LOCUS       NM_027302                857 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus cancer/testis antigen 2 (Ctag2), mRNA.
ACCESSION   NM_027302 NM_001161821 XM_135880
VERSION     NM_027302.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 857)
  AUTHORS   Morimoto K, Numata K, Daitoku Y, Hamada Y, Kobayashi K, Kato K,
            Suzuki H, Ayabe S, Yoshiki A, Takahashi S, Murata K, Mizuno S and
            Sugiyama F.
  TITLE     Reverse genetics reveals single gene of every candidate on Hybrid
            sterility, X Chromosome QTL 2 (Hstx2) are dispensable for
            spermatogenesis
  JOURNAL   Sci Rep 10 (1), 9060 (2020)
   PUBMED   32493902
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 857)
  AUTHORS   Mandic M, Almunia C, Vicel S, Gillet D, Janjic B, Coval K, Maillere
            B, Kirkwood JM and Zarour HM.
  TITLE     The alternative open reading frame of LAGE-1 gives rise to multiple
            promiscuous HLA-DR-restricted epitopes recognized by T-helper
            1-type tumor-reactive CD4+ T cells
  JOURNAL   Cancer Res 63 (19), 6506-6515 (2003)
   PUBMED   14559844
REFERENCE   3  (bases 1 to 857)
  AUTHORS   Aradhya S, Bardaro T, Galgoczy P, Yamagata T, Esposito T, Patlan H,
            Ciccodicola A, Munnich A, Kenwrick S, Platzer M, D'Urso M and
            Nelson DL.
  TITLE     Multiple pathogenic and benign genomic rearrangements occur at a 35
            kb duplication involving the NEMO and LAGE2 genes
  JOURNAL   Hum Mol Genet 10 (22), 2557-2567 (2001)
   PUBMED   11709543
REFERENCE   4  (bases 1 to 857)
  AUTHORS   Aarnoudse CA, van den Doel PB, Heemskerk B and Schrier PI.
  TITLE     Interleukin-2-induced, melanoma-specific T cells recognize CAMEL,
            an unexpected translation product of LAGE-1
  JOURNAL   Int J Cancer 82 (3), 442-448 (1999)
   PUBMED   10399963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006526.1 and AI503560.1.
            
            On or before Apr 25, 2010 this sequence version replaced
            NM_001161821.1, NM_027302.1.
            
            CCDS Note: This CCDS is supported by the mRNAs AK006526.1 and
            BC049681.1, and the encoded protein includes a Pcc1 domain.
            However, it should be noted that this mouse Ctag2 gene shows poor
            conservation with the human CTAG2 gene (represented by CCDS14759.1
            and CCDS35455.1), which may not be a true ortholog. Nonetheless,
            this mouse gene shows conservation in rat, so it may have a
            rodent-specific function. The human gene gives rise to multiple MHC
            epitopes that function in immune responses (e.g., PMIDs 10399963
            and 14559844). Duplications, rearrangements and frequent gene
            conversions have been described for the genomic region in primate
            species (PMID:11709543), so it is possible that significant
            divergence may have occurred.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049681.1, AK006526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-848               AK006526.1         2-849
            849-857             AI503560.1         2-10                c
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 34.64 cM"
     gene            1..857
                     /gene="Ctag2"
                     /gene_synonym="1700030B21Rik"
                     /note="cancer/testis antigen 2"
                     /db_xref="GeneID:70062"
                     /db_xref="MGI:MGI:1917312"
     exon            1..433
                     /gene="Ctag2"
                     /gene_synonym="1700030B21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..701
                     /gene="Ctag2"
                     /gene_synonym="1700030B21Rik"
                     /codon_start=1
                     /product="cancer/testis antigen 2"
                     /protein_id="NP_081578.1"
                     /db_xref="CCDS:CCDS30168.1"
                     /db_xref="GeneID:70062"
                     /db_xref="MGI:MGI:1917312"
                     /translation="MQDPSGDKVCRAGGEEDGEDGQHTSRVHDTEADPHHTEASSHRT
                     EGSSHLTETSSRPSEAENGHDNSPHVNRAQDVGTQASPQGSLNSRVPVEARVVVEEAA
                     IAPQGEQAPIIPGPSGDAATTAGSRLLEFSVTVPFRTAVEANIACRTLASNIQQQQVM
                     VQQEFTVNDTILTVRWTTEDPVLFRTSINAFLDQLSLVVRNIPRPVFMAVFKQGRGRN
                     N"
     exon            434..562
                     /gene="Ctag2"
                     /gene_synonym="1700030B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..857
                     /gene="Ctag2"
                     /gene_synonym="1700030B21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtattatag gggaactctg ggtggataag cccacttaac catgcaggat cctagtgggg
       61 acaaagtttg tagagcaggt ggtgaagaag acggggagga tggacagcac acatccagag
      121 tccatgatac tgaagcagac ccacatcata ctgaagcaag ctcacatcgt actgaaggca
      181 gctcgcatct tactgaaaca agctcacgtc cttctgaagc agagaatggc catgataact
      241 ctccacatgt aaatcgtgca caagatgttg gtacccaggc ttccccccaa ggtagtctca
      301 actcaagggt ccctgtagag gcaagagtgg tggtcgaaga ggcagccata gctcctcagg
      361 gtgagcaggc accaattatc ccgggaccta gtggagatgc tgcaacaaca gctggaagtc
      421 gactcttgga attttccgta acagtgccgt tccggactgc tgtggaggca aacattgcat
      481 gcagaaccct ggcctcaaat atccagcagc agcaagtgat ggttcagcag gagttcactg
      541 tcaatgacac tattctcact gttaggtgga ccacagaaga tcctgttctc ttccgaacat
      601 ccatcaatgc ctttcttgac caactttccc ttgtggtgag aaacatccca cgcccagtgt
      661 ttatggctgt cttcaaacaa ggaagaggaa gaaataatta actctagtta ccacccacaa
      721 cacaaggcaa aggcatttca tgatttgaga aactgtccct ttgcctccat attcactgtt
      781 ttgattctat cacactgttg ttatcagtca gtgttactgg aggagtgaat attgaaaatc
      841 agatactgaa aacagca
//
