LOCUS       NM_001416966            4442 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus casein kinase 2, alpha 1 polypeptide (Csnk2a1),
            transcript variant 3, mRNA.
ACCESSION   NM_001416966 XM_030247075
VERSION     NM_001416966.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4442)
  AUTHORS   Cruz-Gamero,J.M., Ballardin,D., Lecis,B., Zhang,C.L., Cobret,L.,
            Gast,A., Morisset-Lopez,S., Piskorowski,R., Langui,D., Jose,J.,
            Chevreux,G. and Rebholz,H.
  TITLE     Missense mutation in the activation segment of the kinase CK2
            models Okur-Chung neurodevelopmental disorder and alters the
            hippocampal glutamatergic synapse
  JOURNAL   Mol Psychiatry (2024) In press
   PUBMED   39367055
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4442)
  AUTHORS   Shu,C., Wang,S., Hu,J., Xu,M., Deng,H., Maimaiti,Y. and Huang,T.
  TITLE     CircNDST1 promotes papillary thyroid cancer progression via its
            interaction with CSNK2A1 to activate the PI3K-Akt pathway and
            epithelial-mesenchymal transition
  JOURNAL   J Endocrinol Invest 46 (3), 545-557 (2023)
   PUBMED   36306106
  REMARK    GeneRIF: CircNDST1 promotes papillary thyroid cancer progression
            via its interaction with CSNK2A1 to activate the PI3K-Akt pathway
            and epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 4442)
  AUTHORS   Merholz,M., Jian,Y., Wimberg,J., Gessler,L. and Hashemolhosseini,S.
  TITLE     In Skeletal Muscle Fibers, Protein Kinase Subunit CSNK2A1/CK2alpha
            Is Required for Proper Muscle Homeostasis and Structure and
            Function of Neuromuscular Junctions
  JOURNAL   Cells 11 (24), 3962 (2022)
   PUBMED   36552726
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4442)
  AUTHORS   Bertol,J.W., Johnston,S., Ahmed,R., Xie,V.K., Hubka,K.M., Cruz,L.,
            Nitschke,L., Stetsiv,M., Goering,J.P., Nistor,P., Lowell,S.,
            Hoskens,H., Claes,P., Weinberg,S.M., Saadi,I., Farach-Carson,M.C.
            and Fakhouri,W.D.
  TITLE     TWIST1 interacts with beta/delta-catenins during neural tube
            development and regulates fate transition in cranial neural crest
            cells
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35781329
REFERENCE   5  (bases 1 to 4442)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4442)
  AUTHORS   Hoffmann,U., Hecht,R., Boldyreff,B. and Issinger,O.G.
  TITLE     Characterization of the cDNA and three processed pseudogenes from
            the murine protein kinase CK2 alpha subunit
  JOURNAL   Biochim Biophys Acta 1260 (3), 337-340 (1995)
   PUBMED   7873611
REFERENCE   7  (bases 1 to 4442)
  AUTHORS   Seldin,D.C. and Leder,P.
  TITLE     Casein kinase II alpha transgene-induced murine lymphoma: relation
            to theileriosis in cattle
  JOURNAL   Science 267 (5199), 894-897 (1995)
   PUBMED   7846532
REFERENCE   8  (bases 1 to 4442)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   9  (bases 1 to 4442)
  AUTHORS   Boldyreff,B., Wehr,K., Hecht,R. and Issinger,O.G.
  TITLE     Identification of four genomic loci highly related to
            casein-kinase-2-alpha cDNA and characterization of a casein
            kinase-2-alpha pseudogene within the mouse genome
  JOURNAL   Biochem Biophys Res Commun 186 (2), 723-730 (1992)
   PUBMED   1497660
REFERENCE   10 (bases 1 to 4442)
  AUTHORS   Yang-Feng,T.L., Zheng,K., Kopatz,I., Naiman,T. and Canaani,D.
  TITLE     Mapping of the human casein kinase II catalytic subunit genes: two
            loci carrying the homologous sequences for the alpha subunit
  JOURNAL   Nucleic Acids Res 19 (25), 7125-7129 (1991)
   PUBMED   1766873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831735.10.
            
            On Feb 23, 2023 this sequence version replaced XM_030247075.2.
            
            Summary: Casein kinase II is a serine/threonine protein kinase that
            phosphorylates acidic proteins such as casein. It is involved in
            various cellular processes, including cell cycle control,
            apoptosis, and circadian rhythms. The kinase exists as a tetramer
            and is composed of an alpha, an alpha-prime, and two beta subunits.
            The alpha subunits contain the catalytic activity while the beta
            subunits undergo autophosphorylation. The protein encoded by this
            gene represents the alpha subunit. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4464783.1,
                                           SRR13422598.493637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AL831735.10        92636-93029
            395-604             AL831735.10        116200-116409
            605-716             AL831735.10        120008-120119
            717-818             AL831735.10        123176-123277
            819-869             AL831735.10        123739-123789
            870-929             AL831735.10        124474-124533
            930-1013            AL831735.10        126557-126640
            1014-1124           AL831735.10        128981-129091
            1125-1226           AL831735.10        138426-138527
            1227-1327           AL831735.10        139891-139991
            1328-1476           AL831735.10        141196-141344
            1477-1563           AL831735.10        142745-142831
            1564-4442           AL831735.10        144767-147645
FEATURES             Location/Qualifiers
     source          1..4442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..4442
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /note="casein kinase 2, alpha 1 polypeptide"
                     /db_xref="GeneID:12995"
                     /db_xref="MGI:MGI:88543"
     exon            1..394
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            395..604
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..1679
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     casein kinase II subunit alpha; casein kinase II, alpha 1
                     polypeptide; casein kinase II, alpha 1 related sequence 4"
                     /codon_start=1
                     /product="casein kinase II subunit alpha isoform 1"
                     /protein_id="NP_001403895.1"
                     /db_xref="GeneID:12995"
                     /db_xref="MGI:MGI:88543"
                     /translation="MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRK
                     LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK
                     DPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPH
                     NVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSL
                     GCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRH
                     SRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM
                     SSTSMAGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ"
     exon            605..716
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            717..818
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            819..869
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            870..929
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1013
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1124
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1226
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1327
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1476
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1563
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..4442
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4423..4428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /note="hexamer: AATAAA"
     polyA_site      4442
                     /gene="Csnk2a1"
                     /gene_synonym="CK II alpha; CK2; Csnk2a1-rs4"
                     /note="major polyA site"
ORIGIN      
        1 gggagggggc ttccgcttcc ggcagcggag gctgcagcct cgctctggtc cctgcggctg
       61 gcggccgagc cgtgtgtctc ctcctccgcc gccgccatat tgtctgtgtg aagctagggg
      121 agcgcggcta ttgccgctgc cgcttccacc gcaggtaccg tgggaaccgc gagccgaggt
      181 catcggggcg cgcgggtgag cccaggccga ggcagcaggg cgcggtcgcc ccgcacgctc
      241 tcagccgtct tccgagcggc ctgtcgcctc tccctacccc ctcaccgcac acagcagccg
      301 aggcccctgc agtccatccc ggctgcccga gaaagcgcag agcgaggcgg agggactggc
      361 tggttgcggg tgggagctgg ctgtcagact tcagtgtgaa gaaaaagggt ctgaaacaaa
      421 gtcttaccaa cgtctgcttt tgaacacagt gactgctgga tctttaaaca tcaagttcag
      481 ctttgtctgt caacctgtct gacatgtcgg gacccgtgcc aagcagggcc agagtttaca
      541 cagatgttaa cacacacaga ccccgagagt actgggatta tgaatcacat gtggtggaat
      601 gggggaatca agatgactat cagcttgttc gaaaattagg taggggcaaa tacagtgaag
      661 tgtttgaagc catcaacatc acaaataatg aaaaagttgt tgttaaaatt ctcaagccag
      721 taaaaaagaa gaaaattaag cgtgaaataa agattttgga gaatttgaga ggtgggccca
      781 acatcatcac acttgcagac attgtaaaag accctgtgtc acgaacccct gccttggttt
      841 ttgaacatgt aaacaacaca gacttcaagc aattgtacca gacgttaaca gactatgaca
      901 ttcgatttta catgtatgaa attctgaaag ccctggatta ttgtcacagc atggggatta
      961 tgcacagaga tgtgaaaccc cataatgtca tgattgatca tgagcacaga aagcttcggc
     1021 taatagactg gggtttagct gagttttacc atccaggcca agagtataat gtccgagttg
     1081 cttctcgata tttcaaaggt ccagagctac ttgtagatta tcagatgtac gattatagtt
     1141 tggatatgtg gagcttgggt tgtatgctgg ccagtatgat cttccggaag gagccatttt
     1201 tccatggaca tgacaattat gatcagttgg tgaggatagc caaggttctg ggaacagaag
     1261 atttatatga ctatattgac aagtacaaca ttgaattaga tccacgtttc aacgatatct
     1321 tgggcagaca ctcccgtaag cgatgggaac gctttgtcca cagtgaaaac cagcatcttg
     1381 tcagccctga ggccttggat tttctggaca agctgcttcg atatgaccac cagtcacggc
     1441 tcactgcaag agaggccatg gagcaccctt acttctacac tgttgtgaag gaccaggctc
     1501 gaatgagttc cactagcatg gcagggggca gcacacctgt cagcagcgcc aatatgatgt
     1561 cagggatttc ttcagtgcca actccttcac cccttggacc tctggcaggc tcaccagtga
     1621 ttgccgctgc caactcactt gggatacctg ttccagctgc tgctggcgct cagcagtaat
     1681 gacccccatc taccttctga tgcctgagca gaggtgggga agtccaccct ctcctcgatg
     1741 cagcttgcgc ctgtttggga ggggtgagaa cacttcagaa gcaccgtgtc tgaaccgttg
     1801 cttgtggatt tagtagttga gtcataaaaa aaaattatag gctgattttc tttctttctt
     1861 tctttctttt tttttttttt tttttttttt tttaaaacgt ggacttttca taactcaggg
     1921 gattccctga aaaaattacc tgcaggtgga atatttcatg gacaaaattt tttctcccct
     1981 tccaaattca gtttatcacc actaaagaac aaagataaac tggcctcagt cccagctgct
     2041 gcgtttgggt ggaaatttca tccccttccc acgttgctct ttccacattg tacactcttg
     2101 tggcttatat ctcatgttct tctccagaga ttgtaaactg tagctcatca ggggaggggg
     2161 ggggaggggg gaggacccag tccatcctac aacactgttc tgctggctgg ccacttcatc
     2221 tcttctctcc aggactgcag ccctggctta ctccggctct ggtggaggtg ggtctgtctt
     2281 atttacatca agatgttaaa agtctaccca atgtgcagac agatccaaag cttttttttc
     2341 tgaacgaatc atgtcttact aacctaaccc taaatgattt taattttagt tgagtttcta
     2401 tttgtgatac tttccctttc tgggctccta ctttggtctt tcccttttcg tctccagaca
     2461 tgctatgctt catagctgct aggagaggga aggcaaaatc tttttcagtt ttctttgact
     2521 tggccatttt gaagacagtt agttagtggg cataatttat tgctttttaa aaaagaaata
     2581 ttgtccatat aagtttcatg ctagcactct tatgagctaa tgggtgatgt ggccgcactg
     2641 ggttcatttt aagctttgtc ctttctcccc cctgccttgc cctttcttca catgccatcc
     2701 agtgaggagc cctgctctca gaattggaag tgtgtttttt gagaggcagg agcagagcca
     2761 ctatctccag tgaaccagag atggtagacc tgtaattgtg ggaaactatc agttctcttg
     2821 ttatggccct gccgttcctt gctgtgtgta tatatataat actttgtcct tcatatgtga
     2881 aagatccagt gttggaattc tttggtgtaa ataaacgttt ggttttattt atcaaggtta
     2941 gatttaagtt ccctgtgtaa aggtctcgct gggtgggtgt ctcattcaaa cctgagggga
     3001 ctacagccca gaccatggaa gcttcccaag gccctcattt ttatacaacc ctcatttgac
     3061 ccatggtact gggcagggca gagaggcctt aaaaaaagca ccacaagcca aagcgtctct
     3121 ggggattaag gatcctttgc cataaaactc attctgtgtc tcagcattgc agggattggg
     3181 gataggaaag gcgccagttt ttgtgtgttt gtgtgtgtat aaagtggact ttccactgta
     3241 atccagccac ctaagtttat caggtgcttc actgaggaag cctagttttt taagcacaat
     3301 agcaaaacat cagctctgta ttttctcctg ttatttcatt acagtagctg cctgtgggga
     3361 ctaggaaaac aaatcttcca acatatttta aggcctaaaa tcttagttcc ccattctcct
     3421 acctttttag attcataagc atttctcacc tggcatcata gataaaacat aattgtttgg
     3481 ggagttgaat ttaattaact tacctaactt tgtaacccat cttggcttta gtaactttat
     3541 caaggtggtg gctttagcga atgtaatgat aaaagtagag gatgctaatg cttttcttaa
     3601 catttctcaa ccatagagag agctaaaagg actgcagagt gagtttcttc tttttggcca
     3661 cttgcagtga ctatttattg tactcgattc ttgtgtgccc tagcgtgcta tgagggtcac
     3721 catgttggat ttgtgcagag ctgaaagcac caggtgtgcc agagatgcag tttgtgatta
     3781 tgtttgcact ggatcgtgat ttgaacaaga cacttagact gatgaattct ttcttttgag
     3841 gtggaaagga aagttgtaga tcaggactct acaccctgct cacagctcag aagtgtaggt
     3901 gtgtctgagg ctggtgtgga ccgctgtgga taactgggcc tcctcacaca tcaaacctgt
     3961 gcaagagctg agggtaatgc agaggactct ggtgtgccac cgaagagccc tttaaataaa
     4021 tcgaagctta aaagaaaaaa aggagtcatt gcagaaatgt ggagagtttt aaaagatctg
     4081 agtgggtggg gggtagggag ggtcagggtt tacagagtaa caacttctgt gttgtaaatt
     4141 acctcatctg tacaccttgt attgggacac tatttctcag cacttcctgt gtctgtattg
     4201 cttagacggc gggatggatg ccaatatgaa acagctgtgt tggcagttac tctgaaagta
     4261 ttttttaact ttgttttgaa gtgtgccctt ccccccttta agtttaaagt cagaattccc
     4321 ctccttgatt tattggctgt aattgtattg tatttggtat gactaagaca taactgtgct
     4381 gggaagaagt tgtgccatga aggtctttaa tttttttttt taaataaaaa catttaaatc
     4441 aa
//
