LOCUS       NM_001357562            3029 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus cysteine-serine-rich nuclear protein 1 (Csrnp1),
            transcript variant 4, mRNA.
ACCESSION   NM_001357562 XM_006512037
VERSION     NM_001357562.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3029)
  AUTHORS   Ye,X., Lin,J., Lin,Z., Xue,A., Li,L., Zhao,Z., Liu,L., Shen,Y. and
            Cong,B.
  TITLE     Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes
            apoptosis through activating Wnt/beta-catenin signaling
  JOURNAL   Exp Cell Res 359 (2), 441-448 (2017)
   PUBMED   28830684
  REMARK    GeneRIF: Axud1 mediated stress-induced cardiomyocytes apoptosis
            through activating Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 3029)
  AUTHORS   Ze,Y., Hu,R., Wang,X., Sang,X., Ze,X., Li,B., Su,J., Wang,Y.,
            Guan,N., Zhao,X., Gui,S., Zhu,L., Cheng,Z., Cheng,J., Sheng,L.,
            Sun,Q., Wang,L. and Hong,F.
  TITLE     Neurotoxicity and gene-expressed profile in brain-injured mice
            caused by exposure to titanium dioxide nanoparticles
  JOURNAL   J Biomed Mater Res A 102 (2), 470-478 (2014)
   PUBMED   23533084
  REMARK    GeneRIF: significant increases in Col1a1, serine/threonine-protein
            kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and
            great decreases inreceptor D2, Neu1, and Dhcr7 expressions
            following long-term exposure to TiO2 NPs
REFERENCE   3  (bases 1 to 3029)
  AUTHORS   Gingras,S., Pelletier,S., Boyd,K. and Ihle,J.N.
  TITLE     Characterization of a family of novel cysteine- serine-rich nuclear
            proteins (CSRNP)
  JOURNAL   PLoS One 2 (8), e808 (2007)
   PUBMED   17726538
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3029)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
REFERENCE   5  (bases 1 to 3029)
  AUTHORS   Chen,W.V., Delrow,J., Corrin,P.D., Frazier,J.P. and Soriano,P.
  TITLE     Identification and validation of PDGF transcriptional targets by
            microarray-coupled gene-trap mutagenesis
  JOURNAL   Nat Genet 36 (3), 304-312 (2004)
   PUBMED   14981515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117245.3 and AC124662.10.
            
            On Nov 4, 2017 this sequence version replaced XM_006512037.3.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3978737.1,
                                           SRR7652917.223716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC117245.3         113592-113752
            162-405             AC124662.10        3371-3614
            406-665             AC124662.10        6203-6462
            666-980             AC124662.10        6938-7252
            981-3029            AC124662.10        7405-9453
FEATURES             Location/Qualifiers
     source          1..3029
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.34 cM"
     gene            1..3029
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /note="cysteine-serine-rich nuclear protein 1"
                     /db_xref="GeneID:215418"
                     /db_xref="MGI:MGI:2387989"
     exon            1..161
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..405
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1952
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /note="AXIN1 up-regulated 1; TGF-beta induced apoptosis
                     protein 3; axin-1 up-regulated gene 1 protein"
                     /codon_start=1
                     /product="cysteine/serine-rich nuclear protein 1"
                     /protein_id="NP_001344491.1"
                     /db_xref="CCDS:CCDS23620.1"
                     /db_xref="GeneID:215418"
                     /db_xref="MGI:MGI:2387989"
                     /translation="MTGLLKRKFDQLEEDDSSSSSSSSFSSRLSLSSFPASSASPAWN
                     SDEEGPGGQAPQSDQDSCGLQSFTPPSILKRAPRERPGHVAFNGITVYYFPRCQGFTS
                     VPSRGGCTLGMASRHSTCRLFSLAEFTQEQVRARREKLRRRLKEEKLEMLRWKFSVAG
                     VPESGAGVPLTADAIDDASVEEDLAVAVANGRLEEANFLQPHPPRQRRALLRASGVRR
                     IDREEKRELQVLRQSREDCGCHCDGVCDPETCSCSLAGIKCQMDHTSFPCGCCREGCE
                     NPNGRVEFNQTRVQTHFIHTLTRLQMEQGAESLGDLESPVEDTPVEQAALSPFPPSKP
                     PVSSELGDSSCSSDMTDSSTTLSSGSSEPPNHPAHPSLPGPSFRSGVDEDSLEQILNF
                     SDSDLGIEEEEEEGGGVGNLDNLSCFHLADIFGTGDPGSLASWTHSQSGSSLASGILD
                     ENANLDASCFLNSGLGGLREGSLPGSSGSPEGDAVQSSSWDLSLSSCDSFELLQALPD
                     YSLGPHYTSRRVSGSPDSLETFHPLPSFSPPRDASTCFLESLVGLSEPVTEVLAPLLE
                     SQFEDAALAPLLEPVPV"
     exon            406..665
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..980
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..3029
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3008..3013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="Csrnp1"
                     /gene_synonym="4931429D10Rik; Axud1; CSRNP-1; taip-3;
                     URAX1"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgagc cagtctctcc cgccgccgcc ggacgcgcag acctgggccg gctgcaccga
       61 cggccgcccg gccgagcgca ctgcgggtcg ctgtgtgcgc tgcgaccctg gggccggcac
      121 acgagtggct tcggtgaact gggcgagccc tgctagctta ggcgtctgtc ctcggctgtt
      181 ggaaccccct acattccacc atgactgggc tactgaagag gaagtttgac cagctggaag
      241 aggacgactc cagttcctcc tcctcctcat cgttctctag ccggctctct ctctcctcct
      301 tccccgcctc ttctgcctcc cctgcctgga actctgatga ggagggacca ggtggtcagg
      361 caccccagtc tgatcaggac tcctgtggcc tccagagttt cactcccccg tccatcctga
      421 agcgggctcc tcgggagcgt ccaggtcacg tggcctttaa cggcatcacc gtctactatt
      481 tcccacggtg ccagggattc accagtgtgc ccagccgtgg tggctgtacc ctgggcatgg
      541 cttctcggca cagcacctgc cgccttttct ccttagctga gtttacacag gagcaggtcc
      601 gggctcggcg tgagaagctc cgccgccgtt taaaggagga gaagctggag atgctgaggt
      661 ggaagttttc agtggctgga gttccggagt caggggcagg cgtgcctctc acagcggatg
      721 ccatcgatga cgcctctgta gaggaggact tggcagtggc cgtggcaaat ggccgcctgg
      781 aggaagccaa tttcctccag ccccatccac ctcggcagcg acgggctctc cttcgggctt
      841 ccggcgttcg aaggattgac cgagaggaga agcgggagct gcaggtgctg cgccagtccc
      901 gggaggattg tggttgtcac tgtgatggcg tctgtgaccc tgagacctgc agttgcagct
      961 tggccggcat taagtgccag atggatcaca cgtccttccc ctgtggctgc tgcagggagg
     1021 gctgcgagaa ccccaatggt cgagtggaat tcaatcagac aagagttcag acgcacttca
     1081 ttcacaccct cacccgcctg cagatggagc agggtgccga gagcttgggg gacctggagt
     1141 cccccgtgga ggacactcct gttgaacaag ccgcgctttc cccctttccg ccttccaagc
     1201 cccctgtgag cagtgaactg ggggacagca gttgcagcag cgatatgaca gactcttcca
     1261 cgaccttgtc ctctggcagc agcgagcctc caaaccaccc tgcccacccc agcctgccag
     1321 gtcccagctt ccggtctggc gtagatgaag acagcctgga acagatcctg aatttcagtg
     1381 actctgacct cggaattgag gaggaggagg aggagggagg gggtgtgggc aacttggata
     1441 acctcagctg cttccatctg gctgacatct ttggtaccgg tgaccccggc agcctggcca
     1501 gctggactca cagccagtct ggctctagcc tcgcatcggg catcctagat gagaatgcca
     1561 acctggacgc cagttgcttc ctgaacagcg gacttggagg gctgagagaa ggtagcctcc
     1621 ctggcagttc tgggtcccct gagggggacg ccgtccagag cagctcctgg gacctcagct
     1681 tatcctcctg tgactccttt gagcttctcc aggctctgcc agattatagt ctgggacctc
     1741 actatacttc ccgaagggtg tcgggcagcc cggatagcct tgagaccttc cacccattgc
     1801 ccagcttctc tccaccacgg gatgcgagca cttgcttcct ggagtctctc gtgggcctgt
     1861 ctgagccggt tacagaagtc ctggcacccc ttctggagag ccagtttgag gatgctgcct
     1921 tggcaccttt gttggagcct gtgccagtgt aaggattaag gtgccttctt cctgccctga
     1981 gaccctgttg ctgctctttg tgatcttggg gttccccgag gtctatgtat gtaacggtct
     2041 cctacgggct ggtcctgctc atggtgccat gtgggcaccc tctattttta cattaacact
     2101 ctgaatttat ttattttttt atgtttttct gtactgaaga agggagggtg gggagggtac
     2161 ccctctttca atgcctggtc tctttatgtc caaacagagg tcttccacct cctactgtat
     2221 gcctgaagga ggaaggggcg gggctctcct ggagcctcgc agtccctctt tctgtactgt
     2281 aagatgctcc ttgctccaaa gacagcgacg gctgagcgca gggccttagg ggcttctgtg
     2341 aaccatagga gctaggtctt ctggactgtg aagatgtaat ttatatctgt aatttatttg
     2401 gggatggaga cggcagtggt ggagcctctc tggcgggtgg gcaggcagtg ttggggccga
     2461 ggcttcggtg taccctgcca gtctgggctt cggtgtggtg tgtgggttcg agtttatggc
     2521 tgctctatta aacagcggcc tggctcaact gagcagacag aggctgtgct tgaccagcgg
     2581 tgaccaaaac cccttctgcc cccttcccag aaactctact tgccctcttt ccaattccct
     2641 ctccccaagg ccatggatta taaagcccct ctgtaagatg gtgagccagg ggccctaaga
     2701 gggcatgaag cacaccctga tcactgtctc aggcctttct gggcactgac tcgaccctgg
     2761 cccacctcac gcccccaggc cagttggcaa ctggtggctc ttgagagctc ttacgccctt
     2821 cattagctga tgttggattt tatatgcatt tttttattgt ctctaagtgt cagaactata
     2881 atttattcat ttctttgtgt gtgtgtgtgt gccaagaaac gcaggctctg ggcctgcctc
     2941 cttgcccagg aggccttgcc agcctgtgtg cttgtgggaa cacactgtac ctgagctgac
     3001 aggtaccaat aaagatgctc tatttttaa
//
