LOCUS       NM_007792                889 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus cysteine and glycine-rich protein 2 (Csrp2), mRNA.
ACCESSION   NM_007792
VERSION     NM_007792.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 889)
  AUTHORS   Li,Y., Fujishita,T., Mishiro-Sato,E., Kojima,Y., Niu,Y.,
            Taketo,M.M., Urano,Y., Sakai,T., Enomoto,A., Nishida,Y. and Aoki,M.
  TITLE     TGF-beta signaling promotes desmoid tumor formation via CSRP2
            upregulation
  JOURNAL   Cancer Sci 115 (2), 401-411 (2024)
   PUBMED   38041233
  REMARK    GeneRIF: TGF-beta signaling promotes desmoid tumor formation via
            CSRP2 upregulation.
REFERENCE   2  (bases 1 to 889)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 889)
  AUTHORS   Hayashida,N.
  TITLE     Non-Hsp genes are essential for HSF1-mediated maintenance of whole
            body homeostasis
  JOURNAL   Exp Anim 64 (4), 397-406 (2015)
   PUBMED   26251235
  REMARK    GeneRIF: It is a non-Hsp gene, which is essential for HSF1-mediated
            maintenance of whole body homeostasis.
REFERENCE   4  (bases 1 to 889)
  AUTHORS   Chen,C.H., Ho,Y.C., Ho,H.H., Chang,I.C., Kirsch,K.H., Chuang,Y.J.,
            Layne,M.D. and Yet,S.F.
  TITLE     Cysteine-rich protein 2 alters p130Cas localization and inhibits
            vascular smooth muscle cell migration
  JOURNAL   Cardiovasc Res 100 (3), 461-471 (2013)
   PUBMED   23975851
  REMARK    GeneRIF: CRP2 sequesters p130Cas at focal adhesions, thereby
            reducing lamellipodia formation and blunting vascular smooth muscle
            cell migration.
REFERENCE   5  (bases 1 to 889)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 889)
  AUTHORS   Henderson,J.R., Brown,D., Richardson,J.A., Olson,E.N. and
            Beckerle,M.C.
  TITLE     Expression of the gene encoding the LIM protein CRP2: a
            developmental profile
  JOURNAL   J Histochem Cytochem 50 (1), 107-111 (2002)
   PUBMED   11748300
  REMARK    GeneRIF: evolutionarily conserved Lin-11, Isl-1, Mac-3 (LIM) domain
            protein that have been implicated in cell differentiation.
REFERENCE   7  (bases 1 to 889)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (bases 1 to 889)
  AUTHORS   Jain,M.K., Kashiki,S., Hsieh,C.M., Layne,M.D., Yet,S.F.,
            Sibinga,N.E., Chin,M.T., Feinberg,M.W., Woo,I., Maas,R.L., Haber,E.
            and Lee,M.E.
  TITLE     Embryonic expression suggests an important role for CRP2/SmLIM in
            the developing cardiovascular system
  JOURNAL   Circ Res 83 (10), 980-985 (1998)
   PUBMED   9815145
REFERENCE   9  (bases 1 to 889)
  AUTHORS   Yet,S.F., Folta,S.C., Jain,M.K., Hsieh,C.M., Maemura,K.,
            Layne,M.D., Zhang,D., Marria,P.B., Yoshizumi,M., Chin,M.T.,
            Perrella,M.A. and Lee,M.E.
  TITLE     Molecular cloning, characterization, and promoter analysis of the
            mouse Crp2/SmLim gene. Preferential expression of its promoter in
            the vascular smooth muscle cells of transgenic mice
  JOURNAL   J Biol Chem 273 (17), 10530-10537 (1998)
   PUBMED   9553112
REFERENCE   10 (bases 1 to 889)
  AUTHORS   Jain,M.K., Fujita,K.P., Hsieh,C.M., Endege,W.O., Sibinga,N.E.,
            Yet,S.F., Kashiki,S., Lee,W.S., Perrella,M.A., Haber,E. and
            Lee,M.E.
  TITLE     Molecular cloning and characterization of SmLIM, a developmentally
            regulated LIM protein preferentially expressed in aortic smooth
            muscle cells
  JOURNAL   J Biol Chem 271 (17), 10194-10199 (1996)
   PUBMED   8626582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY333413.1, CK031156.1 and AK012647.1.
            
            On Nov 20, 2007 this sequence version replaced NM_007792.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF037208.1, AK003328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               BY333413.1         2-332
            332-766             CK031156.1         318-752
            767-889             AK012647.1         765-887
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 57.84 cM"
     gene            1..889
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /note="cysteine and glycine-rich protein 2"
                     /db_xref="GeneID:13008"
                     /db_xref="MGI:MGI:1202907"
     exon            1..79
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /inference="alignment:Splign:2.1.0"
     exon            80..192
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..662
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /note="DLP-1; double LIM protein 1; cysteine-rich protein
                     2"
                     /codon_start=1
                     /product="cysteine and glycine-rich protein 2"
                     /protein_id="NP_031818.3"
                     /db_xref="CCDS:CCDS24165.1"
                     /db_xref="GeneID:13008"
                     /db_xref="MGI:MGI:1202907"
                     /translation="MPVWGGGNKCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNL
                     DSTTVAIHDEEIYCKSCYGKKYGPKGYGYGQGAGTLNMDRGERLGIKPESAQPHRPTT
                     NPNTSKFAQKYGGAEKCSRCGDSVYAAEKIIGAGKPWHKNCFRCAKCGKSLESTTLTE
                     KEGEIYCKGCYAKNFGPKGFGYGQGAGALVHAQ"
     exon            193..361
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /inference="alignment:Splign:2.1.0"
     exon            362..491
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /inference="alignment:Splign:2.1.0"
     exon            492..585
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /inference="alignment:Splign:2.1.0"
     exon            586..889
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /inference="alignment:Splign:2.1.0"
     regulatory      853..858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /note="hexamer: AATAAA"
     polyA_site      870
                     /gene="Csrp2"
                     /gene_synonym="Crp2; SmLim"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgga tccgcccgcg gctttcctcg gtcagacctc gttagctccg cccgccgcgt
       61 gctccctcct cccactcgga atgcctgtct ggggcggtgg aaataagtgc ggggcctgcg
      121 ggagaaccgt gtaccacgcg gaagaggtgc agtgcgatgg gcggagcttc catcgctgct
      181 gcttcctgtg catggtttgc aggaaaaatt tagacagcac aacagtggcg attcatgatg
      241 aagagatcta ctgcaaatcc tgctacggaa agaagtatgg accaaaaggc tatggttatg
      301 gccagggcgc tggcacgctc aacatggacc gcggtgagag actgggcatc aagccagaga
      361 gtgctcaacc tcacaggcct acgacaaatc caaacacttc taaatttgcc cagaaatatg
      421 gaggagctga gaagtgttcc aggtgtgggg attccgtgta tgctgcggag aagatcattg
      481 gagctgggaa gccctggcac aaaaactgtt tccggtgtgc caagtgtggg aagagtctgg
      541 agtctacaac tctgactgag aaagaaggcg aaatctactg taaagggtgc tacgcaaaga
      601 actttgggcc caagggattt ggctatggtc aaggggcagg ggcccttgtt catgctcagt
      661 aatggtgtga acccagtaag cacgacagag aatctccatt accaaactgc agatggcgtt
      721 tatggcgctc actactgtga aacagccagc acttggcact gggcatcacc gagctgcctg
      781 tgggggctgg accgacagcg ctgcactctc ccgcccactc actagcgtct aagagcattc
      841 ttttacattt gaaataaaat tttggcttga tttgggtacc acctcttaa
//
