LOCUS       NM_031249               3764 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus cleavage stimulation factor, 3' pre-RNA subunit 2, tau
            (Cstf2t), mRNA.
ACCESSION   NM_031249
VERSION     NM_031249.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3764)
  AUTHORS   Grozdanov,P.N., Li,J., Yu,P., Yan,W. and MacDonald,C.C.
  TITLE     Cstf2t Regulates expression of histones and histone-like proteins
            in male germ cells
  JOURNAL   Andrology 6 (4), 605-615 (2018)
   PUBMED   29673127
  REMARK    GeneRIF: Cstf2t may control other reproductive functions that are
            not directly linked to the formation of 3' ends of mature
            polyadenylated mRNAs during male germ cell formation.
REFERENCE   2  (bases 1 to 3764)
  AUTHORS   Harris,J.C., Martinez,J.M., Grozdanov,P.N., Bergeson,S.E.,
            Grammas,P. and MacDonald,C.C.
  TITLE     The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in
            Learning Behaviors in Mice
  JOURNAL   PLoS One 11 (11), e0165976 (2016)
   PUBMED   27812195
  REMARK    GeneRIF: Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in
            Learning Behaviors in Mice
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3764)
  AUTHORS   Grozdanov,P.N., Amatullah,A., Graber,J.H. and MacDonald,C.C.
  TITLE     TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of
            Activator and Repressor Isoforms of the Cyclic AMP-Responsive
            Element Modulator (CREM) in Mouse Testis
  JOURNAL   Biol Reprod 94 (2), 34 (2016)
   PUBMED   26700942
  REMARK    GeneRIF: This demonstrates that tauCstF-64 is an important
            stage-specific regulator of Crem mRNA processing that modulates the
            spatial and temporal expression of downstream stage-specific genes
            necessary for the proper development of sperm in mice.
REFERENCE   4  (bases 1 to 3764)
  AUTHORS   Li,W., Yeh,H.J., Shankarling,G.S., Ji,Z., Tian,B. and
            MacDonald,C.C.
  TITLE     The tauCstF-64 polyadenylation protein controls genome expression
            in testis
  JOURNAL   PLoS One 7 (10), e48373 (2012)
   PUBMED   23110235
  REMARK    GeneRIF: The results suggest that tauCstF-64 plays a role in 3' end
            determination and transcription termination for a large range of
            germ cell-expressed genes.
REFERENCE   5  (bases 1 to 3764)
  AUTHORS   Hockert,K.J., Martincic,K., Mendis-Handagama,S.M., Borghesi,L.A.,
            Milcarek,C., Dass,B. and MacDonald,C.C.
  TITLE     Spermatogenetic but not immunological defects in mice lacking the
            tauCstF-64 polyadenylation protein
  JOURNAL   J Reprod Immunol 89 (1), 26-37 (2011)
   PUBMED   21489638
  REMARK    GeneRIF: primarily supports spermatogenesis, but only incidently
            supports immune cell function
REFERENCE   6  (bases 1 to 3764)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3764)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 3764)
  AUTHORS   Wallace,A.M., Denison,T.L., Attaya,E.N. and MacDonald,C.C.
  TITLE     Developmental distribution of the polyadenylation protein CstF-64
            and the variant tauCstF-64 in mouse and rat testis
  JOURNAL   Biol Reprod 70 (4), 1080-1087 (2004)
   PUBMED   14681198
REFERENCE   9  (bases 1 to 3764)
  AUTHORS   Dass,B., McDaniel,L., Schultz,R.A., Attaya,E. and MacDonald,C.C.
  TITLE     The gene CSTF2T, encoding the human variant CstF-64 polyadenylation
            protein tauCstF-64, lacks introns and may be associated with male
            sterility
  JOURNAL   Genomics 80 (5), 509-514 (2002)
   PUBMED   12408968
REFERENCE   10 (bases 1 to 3764)
  AUTHORS   Dass,B., McMahon,K.W., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and MacDonald,C.C.
  TITLE     The gene for a variant form of the polyadenylation protein CstF-64
            is on chromosome 19 and is expressed in pachytene spermatocytes in
            mice
  JOURNAL   J Biol Chem 276 (11), 8044-8050 (2001)
   PUBMED   11113135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ182579.1, AK082910.1 and BY637182.1.
            
            On May 23, 2007 this sequence version replaced NM_031249.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               CJ182579.1         6-133
            129-3683            AK082910.1         1-3555
            3684-3764           BY637182.1         345-425
FEATURES             Location/Qualifiers
     source          1..3764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 25.94 cM"
     gene            1..3764
                     /gene="Cstf2t"
                     /gene_synonym="64kDa; tauCstF-64; tCstF-64"
                     /note="cleavage stimulation factor, 3' pre-RNA subunit 2,
                     tau"
                     /db_xref="GeneID:83410"
                     /db_xref="MGI:MGI:1932622"
     exon            1..3752
                     /gene="Cstf2t"
                     /gene_synonym="64kDa; tauCstF-64; tCstF-64"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2124
                     /gene="Cstf2t"
                     /gene_synonym="64kDa; tauCstF-64; tCstF-64"
                     /note="cleavage stimulation factor 64 kDa subunit, tau;
                     cleavage stimulation factor subunit 2 tau; CF-1 64 kDa
                     subunit, tau; CSTF 64 kDa subunit, tau; cleavage
                     stimulation factor, 3' pre-RNA subunit 2, 64 kDa, tau"
                     /codon_start=1
                     /product="cleavage stimulation factor subunit 2 tau
                     variant"
                     /protein_id="NP_112539.2"
                     /db_xref="CCDS:CCDS37958.1"
                     /db_xref="GeneID:83410"
                     /db_xref="MGI:MGI:1932622"
                     /translation="MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVS
                     FRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELK
                     SLGPAAPIIDSPYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARN
                     MLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQPVSGPGPGGPGP
                     SGPGGPGPGPAPGLCPGPNVMLNQQNPPAPQPQHLPRRPVKDIPPLMQTSIQGGIPAP
                     GPIPAAVPGPGPGSLTPGGAMQPQVGMPVVGPVPLERGQMQISDPRPPMPRGPMPSGG
                     IPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYMGPPHQGPPMHHGHDNRGPASHDMRGG
                     PLAADPRMLIGEPRGPMIDQRGLPMDGRGGRESRGMETRPMETEVLEPRGMERRMETC
                     AMETRGMDARGLEMRGPGPSSRGPMTGGIQGPGPINMGAGGPQGPRQVPNIAGVGNPG
                     GTMQGAGIQGGGMQGAGMQGGGMQGAGMQGGGMQGAGMQAGMQGASMQGGMQGAGMQG
                     ASKQGGGQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQ
                     IQKSTGAS"
     regulatory      3731..3736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cstf2t"
                     /gene_synonym="64kDa; tauCstF-64; tCstF-64"
                     /note="hexamer: AATAAA"
     polyA_site      3752
                     /gene="Cstf2t"
                     /gene_synonym="64kDa; tauCstF-64; tCstF-64"
                     /note="major polyA site"
ORIGIN      
        1 gtaagtaggc gcggacaacc gagctcacgg cccggggcgg aaggcgttag ataaattagt
       61 ccggtctcag gaagcagtgt ctgcggccta acggaactac agattcctaa cagaaaggtt
      121 tctgtccgga gcttgctatc tgcttccgtt acagagcgga agtgtggttc gccagaggac
      181 gacccttaga cgaattcaat ctccgctgtc ctctcggcag caatcatgtc gagtttggcg
      241 gtcagagacc cagccatgga tcgatcgctg cgttcggtgt tcgtggggaa cattccgtat
      301 gaggcgacgg aggagcagtt aaaggacatt ttctcagagg ttggttcagt tgtcagtttc
      361 cgtctcgtct acgatagaga gactgggaag cccaagggtt atggcttctg cgagtaccaa
      421 gaccaggaga ctgcgctcag tgccatgcga aacctcaatg ggcgagagtt tagtgggaga
      481 gcgcttcggg tggacaatgc cgccagcgaa aagaacaagg aggagttaaa gagcttaggc
      541 ccggcggccc ccatcattga ctccccctat ggggacccta tcgacccaga agatgctcca
      601 gaatcgatta ctagagcagt cgccagcttg cccccagagc agatgtttga gctcatgaag
      661 cagatgaagt tgtgtgtcca gaacagtcac caggaagctc gaaacatgct acttcagaac
      721 ccacagttgg cgtatgcttt gctgcaggca caagtggtga tgagaatcat ggatccagag
      781 attgcactga aaattttgca tcgtaagata catgtcacac cactgatccc aggcaaatct
      841 cagccggtct ctgggcctgg ccctggtggg cctgggccta gtgggcctgg cggccctggc
      901 cccggccctg cccctggcct ctgcccggga cctaacgtca tgttgaacca acagaatcct
      961 cctgcccctc agcctcagca tctgccaaga agacctgtga aggacattcc acctctgatg
     1021 cagacctcta tccagggagg aattccagct ccggggccaa taccagctgc agttcctgga
     1081 cctggacctg gttccttaac tccaggagga gcaatgcagc cacaagttgg catgccagtg
     1141 gttggtccag tgcccctgga gcgaggacag atgcagatat cagatcctag acctccgatg
     1201 cctcgtggac ccatgccttc tggtggcata cctcctcgag gactactggg agatgctcca
     1261 aatgacccac gtggagggac tttgctctca gtgactggag aagtagagcc caggggctat
     1321 atgggaccac cccatcaggg tcctccaatg catcatggtc atgacaaccg tggccctgcc
     1381 tcacatgata tgagaggagg accattggca gcagatccca gaatgctaat tggagagccc
     1441 agaggtccca tgatagatca gagaggtcta cctatggatg gtagaggagg tagagaatct
     1501 cgagggatgg agactcggcc catggaaact gaggtcttgg agccacgagg aatggagaga
     1561 aggatggaga cctgcgcgat ggaaaccaga ggcatggatg caagaggact agagatgagg
     1621 ggccctggcc ctagttccag aggtccgatg actggtggaa tccagggtcc tggccctatt
     1681 aatatggggg caggtggccc tcagggacct agacaggttc caaatattgc aggagtggga
     1741 aatcctggag gtaccatgca gggggcaggt atacaaggag gagggatgca gggagcaggt
     1801 atgcaaggag gagggatgca aggagcaggc atgcaaggag gagggatgca gggagctggc
     1861 atgcaagcag ggatgcaggg agctagcatg caaggaggga tgcagggagc tggcatgcaa
     1921 ggagccagta agcaaggtgg aggccagcct agcagtttta gccctgggca aagccaggta
     1981 actccacaag atcaagaaaa agcagctttg atcatgcagg ttctccagct gactgcggat
     2041 cagattgcca tgctgcctcc cgaacaaagg cagagcattt tgattttaaa ggaacaaatc
     2101 cagaaatcca ctggggcttc ttgaatggtt ttcaactaag aagcacttag ttactccttc
     2161 agagtttatt ctgtggcatg aagtggtgca aaaagctgtc ttctgtgttc gcacacttta
     2221 accatttaag gtttccttct ccctagatct taatctttct tctagtcctg tcactttctg
     2281 cttccctttt agctttttga tggaggttat ggagtggaag gagtgggcct gttcactttg
     2341 tcactgttac tctaccacgt accctgaaaa taactacatc atccaccaag taaggctatg
     2401 aggaagatgc aggaggaata acatgtctgc actttgttaa ctgcgtcttt aaaaatcccg
     2461 agtaagctgg gaactacata aaaattgaaa gtgacttgtt acagtattga tatactaaga
     2521 tggtttaaag gtttttggtt gtatattaac tgaatgtcag catcttaaga tacacttttt
     2581 ggtaaaccaa aatactgtag agtaataaga ttaatgttta gttattttgg aattattttg
     2641 aaatattgga gctaacagtc tgtggtgtag atgtagggtt ttttttgttt ttgttttttt
     2701 ttttttaagc attgttatct gtaaaaaggt aattttcatt tacctgactt ttttgagaca
     2761 actaatattc ttgcctggtc ccacctggtg attttgcaga atagttgtag tgtcagctga
     2821 attatataaa gccgcctctg aggagactca agtgatttcc taatacattt ctctaaaaaa
     2881 attcttaagc accaagtctg gttgtaagta gttttttcat gtcatctgaa aatagcagtt
     2941 agacatgggg tcggactttc ttgagtaatg gagggttttt cagtaaagct cccacccagg
     3001 ttcttgataa accactatcc atacgcagat ggaatccatt tggtcagcag gaatcagaag
     3061 ttaaaaaatc ttagtcttcg aattttgacg tgtcttacag tttgataact ttcacaaagt
     3121 actttcctgc catcagctta actagaactg aggcccaagt gatctgacag ctctgctcaa
     3181 cttagtattt tatttcttag aactctcaag agccatttgg tcataacata cattcctatc
     3241 agatgtgttt taaaataagg agtgtggaat ttaatacatt tcctttagag ctaccatact
     3301 attttttgac attaagtgtg tggcacctag acaccatgtc atatctagtt aatgagcaga
     3361 aacaagcaca agttcccact tgaccaagtg atagtcctct gtaggaaact aactacccag
     3421 ctacagaggg aagagtagcc ttagggagag agctgaccca agggtctact ttgtccttgg
     3481 aaagtttgag cattttcagt gtacagagtt ttcattccta ggctattttc catcgactta
     3541 gttttttgtg ctagtgttaa actctctgtg gtttcctctg cttctccttt gctgaagttg
     3601 gtttgtgttt tgtacttttg tgctagttct ggctaattcc aattgcttgc tttcgaaatt
     3661 gcggttgcta gcccaaaact tcttatagtc tttgttataa gaaaatctct gcattgttta
     3721 atgaaaatta aataaaaagg ttgtataatt aaaaaaaaaa aaaa
//
