LOCUS       NM_001198861            2498 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus C-terminal binding protein 1 (Ctbp1), transcript
            variant 4, mRNA.
ACCESSION   NM_001198861
VERSION     NM_001198861.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2498)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2498)
  AUTHORS   Hamada,N., Matsuki,T., Iwamoto,I., Nishijo,T., Noda,M., Tabata,H.,
            Nakayama,A. and Nagata,K.I.
  TITLE     Expression Analyses of C-Terminal-Binding Protein 1 (CtBP1) during
            Mouse Brain Development
  JOURNAL   Dev Neurosci 46 (4), 262-272 (2024)
   PUBMED   37906993
  REMARK    GeneRIF: Expression Analyses of C-Terminal-Binding Protein 1
            (CtBP1) during Mouse Brain Development.
REFERENCE   3  (bases 1 to 2498)
  AUTHORS   Chen,X., Wang,C., Zhou,D., Zhao,G., Li,Z. and Duan,N.
  TITLE     Accumulation of advanced glycation end products promotes atrophic
            nonunion incidence in mice through a CtBP1/2-dependent mechanism
  JOURNAL   Exp Cell Res 432 (1), 113765 (2023)
   PUBMED   37696386
REFERENCE   4  (bases 1 to 2498)
  AUTHORS   Wang,F., Cui,D., Zhang,Q., Shao,Y., Zheng,B., Chen,L., Luo,Y.,
            Yuan,L. and Wang,D.
  TITLE     LncRNA00492 is required for marginal zone B-cell development
  JOURNAL   Immunology 165 (1), 88-98 (2022)
   PUBMED   34435359
REFERENCE   5  (bases 1 to 2498)
  AUTHORS   Ivanova,D., Imig,C., Camacho,M., Reinhold,A., Guhathakurta,D.,
            Montenegro-Venegas,C., Cousin,M.A., Gundelfinger,E.D.,
            Rosenmund,C., Cooper,B. and Fejtova,A.
  TITLE     CtBP1-Mediated Membrane Fission Contributes to Effective Recycling
            of Synaptic Vesicles
  JOURNAL   Cell Rep 30 (7), 2444-2459 (2020)
   PUBMED   32075774
REFERENCE   6  (bases 1 to 2498)
  AUTHORS   Spano,S., Silletta,M.G., Colanzi,A., Alberti,S., Fiucci,G.,
            Valente,C., Fusella,A., Salmona,M., Mironov,A., Luini,A. and
            Corda,D.
  TITLE     Molecular cloning and functional characterization of brefeldin
            A-ADP-ribosylated substrate. A novel protein involved in the
            maintenance of the Golgi structure
  JOURNAL   J Biol Chem 274 (25), 17705-17710 (1999)
   PUBMED   10364211
  REMARK    Erratum:[J Biol Chem 1999 Aug 27;274(35):25188. Spanfo S [corrected
            to Spano S]]
REFERENCE   7  (bases 1 to 2498)
  AUTHORS   Katsanis,N. and Fisher,E.M.
  TITLE     A novel C-terminal binding protein (CTBP2) is closely related to
            CTBP1, an adenovirus E1A-binding protein, and maps to human
            chromosome 21q21.3
  JOURNAL   Genomics 47 (2), 294-299 (1998)
   PUBMED   9479502
REFERENCE   8  (bases 1 to 2498)
  AUTHORS   Nasir,J., Lin,B., Bucan,M., Koizumi,T., Nadeau,J.H. and Hayden,M.R.
  TITLE     The murine homologues of the Huntington disease gene (Hdh) and the
            alpha-adducin gene (Add1) map to mouse chromosome 5 within a region
            of conserved synteny with human chromosome 4p16.3
  JOURNAL   Genomics 22 (1), 198-201 (1994)
   PUBMED   7959767
REFERENCE   9  (bases 1 to 2498)
  AUTHORS   Grosson,C.L., MacDonald,M.E., Duyao,M.P., Ambrose,C.M.,
            Roffler-Tarlov,S. and Gusella,J.F.
  TITLE     Synteny conservation of the Huntington's disease gene and
            surrounding loci on mouse Chromosome 5
  JOURNAL   Mamm Genome 5 (7), 424-428 (1994)
   PUBMED   7919654
REFERENCE   10 (bases 1 to 2498)
  AUTHORS   Koizumi,T., MacDonald,M., Bucan,M., Hopwood,J.J., Morris,C.P.,
            Scott,H.S., Gusella,J.F. and Nadeau,J.H.
  TITLE     Linkage, but not gene order, of homologous loci, including
            alpha-L-iduronidase (Idua), is conserved in the Huntington disease
            region of the mouse and human genomes
  JOURNAL   Mamm Genome 3 (1), 23-27 (1992)
   PUBMED   1533802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ163412.1, AK133816.1 and BE991938.1.
            
            Transcript Variant: This variant (4) contains an alternate exon in
            the 5' region and initiates translation at an alternate start
            codon, compared to variant 3. It encodes a shorter isoform (4) with
            a distinct N-terminus compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042425.1, AK133816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               CJ163412.1         6-457
            453-2468            AK133816.1         424-2439
            2469-2498           BE991938.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..2498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.52 cM"
     gene            1..2498
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /note="C-terminal binding protein 1"
                     /db_xref="GeneID:13016"
                     /db_xref="MGI:MGI:1201685"
     exon            1..226
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            227..419
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            420..574
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            575..719
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            720..926
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1141
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1272
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1400
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1518
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..2482
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /note="hexamer: AATAAA"
     polyA_site      2482
                     /gene="Ctbp1"
                     /gene_synonym="BARS; CtBP3/BARS; D4S115h; D5H4S115;
                     D5H4S115E"
                     /note="major polyA site"
ORIGIN      
        1 ccgcgtgtcc ccgcccgctc gtcggtcgga gcgcggctgg cggcgcggtg gcggctcggc
       61 acggcggtgg ccgggcgcag gcggccgggc ggagtagcag actgcgccga agccgcccca
      121 ggcgcagggc tcgcggcggc ggagagcgcc ggactcatcg gggcccgcgg ccacccgcac
      181 ctttcaatgg gcagctccca cttgctcaac aagggcctgc cgctggtaag actttgaacc
      241 cgacgcaggc ttcagtggct gctgtggagc agaagcctga gagctttggt tggagacaat
      301 aagacgtggg atgaggctcc gtgacagaac gcggttcggc ctggggattc tgaagacaaa
      361 aagctttgga caggcgaatt catggtcgtg gaaaccccgc cccaattaag caatgtcagg
      421 cgtccgacct cccatcatga acgggcccat gcacccccgg cccctggtgg cgctgctgga
      481 tggccgggac tgcacagtgg agatgcctat cctgaaggat gtggccacag tagccttctg
      541 tgatgcacag tccacacagg agatccatga gaaggtactg aatgaggctg tgggtgccct
      601 gatgtaccat accatcacac tgaccagaga agatctggag aagtttaaag ctcttagaat
      661 catcgtccga attggcagcg ggtttgacaa tatcgacatc aagtcagctg gggatctagg
      721 catcgcagtg tgcaatgtgc cggcagcatc tgtggaagaa acggcagact ccaccctgtg
      781 ccacatcctg aacctgtacc gacgaaccac ctggctacac caggcccttc gggaaggcac
      841 tcgagtccag agtgtagagc agatccgaga ggtggcttca ggagctgcca ggatccgtgg
      901 agagaccttg ggcatcattg gactaggtcg tgtgggccag gcggtggcac ttcgggcaaa
      961 ggcttttggc ttcaacgtcc tcttctatga tccataccta tctgatggaa tcgagcgggc
     1021 cctggggcta cagcgcgtga gcacgctgca ggacctgctc ttccacagtg actgcgttac
     1081 cctgcattgc ggcctcaatg agcacaacca ccacctcatc aatgacttta ctgtcaagca
     1141 gatgagacaa ggagcctttc tggtgaacac agcccgtggt ggcctggtgg atgagaaggc
     1201 actggcccag gccctgaagg aagggcggat ccgtggcgca gcgctggacg tgcatgagtc
     1261 agagcccttc agctttagcc agggaccctt aaaggatgca cccaacctca tctgcacacc
     1321 ccatgctgca tggtacagtg agcaggcgtc cattgagatg agagaggagg cagcccggga
     1381 aatccggcga gccatcacag gccggatccc agatagcttg aaaaactgtg tcaacaagga
     1441 ccacctgaca gccgccacgc actgggccag catggaccct gctgtggtgc accctgagct
     1501 caatggggct gcctacagca ggtaccctcc aggcgtcgtg agtgtggccc ccactggcat
     1561 cccagctgct gtggaaggga ttgttcccag tgccatgtcc ctgtctcatg gcctgccccc
     1621 tgtggcccac ccaccccacg ctccctctcc tggccagact gtcaagcctg aggcggatag
     1681 agaccatacg agtgaccagt tgtagcctgt gaggagctgt ccagccttgg cacctggtgg
     1741 agggtgctgc acgctcttgg acccaagtgt gcagaggtgg catccagtgt gggccctagc
     1801 actccagaga ctggcccggg cgtgcactag gcggggcaag aggaagcacg tccccaagtt
     1861 gattgtagtt gtcccgtcct gtgggctggc tcactgtcct gtgtcctttg cgttcctcgt
     1921 ttaagcaaaa gaagttagta gctaattcta tcacgaatgt tcttgtctgt gtacagtttt
     1981 tagaacatta caaaggattt gtttgcttag ctgtcaacaa aaagaaaacc tgagggagca
     2041 ttcagcaagt cagtttgaga ttatttttcc ttttctacgt tggaacgtgc cccggaatgt
     2101 ggccgtcggc acacttctca ggacaatgaa tccttcctgt ttttcttttt atgccacaca
     2161 gtgcattgtt tttctacctg cttgtcttat ttttagaata atttagaaaa acaacaaagg
     2221 ctgtttttcc taattttggc atgaacccct tgttccaagt gaaggcggca tcacgagtgg
     2281 ctccgaggcg tctgcagtgc ccagggtgct caggaccacc ggggtctgtc ctgggggagg
     2341 caggggttgg cagacccttg cctgcgtggt gccgtcctgc tcatgtggta ggctagcaat
     2401 attttggtta aaatcatgtt tgtgactgta accatttgta tgaattattt taaagaaata
     2461 aaaatcccag aaagagccgg caaaaaaaaa aaaaaaaa
//
