672.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2906)
  AUTHORS   Hussain M and Wilson JB.
  TITLE     New paralogues and revised time line in the expansion of the
            vertebrate GH18 family
  JOURNAL   J Mol Evol 76 (4), 240-260 (2013)
   PUBMED   23558346
REFERENCE   2  (bases 1 to 2906)
  AUTHORS   Persichetti E, Klein K, Paciotti S, Lecointe K, Balducci C, Franken
            S, Duvet S, Matzner U, Roberti R, Hartmann D, Gieselmann V and
            Beccari T.
  TITLE     Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate
            Man2GlcNAc2 and Man3GlcNAc2
  JOURNAL   Biochim Biophys Acta 1822 (7), 1137-1146 (2012)
   PUBMED   22465033
  REMARK    GeneRIF: In di-N-acetylchitobiase-deficient mice Man2GlcNAc2 urine
            levels were up to 10-fold higher than in urine of wild-type
            animals.
REFERENCE   3  (bases 1 to 2906)
  AUTHORS   Balducci C, Bibi L, Berg T, Persichetti E, Tiribuzi R, Martino S,
            Paciotti S, Roberti R, Orlacchio A and Beccari T.
  TITLE     Molecular cloning and structural organization of the gene encoding
            the mouse lysosomal di-N-acetylchitobiase (ctbs)
  JOURNAL   Gene 416 (1-2), 85-91 (2008)
   PUBMED   18440730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124987.9, AK008791.2 and BE947124.1.
            
            [WARNING] On Apr 11, 2024 this sequence was replaced by
            NM_001293672.2.
            
            On Jun 13, 2014 this sequence version replaced XM_006502151.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.191064.1, DQ100384.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC124987.9         144664-144827
            165-303             AC124987.9         148544-148682
            304-512             AC124987.9         149145-149353
            513-684             AC124987.9         151533-151704
            685-782             AC124987.9         152940-153037
            783-944             AC124987.9         153876-154037
            945-1162            AC124987.9         158096-158313
            1163-1917           AK008791.2         976-1730
            1918-1918           AC124987.9         159069-159069
            1919-2817           AK008791.2         1732-2630
            2818-2906           BE947124.1         1-89                c
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.26 cM"
     gene            1..2906
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /note="chitobiase"
                     /db_xref="GeneID:74245"
                     /db_xref="MGI:MGI:1921495"
     exon            1..164
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1136
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; di-N-acetylchitobiase; chitobiase,
                     di-N-acetyl-"
                     /codon_start=1
                     /product="di-N-acetylchitobiase isoform 1 precursor"
                     /protein_id="NP_001280601.1"
                     /db_xref="CCDS:CCDS80048.1"
                     /db_xref="GeneID:74245"
                     /db_xref="MGI:MGI:1921495"
                     /translation="MALCGLPEFTLLLLPLLARLSAGDCPCSEAALCQPIRHRPDFEV
                     FVFDVGQKTWKSYDWSQITTVAAFGKYDPELMCYAHSKGARVVLKGDISLKNIIDPTF
                     RASWIAQKVDLAKAQYMDGINIDIEQEVNCSSPEYEALTALVKETTESFQREIEGSQV
                     TFDVAWSPKRIDKRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGY
                     IDYIKMGISPKKLVMGVPWYGYDYICLNLSKDDICTITKVPFRGAPCSDAAGHQVPYK
                     VIMKQVNGSVSGSQWNKDQQAPYYNYKDPAGRFHQVWYDNPQSISLKAAYVKNYGLRG
                     IGMWNANCLDYSDDALAREQTQEMWGALKPRL"
     exon            165..303
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            304..512
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            513..684
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            685..782
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            783..944
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            945..2895
                     /gene="Ctbs"
                     /gene_synonym="2210401K11Rik; CTB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagaggcgt cattcccgca gcctccaccc caggcatggc gctgtgtggc ctcccggaat
       61 tcactctgct gctgctgccg ctgttggcac ggctctcggc cggggactgc ccgtgctccg
      121 aggctgctct ctgccaaccg atccgccacc gtcccgactt cgaggtcttt gtatttgatg
      181 ttggacagaa aacctggaaa tcttatgact ggtcacagat tacaactgtg gcagcttttg
      241 gaaaatatga cccagaactt atgtgctatg ctcattcaaa aggagccagg gtagtgctaa
      301 aaggtgacat ctctctgaag aatatcattg atcctacctt cagagcatcg tggatagctc
      361 agaaagttga tttagccaaa gcacagtata tggatgggat taatatagac atagagcaag
      421 aagttaactg ctcatcacct gaatatgaag cactgacagc tctggtcaaa gaaaccacag
      481 agagtttcca acgtgagatc gagggatcac aggtaacctt tgatgtagct tggtcaccaa
      541 agcgcataga caaaaggtgc tataattaca ctgggatcgc agatgcctgt gactttcttt
      601 ttgtgatgtc ttacgatgag caaagtcaga tctggtcaga atgtattgca gccgccaatg
      661 ctccctacaa tcagacatta actggatata ttgactacat caagatgggc attagcccta
      721 agaaacttgt aatgggtgtt ccctggtatg gctatgatta catttgccta aatctctcaa
      781 aggatgacat ttgcaccatt acaaaggtcc ctttcagggg ggctccttgt agcgatgctg
      841 caggccatca agtgccctac aaggtgatca tgaagcaggt aaatggctct gtttctggaa
      901 gccagtggaa taaagaccag caagctccct attataacta caaggatcct gctggccgtt
      961 ttcatcaagt gtggtatgat aacccacaga gcatctcact aaaggcagca tatgtcaaaa
     1021 actacggctt gcggggcatt ggcatgtgga atgcaaactg tcttgactac tccgatgatg
     1081 ctctagccag agagcaaaca caagaaatgt ggggagcctt aaaaccaagg ctgtgatgga
     1141 gaggggcatc ttttgtcaga ctatcagact tgtaggactg acctgtataa gtagatctac
     1201 ctcttgaaga gataaaaatg tatatatttt tgtcatgttg ccataactta cttattggta
     1261 tactcaatta cacaggtaag aaataaagaa aattttcatt tgtacctgaa aaatacatac
     1321 atatcttaga tatccaggaa tataaaagga agaaacaagt caatttactc tattaaatat
     1381 tcctccatgt ttcagaatta taattagaaa acttgttttc aaaatttcat gctcaatttt
     1441 ctctcctatt attgaaatat actgttaaaa atcaatacag attttaaaaa tgtgcaactg
     1501 gtagacaagt gaagataatg gggaagggag tgcacatgac cacagtatga tacacacatg
     1561 tatagaatat tataataaag cccactattt ttatattaat atatgctaat aaaaggccaa
     1621 caagaactat gtgtaacttg aaatggaaat cactggcttt ggacacagtc tttaaaactt
     1681 agcctttgag aagcagttta tgttgaatga gtaggcatgg cttttctggt tcctgatttc
     1741 ttacagtaca tatgaatatt tcaggacata cacacattag tgtcacttag acatttagac
     1801 agcgtatgac ataaagatag gcatgcaaat ggaatgcgag aggataactg agggatgcct
     1861 ggaccctgga ctagagctac ctgaggagat ccaggtgaga gcttgctgcc agggtcagct
     1921 gctgctgagt ctgaccctag tcactgttca ccctgcagtc gcccagggtc cctcacgggc
     1981 taacactcac tgcttgccta cttttcacat ttttcttccg catttgcatt ttgcttttaa
     2041 gctatctaag aacattattc tttcaacttg ttcctttttc taaaagacta tttttgggaa
     2101 aataaatgtc tagcataaag cagttcttgt ttcctttctc aaagcaatca acacagttac
     2161 tgggctggag cgctggctcg caggtcagag cactggctct cctccagagg acttgggttc
     2221 agttcccaga actacatggt tggtcacaac cccagttcca gaggatctga ttcactcttc
     2281 ctgcacacac atggtacatg gacatacgtc catgcatata aagttaagta aaaataaaac
     2341 aaatcattac attatattta cattatttcc tgaaagaaca tagattaaat gtttgtatcc
     2401 tttgaactcc attacataag gcctatcttc tttacatatg atccccttcc aaattggaat
     2461 aagtgactaa tcaactgtct gttatgacaa tattatattt tctatttaca taactattta
     2521 tgacagtaaa actatttact tctatggtga ataactttgt atttataaaa atcactttac
     2581 atttctaaaa ttaatacaaa ttaaattatg agacacacat ttgttgtgca tgtagttgca
     2641 attgttttta atcaaaatgt gattaacaaa attgtattta ctaaaatata tgttttacta
     2701 atcatttatt ttgccatcat actggtaatt attttgtaat aagtaattat aaaatatagt
     2761 actaaaaaat aagtaataga caaaatcttt aaaataaaca cctactatac aaaaggtaaa
     2821 aattaaatat aatttttaat ttttttcttt aactgttaaa tcagctttat gatttaataa
     2881 aacattacca agaaaaaaaa aaaaaa
//
