LOCUS       NM_001198841            1035 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus cysteine and glycine-rich protein 3 (Csrp3),
            transcript variant 2, mRNA.
ACCESSION   NM_001198841
VERSION     NM_001198841.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1035)
  AUTHORS   Eden,M., Leye,M., Hahn,J., Heilein,E., Luzarowski,M., Volschow,B.,
            Tannert,C., Sossalla,S., Lucena-Porcel,C., Frank,D. and Frey,N.
  TITLE     Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates
            cardiomyocyte growth and survival and is upregulated in human
            cardiomyopathy
  JOURNAL   J Biol Chem 300 (5), 107255 (2024)
   PUBMED   38579991
REFERENCE   2  (bases 1 to 1035)
  AUTHORS   Holmes,J.B., Lemieux,M.E. and Stelzer,J.E.
  TITLE     Torsional and strain dysfunction precede overt heart failure in a
            mouse model of dilated cardiomyopathy pathogenesis
  JOURNAL   Am J Physiol Heart Circ Physiol 325 (3), H449-H467 (2023)
   PUBMED   37417875
REFERENCE   3  (bases 1 to 1035)
  AUTHORS   Grote Beverborg,N., Spater,D., Knoll,R., Hidalgo,A., Yeh,S.T.,
            Elbeck,Z., Sillje,H.H.W., Eijgenraam,T.R., Siga,H., Zurek,M.,
            Palmer,M., Pehrsson,S., Albery,T., Bomer,N., Hoes,M.F.,
            Boogerd,C.J., Frisk,M., van Rooij,E., Damle,S., Louch,W.E.,
            Wang,Q.D., Fritsche-Danielson,R., Chien,K.R., Hansson,K.M.,
            Mullick,A.E., de Boer,R.A. and van der Meer,P.
  TITLE     Phospholamban antisense oligonucleotides improve cardiac function
            in murine cardiomyopathy
  JOURNAL   Nat Commun 12 (1), 5180 (2021)
   PUBMED   34462437
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1035)
  AUTHORS   Vanhoutte,D., Schips,T.G., Vo,A., Grimes,K.M., Baldwin,T.A.,
            Brody,M.J., Accornero,F., Sargent,M.A. and Molkentin,J.D.
  TITLE     Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated
            autophagy
  JOURNAL   Nat Commun 12 (1), 3928 (2021)
   PUBMED   34168130
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1035)
  AUTHORS   Agarwal,M., Sharma,A., Kumar,P., Kumar,A., Bharadwaj,A., Saini,M.,
            Kardon,G. and Mathew,S.J.
  TITLE     Myosin heavy chain-embryonic regulates skeletal muscle
            differentiation during mammalian development
  JOURNAL   Development 147 (7) (2020)
   PUBMED   32094117
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1035)
  AUTHORS   Jain,M.K., Kashiki,S., Hsieh,C.M., Layne,M.D., Yet,S.F.,
            Sibinga,N.E., Chin,M.T., Feinberg,M.W., Woo,I., Maas,R.L., Haber,E.
            and Lee,M.E.
  TITLE     Embryonic expression suggests an important role for CRP2/SmLIM in
            the developing cardiovascular system
  JOURNAL   Circ Res 83 (10), 980-985 (1998)
   PUBMED   9815145
REFERENCE   7  (bases 1 to 1035)
  AUTHORS   Rockman,H.A., Chien,K.R., Choi,D.J., Iaccarino,G., Hunter,J.J.,
            Ross,J. Jr., Lefkowitz,R.J. and Koch,W.J.
  TITLE     Expression of a beta-adrenergic receptor kinase 1 inhibitor
            prevents the development of myocardial failure in gene-targeted
            mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 7000-7005 (1998)
   PUBMED   9618528
REFERENCE   8  (bases 1 to 1035)
  AUTHORS   Baumeister,A., Arber,S. and Caroni,P.
  TITLE     Accumulation of muscle ankyrin repeat protein transcript reveals
            local activation of primary myotube endcompartments during muscle
            morphogenesis
  JOURNAL   J Cell Biol 139 (5), 1231-1242 (1997)
   PUBMED   9382869
REFERENCE   9  (bases 1 to 1035)
  AUTHORS   Arber,S., Hunter,J.J., Ross,J. Jr., Hongo,M., Sansig,G., Borg,J.,
            Perriard,J.C., Chien,K.R. and Caroni,P.
  TITLE     MLP-deficient mice exhibit a disruption of cardiac
            cytoarchitectural organization, dilated cardiomyopathy, and heart
            failure
  JOURNAL   Cell 88 (3), 393-403 (1997)
   PUBMED   9039266
REFERENCE   10 (bases 1 to 1035)
  AUTHORS   Harrod,G.V., Kettunen,P.J. and Jowett,A.K.
  TITLE     Murine MLP: cloning and expression in the embryonic head
  JOURNAL   J Craniofac Genet Dev Biol 16 (2), 65-73 (1996)
   PUBMED   8773898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG793105.1, BY067937.1 and BC061131.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003120.1, AK011624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BG793105.1         1-21
            22-389              BY067937.1         2-369
            390-1035            BC061131.1         392-1037
FEATURES             Location/Qualifiers
     source          1..1035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.11 cM"
     gene            1..1035
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /note="cysteine and glycine-rich protein 3"
                     /db_xref="GeneID:13009"
                     /db_xref="MGI:MGI:1330824"
     exon            1..54
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            55..192
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..665
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /note="LIM domain protein, cardiac; muscle LIM protein;
                     cysteine-rich protein 3; cardiac LIM protein"
                     /codon_start=1
                     /product="cysteine and glycine-rich protein 3"
                     /protein_id="NP_001185770.1"
                     /db_xref="CCDS:CCDS21305.1"
                     /db_xref="GeneID:13009"
                     /db_xref="MGI:MGI:1330824"
                     /translation="MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKAL
                     DSTTVAAHESEIYCKVCYGRRYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAA
                     TTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVT
                     DKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE"
     exon            193..361
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            362..494
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            495..588
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /inference="alignment:Splign:2.1.0"
     exon            589..897
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      872..877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /note="hexamer: AATAAA"
     polyA_site      895
                     /gene="Csrp3"
                     /gene_synonym="CRP3; MLP; MMLP"
                     /note="major polyA site"
ORIGIN      
        1 aggacaagag tccccttact cagttgagcc ggcagagacc acacaggcag gcagattgac
       61 cttggcccag agtcttcacc atgccaaact ggggtggagg tgcaaaatgt ggagcctgtg
      121 aaaagacggt ctaccatgca gaagaaatcc agtgcaatgg gaggagtttc cacaagacct
      181 gtttccactg catggcctgc aggaaagctc tggacagcac cacagtggca gctcatgagt
      241 cagagatcta ctgtaaggtg tgctatgggc gcaggtatgg ccccaagggg atcgggttcg
      301 gacaaggcgc tggctgcctc agcacagaca ctggcgagca tcttggcctg cagttccaac
      361 aatccccaaa gccagctcga gcagccacca caagcaaccc ttccaaattc tctgcaaagt
      421 ttggagaatc agagaagtgc ccacgatgtg gaaagtcggt atacgctgct gagaaggtca
      481 tgggaggtgg caagccctgg cacaagacct gcttccgctg tgccatctgt gggaagagcc
      541 tggagtctac aaatgtcact gacaaggatg gggagctcta ctgcaaagtt tgctatgcca
      601 aaaattttgg ccccacaggc attgggtttg gagggcttac acagcaagtg gaaaagaagg
      661 agtgaagctg cctgctttct cacagcccta tcagtcaaca gcagtgccac gtgatcccac
      721 agatgtagtt tgtccccaac agcctccttt gtagctggac agcatttctc ttcagaagca
      781 gtcataggct gcaccgaagt aacaagagac cactgggaat gttatctgca acagatgctt
      841 cactatttac tattcttggg atgggagaga caataaatgt tttagtggta ccatctcaaa
      901 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      961 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1021 aaaaaaaaaa aaaaa
//
