LOCUS       NM_029142               1203 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cancer/testis antigen 55 (Ct55), mRNA.
ACCESSION   NM_029142 XM_135429 XM_914296 XM_992997
VERSION     NM_029142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1203)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1203)
  AUTHORS   Zhang,G., Jiang,C., Yang,Y., Wang,Y., Zhou,H., Dai,S., Liu,M.,
            Yang,Y., Yang,L., Shen,Q., Zhang,T., Zhang,X., Yang,Y. and Shen,Y.
  TITLE     Deficiency of cancer/testis antigen gene CT55 causes male
            infertility in humans and mice
  JOURNAL   Cell Death Differ 30 (2), 500-514 (2023)
   PUBMED   36481789
  REMARK    GeneRIF: Deficiency of cancer/testis antigen gene CT55 causes male
            infertility in humans and mice.
REFERENCE   3  (bases 1 to 1203)
  AUTHORS   Zhao,H., Pan,W.M., Zhang,H.H., Song,Y., Chen,J., Xiang,Y., Gu,B.,
            Li,S.Z., Du,R.L. and Zhang,X.D.
  TITLE     Cancer testis antigen 55 deficiency attenuates colitis-associated
            colorectal cancer by inhibiting NF-kappaB signaling
  JOURNAL   Cell Death Dis 10 (4), 304 (2019)
   PUBMED   30944312
  REMARK    GeneRIF: CT55 acts as an accelerator of tumor necrosis factor
            (TNF)-alpha-induced nuclear factor-kappaB (NF-kappaB) signaling.
            Upon stimulation with TNF-alpha, CT55 interacts with the IkappaB
            kinase (IKK) complex, which increases the phosphorylation of
            IKKalpha/beta and activates IKK-p65 signaling, while knockout of
            CT55 blocks IKK-p65 signaling. Collectively, CT55 deficiency
            suppresses the development of colitis-associated can...
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC115664.1.
            
            On or before Jul 24, 2006 this sequence version replaced
            XM_914296.2, XM_135429.3, XM_992997.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115663.1, AK015678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 29.99 cM"
     gene            1..1203
                     /gene="Ct55"
                     /gene_synonym="4930502E18Rik"
                     /note="cancer/testis antigen 55"
                     /db_xref="GeneID:75013"
                     /db_xref="MGI:MGI:1922263"
     exon            1..218
                     /gene="Ct55"
                     /gene_synonym="4930502E18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..838
                     /gene="Ct55"
                     /gene_synonym="4930502E18Rik"
                     /codon_start=1
                     /product="cancer/testis antigen 55"
                     /protein_id="NP_083418.1"
                     /db_xref="CCDS:CCDS30136.1"
                     /db_xref="GeneID:75013"
                     /db_xref="MGI:MGI:1922263"
                     /translation="MHRLISRLRAFFQRKADPKEAKEERQKLLEDATSLQNKQGVVAG
                     SCSNYDCMTKHTRSSADVETGDNPLKAEPNLPAAVEEQSPRGLNAVTVDNDHDEEPSE
                     SHMRILLASITSLVGDADYNGHGFSFSLDIACKDFKPYNGDLVEIEFSDEQDTQSRRA
                     ILVKPLKHCHLNEVRVTRTDGSTGVLEDTIFFTLDSLKLPSGYVPQPDDVVNVVAVQS
                     MQSNYFWRAVAMTPVQVL"
     exon            219..400
                     /gene="Ct55"
                     /gene_synonym="4930502E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            401..533
                     /gene="Ct55"
                     /gene_synonym="4930502E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            534..646
                     /gene="Ct55"
                     /gene_synonym="4930502E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            647..1203
                     /gene="Ct55"
                     /gene_synonym="4930502E18Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacggacgt agaattggcg tctgtgagag ttgctgatta gggctctccc gggagacaga
       61 gaactagata gaaggaagcc ttagtcctgg taccacctgg tgcccaaggt tgctcagagc
      121 acgaactatg caccggctaa tttccagact tcgtgccttc tttcaaagga aagcagaccc
      181 gaaggaggcc aaagaagagc ggcagaagct cttggaagat gctacctcac tacaaaacaa
      241 acagggagtt gtggcagggt cctgtagtaa ctatgactgc atgactaagc acacccgctc
      301 cagtgctgac gttgagactg gcgacaatcc tctgaaagct gagccaaacc ttcctgcagc
      361 tgtggaagaa caaagccctc gtggattgaa cgcagtcaca gtggataatg accatgatga
      421 agaaccctca gaatctcaca tgagaatttt gcttgcctct atcacctctc tagtgggtga
      481 tgctgactac aatggtcacg gattttcctt ctctctagac attgcttgta aagatttcaa
      541 accttataat ggtgacctgg tagaaattga attttctgat gagcaagaca cccagagcag
      601 aagggccatc ttggtgaagc ctctgaaaca ttgccattta aatgaggtcc gtgttaccag
      661 aacagatgga agcactgggg tgttggaaga caccatcttt ttcaccttgg attctcttaa
      721 acttccttct ggatatgtgc cgcaaccaga tgatgttgtc aatgtggttg cagtgcagag
      781 catgcaatcc aactatttct ggagagcagt tgcaatgacc ccagtacaag tattgtagga
      841 accaaacccc tgtgtgcctt cttcagtgtt atttgtatgg gtaatgaagg gcctggttta
      901 atgcaatagt ttgtagaata ggaatagcaa cagttagcca aaacacatgt aaaatacatt
      961 ttttttcttg aaaatgccct ggtaattttg ttggaagtat gaactaactt tagaaaggtg
     1021 cctgatctac tggaaaacat ccccaaacat ttttgtttgt ttgtttgttt gtttgttttt
     1081 tgtctacagc aaagaaacaa cactgcatat taggttaaat tctgtttttt tccaaggtca
     1141 ggaatcctgc tagtggcttt gtttattgat tgagagacat gcagagggag gccagcaagt
     1201 gaa
//
