LOCUS       NM_007793                620 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cystatin B (Cstb), mRNA.
ACCESSION   NM_007793
VERSION     NM_007793.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Pollari,E., Tegelberg,S., Bjorklund,H., Kalviainen,R.,
            Lehesjoki,A.E. and Haapalinna,A.
  TITLE     In depth behavioral phenotyping unravels complex motor disturbances
            in Cstb-/- mouse, a model for progressive myoclonus epilepsy type 1
  JOURNAL   Front Behav Neurosci 17, 1325051 (2023)
   PUBMED   38179183
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 620)
  AUTHORS   Gorski,K., Jackson,C.B., Nyman,T.A., Rezov,V., Battersby,B.J. and
            Lehesjoki,A.E.
  TITLE     Progressive mitochondrial dysfunction in cerebellar synaptosomes of
            cystatin B-deficient mice
  JOURNAL   Front Mol Neurosci 16, 1175851 (2023)
   PUBMED   37251643
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 620)
  AUTHORS   Daura,E., Tegelberg,S., Yoshihara,M., Jackson,C., Simonetti,F.,
            Aksentjeff,K., Ezer,S., Hakala,P., Katayama,S., Kere,J.,
            Lehesjoki,A.E. and Joensuu,T.
  TITLE     Cystatin B-deficiency triggers ectopic histone H3 tail cleavage
            during neurogenesis
  JOURNAL   Neurobiol Dis 156, 105418 (2021)
   PUBMED   34102276
  REMARK    GeneRIF: Cystatin B-deficiency triggers ectopic histone H3 tail
            cleavage during neurogenesis.
REFERENCE   5  (bases 1 to 620)
  AUTHORS   Wu,Y., Whittaker,H.T., Noy,S., Cleverley,K., Brault,V., Herault,Y.,
            Fisher,E.M.C. and Wiseman,F.K.
  TITLE     The effects of Cstb duplication on APP/amyloid-beta pathology and
            cathepsin B activity in a mouse model
  JOURNAL   PLoS One 16 (7), e0242236 (2021)
   PUBMED   34292972
  REMARK    GeneRIF: The effects of Cstb duplication on APP/amyloid-beta
            pathology and cathepsin B activity in a mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 620)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   7  (bases 1 to 620)
  AUTHORS   Cole,S.E., Wiltshire,T., Rue,E.E., Morrow,D., Hieter,P., Brahe,C.,
            Fisher,E.M., Katsanis,N. and Reeves,R.H.
  TITLE     High-resolution comparative physical mapping of mouse chromosome 10
            in the region of homology with human chromosome 21
  JOURNAL   Mamm Genome 10 (3), 229-234 (1999)
   PUBMED   10051316
REFERENCE   8  (bases 1 to 620)
  AUTHORS   Cole,S.E. and Reeves,R.H.
  TITLE     A cluster of keratin-associated proteins on mouse chromosome 10 in
            the region of conserved linkage with human chromosome 21
  JOURNAL   Genomics 54 (3), 437-442 (1998)
   PUBMED   9878246
REFERENCE   9  (bases 1 to 620)
  AUTHORS   Pennacchio,L.A., Bouley,D.M., Higgins,K.M., Scott,M.P.,
            Noebels,J.L. and Myers,R.M.
  TITLE     Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in
            cystatin B-deficient mice
  JOURNAL   Nat Genet 20 (3), 251-258 (1998)
   PUBMED   9806543
REFERENCE   10 (bases 1 to 620)
  AUTHORS   Pennacchio,L.A. and Myers,R.M.
  TITLE     Isolation and characterization of the mouse cystatin B gene
  JOURNAL   Genome Res 6 (11), 1103-1109 (1996)
   PUBMED   8938434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY091749.1 and BC056170.1.
            
            On Dec 23, 2005 this sequence version replaced NM_007793.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056170.1, CK792726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               BY091749.1         2-380
            380-620             BC056170.1         333-573
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..620
                     /gene="Cstb"
                     /gene_synonym="Stfb"
                     /note="cystatin B"
                     /db_xref="GeneID:13014"
                     /db_xref="MGI:MGI:109514"
     exon            1..188
                     /gene="Cstb"
                     /gene_synonym="Stfb"
                     /inference="alignment:Splign:2.1.0"
     exon            189..290
                     /gene="Cstb"
                     /gene_synonym="Stfb"
                     /inference="alignment:Splign:2.1.0"
     exon            291..602
                     /gene="Cstb"
                     /gene_synonym="Stfb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      580..585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cstb"
                     /gene_synonym="Stfb"
                     /note="hexamer: AATATA"
     polyA_site      602
                     /gene="Cstb"
                     /gene_synonym="Stfb"
                     /note="major polyA site"
ORIGIN      
        1 gtcacgtgct acgggtccgg gggggcggag ccaagccagg tttttctagg gtccaggcac
       61 ccaggtctcc tagttggatc tgtcttcagc ttctccgtgc taccccgact actgctgcca
      121 agatgatgtg tggcgcgcca tctgccacaa tgccagccac ggccgagacg caggaggtcg
      181 ccgaccaggt gaagtcccag cttgaatcga aagaaaatca gaagtttgat gtctttaaag
      241 ccatatcctt caagagacag atagtggctg gcaccaacct cttcatcaag gttgatgttg
      301 gtggagataa atgcgtgcac ttgagggtgt ttcaacccct cccccatgaa aacaagcctt
      361 tgaccctgtc ttcctatcag accaacaaag aaaggcacga tgagctctcc tacttctgat
      421 tcggggctcc tttgcacctg tgtttgggac cacgtagtaa aacccccctc ggtgatggag
      481 agaagggagt tgagcagctt ctgttgtgat tctcaaactg cgttgtattt tgcatccttc
      541 caaataatta ttttcagaaa actgtatatg atctctctaa atatatattt ttagagacta
      601 taaaaaaaaa aaaaaaaaaa
//
