LOCUS       NM_009974               3766 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus casein kinase 2, alpha prime polypeptide (Csnk2a2),
            mRNA.
ACCESSION   NM_009974 XM_911928
VERSION     NM_009974.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3766)
  AUTHORS   Ampofo,E., Pack,M., Wrublewsky,S., Boewe,A.S., Spigelman,A.F.,
            Koch,H., MacDonald,P.E., Laschke,M.W., Montenarh,M. and Gotz,C.
  TITLE     CK2 activity is crucial for proper glucagon expression
  JOURNAL   Diabetologia 67 (7), 1368-1385 (2024)
   PUBMED   38503901
  REMARK    GeneRIF: CK2 activity is crucial for proper glucagon expression.
REFERENCE   2  (bases 1 to 3766)
  AUTHORS   Yang,J., Lin,L., Zou,G.J., Wang,L.F., Li,F., Li,C.Q., Cui,Y.H. and
            Huang,F.L.
  TITLE     CK2 negatively regulates the extinction of remote fear memory
  JOURNAL   Behav Brain Res 465, 114960 (2024)
   PUBMED   38494129
  REMARK    GeneRIF: CK2 negatively regulates the extinction of remote fear
            memory.
REFERENCE   3  (bases 1 to 3766)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3766)
  AUTHORS   Zarate,N., Gundry,K., Yu,D., Casby,J., Eberly,L.E., Oz,G. and
            Gomez-Pastor,R.
  TITLE     Neurochemical correlates of synapse density in a Huntington's
            disease mouse model
  JOURNAL   J Neurochem 164 (2), 226-241 (2023)
   PUBMED   36272099
REFERENCE   5  (bases 1 to 3766)
  AUTHORS   Merholz,M., Jian,Y., Wimberg,J., Gessler,L. and Hashemolhosseini,S.
  TITLE     In Skeletal Muscle Fibers, Protein Kinase Subunit CSNK2A1/CK2alpha
            Is Required for Proper Muscle Homeostasis and Structure and
            Function of Neuromuscular Junctions
  JOURNAL   Cells 11 (24), 3962 (2022)
   PUBMED   36552726
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3766)
  AUTHORS   Orlandini,M., Semplici,F., Ferruzzi,R., Meggio,F., Pinna,L.A. and
            Oliviero,S.
  TITLE     Protein kinase CK2alpha' is induced by serum as a delayed early
            gene and cooperates with Ha-ras in fibroblast transformation
  JOURNAL   J Biol Chem 273 (33), 21291-21297 (1998)
   PUBMED   9694889
REFERENCE   7  (bases 1 to 3766)
  AUTHORS   Xu,X., Rich,E.S. Jr. and Seldin,D.C.
  TITLE     Murine protein kinase CK2 alpha': cDNA and genomic cloning and
            chromosomal mapping
  JOURNAL   Genomics 48 (1), 79-86 (1998)
   PUBMED   9503019
REFERENCE   8  (bases 1 to 3766)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   9  (bases 1 to 3766)
  AUTHORS   Boldyreff,B., Wehr,K., Hecht,R. and Issinger,O.G.
  TITLE     Identification of four genomic loci highly related to
            casein-kinase-2-alpha cDNA and characterization of a casein
            kinase-2-alpha pseudogene within the mouse genome
  JOURNAL   Biochem Biophys Res Commun 186 (2), 723-730 (1992)
   PUBMED   1497660
REFERENCE   10 (bases 1 to 3766)
  AUTHORS   Yang-Feng,T.L., Zheng,K., Kopatz,I., Naiman,T. and Canaani,D.
  TITLE     Mapping of the human casein kinase II catalytic subunit genes: two
            loci carrying the homologous sequences for the alpha subunit
  JOURNAL   Nucleic Acids Res 19 (25), 7125-7129 (1991)
   PUBMED   1766873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002927.1, BM963966.1, CB056745.1, AK030035.1 and AC165414.9.
            
            On Jan 9, 2008 this sequence version replaced NM_009974.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002927.1, AJ001420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1883              AK002927.1         9-1891
            1884-2452           BM963966.1         162-730
            2453-2823           CB056745.1         345-715
            2824-3343           AK030035.1         1864-2383
            3344-3345           AC165414.9         141051-141052       c
            3346-3766           AK030035.1         2386-2806
FEATURES             Location/Qualifiers
     source          1..3766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..3766
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /note="casein kinase 2, alpha prime polypeptide"
                     /db_xref="GeneID:13000"
                     /db_xref="MGI:MGI:88547"
     exon            1..477
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1426
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /EC_number="2.7.11.1"
                     /note="CK II alpha'; casein kinase II, alpha 2,
                     polypeptide"
                     /codon_start=1
                     /product="casein kinase II subunit alpha'"
                     /protein_id="NP_034104.1"
                     /db_xref="CCDS:CCDS22562.1"
                     /db_xref="GeneID:13000"
                     /db_xref="MGI:MGI:88547"
                     /translation="MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVR
                     KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTV
                     KDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKP
                     HNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS
                     LGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIDLDPHFNDILGQ
                     HSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQ
                     PCAENTVLSSGLTAAR"
     exon            478..589
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..691
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..742
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..802
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..886
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..997
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1099
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1200
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1349
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1443
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..3766
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /note="hexamer: AATAAA"
     polyA_site      1890
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /note="major polyA site"
     regulatory      2742..2747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
                     /note="hexamer: ATTAAA"
     polyA_site      2767
                     /gene="Csnk2a2"
                     /gene_synonym="1110035J23Rik; CK2"
ORIGIN      
        1 tcctccctct tcgccgccgc cgccgctgcc gctgcccctc tcccgaccgg tggctgccgc
       61 tgccgccacc accgcctctg gggggccgcg agccgagcgg aggcctccgc ggagcacgaa
      121 ccccgccgtc cctccggcag ccgaaggccc cgggccggct cggccggcgc cttccgcgcc
      181 ccccggcccg agcgtccgtc cgtccgcccg cccccgcggg cccggcctgg cgcggacgcc
      241 cgccgccgcc gccgcgctcc tcctcttgct tgggcagccc gcggcccgcc gcttcccgtg
      301 cctgccgccc cgcgccccgc gccgcgccgc cgccgccctc ggcgccccgc ggcgcccccc
      361 ggtcccgccc gccatgcccg gcccggccgc gggcagtcgg gcccgggtct acgccgaggt
      421 gaacagcctg aggagccgcg agtactggga ctacgaagcc cacgtcccga gctggggtaa
      481 tcaagatgat taccaactgg ttcgaaaact tggtcggggc aagtatagtg aagtatttga
      541 ggccattaac atcaccaaca atgagagggt ggttgtaaaa attctcaagc cagtgaagaa
      601 aaagaagata aaacgagagg ttaagattct ggagaacctt cgtggtggaa caaatatcat
      661 taagctgatt gacactgtaa aggaccctgt gtcaaagaca ccagctttgg tatttgaata
      721 tatcaataat acagatttta agcaactcta ccagatcctg actgactttg atatccggtt
      781 ttatatgtat gaactactta aagctctgga ttactgccac agcaagggaa tcatgcacag
      841 ggatgtgaaa cctcacaatg tcatgataga tcaccaacaa aaaaagctcc gactgattga
      901 ttggggtctg gcagagttct atcatcctgc tcaggagtac aatgttcgag tggcctcgag
      961 gtacttcaag ggaccagagc tccttgtgga ctatcagatg tatgattata gcttggacat
     1021 gtggagcttg ggctgcatgt tagcgagcat gatattccga aaggagccat tcttccacgg
     1081 gcaggacaac tatgaccagc ttgttcgaat tgccaaggtt ctggggacag atgaactata
     1141 tggttatctg aagaagtacc acatagacct agatccacac ttcaatgata tcctgggaca
     1201 acattcacgg aagcgctggg aaaactttat ccatagtgag aacaggcacc ttgtcagccc
     1261 ggaggcccta gatcttcttg acaagctcct gcggtacgac catcaacaga gattgaccgc
     1321 caaagaggcc atggagcacc catatttcta cccggtggtg aaggagcagt cccagccttg
     1381 tgctgagaac accgtgcttt ccagtggtct caccgcagca cgatgaagcc tggggaatcg
     1441 acggtctgtt gcggttcctc ccacttttcc ataagcagaa caagaaccaa atcaaaacgt
     1501 cttaacgcgt gtagcgagat cacgtcccga gagcagacac aaaatggtgg caggcttggc
     1561 gaacaggaac tagaccaccc gaagggcagc ccaccaccgt aaatcagacc tcacttccga
     1621 atgtaaaagg ttcacatgcc tttggcttcc tgttgacttc ctcccgaccc agaaagcatg
     1681 ggaaatgtga agggtatgca aaaatggttg ttggttactg ttgctccccg tgcccttgac
     1741 ccatcccatg gtcgcctgtc gctccagcaa accccaagga ctagctgacc acagactcca
     1801 cagacgggat gggagcagtg tatggcatga tgggcagtta catattattt taaaagtata
     1861 tatattattg aataaaacgt tttaaaagaa gtggatggag cgtatttagt gtgcaagggg
     1921 ccattgaccg agacctgtgg acagagagga ctgagtcacc agcgcactgt gccaagctct
     1981 aactagaggg aagcagggcc agggtggcat tgtcaggcag tggagtgaac agcctggctc
     2041 actgcatagg ctgggagagc ggggccgtgt cttgactgag gtccccatca gttgtccacc
     2101 cttacctctt ccaaatgagg agtggctcag tatttgaggg ggataagtgt ccccatggtg
     2161 acttcaggct ataagccacc ctttgctgtt tctctgctca cacctctaca ttttgttaca
     2221 ttgctcagtt aagcctactc ccttcggaag aaatgcctca gagtcctgga ggcaggttga
     2281 atctgctaac caatgagagg gaggagatca agcccaaagg tacttctcat cctgccctga
     2341 tactcgaggg aaaataggga gagcaacccc cacatgcatg catgcatgca tacatacata
     2401 catacataca tacatatgta catgcattac atacacacaa cggtctgcag tggaagccgt
     2461 taacaggaaa cagccagttg acagtgccct ttcaatgtcc tcagacgact gatcccagca
     2521 cagctatgca ggcgctgtaa ccacagctga gggatgacca acctggggtt tggctactgg
     2581 tcattctcat gctgcctata gatctagcac agaggcccta gcaggtttga ggccatcgag
     2641 aaggttgggg tgccagcttg ctcctcacaa ggaccacttg ctctgtattc ttctgccacg
     2701 cgttctgaat ggccatgcga atccaagtgt gaacactcag tattaaagtg attatgtggg
     2761 aaggaaacaa caggcctctc caaggccacc gtggtgtcag tgtccttgga ccccatttct
     2821 gtcagatctg gtcagttcac caggtgtgag accttaacac gccccacccc accccaacag
     2881 gggacaccag caagtaccct ccaggccact ggccatagac cagaaagcca atgggctaca
     2941 agcaccttgc cttggtttct ttctgtttgc ttgttttctt gaggcagggt ttctctgtgt
     3001 aaccttgact atcctggaac tcactcttga ccagtctggc ctcgaactca gagatcttcc
     3061 cacatctgcc tctagagtgt tgggatttaa gatgtgtgcc accaccaccc agctttgcct
     3121 tcatttctaa ccctacactg gcttactatc cttaagctgt ctcaggggag ccttttcaac
     3181 tcaaggctct agaaagtcca gtatcagttg ctcatccata cgctcttgca gatgtacata
     3241 gtgggtatgg gctgtctcca cagacctgtg cagatgtgca gggtctctgc tggacagatg
     3301 ggtgtggaga tccagcagtg ctcttaagga gccgggaagg ctagctttag tccttgggct
     3361 tctcctgctt tttagccctg gttctccttc atttcccagc gtgaaagtct tcctttcctg
     3421 aagtcccagg cctgtcagat actcaggttt tgtgggtggc aagaaaggaa aagagggaag
     3481 ggaaagaaag gggttcgggg gaagggggag gaaggagagt tttcacttga gctttgactt
     3541 tgagaagagt acctggaggc ccccacccac ccagaacccg agtagcccat ccaccgctca
     3601 cacggcctgt cagagaactc ttgccatctg cattagtcct gaatgacttc tgactgcttg
     3661 tagttatcaa gaggtaatag ttgttactat tacctccaag ccatactgtt gttcaatttg
     3721 atctttttgt ttgtttgttt caataaacct ttattatcta catttt
//
