LOCUS       NM_021405                735 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus cystatin D (Cst5), mRNA.
ACCESSION   NM_021405 XM_918182
VERSION     NM_021405.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 735)
  AUTHORS   Mo,Q., Salley,J., Roshan,T., Baer,L.A., May,F.J., Jaehnig,E.J.,
            Lehnig,A.C., Guo,X., Tong,Q., Nuotio-Antar,A.M., Shamsi,F.,
            Tseng,Y.H., Stanford,K.I. and Chen,M.H.
  TITLE     Identification and characterization of a supraclavicular brown
            adipose tissue in mice
  JOURNAL   JCI Insight 2 (11), 93166 (2017)
   PUBMED   28570265
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 735)
  AUTHORS   Frygelius,J., Oscarson,M., Nordqvist,K., Wedell,A. and Tohonen,V.
  TITLE     The reproductive tissue specific cystatin subgroup of genes:
            expression during gonadal development in wildtype and testatin
            knockout animals
  JOURNAL   Sex Dev 1 (6), 363-372 (2007)
   PUBMED   18391548
REFERENCE   3  (bases 1 to 735)
  AUTHORS   Yamada,T., Kawano,H., Koshizuka,Y., Fukuda,T., Yoshimura,K.,
            Kamekura,S., Saito,T., Ikeda,T., Kawasaki,Y., Azuma,Y., Ikegawa,S.,
            Hoshi,K., Chung,U.I., Nakamura,K., Kato,S. and Kawaguchi,H.
  TITLE     Carminerin contributes to chondrocyte calcification during
            endochondral ossification
  JOURNAL   Nat Med 12 (6), 665-670 (2006)
   PUBMED   16680148
  REMARK    GeneRIF: Data show that cystatin 10 (carminerin) contributes to
            chondrocyte calcification during endochondral ossification under
            physiological and pathological conditions through the
            transcriptional inhibition of NPP1.
REFERENCE   4  (bases 1 to 735)
  AUTHORS   Koshizuka,Y., Yamada,T., Hoshi,K., Ogasawara,T., Chung,U.I.,
            Kawano,H., Nakamura,Y., Nakamura,K., Ikegawa,S. and Kawaguchi,H.
  TITLE     Cystatin 10, a novel chondrocyte-specific protein, may promote the
            last steps of the chondrocyte differentiation pathway
  JOURNAL   J Biol Chem 278 (48), 48259-48266 (2003)
   PUBMED   13679380
  REMARK    GeneRIF: Cst10 may play an important role in the last steps of the
            chondrocyte differentiation pathway as an inducer of maturation,
            followed by apoptosis of chondrocytes
REFERENCE   5  (bases 1 to 735)
  AUTHORS   Koshizuka,Y., Ikegawa,S., Sano,M., Nakamura,K. and Nakamura,Y.
  TITLE     Isolation of novel mouse genes associated with ectopic ossification
            by differential display method using ttw, a mouse model for ectopic
            ossification
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 163-168 (2001)
   PUBMED   11856874
REFERENCE   6  (bases 1 to 735)
  AUTHORS   Shoemaker,K., Holloway,J.L., Whitmore,T.E., Maurer,M. and
            Feldhaus,A.L.
  TITLE     Molecular cloning, chromosome mapping and characterization of a
            testis-specific cystatin-like cDNA, cystatin T
  JOURNAL   Gene 245 (1), 103-108 (2000)
   PUBMED   10713450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845478.6.
            
            On Oct 27, 2022 this sequence version replaced NM_021405.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG866507.1, BG872501.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AL845478.6         62774-63066
            294-407             AL845478.6         64733-64846
            408-735             AL845478.6         67422-67749
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 73.8 cM"
     gene            1..735
                     /gene="Cst5"
                     /gene_synonym="Cst10; DD72"
                     /note="cystatin D"
                     /db_xref="GeneID:58214"
                     /db_xref="MGI:MGI:1930004"
     exon            1..293
                     /gene="Cst5"
                     /gene_synonym="Cst10; DD72"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..491
                     /gene="Cst5"
                     /gene_synonym="Cst10; DD72"
                     /note="carminerin; cystatin 10 (chondrocytes)"
                     /codon_start=1
                     /product="cystatin 10 precursor"
                     /protein_id="NP_067380.1"
                     /db_xref="CCDS:CCDS16853.1"
                     /db_xref="GeneID:58214"
                     /db_xref="MGI:MGI:1930004"
                     /translation="MASLLSPSMPVLAAVALTLTLAVIPEASTNAEAKQVVLGGVEPA
                     DPKDKEVQKVVKFAVRTYNDMDNDLYLSKPIRLMSASQQVVAGKNYYLKIELGRTTCT
                     KTESNLVDCPFNEQPDQQKRVICNFQINVAPWLNKMSMTNFNCYNF"
     exon            294..407
                     /gene="Cst5"
                     /gene_synonym="Cst10; DD72"
                     /inference="alignment:Splign:2.1.0"
     exon            408..735
                     /gene="Cst5"
                     /gene_synonym="Cst10; DD72"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctggatc atttcttctc tgctcctcta aagcttcatc aaccatggca agtttgctga
       61 gcccctcgat gcctgtgttg gctgctgtgg ccttgacact gaccctggct gtgatccctg
      121 aagccagtac taatgctgaa gccaagcagg tggtattagg tggagtggag ccagctgacc
      181 ctaaggataa ggaggtgcag aaagtggtaa agtttgctgt tagaacctac aatgatatgg
      241 acaatgacct gtatcttagc aagccaatac gactgatgag cgccagccag caggttgtgg
      301 ctgggaagaa ctactacttg aaaattgagc taggccgaac cacatgtacc aaaactgagt
      361 ctaatttggt tgattgtccc ttcaatgaac agccagatca gcagaagagg gtcatctgta
      421 atttccagat caacgttgca ccttggctga acaagatgtc catgacaaac ttcaactgtt
      481 acaatttctg aggatatatg tcaggctaca cttctgctga ttgtctctta cttttactca
      541 atcttatcct taagttctcc tttcctcaga cagagatctt agtcccaaag gttgtctctt
      601 gagaatgata gcaccaagag aaaagtagag ataggccctg cacacctaag tgacagttcc
      661 cttgttcctt tcatctactt gtttttcaaa ggcccactgt tcattatttg ctcaataaaa
      721 aaatagccat aggtc
//
