LOCUS       NM_145529               2852 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cleavage stimulation factor, 3' pre-RNA, subunit 3
            (Cstf3), transcript variant 1, mRNA.
ACCESSION   NM_145529
VERSION     NM_145529.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2852)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2852)
  AUTHORS   Bai,Y., Auperin,T.C., Chou,C.Y., Chang,G.G., Manley,J.L. and
            Tong,L.
  TITLE     Crystal structure of murine CstF-77: dimeric association and
            implications for polyadenylation of mRNA precursors
  JOURNAL   Mol Cell 25 (6), 863-875 (2007)
   PUBMED   17386263
  REMARK    GeneRIF: Crystal structure of the HAT (half a TPR) domain of murine
            CstF-77, as well as its C-terminal subdomain.
REFERENCE   3  (bases 1 to 2852)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 2852)
  AUTHORS   Kleinjan,D.A., Seawright,A., Elgar,G. and van Heyningen,V.
  TITLE     Characterization of a novel gene adjacent to PAX6, revealing
            synteny conservation with functional significance
  JOURNAL   Mamm Genome 13 (2), 102-107 (2002)
   PUBMED   11889558
REFERENCE   5  (bases 1 to 2852)
  AUTHORS   Gawin,B., Niederfuhr,A., Schumacher,N., Hummerich,H., Little,P.F.
            and Gessler,M.
  TITLE     A 7.5 Mb sequence-ready PAC contig and gene expression map of human
            chromosome 11p13-p14.1
  JOURNAL   Genome Res 9 (11), 1074-1086 (1999)
   PUBMED   10568747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844603.5.
            
            On Oct 24, 2007 this sequence version replaced NM_145529.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003241.1, SRR1660819.76474.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AL844603.5         24382-24600
            220-321             AL844603.5         42769-42870
            322-417             AL844603.5         42989-43084
            418-450             AL844603.5         78187-78219
            451-548             AL844603.5         78877-78974
            549-615             AL844603.5         80298-80364
            616-650             AL844603.5         80507-80541
            651-777             AL844603.5         80622-80748
            778-855             AL844603.5         82068-82145
            856-1018            AL844603.5         83351-83513
            1019-1128           AL844603.5         85540-85649
            1129-1245           AL844603.5         86343-86459
            1246-1320           AL844603.5         86902-86976
            1321-1464           AL844603.5         88059-88202
            1465-1567           AL844603.5         89587-89689
            1568-1637           AL844603.5         93164-93233
            1638-1833           AL844603.5         94417-94612
            1834-1987           AL844603.5         97192-97345
            1988-2082           AL844603.5         97967-98061
            2083-2143           AL844603.5         98195-98255
            2144-2852           AL844603.5         98615-99323
FEATURES             Location/Qualifiers
     source          1..2852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.84 cM"
     gene            1..2852
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /note="cleavage stimulation factor, 3' pre-RNA, subunit 3"
                     /db_xref="GeneID:228410"
                     /db_xref="MGI:MGI:1351825"
     exon            1..219
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2346
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cleavage stimulation factor 77 kDa subunit; cleavage
                     stimulation factor subunit 3; CF-1 77 kDa subunit; CSTF 77
                     kDa subunit"
                     /codon_start=1
                     /product="cleavage stimulation factor subunit 3 isoform 1"
                     /protein_id="NP_663504.1"
                     /db_xref="CCDS:CCDS16490.1"
                     /db_xref="GeneID:228410"
                     /db_xref="MGI:MGI:1351825"
                     /translation="MSGDAAAEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQN
                     QPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWK
                     CYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYA
                     ENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARR
                     VAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRV
                     MFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAIST
                     LLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIK
                     SGRMIFKKAREDARTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAY
                     IDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRR
                     FTAFREEYEGKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAIIPDPVVAPS
                     IVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLP
                     PPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESSAVLTK
                     AVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR"
     exon            220..321
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            322..417
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            418..450
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            451..548
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            549..615
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            616..650
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            651..777
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            778..855
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1018
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1128
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1245
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1320
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1464
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1567
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1637
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1833
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1987
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2082
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2143
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2852
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2832..2837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /note="hexamer: AATAAA"
     polyA_site      2852
                     /gene="Cstf3"
                     /gene_synonym="4732468G05Rik; CstF-77"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcagc cattttaatt caaatctgag tgggcggcgg cggcggcggc ggcggcagcg
       61 gatttggcgg cggctttggc tctgagggac aggggtagtg ttcctggttt tggtggggtt
      121 tgcctttagt ttaattttcc ttttctagct tccctttgcc ggctggtgcg tacgttgtag
      181 tcccccgagg ccatgtcagg agacgcagcc gcggagcagg cagcggaata tgtcccagag
      241 aaggtgaaga aagcggaaaa gaaattagaa gaaaatccat atgaccttga tgcttggagc
      301 attctcattc gagaggcaca gaatcaacct atagacaaag cacggaagac ttacgaacgc
      361 cttgttgccc agttccccag ttctggcaga ttctggaaac tgtacattga agcagagatt
      421 aaagctaaaa attatgacaa ggttgaaaag ctatttcaaa gatgccttat gaaggttttg
      481 cacattgatt tatggaagtg ttatctttca tacgtcagag aaaccaaggg taaactgccc
      541 agctacaaag aaaaaatggc tcaagcttat gactttgcac tagataaaat tggaatggaa
      601 attatgtcct atcagatttg ggtggattac atcaatttct taaaaggagt ggaagctgta
      661 ggatcttatg cagaaaatca gagaataact gctgtccgaa gagtttatca acgaggttgt
      721 gttaatccaa tgatcaacat tgaacaactc tggagagact acaacaagta tgaagagggt
      781 atcaatattc atttagctaa aaagatgatt gaagatcgga gtagagacta catgaatgct
      841 agacgtgtag caaaggaata cgagacagtc atgaaaggtt tggaccgcaa tgctccttca
      901 gtgcctcctc agaatactcc tcaagaagct cagcaagtgg acatgtggaa gaagtacatc
      961 cagtgggaga agagcaaccc tcttcgcaca gaggaccaga ccctgataac caaaagagtt
     1021 atgtttgcct atgaacagtg cctccttgtg ctgggccatc accctgatat ctggtatgaa
     1081 gctgcccagt atctggaaca gtcgagtaag ctgcttgcag aaaaggggga catgaacaat
     1141 gccaagttat ttagtgacga agctgctaat atttatgaaa gagccataag cacgttatta
     1201 aagaagaaca tgctccttta ttttgcatat gcagattatg aagagagtcg catgaagtat
     1261 gagaaggttc acagtatata taacagactt ctggcaattg aggacattga ccccacctta
     1321 gtatatattc agtatatgaa atttgcaagg agagcagaag gtatcaaatc tggaagaatg
     1381 atatttaaaa aagcaagaga ggatgccagg acccgccatc atgtctatgt aactgcagcc
     1441 ctcatggaat attactgtag caaggacaaa tctgttgcct ttaagatttt tgaattggga
     1501 ctaaagaaat atggagacat tccagaatat gttttggctt atattgacta tctctctcac
     1561 ctcaatgagg acaataatac tcgagttttg tttgaaagag ttctaacgtc tggaagcctt
     1621 cctcctgaga agtctggaga aatctgggct cgatttctag cttttgaaag taatattggt
     1681 gatttagcta gtatactcaa agtggaaaaa agacggttta cagcattcag agaagagtat
     1741 gaaggcaagg aaacagcttt actggtggac agatacaagt ttatggattt atacccttgt
     1801 tctgcaagtg aactcaaagc actgggctat aaggatgtct cccgtgctaa gctagctgct
     1861 ataattccag acccagttgt agctccttcc atagtgcctg ttctgaaaga tgaagtggat
     1921 agaaaacctg agtaccctaa gccagacact cagcagatga ttccatttca gccacgacat
     1981 ttagcacctc caggcttgca ccctgtcccc ggtggagtgt ttccagtgcc tcctgccgct
     2041 gttgttttga tgaaactgct cccacctcct atctgcttcc agggtccttt tgtacaagtg
     2101 gatgagctga tggaaatttt ccgaagatgc aagataccaa acactgttga ggaagccgtg
     2161 aggatcatca ctggtggggc cccagagctg gctgtggaag gcaacggccc agtggaaagt
     2221 agtgctgtac tgactaaggc tgtcaaaagg cccaacgagg attcagacga agatgaagaa
     2281 aagggggctg tagtcccccc tgttcatgac atttacagag cacggcagca gaagcgaata
     2341 cgatgagtcg gcttaaacct acctgcctct gagagaaaaa ctcttaccca ggactcctgt
     2401 tttgcctctt aagtcatatg ttttaaagag acaacacttt gttacaaggt tttggaaaca
     2461 aagttgtatt gtcattggtg cctctgtcat atggttcttg agaaaaaacc caagcctgtg
     2521 tggattttga atttggagca gacctatcct ctaagcaaga ttaggtttta aataacagta
     2581 caaaatgaca acgccacatc ttgttccttt tcaagggtgt cttgtatgtg ccacttgaag
     2641 atttgtaagt tttccacagt tttattttaa aaactggatg gcttatgatt gtaaaacatt
     2701 ttcacatttt ctgaaaaacg tttgttctca gtttgcttac gtagtcctgc cttactgttt
     2761 gtttttattt atggcagaat gtatggcgac tgttttgtag ttataaattt ttaaaagggt
     2821 cctttgaaag gaataaaagg acctcaaaaa ca
//
