LOCUS       NM_009975                970 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus casein kinase 2, beta polypeptide (Csnk2b), transcript
            variant 2, mRNA.
ACCESSION   NM_009975
VERSION     NM_009975.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Qiu,F., He,S., Zhang,Z., Dai,S., Wang,J., Liu,N., Li,Z., Hu,X.,
            Xiang,S. and Wei,C.
  TITLE     MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by
            negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated
            degradation of CK2beta
  JOURNAL   Food Chem Toxicol 178, 113888 (2023)
   PUBMED   37302538
  REMARK    GeneRIF: MiR-93 alleviates DEHP plasticizer-induced neurotoxicity
            by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated
            degradation of CK2beta.
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Quotti Tubi,L., Mandato,E., Canovas Nunes,S., Arjomand,A.,
            Zaffino,F., Manni,S., Casellato,A., Macaccaro,P., Vitulo,N.,
            Zumerle,S., Filhol,O., Boldyreff,B., Siebel,C.W., Viola,A.,
            Valle,G., Mainoldi,F., Casola,S., Cancila,V., Gulino,A.,
            Tripodo,C., Pizzi,M., Dei Tos,A.P., Trentin,L., Semenzato,G. and
            Piazza,F.
  TITLE     CK2beta-regulated signaling controls B cell differentiation and
            function
  JOURNAL   Front Immunol 13, 959138 (2023)
   PUBMED   36713383
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Kim,J.M., Yang,Y.S., Park,K.H., Ge,X., Xu,R., Li,N., Song,M.,
            Chun,H., Bok,S., Charles,J.F., Filhol-Cochet,O., Boldyreff,B.,
            Dinter,T., Yu,P.B., Kon,N., Gu,W., Takarada,T., Greenblatt,M.B. and
            Shim,J.H.
  TITLE     A RUNX2 stabilization pathway mediates physiologic and pathologic
            bone formation
  JOURNAL   Nat Commun 11 (1), 2289 (2020)
   PUBMED   32385263
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Lettieri,A., Borgo,C., Zanieri,L., D'Amore,C., Oleari,R.,
            Paganoni,A., Pinna,L.A., Cariboni,A. and Salvi,M.
  TITLE     Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and
            Migration of GN11 Cells: A Model of Immature Migrating Neurons
  JOURNAL   Int J Mol Sci 20 (23), 5951 (2019)
   PUBMED   31779225
  REMARK    GeneRIF: Results found that the regulatory CK2 beta subunits are
            essential for GN11 neuronal cell migration and their deletion
            induces deep changes in cytoskeletal structures that totally
            prevent cell migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 970)
  AUTHORS   Hernandez-Torres,F., Rastrojo,A. and Aguado,B.
  TITLE     Intron retention and transcript chimerism conserved across mammals:
            Ly6g5b and Csnk2b-Ly6g5b as examples
  JOURNAL   BMC Genomics 14, 199 (2013)
   PUBMED   23521802
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 970)
  AUTHORS   Boldyreff,B. and Issinger,O.G.
  TITLE     Structure of the gene encoding the murine protein kinase CK2 beta
            subunit
  JOURNAL   Genomics 29 (1), 253-256 (1995)
   PUBMED   8530080
REFERENCE   8  (bases 1 to 970)
  AUTHORS   Mestres,P., Boldyreff,B., Ebensperger,C., Hameister,H. and
            Issinger,O.G.
  TITLE     Expression of casein kinase 2 during mouse embryogenesis
  JOURNAL   Acta Anat (Basel) 149 (1), 13-20 (1994)
   PUBMED   8184654
REFERENCE   9  (bases 1 to 970)
  AUTHORS   Boldyreff,B., Piontek,K., Schmidt-Spaniol,I. and Issinger,O.G.
  TITLE     The beta subunit of casein kinase II: cloning of cDNAs from murine
            and porcine origin and expression of the porcine sequence as a
            fusion protein
  JOURNAL   Biochim Biophys Acta 1088 (3), 439-441 (1991)
   PUBMED   2015307
REFERENCE   10 (bases 1 to 970)
  AUTHORS   Kopatz,I., Naiman,T., Eli,D. and Canaani,D.
  TITLE     The nucleotide sequence of the mouse cDNA encoding the beta subunit
            of casein kinase II
  JOURNAL   Nucleic Acids Res 18 (12), 3639 (1990)
   PUBMED   2362816
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR974444.18.
            
            On Jan 8, 2015 this sequence version replaced NM_009975.2.
            
            Summary: This gene encodes the beta subunit of the casein kinase 2
            enzyme, which is a heterotetramer comprised of alpha and/or
            alpha-prime catalytic subunits and two regulatory beta subunits.
            Casein kinase 2 is involved in the regulation of several cellular
            processes including gene expression, protein synthesis and cell
            proliferation. Knockout of this gene in mice leads to embryonic
            lethality. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon and uses a downstream start codon compared to variant
            1. It encodes isoform 2 which has a shorter N-terminus compared to
            isoform 1. Variants 2 and 3 encode the same isoform (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56502.1, BC003775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CR974444.18        57252-57287         c
            37-171              CR974444.18        57117-57251         c
            172-254             CR974444.18        56440-56522         c
            255-357             CR974444.18        55749-55851         c
            358-473             CR974444.18        54454-54569         c
            474-549             CR974444.18        53991-54066         c
            550-739             CR974444.18        53691-53880         c
            740-967             CR974444.18        52193-52420         c
            968-970             CR974444.18        52190-52192         c
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..970
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /note="casein kinase 2, beta polypeptide"
                     /db_xref="GeneID:13001"
                     /db_xref="MGI:MGI:88548"
     exon            1..171
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /inference="alignment:Splign:2.1.0"
     exon            172..254
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..830
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phosvitin"
                     /codon_start=1
                     /product="casein kinase II subunit beta isoform 2"
                     /protein_id="NP_034105.1"
                     /db_xref="CCDS:CCDS28684.1"
                     /db_xref="GeneID:13001"
                     /db_xref="MGI:MGI:88548"
                     /translation="MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVP
                     HYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQ
                     QGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFG
                     TGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR"
     exon            255..357
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /inference="alignment:Splign:2.1.0"
     exon            358..473
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /inference="alignment:Splign:2.1.0"
     exon            474..549
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /inference="alignment:Splign:2.1.0"
     exon            550..739
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /inference="alignment:Splign:2.1.0"
     exon            740..970
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      948..953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /note="hexamer: AATAAA"
     polyA_site      967
                     /gene="Csnk2b"
                     /gene_synonym="CK II beta"
                     /note="major polyA site"
ORIGIN      
        1 cgcctgcgcg ttgccctttt ctcacccaaa tcctcaccag tttccagtgg ccccccccct
       61 ccctacttcg tctgctgcgg ccgggtcggc tttttgcgct gtagtggtct ctgcggttcc
      121 ttggaagcac agctcccctt ccccgcccca gtcccagtcc ccgtccggcc gcggacataa
      181 agatgagtag ctctgaggag gtgtcctgga tttcctggtt ctgtgggctc cgtggtaatg
      241 aattcttctg tgaggtggat gaagactaca tccaggacaa atttaatctt actggactca
      301 atgagcaggt gcctcactat cgacaagctc tggacatgat cttagacctg gaacctgatg
      361 aagagctgga agacaacccc aaccagagcg acttgatcga acaggcagct gagatgcttt
      421 atgggttgat ccacgcccgc tacatcctca ccaaccgagg catcgcacaa atgttggaaa
      481 agtaccagca gggagacttt ggctactgtc ctcgtgtata ctgtgagaac cagccaatgc
      541 ttcctatcgg cctttcagac atcccaggcg aggccatggt gaaactctac tgccccaagt
      601 gcatggacgt gtacacaccc aagtcctcca gacaccacca cacggacggc gcatacttcg
      661 gcactggttt ccctcacatg ctcttcatgg tgcatccaga gtaccggccc aagcgacctg
      721 ccaaccagtt tgtacccagg ctctatggtt tcaagatcca tccaatggct taccagctgc
      781 agctccaagc cgccagcaac ttcaagagcc cagtcaagac tattcgctga ttgcccaccc
      841 acctctccct ctgtctgtga caccaccatt cctctgctgc caccctttca ggaagtctat
      901 ggtttttagt ttaaattaaa ggaattgtta ctgtggtggg aatatgaaat aaaggaagaa
      961 aaggccatga
//
