LOCUS       NM_001033239            2731 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cystatin A1 (Csta1), mRNA.
ACCESSION   NM_001033239 XM_622634 XM_901666 XM_916869 XM_924539
VERSION     NM_001033239.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2731)
  AUTHORS   Liang,W., Chen,Q., Cheng,S., Wei,R., Li,Y., Yao,C., Ouyang,Z.,
            Kang,D., Chen,A., Liu,Z., Li,K., Bai,X., Li,Q. and Huang,B.
  TITLE     Skin chronological aging drives age-related bone loss via secretion
            of cystatin-A
  JOURNAL   Nat Aging 2 (10), 906-922 (2022)
   PUBMED   37118283
  REMARK    GeneRIF: Skin chronological aging drives age-related bone loss via
            secretion of cystatin-A.
            Erratum:[Nat Aging. 2023 Aug;3(8):1037. doi:
            10.1038/s43587-023-00458-2.. PMID: 37365344]
REFERENCE   2  (bases 1 to 2731)
  AUTHORS   Gupta,A., Nitoiu,D., Brennan-Crispi,D., Addya,S., Riobo,N.A.,
            Kelsell,D.P. and Mahoney,M.G.
  TITLE     Cell cycle- and cancer-associated gene networks activated by Dsg2:
            evidence of cystatin A deregulation and a potential role in
            cell-cell adhesion
  JOURNAL   PLoS One 10 (3), e0120091 (2015)
   PUBMED   25785582
  REMARK    GeneRIF: a novel pathway of CSTA regulation involving Dsg2
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2731)
  AUTHORS   Bilodeau,M., MacRae,T., Gaboury,L., Laverdure,J.P., Hardy,M.P.,
            Mayotte,N., Paradis,V., Harton,S., Perreault,C. and Sauvageau,G.
  TITLE     Analysis of blood stem cell activity and cystatin gene expression
            in a mouse model presenting a chromosomal deletion encompassing
            Csta and Stfa2l1
  JOURNAL   PLoS One 4 (10), e7500 (2009)
   PUBMED   19838297
  REMARK    GeneRIF: analysis of a mouse model presenting a chromosomal
            deletion encompassing Csta and Stfa2l1
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2731)
  AUTHORS   Sasaki,N., Nagaoka,S., Itoh,M., Izawa,M., Konno,H., Carninci,P.,
            Yoshiki,A., Kusakabe,M., Moriuchi,T., Muramatsu,M., Okazaki,Y. and
            Hayashizaki,Y.
  TITLE     Characterization of gene expression in mouse blastocyst using
            single-pass sequencing of 3995 clones
  JOURNAL   Genomics 49 (2), 167-179 (1998)
   PUBMED   9598303
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK137702.1.
            
            On Oct 2, 2009 this sequence version replaced NM_001033239.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137702.1, BC139156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2731              AK137702.1         2-2732
FEATURES             Location/Qualifiers
     source          1..2731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.43 cM"
     gene            1..2731
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /note="cystatin A1"
                     /db_xref="GeneID:209294"
                     /db_xref="MGI:MGI:3524930"
     exon            1..205
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..433
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /note="stefin-A"
                     /codon_start=1
                     /product="cystatin-A"
                     /protein_id="NP_001028411.1"
                     /db_xref="CCDS:CCDS37327.1"
                     /db_xref="GeneID:209294"
                     /db_xref="MGI:MGI:3524930"
                     /translation="MIPGGLTEARPATAEVQEIADRVKAQLEEETNEKYEIFKAVEYK
                     TQVVAGVNYFIKMDVGGGCFTHIKVFKDLSGKNNLELTGYQTNKTEDDELTYF"
     exon            206..307
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /inference="alignment:Splign:2.1.0"
     exon            308..2731
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      488..493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /note="hexamer: AATAAA"
     regulatory      492..497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /note="hexamer: AAGAAA"
     polyA_site      504
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /note="major polyA site"
     polyA_site      508
                     /gene="Csta1"
                     /gene_synonym="Csta"
                     /note="major polyA site"
ORIGIN      
        1 ccccattccc tcagatactg tggtgattag acatttcata ggaggagttt atggatacct
       61 ttaaaatcct aagtctccct gcttgccaga tcatttcttc tcagcatcct gcccagcaaa
      121 gaagcaactt gtgatcagaa tgatacccgg aggcttgacg gaggccagac ctgccacagc
      181 agaagtccag gagattgctg accgggtcaa agcacagctc gaagaggaaa ccaatgagaa
      241 atatgaaata ttcaaagccg ttgagtataa aactcaagtt gtcgctggag tcaattactt
      301 cattaagatg gatgtagggg gtggttgttt cacccacata aaagtcttca aggatctttc
      361 tggaaagaat aatttggaac ttactggtta ccagactaac aaaaccgagg atgatgagct
      421 gacctacttc taagcagcaa attctaaagt gacctgattc ctctcattgt aaactgattc
      481 ggccatcaat aaagaaatat tctccaaata actgtttact tcccttgttt ctcagtattg
      541 tgtcaacctt tactttgtaa acaattgttt ttaaacacgg attgtttctt gaatttgtac
      601 cctccttggg caagggtaat ctctgtatca ttccaatttt taatatacat gctgccaaag
      661 agggcatagt gttcatggtt cagagtagaa gctccacaat aagtgattcc atctagaaac
      721 cttataaaga ctacggctca gttgcaactg cataaaggat cttatcatcc cttcctcact
      781 gcaggtgcac tggtggttgt cagggaagct cactccttgg tcccttcggt tgcccagaac
      841 ccagcatgtc aactctgcct tcatatttga aaattaaatt tgtattttac aagtcatgtt
      901 ttaaaacaat cataatgttt aaagaagctg ccctctccct ttcccccatg cttccactgc
      961 acttgagagt cagttgcagt gattttccat caccaacaaa ggctttctgg tactcagtag
     1021 tgcaaatatt tgtgtgagct tcccacgaga cccttctcct gcacagccaa aaaccaacaa
     1081 tcgagaccag gaaatgtaca ttgatgacgc actgacatct agtctccagg tgccactcaa
     1141 gcctctcaaa ttgttataat aatgtaattt ttgataaaat gtagtaaaaa aaatagtttt
     1201 aaaatcacag catggtcttt cttcccacga gttaggtttt caaatgaaac acacatccta
     1261 tgtattttaa tatgccttag gcagcattat agctggcaac tatctaccct ccataaccca
     1321 agttattact tagtttcatc agtactgccc ataagacagc cctatgggcc atgttctctt
     1381 ggcctctagc ccatgacatc tctctctcct cctgttcctt cctcgtggtc tctagcctgg
     1441 ggaaacctaa accccaccga tgtctcttct ccacaactat tggctgctgg catctttatt
     1501 taccaaatat aattaagtgg gggcagggtc ccttagggta tgtgcagact ccaaatcttg
     1561 gaggtcagca ttacaataaa cagtaaaaga caaaacctca acaattcccc cttttagtcc
     1621 aggagggatt tgcactagtg agtaccagga ttctaataaa aggctctttt ctcttagata
     1681 taatttgaac acaattataa caattatgta aattataagg tatgatatac acttataaca
     1741 tccagtccat catatttgac aatttaggta aagtattctg tgatttatcc taacttaaag
     1801 actttagaat tctgcaccta aaaaatgttt gatttttaac ttttattacc attacaaaac
     1861 catcttttca agtctagaac attttcttta acgttaagca acttaagttc agttgtgaga
     1921 tcataattag tatattcttc cctgtcagag atttgagaag gaagtaaata ttgcttgaat
     1981 atgtaggaag cacaaagaca cagcttccaa aacttaaaca actggcagag acagctgact
     2041 gcccggacaa cccccaatat ttcttataaa gttggagcat ctgtgttcag ccttctggcc
     2101 cagagaatct gagagacctt aagtgaagtg gaaattatga agaactagtt tattttatct
     2161 tggcagagca tagcagttaa ctatcctgtg tttgtttgtc ctttttggat ggtgttctgt
     2221 ctgtagatga aattggggca tttcttgtcc aatggctagc ttgtcacatt tgaggcaacc
     2281 ccatatgtag gtagtgatgt tcatttcctt ccttgaaatg gatgggagta ctgtcaggag
     2341 cagacatgtc tcatagtcaa aagatctatt atttatgaag taacattaaa tgttatagtt
     2401 tgttgctttt gaagaccatc tatctacata tagcataact gaattgttaa gcattattgt
     2461 ttctagctat ttactacttg agtaaccttg ataatacttt attgtaaata actacattag
     2521 agtctaacat gatcatgagt ttgactgact attaacctgt attacttaat cattttaaac
     2581 attttgtaat agcagctgtt aaaaaggact gggtctaagc cttgtattct taaatgagct
     2641 gcataggcac tgtgcctatc taagagtaac aaaattaatt taaaattttg tatcagtgca
     2701 taaagattta taccaataaa aaccttaaac t
//
