LOCUS       NP_034107                144 aa            linear   ROD 15-OCT-2024
DEFINITION  cystatin-F precursor [Mus musculus].
ACCESSION   NP_034107
VERSION     NP_034107.2
DBSOURCE    REFSEQ: accession NM_009977.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 144)
  AUTHORS   Syage,A.R., Pachow,C., Murray,K.M., Henningfield,C., Fernandez,K.,
            Du,A., Cheng,Y., Olivarria,G., Kawauchi,S., MacGregor,G.R.,
            Green,K.N. and Lane,T.E.
  TITLE     Cystatin F attenuates neuroinflammation and demyelination following
            murine coronavirus infection of the central nervous system
  JOURNAL   J Neuroinflammation 21 (1), 157 (2024)
   PUBMED   38879499
  REMARK    GeneRIF: Cystatin F attenuates neuroinflammation and demyelination
            following murine coronavirus infection of the central nervous
            system.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 144)
  AUTHORS   Li,Q., Li,B., Liu,L., Wang,K.J., Liu,M.Y., Deng,Y., Li,Z.,
            Zhao,W.D., Wu,L.Y., Chen,Y.H. and Zhang,K.
  TITLE     Monocytes release cystatin F dimer to associate with Abeta and
            aggravate amyloid pathology and cognitive deficits in Alzheimer's
            disease
  JOURNAL   J Neuroinflammation 21 (1), 125 (2024)
   PUBMED   38730470
  REMARK    GeneRIF: Monocytes release cystatin F dimer to associate with Abeta
            and aggravate amyloid pathology and cognitive deficits in
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 144)
  AUTHORS   Daniels,M.J.D., Lefevre,L., Szymkowiak,S., Drake,A., McCulloch,L.,
            Tzioras,M., Barrington,J., Dando,O.R., He,X., Mohammad,M.,
            Sasaguri,H., Saito,T., Saido,T.C., Spires-Jones,T.L. and
            McColl,B.W.
  TITLE     Cystatin F (Cst7) drives sex-dependent changes in microglia in an
            amyloid-driven model of Alzheimer's disease
  JOURNAL   Elife 12, e85279 (2023)
   PUBMED   38085657
  REMARK    GeneRIF: Cystatin F (Cst7) drives sex-dependent changes in
            microglia in an amyloid-driven model of Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 144)
  AUTHORS   Li,J., Durose,W.W., Ito,J., Kakita,A., Iguchi,Y., Katsuno,M.,
            Kunisawa,K., Shimizu,T. and Ikenaka,K.
  TITLE     Exploring the factors underlying remyelination arrest by studying
            the post-transcriptional regulatory mechanisms of cystatin F gene
  JOURNAL   J Neurochem 157 (6), 2070-2090 (2021)
   PUBMED   32947653
  REMARK    GeneRIF: Exploring the factors underlying remyelination arrest by
            studying the post-transcriptional regulatory mechanisms of cystatin
            F gene.
REFERENCE   5  (residues 1 to 144)
  AUTHORS   Duan,W., Wang,H., Fan,Q., Chen,L., Huang,H. and Ran,H.
  TITLE     Cystatin F involvement in adenosine A2A receptor-mediated
            neuroinflammation in BV2 microglial cells
  JOURNAL   Sci Rep 8 (1), 6820 (2018)
   PUBMED   29717153
  REMARK    GeneRIF: These results indicate that hypoxia BV2 cells highly
            express Cystatin F, which is involved in A2A R activation-mediated
            neuroinflammation via the PKA/CREB and PKC/CREB or ERK1/2 signaling
            pathways.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 144)
  AUTHORS   Hamilton,G., Colbert,J.D., Schuettelkopf,A.W. and Watts,C.
  TITLE     Cystatin F is a cathepsin C-directed protease inhibitor regulated
            by proteolysis
  JOURNAL   EMBO J 27 (3), 499-508 (2008)
   PUBMED   18256700
REFERENCE   7  (residues 1 to 144)
  AUTHORS   Cappello,F., Gatti,E., Camossetto,V., David,A., Lelouard,H. and
            Pierre,P.
  TITLE     Cystatin F is secreted, but artificial modification of its
            C-terminus can induce its endocytic targeting
  JOURNAL   Exp Cell Res 297 (2), 607-618 (2004)
   PUBMED   15212960
REFERENCE   8  (residues 1 to 144)
  AUTHORS   Morita,M., Hara,Y., Tamai,Y., Arakawa,H. and Nishimura,S.
  TITLE     Genomic construct and mapping of the gene for CMAP
            (leukocystatin/cystatin F, CST7) and identification of a proximal
            novel gene, BSCv (C20orf3)
  JOURNAL   Genomics 67 (1), 87-91 (2000)
   PUBMED   10945474
REFERENCE   9  (residues 1 to 144)
  AUTHORS   Morita,M., Yoshiuchi,N., Arakawa,H. and Nishimura,S.
  TITLE     CMAP: a novel cystatin-like gene involved in liver metastasis
  JOURNAL   Cancer Res 59 (1), 151-158 (1999)
   PUBMED   9892200
REFERENCE   10 (residues 1 to 144)
  AUTHORS   Halfon,S., Ford,J., Foster,J., Dowling,L., Lucian,L., Sterling,M.,
            Xu,Y., Weiss,M., Ikeda,M., Liggett,D., Helms,A., Caux,C.,
            Lebecque,S., Hannum,C., Menon,S., McClanahan,T., Gorman,D. and
            Zurawski,G.
  TITLE     Leukocystatin, a new Class II cystatin expressed selectively by
            hematopoietic cells
  JOURNAL   J Biol Chem 273 (26), 16400-16408 (1998)
   PUBMED   9632704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004420.1 and BX630680.1.
            
            On Oct 31, 2009 this sequence version replaced NP_034107.1.
            
            Sequence Note: An in-frame AUG is located 23 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it is not conserved and would disrupt the putative
            N-terminal signal peptide.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004420.1, AB015224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..144
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.67 cM"
     Protein         1..144
                     /product="cystatin-F precursor"
                     /note="cystatin-F; cystatin-7; cystatin-like
                     metastasis-associated protein"
                     /calculated_mol_wt=14437
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1961
     mat_peptide     19..144
                     /product="Cystatin-F. /id=PRO_0000006647"
                     /note="propagated from UniProtKB/Swiss-Prot (O89098.1)"
                     /calculated_mol_wt=14437
     Region          35..144
                     /region_name="CY"
                     /note="Cystatin-like domain; smart00043"
                     /db_xref="CDD:214484"
     Site            order(36,80..82,84)
                     /site_type="active"
                     /note="putative proteinase inhibition site [active]"
                     /db_xref="CDD:238002"
     Site            36
                     /site_type="other"
                     /note="Reactive site; propagated from UniProtKB/Swiss-Prot
                     (O89098.1)"
     Site            61
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O89098.1)"
     Region          80..84
                     /region_name="Secondary area of contact"
                     /note="propagated from UniProtKB/Swiss-Prot (O89098.1)"
     CDS             1..144
                     /gene="Cst7"
                     /gene_synonym="Cmap"
                     /coded_by="NM_009977.3:105..539"
                     /db_xref="CCDS:CCDS16857.2"
                     /db_xref="GeneID:13011"
                     /db_xref="MGI:MGI:1298217"
ORIGIN      
        1 mwlaillalc cltsdthgar ppdfcskdli ssvkpgfpkt ietnnpgvlk aarhsvekfn
       61 nctndiflfk eshvskalvq vvkglkymle vkigrttcrk tmhhqldncd fqtnpalkrt
      121 lycysevwvi pwlhsfevpv llcq
//
