LOCUS       NM_001159591            2259 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus casein kinase 1, gamma 2 (Csnk1g2), transcript variant
            2, mRNA.
ACCESSION   NM_001159591
VERSION     NM_001159591.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   Li,D., Ai,Y., Guo,J., Dong,B., Li,L., Cai,G., Chen,S., Xu,D.,
            Wang,F. and Wang,X.
  TITLE     Casein kinase 1G2 suppresses necroptosis-promoted testis aging by
            inhibiting receptor-interacting kinase 3
  JOURNAL   Elife 9, e61564 (2020)
   PUBMED   33206046
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2259)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2259)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (bases 1 to 2259)
  AUTHORS   Mishra,S.K., Yang,Z., Mazumdar,A., Talukder,A.H., Larose,L. and
            Kumar,R.
  TITLE     Metastatic tumor antigen 1 short form (MTA1s) associates with
            casein kinase I-gamma2, an estrogen-responsive kinase
  JOURNAL   Oncogene 23 (25), 4422-4429 (2004)
   PUBMED   15077195
  REMARK    GeneRIF: CKI-gamma2 could further potentiate the ER corepressive
            function of MTA1s. Kinase dead CK1-gamma2 could not repress
            estrogen-induced ER transactivation functions.
REFERENCE   6  (bases 1 to 2259)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2259)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132871.1, AK152413.1 and CF612914.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon
            and lacks an in-frame internal segment in the CDS, as compared to
            variant 1. The resulting isoform (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132871.1, AK077076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1825              AK132871.1         2-1826
            1826-2233           AK152413.1         2002-2409
            2234-2259           CF612914.1         354-379
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2259
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /note="casein kinase 1, gamma 2"
                     /db_xref="GeneID:103236"
                     /db_xref="MGI:MGI:1920014"
     exon            1..75
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            76..503
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1564
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     CKI-gamma 2"
                     /codon_start=1
                     /product="casein kinase I isoform gamma-2 isoform 2"
                     /protein_id="NP_001153063.1"
                     /db_xref="CCDS:CCDS48638.1"
                     /db_xref="GeneID:103236"
                     /db_xref="MGI:MGI:1920014"
                     /translation="MDFDKKGGKGELEEGRRMSKTGTSRSNHGVRSSGTSSGVLMVGP
                     NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTTEGV
                     PQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKS
                     LIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY
                     MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI
                     EVLCESFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGYVFDYEYDWAGKPL
                     PTPIGTVHPDVPSQPPHRDKAQLHTKNQALNSTNGELNTDDPTAGHSNAPIAAPAEVE
                     VADETKCCCFFKRRKRKSLQRHK"
     exon            504..544
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            545..614
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            615..763
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            764..998
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1084
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1169
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1318
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1402
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1509
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2259
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1805..1810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /note="hexamer: CATAAA"
     polyA_site      1829
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /note="major polyA site"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /note="hexamer: AATAAA"
     regulatory      2220..2225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      2234
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
                     /note="major polyA site"
     polyA_site      2237
                     /gene="Csnk1g2"
                     /gene_synonym="2810429I12Rik"
ORIGIN      
        1 agggacttgg ggacctctgg cagaggagca gccagggccc cagcaagatg ggggacccca
       61 aaaagaacag ggcagctggg caccacaaga tttaaggcag tgggacctgt tggcagaatg
      121 tcttctctct ctgcaagcaa ccctgaagcc accaagatga gcaccccagt ccggcctgtg
      181 agcgtacccg ggtgtcaata gccgggagcc gaggggccac cgggagcaat ggtgtactag
      241 gccgggcgcg agctcaggtt tcgcactcgg atctcacggc agagtcaccg tggagaggcc
      301 agggtaccac aaacttatgg attttgacaa gaaaggaggg aagggggagt tggaggaggg
      361 caggagaatg tccaaaaccg gcacgagtcg gagcaaccac ggcgtccgca gttcggggac
      421 cagctcaggg gtcctgatgg tgggcccaaa cttccgagtc ggcaagaaga taggctgtgg
      481 gaacttcggg gagcttcgcc taggaaagaa tctgtataca aatgagtacg tggctatcaa
      541 gctggagccc atcaagtccc gggccccaca gctgcacctg gagtaccgct tttacaagca
      601 gctcagcacg acagagggcg tccctcaggt ctactacttc ggcccttgtg ggaagtacaa
      661 cgccatggtg ctggagctgc tggggcccag cctggaggac cttttcgacc tgtgcgaccg
      721 caccttcacg ctgaagacgg tgctgatgat cgccatccag ctgatcacgc gcatggagta
      781 cgtgcacacc aagagcctca tctaccgtga cgtgaagccc gagaacttcc tggttgggcg
      841 gccgggcagc aagcggcagc actccatcca catcatcgac tttgggctgg ccaaggagta
      901 catcgaccct gagactaaga agcacatccc atatcgcgag cacaagagcc tgacaggcac
      961 tgcgcgctac atgagcatca acacgcactt gggcaaagag cagagccgcc gggatgacct
     1021 ggaggcgctg ggacacatgt tcatgtactt cctgcgcggc agtctgccct ggcaggggct
     1081 caaggcagac acgctgaagg agcgctacca gaagattgga gacaccaagc gtgccacacc
     1141 aatcgaggtg ctgtgtgaga gcttcccgga ggagatggcc acctatttgc gctatgtgcg
     1201 gcgcctagac ttttttgaga agccagacta cgactacctg aggaagctct tcactgacct
     1261 ctttgaccgc agcggctacg tgtttgacta cgagtatgac tgggccggca agcccctgcc
     1321 gacacccatc ggcaccgtcc accctgacgt gccctcccag ccaccacatc gcgacaaagc
     1381 tcagctccac accaagaacc aggcgctcaa ctccactaat ggagagctga acacagacga
     1441 ccccaccgcg ggccactcca acgcccccat cgcggccccc gcagaagtag aggtggcaga
     1501 tgaaacaaag tgctgctgct tcttcaagag gagaaagaga aaatcgctgc agcgacataa
     1561 gtgagggtgg gtgcagccgc tcaagatccc caggcgggtg tctaggaaac tggcagtgtc
     1621 cttggtggtg tggggctcct tggcccacct gcaggcacca tctttcggga cttggggtcc
     1681 cttccttcac acaggacttt ggcggaaatc tctacacccg tgtctcatca tccccttcga
     1741 gagcattaac tatttaaacc caggagagaa gcgctgtgcc gtccctgctg cgcccctgtt
     1801 agctcataaa gtccagcttg tcccctcaat ccaaaggcca ttttctcgag gggggcaggc
     1861 ccggggcatg ggtgtcacat ggggaggcct cagccaccaa aggggaggcg cgtgcacttc
     1921 cacaatgctg caccaaagcc ggggcggagc gcgggacggt caccgcatag ggactggtat
     1981 gggccccaca gtaccagggc ggccgtgatc cgtgtccctg cgtgcagggc ccacgggaca
     2041 gaatcgcctt aacgccaggc ctggggcagc agagaggcgg tcccacagga gggccaggcc
     2101 ttggtcgtgg gaactgagtt cttgctttac gacgtgtaca gaaatgaact tatgtttctc
     2161 tggcgcttcc ttgaagccgt agagtttagg ggcttttttt aaaaaaaaaa ataaaagaaa
     2221 agaaaaacat cccagaatgt tggcctgggc tttaccatc
//
