LOCUS       NM_001412295            3025 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus C-terminal binding protein 2 (Ctbp2), transcript
            variant 5, mRNA.
ACCESSION   NM_001412295 XM_006507311
VERSION     NM_001412295.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3025)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3025)
  AUTHORS   Chen,X., Wang,C., Zhou,D., Zhao,G., Li,Z. and Duan,N.
  TITLE     Accumulation of advanced glycation end products promotes atrophic
            nonunion incidence in mice through a CtBP1/2-dependent mechanism
  JOURNAL   Exp Cell Res 432 (1), 113765 (2023)
   PUBMED   37696386
REFERENCE   4  (bases 1 to 3025)
  AUTHORS   Sekiya,M., Ma,Y., Kainoh,K., Saito,K., Yamazaki,D., Tsuyuzaki,T.,
            Chen,W., Adi Putri,P.I.P., Ohno,H., Miyamoto,T., Takeuchi,Y.,
            Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
            Motomura,K., Matsuzaka,T., Murata,K., Mizuno,S., Takahashi,S. and
            Shimano,H.
  TITLE     Loss of CtBP2 may be a mechanistic link between metabolic
            derangements and progressive impairment of pancreatic beta cell
            function
  JOURNAL   Cell Rep 42 (8), 112914 (2023)
   PUBMED   37557182
REFERENCE   5  (bases 1 to 3025)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   6  (bases 1 to 3025)
  AUTHORS   Spano,S., Silletta,M.G., Colanzi,A., Alberti,S., Fiucci,G.,
            Valente,C., Fusella,A., Salmona,M., Mironov,A., Luini,A. and
            Corda,D.
  TITLE     Molecular cloning and functional characterization of brefeldin
            A-ADP-ribosylated substrate. A novel protein involved in the
            maintenance of the Golgi structure
  JOURNAL   J Biol Chem 274 (25), 17705-17710 (1999)
   PUBMED   10364211
  REMARK    Erratum:[J Biol Chem 1999 Aug 27;274(35):25188. Spanfo S [corrected
            to Spano S]]
REFERENCE   7  (bases 1 to 3025)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Cloning and characterization of mCtBP2, a co-repressor that
            associates with basic Kruppel-like factor and other mammalian
            transcriptional regulators
  JOURNAL   EMBO J 17 (17), 5129-5140 (1998)
   PUBMED   9724649
REFERENCE   8  (bases 1 to 3025)
  AUTHORS   Liu,Q., Bai,C., Chen,F., Wang,R., MacDonald,T., Gu,M., Zhang,Q.,
            Morsy,M.A. and Caskey,C.T.
  TITLE     Uncoupling protein-3: a muscle-specific gene upregulated by leptin
            in ob/ob mice
  JOURNAL   Gene 207 (1), 1-7 (1998)
   PUBMED   9511737
REFERENCE   9  (bases 1 to 3025)
  AUTHORS   Katsanis,N. and Fisher,E.M.
  TITLE     A novel C-terminal binding protein (CTBP2) is closely related to
            CTBP1, an adenovirus E1A-binding protein, and maps to human
            chromosome 21q21.3
  JOURNAL   Genomics 47 (2), 294-299 (1998)
   PUBMED   9479502
REFERENCE   10 (bases 1 to 3025)
  AUTHORS   Baker,R.K., Haendel,M.A., Swanson,B.J., Shambaugh,J.C.,
            Micales,B.K. and Lyons,G.E.
  TITLE     In vitro preselection of gene-trapped embryonic stem cell clones
            for characterizing novel developmentally regulated genes in the
            mouse
  JOURNAL   Dev Biol 185 (2), 201-214 (1997)
   PUBMED   9187083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138624.4 and AC119806.6.
            
            On Sep 28, 2022 this sequence version replaced XM_006507311.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.1329044.1,
                                           SRR17784646.432064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AC138624.4         93311-93625         c
            316-419             AC119806.6         16728-16831
            420-579             AC119806.6         72716-72875
            580-734             AC119806.6         99243-99397
            735-879             AC119806.6         99637-99781
            880-1086            AC119806.6         103223-103429
            1087-1301           AC119806.6         106812-107026
            1302-1432           AC119806.6         107419-107549
            1433-1560           AC119806.6         108030-108157
            1561-1678           AC119806.6         108481-108598
            1679-3025           AC119806.6         110237-111583
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.32 cM"
     gene            1..3025
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /note="C-terminal binding protein 2"
                     /db_xref="GeneID:13017"
                     /db_xref="MGI:MGI:1201686"
     exon            1..315
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            316..419
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            420..579
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..1859
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /note="isoform 2 is encoded by transcript variant 5; gene
                     trap ROSA b-geo 6"
                     /codon_start=1
                     /product="C-terminal-binding protein 2 isoform 2"
                     /protein_id="NP_001399224.1"
                     /db_xref="GeneID:13017"
                     /db_xref="MGI:MGI:1201686"
                     /translation="MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDC
                     TVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIV
                     RIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGT
                     RVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIE
                     RSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLV
                     DEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMR
                     EAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIV
                     GVAPGGLPPAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ"
     exon            580..734
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            735..879
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1086
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1301
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1432
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1560
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1678
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..3025
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3000..3005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /note="hexamer: AATAAA"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /note="hexamer: ATTAAA"
     polyA_site      3019
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
     polyA_site      3025
                     /gene="Ctbp2"
                     /gene_synonym="D7Ertd45e; Gtrgeo6; Ribeye"
                     /note="major polyA site"
ORIGIN      
        1 agggcagcgg cggcggcgtc tggcgacggt ttcctaggcg ccccgggctt gctcctggag
       61 cccggtgggt gcgcgcgcgg gggccgctgg cgatctcgga cgagcgcgct gcgcgccgcg
      121 gggacaatac ggccagatcc ctggggatca ggagtccgag catgacgggg tgcggcaggc
      181 cttgcgcctg ggaggcgggc gggcaggggg gagtagacac cggggtcggc ggggacaagt
      241 cggggcgcgc gtggctcggg gcccctgggg gcgcggcccc tatcggcccg ggatcccgcg
      301 cggttctccc agagtggctt catcactgta aatggttgca agccgacaaa gctgcacctc
      361 ctgaaaaaga cggacagccc atcgcgtgag ctgtagagtt tgtggacgca tttctatcgg
      421 gttcatagtg gcgcaatgca cgcagactcc tgcgaattcc cctaagttct tagcggactg
      481 ctttgccttt tgaatcagag agttgcaaag ttcgataaag aatggccctt gtggataagc
      541 acaaagtcaa gcggcagcga ttggacagga tttgtgaagg tatccgcccc cagatcatga
      601 acggccccct gcacccccgc cccctggtgg cactgctgga tggcagagac tgcactgtgg
      661 agatgcccat cctgaaggac ctggccactg tggccttctg tgatgcacag tccactcagg
      721 aaatccatga gaaggtgttg aatgaggctg tgggtgccat gatgtaccac accatcaccc
      781 tcaccaggga agacctggag aagttcaagg ccctgagagt gatcgtgcga atcggtagtg
      841 gctacgacaa cgtggacatc aaggctgctg gcgagctcgg gatcgctgtg tgcaacatcc
      901 catctgctgc agtggaggag acagcagatt cgacagtctg ccacattctc aatctgtatc
      961 ggcggaacac atggctctac caggccctcc gagaaggcac tcgagtacag agtgtggaac
     1021 agatccgtga ggtcgcctca ggagctgctc ggatccgagg ggaaacactg ggcctcattg
     1081 gctttggtcg cacagggcag gcagttgctg ttcgagccaa ggcctttgga ttcagcgtca
     1141 tattttatga cccctactta caggatggga tagaacgatc tctgggcgtg caaagggtct
     1201 acaccctgca ggacttgcta tatcagagcg actgcgtctc cttgcactgc aacctgaacg
     1261 agcacaacca tcacctcatc aatgacttca ctatcaagca gatgaggcaa ggtgcattcc
     1321 ttgtgaatgc agcccgaggt ggcctggtgg atgagaaagc cttagctcag gccctcaagg
     1381 agggcaggat acgaggagct gccctggatg tgcacgagtc tgagcccttc agcttcgccc
     1441 agggcccatt gaaggatgct ccaaatctca tctgcacacc acacacagcc tggtacagtg
     1501 aacaagcatc actagagatg agggaagcag cagccactga gatccgccga gcaatcacag
     1561 gtcgcatccc agaaagctta cgaaactgtg tcaacaaaga attcttcgtg acttcagctc
     1621 cttggtcagt cattgaccag caagcaattc accccgagct caatggtgcc acatacaggt
     1681 atccacccgg cattgtaggt gtggctccag gagggcttcc tccagcgatg gaagggatca
     1741 tccctggggg catccccgtg actcacaacc tccccacagt ggcacacccc tcccaagctc
     1801 cttcccccaa ccagcccaca aaacacgggg acaatcgaga gcaccccaac gagcaatagc
     1861 agagaatgcc tgaagctaat ccgataaact tgggaccaag agacagtaga aaacggatga
     1921 atttgatggt cttttaaact gatcctggac atcactgata ctgcagtgtt aaagctacaa
     1981 aagctagaaa actgaagatg gtatctgctt ccagaggtgt gggaagacta ggacgtgatt
     2041 attaacgacc aacttctgtt attgtgtgtt aagtttttca tctgtgcatc aaatcacaaa
     2101 gaataaatag agcttttcct ttatcaatcc cctgggcaca gcaggtcctg cagagcttgc
     2161 tctagaatgt tgcatcaaga gctccgaata tcaataaaaa gttgagagga aatccccatc
     2221 aagactagtc cctttggtct ccaggggctg gtgcctctgc tgataggaag attaaaatta
     2281 agccaagatg gggaggacat tgtttgcctg tgtagacatc tccacgcaca ggattgaaga
     2341 agtaaaagct cctatacaga aggtttcaca tctgagcagc agagtcggtt cagtaaaacc
     2401 ctctgataca aaaaaaaaaa aaaaacaaaa aaacaaaaaa aaaaaaggaa aagaacaaaa
     2461 gaaaaaagta ttaagtttca caagctgttt gtactcaaat ctattttctc agtttcagat
     2521 cctcagctat tttattgagt ggaaagtctt ggacgagaag ggttcaagaa gaataatgtt
     2581 gcatttcctt atgtctcagg aaacactttt tatggtaact tgtcagattg tctatgaaca
     2641 aacccacttt tttagacatt gataaattct tttcttcacg tgatatttta tacaagaaca
     2701 cttcagatgt gctattagat gtgactgatt ttaacaaatc ctattagatt tgtatcagct
     2761 agttacatgt tctattcata gtcttttgtg aatcattgcc tttttgtttt taaagatggc
     2821 ctattttgag cctttgtata ggtacattcc tgtttttgtg acacaaaaga aaaaaaaaac
     2881 tttaaactgt cccaaacaga aaaataatgg ctatcagaaa tgttttgttt tagtgtgagt
     2941 tatcgttact gtatttgttt attgtaaagg tggacatttt agcattcagt gcagttttca
     3001 ataaagtaat taaaatttct tttaa
//
