LOCUS       NM_001310535            2134 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus C-terminal binding protein 1 (Ctbp1), transcript
            variant 5, mRNA.
ACCESSION   NM_001310535 XM_006503710
VERSION     NM_001310535.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Hamada,N., Matsuki,T., Iwamoto,I., Nishijo,T., Noda,M., Tabata,H.,
            Nakayama,A. and Nagata,K.I.
  TITLE     Expression Analyses of C-Terminal-Binding Protein 1 (CtBP1) during
            Mouse Brain Development
  JOURNAL   Dev Neurosci 46 (4), 262-272 (2024)
   PUBMED   37906993
  REMARK    GeneRIF: Expression Analyses of C-Terminal-Binding Protein 1
            (CtBP1) during Mouse Brain Development.
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Chen,X., Wang,C., Zhou,D., Zhao,G., Li,Z. and Duan,N.
  TITLE     Accumulation of advanced glycation end products promotes atrophic
            nonunion incidence in mice through a CtBP1/2-dependent mechanism
  JOURNAL   Exp Cell Res 432 (1), 113765 (2023)
   PUBMED   37696386
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Wang,F., Cui,D., Zhang,Q., Shao,Y., Zheng,B., Chen,L., Luo,Y.,
            Yuan,L. and Wang,D.
  TITLE     LncRNA00492 is required for marginal zone B-cell development
  JOURNAL   Immunology 165 (1), 88-98 (2022)
   PUBMED   34435359
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Ivanova,D., Imig,C., Camacho,M., Reinhold,A., Guhathakurta,D.,
            Montenegro-Venegas,C., Cousin,M.A., Gundelfinger,E.D.,
            Rosenmund,C., Cooper,B. and Fejtova,A.
  TITLE     CtBP1-Mediated Membrane Fission Contributes to Effective Recycling
            of Synaptic Vesicles
  JOURNAL   Cell Rep 30 (7), 2444-2459 (2020)
   PUBMED   32075774
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Spano,S., Silletta,M.G., Colanzi,A., Alberti,S., Fiucci,G.,
            Valente,C., Fusella,A., Salmona,M., Mironov,A., Luini,A. and
            Corda,D.
  TITLE     Molecular cloning and functional characterization of brefeldin
            A-ADP-ribosylated substrate. A novel protein involved in the
            maintenance of the Golgi structure
  JOURNAL   J Biol Chem 274 (25), 17705-17710 (1999)
   PUBMED   10364211
  REMARK    Erratum:[J Biol Chem 1999 Aug 27;274(35):25188. Spanfo S [corrected
            to Spano S]]
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Katsanis,N. and Fisher,E.M.
  TITLE     A novel C-terminal binding protein (CTBP2) is closely related to
            CTBP1, an adenovirus E1A-binding protein, and maps to human
            chromosome 21q21.3
  JOURNAL   Genomics 47 (2), 294-299 (1998)
   PUBMED   9479502
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Nasir,J., Lin,B., Bucan,M., Koizumi,T., Nadeau,J.H. and Hayden,M.R.
  TITLE     The murine homologues of the Huntington disease gene (Hdh) and the
            alpha-adducin gene (Add1) map to mouse chromosome 5 within a region
            of conserved synteny with human chromosome 4p16.3
  JOURNAL   Genomics 22 (1), 198-201 (1994)
   PUBMED   7959767
REFERENCE   9  (bases 1 to 2134)
  AUTHORS   Grosson,C.L., MacDonald,M.E., Duyao,M.P., Ambrose,C.M.,
            Roffler-Tarlov,S. and Gusella,J.F.
  TITLE     Synteny conservation of the Huntington's disease gene and
            surrounding loci on mouse Chromosome 5
  JOURNAL   Mamm Genome 5 (7), 424-428 (1994)
   PUBMED   7919654
REFERENCE   10 (bases 1 to 2134)
  AUTHORS   Koizumi,T., MacDonald,M., Bucan,M., Hopwood,J.J., Morris,C.P.,
            Scott,H.S., Gusella,J.F. and Nadeau,J.H.
  TITLE     Linkage, but not gene order, of homologous loci, including
            alpha-L-iduronidase (Idua), is conserved in the Huntington disease
            region of the mouse and human genomes
  JOURNAL   Mamm Genome 3 (1), 23-27 (1992)
   PUBMED   1533802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115070.9.
            
            On Jul 15, 2015 this sequence version replaced XM_006503710.1.
            
            Transcript Variant: This variant (5) lacks an alternate exon in the
            5' region and initiates translation at a downstream start codon,
            compared to variant 3.  It encodes a shorter isoform (5) with a
            shorter N-terminus compared to isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171650.1, SRR11927931.183547.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AC115070.9         145670-145895       c
            227-371             AC115070.9         131900-132044       c
            372-578             AC115070.9         130029-130235       c
            579-793             AC115070.9         121749-121963       c
            794-924             AC115070.9         121262-121392       c
            925-1052            AC115070.9         120478-120605       c
            1053-1170           AC115070.9         119998-120115       c
            1171-2134           AC115070.9         118614-119577       c
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.52 cM"
     gene            1..2134
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /note="C-terminal binding protein 1"
                     /db_xref="GeneID:13016"
                     /db_xref="MGI:MGI:1201685"
     exon            1..226
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            227..371
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1357
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="C-terminal-binding protein 1 isoform 5"
                     /protein_id="NP_001297464.1"
                     /db_xref="CCDS:CCDS80255.1"
                     /db_xref="GeneID:13016"
                     /db_xref="MGI:MGI:1201685"
                     /translation="MYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVC
                     NVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGET
                     LGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQDLLFHSDCVT
                     LHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVH
                     ESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNC
                     VNKDHLTAATHWASMDPAVVHPELNGAAYSRYPPGVVSVAPTGIPAAVEGIVPSAMSL
                     SHGLPPVAHPPHAPSPGQTVKPEADRDHTSDQL"
     exon            372..578
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            579..793
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            794..924
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1052
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1170
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..2134
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /note="hexamer: AATAAA"
     polyA_site      2134
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /note="major polyA site"
ORIGIN      
        1 ccgcgtgtcc ccgcccgctc gtcggtcgga gcgcggctgg cggcgcggtg gcggctcggc
       61 acggcggtgg ccgggcgcag gcggccgggc ggagtagcag actgcgccga agccgcccca
      121 ggcgcagggc tcgcggcggc ggagagcgcc ggactcatcg gggcccgcgg ccacccgcac
      181 ctttcaatgg gcagctccca cttgctcaac aagggcctgc cgctgggtac tgaatgaggc
      241 tgtgggtgcc ctgatgtacc ataccatcac actgaccaga gaagatctgg agaagtttaa
      301 agctcttaga atcatcgtcc gaattggcag cgggtttgac aatatcgaca tcaagtcagc
      361 tggggatcta ggcatcgcag tgtgcaatgt gccggcagca tctgtggaag aaacggcaga
      421 ctccaccctg tgccacatcc tgaacctgta ccgacgaacc acctggctac accaggccct
      481 tcgggaaggc actcgagtcc agagtgtaga gcagatccga gaggtggctt caggagctgc
      541 caggatccgt ggagagacct tgggcatcat tggactaggt cgtgtgggcc aggcggtggc
      601 acttcgggca aaggcttttg gcttcaacgt cctcttctat gatccatacc tatctgatgg
      661 aatcgagcgg gccctggggc tacagcgcgt gagcacgctg caggacctgc tcttccacag
      721 tgactgcgtt accctgcatt gcggcctcaa tgagcacaac caccacctca tcaatgactt
      781 tactgtcaag cagatgagac aaggagcctt tctggtgaac acagcccgtg gtggcctggt
      841 ggatgagaag gcactggccc aggccctgaa ggaagggcgg atccgtggcg cagcgctgga
      901 cgtgcatgag tcagagccct tcagctttag ccagggaccc ttaaaggatg cacccaacct
      961 catctgcaca ccccatgctg catggtacag tgagcaggcg tccattgaga tgagagagga
     1021 ggcagcccgg gaaatccggc gagccatcac aggccggatc ccagatagct tgaaaaactg
     1081 tgtcaacaag gaccacctga cagccgccac gcactgggcc agcatggacc ctgctgtggt
     1141 gcaccctgag ctcaatgggg ctgcctacag caggtaccct ccaggcgtcg tgagtgtggc
     1201 ccccactggc atcccagctg ctgtggaagg gattgttccc agtgccatgt ccctgtctca
     1261 tggcctgccc cctgtggccc acccacccca cgctccctct cctggccaga ctgtcaagcc
     1321 tgaggcggat agagaccata cgagtgacca gttgtagcct gtgaggagct gtccagcctt
     1381 ggcacctggt ggagggtgct gcacgctctt ggacccaagt gtgcagaggt ggcatccagt
     1441 gtgggcccta gcactccaga gactggcccg ggcgtgcact aggcggggca agaggaagca
     1501 cgtccccaag ttgattgtag ttgtcccgtc ctgtgggctg gctcactgtc ctgtgtcctt
     1561 tgcgttcctc gtttaagcaa aagaagttag tagctaattc tatcacgaat gttcttgtct
     1621 gtgtacagtt tttagaacat tacaaaggat ttgtttgctt agctgtcaac aaaaagaaaa
     1681 cctgagggag cattcagcaa gtcagtttga gattattttt ccttttctac gttggaacgt
     1741 gccccggaat gtggccgtcg gcacacttct caggacaatg aatccttcct gtttttcttt
     1801 ttatgccaca cagtgcattg tttttctacc tgcttgtctt atttttagaa taatttagaa
     1861 aaacaacaaa ggctgttttt cctaattttg gcatgaaccc cttgttccaa gtgaaggcgg
     1921 catcacgagt ggctccgagg cgtctgcagt gcccagggtg ctcaggacca ccggggtctg
     1981 tcctggggga ggcaggggtt ggcagaccct tgcctgcgtg gtgccgtcct gctcatgtgg
     2041 taggctagca atattttggt taaaatcatg tttgtgactg taaccatttg tatgaattat
     2101 tttaaagaaa taaaaatccc agaaagagcc ggca
//
