LOCUS       NM_173185               7183 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus casein kinase 1, gamma 1 (Csnk1g1), mRNA.
ACCESSION   NM_173185
VERSION     NM_173185.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7183)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7183)
  AUTHORS   Lee,S.Y., Kim,H., Li,C.M., Kang,J., Najafov,A., Jung,M., Kang,S.,
            Wang,S., Yuan,J. and Jung,Y.K.
  TITLE     Casein kinase-1gamma1 and 3 stimulate tumor necrosis factor-induced
            necroptosis through RIPK3
  JOURNAL   Cell Death Dis 10 (12), 923 (2019)
   PUBMED   31801942
  REMARK    GeneRIF: Casein kinase-1gamma1 and 3 stimulate tumor necrosis
            factor-induced necroptosis through RIPK3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7183)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 7183)
  AUTHORS   Chergui,K., Svenningsson,P. and Greengard,P.
  TITLE     Physiological role for casein kinase 1 in glutamatergic synaptic
            transmission
  JOURNAL   J Neurosci 25 (28), 6601-6609 (2005)
   PUBMED   16014721
  REMARK    GeneRIF: CK1 regulates fast synaptic transmission by glutamate in
            brain. Activation of CK1 decreases NMDA receptor activity in the
            striatum via activation by this kinase of protein phosphatase 1
            &/or 2A & increased dephosphorylation of NMDA receptors.
REFERENCE   5  (bases 1 to 7183)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 7183)
  AUTHORS   Fujimoto,S., Morita,K., Kanaitsuka,T., Germeraad,W.T., Mazda,O. and
            Katsura,Y.
  TITLE     Nucleotide sequence of a cDNA encoding an alternative form of LEF-1
  JOURNAL   Nucleic Acids Res 21 (18), 4403 (1993)
   PUBMED   8415007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK090262.1, BC064645.1 and AC112676.8.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_173185.3.
            
            On Aug 3, 2005 this sequence version replaced NM_173185.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090262.1, SRR9219381.213911.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               AK090262.1         2-533
            533-1527            BC064645.1         549-1543
            1528-2606           AK090262.1         1529-2607
            2607-7183           AC112676.8         140013-144589
FEATURES             Location/Qualifiers
     source          1..7183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.6 cM"
     gene            1..7183
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /note="casein kinase 1, gamma 1"
                     /db_xref="GeneID:214897"
                     /db_xref="MGI:MGI:2660884"
     exon            1..159
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            160..208
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            209..601
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..1800
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /EC_number="2.7.11.1"
                     /note="casein kinase I, gamma 1; CKI-gamma 1"
                     /codon_start=1
                     /product="casein kinase I isoform gamma-1"
                     /protein_id="NP_775277.2"
                     /db_xref="CCDS:CCDS23300.1"
                     /db_xref="GeneID:214897"
                     /db_xref="MGI:MGI:2660884"
                     /translation="MDHSNREKDDRQRTTKTMAQRNTHCSRPSGTSTSSGVLMVGPNF
                     RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLP
                     QVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNL
                     IYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYVDPETKKHIPYREHKSLTGTARYM
                     SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIE
                     ALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFERKGYTFDYAYDWVGRPIP
                     TPVGSVHVDSGASAITRESHTHRDRPSQQQPLRNQTTSSERRGEWEIQPSRQTNTSYL
                     TSHLAADRHGGSVQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRK
                     RKKTAQRHK"
     exon            602..642
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..712
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            713..864
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1099
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1185
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1270
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1419
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1527
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1638
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1745
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..7183
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7152..7157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
     polyA_site      7178
                     /gene="Csnk1g1"
                     /gene_synonym="9130020E21Rik"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 tggtcttccc cctcccctcc gcctcctccg ctccctccgc tccctcccgc tcctgggaaa
       61 gcaaagctgc ggcttaaggg gtggttgaga gaagcagtag gcgcctcggg gaggggaccg
      121 cgcccgcccc cttggaacac tggagcaccg ctgatttagg aggacaggtg tgaggccagt
      181 gcacctttga cccaatgggg cttaactggt tacaaaatgt ccttctatgc atgagatcta
      241 cggactatat gttcttcaag aactgatcag tggttttcac cttctggaag aacactagaa
      301 gcataaatat ggtgccaaaa ctcctcattc tctgactgtg gtgatttgga catacttctg
      361 tgtggaggag aagtatacac gctgaggtca ctcattgttc agagactgtc gtgtaggaac
      421 atggaccatt ctaataggga aaaggatgat agacaacgga caactaaaac catggcacaa
      481 aggaatacac actgttcgag accatctggc acttcaacat cctctggggt tctcatggtg
      541 ggacccaact tcagggttgg caagaagata gggtgtggga acttcggaga gctcagatta
      601 ggtaaaaatc tctacaccaa tgaatatgta gccattaaac tggaaccaat aaaatcacgt
      661 gctccacaac ttcatttaga gtacaggttt tataaacagc ttggcagtgc aggtgaaggc
      721 ctcccacagg tttattactt tggaccatgt gggaagtaca atgccatggt gctggaactc
      781 cttggcccta gcttggaaga cttgtttgac ctctgtgacc gaacgtttac tttgaagacg
      841 gtgttaatga tagccatcca gttgctttct cgaatggagt atgtacactc aaagaatctt
      901 atttaccgag atgtcaaacc agagaacttc ttgattggcc gacaaggcaa taagaaagag
      961 catgtaatac acattataga ttttggactg gccaaggaat atgttgatcc tgaaaccaaa
     1021 aaacacatac cttacagaga gcacaaaagt ttgactggaa ctgcgagata catgtctatc
     1081 aacacacatc taggcaaaga gcaaagccgg cgagatgatt tggaagcctt aggccatatg
     1141 ttcatgtact tcctccgagg cagcctaccc tggcaaggac tcaaggctga tacattaaaa
     1201 gagagatatc aaaaaatcgg tgataccaaa aggaatactc ccatcgaagc tctctgtgag
     1261 aactttccag aggagatggc aacctacctt cgatatgtca ggcgattaga cttctttgaa
     1321 aaacctgatt atgagtattt acggaccctc ttcacagatc tgtttgaacg gaaaggctat
     1381 acctttgact atgcctatga ttgggttgga aggcctattc ctactccagt aggatcagtt
     1441 catgtagatt ctggtgcatc tgcaataact cgagaaagcc acacacacag ggatcggcca
     1501 tcacaacaac agcctcttag aaatcagact acatcatcag agcgccgagg agagtgggaa
     1561 atccagccca gccggcagac caatacctca tacctgacgt ctcacttggc cgcagaccgc
     1621 catgggggtt cagtacaggt ggttagctca accaatggag agctgaatgt cgatgacccc
     1681 actggagctc actccaatgc accaatcaca gctcatgccg aagtggaggt agtggaggaa
     1741 gctaagtgct gctgtttctt taagaggaaa aggaagaaga cagcccagcg acacaagtga
     1801 ccagtgcctc ccaggagtcc tcaagtcctg gggactctgg ctccaattgc acctgcagct
     1861 cctgccattt ctcattggaa gggactcctc tgtgggggag ggtagagatc caaaccaaaa
     1921 agaagaaaac agatgccccc agaaggagcc agtgcaggca gccagggccg agtgggccag
     1981 tggcaatccc ctctgtctga gctctgagcg ggtccagagc tgctgcttct ccactgcttg
     2041 cccttgggct atctggttga ctctcttccc attgtttaca gtgaaggtgt cattcacaaa
     2101 aactcaagga ctactattct cttcccccct ttttactcct ggctcttgca ccatcctcaa
     2161 ccctctccag cataaagaaa ctactaagct aaaggctcta tcaagaagct ggtggtgtgg
     2221 ccaagaagat aggggaagat gacagccctg ggctggagaa cttctccact tcccaggtgt
     2281 gtctggtagt gtggcttcct ctccctctgt gcctgggtaa cccctcagcc cagctggcca
     2341 cagggttcag gtcccttcct ttgtccttcc cttcctccct ccctccttcc ctcctgtgaa
     2401 gttacactgt aggacacaag ctgtgagcag tctgcagtct actgtccctg tgtgttggcg
     2461 ttcttagctt ttttgacaag cagatccctt gctccgggct gtagcaaaat atgcctgtgg
     2521 ttctgagcaa aggaaaggaa actgacttta ttgcactttt agttttttgg gtttttgttt
     2581 ttattttata aacaacatgg cagatgcata ttgtgtctgg ttatattggg gggtttgttt
     2641 tttttttttt tttctttttc aagggggatg ggccagccaa gccattcaga gaaaatgtgg
     2701 gtccagagga catttttgat ggaaagagtc tgatttgcag cacttggaag agaagaagcc
     2761 aaactctgcg tcatcctgag taatattcag gttggcaagg aaacatactt gaattttcat
     2821 tcatcttctc tgctgcagaa aaaagtccag agccctgacc taatcaatca gcccagacct
     2881 aatcaatcag cccagagctt gagcccagct cctgagcccg tgggatgagc accgagccag
     2941 actgtgacca accagaaggc acctcgtctc agagaggaga tactgaacaa caacaacaaa
     3001 gcaaatttct gtttcctcca ctgccaggga cttcctacta gatagccatg tgactttctg
     3061 ttgactcggg ggacaaaatt agtgactaaa cacccaccac cgtattgcca gtagtggaca
     3121 aaagaaggca ccacatttgc cttccaactg ccagaggagt ctcaggatgc agcatcctag
     3181 ggccaggaaa agaaaatatt ttctgtctgc ctgaagtgag ctagaacatg tgggtcagtc
     3241 tgccttagaa accatgcctg tgataatttt ggagcatatc catagcaaca ggcttagaac
     3301 gtggtacatg gggctgctgc aagcagagaa ggtaagattg gttggtgcta ggaaattcca
     3361 gggaaaagga aactgtaatg aaaggtctaa aattttatct aaacaatcga acagagactg
     3421 tccagacagt atgaccacat atcttagcat gttttccccg gtacacactc tatctgctac
     3481 ggtgaagcat cactggttgc acagttaaca gtgtgtgggg ttactcctcc catgttctat
     3541 tttatttgag attagtggca tttccagata gtaacttctt atgctagttg tggcaaaaag
     3601 gcttattcac gtgggtaaag aggtcttgtg tttgggtata aagaactaac caccgagagc
     3661 agtggctagt gacttagtac agcacagaac tctttgcttt tatatgtaga ggactggact
     3721 ggaagatgtc aggacacttg tggtcatgga tcaaatttag tatcaaatga agcagagttt
     3781 gtgcacctta cctgttctat tggactgtgg ctagggaatc tcctcactga cttcaaacct
     3841 ggttagcatt tgtaaatatt gccacctggc catttcttta caagaaatgt ttttgtctgt
     3901 gaatcagagt ggcagggaga agtcaggtca gaccccttcc ccataaggag ttggagtgtt
     3961 aggatttgct tcctttttac tatatagtag ttaaagctca tcactaacat ttatacagtc
     4021 cctcatttgg catgtgggca actctgactt cccctacaga aacttaaaag tctttatccc
     4081 aggaaatggt ggcaacctgg cactctctgc cctactaagt gcctccccca ccctgcttcc
     4141 aaggtaaagt aaaggcagtg accagcttgg ctgcagggtg ggatgccctg cagctgggct
     4201 taagacttct tttttgtctt aaaatatttt tataggctag ctcttgaggg gttaaacctg
     4261 agtggtttgt gtatgtgggg gagtgtcctt cctaatgcac tgttggcacc ctccagcacc
     4321 cacaaatccc ttactaggta tttgggtttt gtagcaaagg tccctttaac gtgcagggtg
     4381 gtggtgatcc tttcaaggcc agtgacacgc caaggtgatc ccaaacctga ggaattctca
     4441 tcttccttaa agttaaaata gaactaaatt cccccaaaac actcttctca tcatttcagc
     4501 ccccaccccc agcccagcac ttgaggcttc atgcacatcc ctgcttcttt tacctgcctg
     4561 actgcaagct cagcagatcc tcgggcacag gcaaccccct ccatctcctt gcatccaggt
     4621 ccacttgctc catctcaccc gacacttgag acagcaggca tttgatactg tactatctgg
     4681 agtttcctcg agctttgctg tccttgagac attgcagttt gagcagactg aggtccagcc
     4741 aggccagggt tacaccaggg tgtaaagtgt tcagtcatat aagtggattt tcagaattct
     4801 tgctccagac tgcccccaag gctgcactga atgtcccagc agctggtgaa cactcatgac
     4861 tgccttaaca ttcttctact tcgggtctgt ccaggagcaa acagggtctg tgaagatgtc
     4921 tgagtcaggc gactaggtaa gtctccagtt aaaagtccca tttcgattgg aacaaactgc
     4981 aggaaacagc aagtccccaa gatttctgaa agtgttcact tccttttcat ttttagtgaa
     5041 tgacaagaac tcagaagcac cccgtgtcca ttagccagat ggtgtacatc ttctgtaaaa
     5101 taacttccag tttagttcag aaggaaagtg tgctgtagtg cttatttagt gttgatgttc
     5161 aatgttagca accacttgaa ttgccagaag tatgctatgt taaagtggtt gctaaggatc
     5221 atagccttaa tttaaaaaaa aaaatgtaaa agataattca ttcccctcca tgttgagcta
     5281 gtatggctgc atttctcaag aataagtcca caggcgccta ggaagcattt cctcaaagga
     5341 acttggtctt aatttctctt gacccatccc tcccaagccc atatggctcc tgtgtcccag
     5401 ccacctcttc catgttcata agtgagacca gtttttcatg tctatttagt tgttctgatg
     5461 atgctttgtc tagtgtcggt cggtcatacc atgacctgaa tttgaagacc aggagtttgc
     5521 atggtcatat aaccaacatt gcctttgcca ggccactgcc accatccctc gattgcccca
     5581 ggtgggcagg ttgattccag agaccctcag ggagccagaa taactaggta cccatctgga
     5641 ttggccatgt gggtgatgag cacttatctc tggatttctt gattttgcag acttcaagga
     5701 agtccaggta gaggttgatg gccaatgact ccagccttcc ccatgatggg ttggtaggaa
     5761 tcaaattaga attcctttgt ttatcaggca actttgtttt aaggtggttt gttttttgat
     5821 tatgaaaagg aagaggccac catggccctt ctgtgagttt gtaagttttg agcagtgttt
     5881 tcatcaccag tcctgggagt ctctgatcca atcaccagtc tgaaggtgtt ttttcctact
     5941 tttgcaagta actaagtaca gaagaataga gttcttaatg tattcaaaat agtaagtaga
     6001 tccctgaata taggcaatag tagttgaaat attttctcag aaaaacaaaa caaccaggaa
     6061 acccactcca gtatttatag atcagattat caagggaaaa aagtgaatat gcactccata
     6121 tatctctagt tcagttacca aacttgatct tataaagaaa cctcagttgt atggacagaa
     6181 ttatccccct ccccaatctt tttctggtgc catcaccatc ttgaaggtct aagagccagg
     6241 aaacattgta gtcatctcag cagtgtgcag acagctgccg tcctggttac cccaagccca
     6301 cctttcaggg tcggtgaaac cttttggtgc ccctcttcag gagctccaga ccaaacccca
     6361 ggccactcca tgcaccaaaa gccttttaga aggcttccca gtctgttagg atgtctcagg
     6421 agacatgagc catttcgtgg gggatgcatg tactcacaga tggatgtgtg cactctgctt
     6481 tgtgggcttt cttctcagag acagcacagc tcctgcgaac tgatctcggt gagctgctca
     6541 gaccagcgag taagctggct ctgaggcaga gcagagaatg acaggaaaga tgaaaccaaa
     6601 aatgctataa ctctccaatg gaaagtaatg ttgatgcagc aattcccatt ggatgtatta
     6661 cactcttcta atttattgtt tgtctcttaa gttttaccca ttgtactctt tagaagatgt
     6721 taggatgttg gttgcaggtt ttttttttaa gtagatgatg tgggaatcag ttttaattca
     6781 tgtgtggatg tgtctagtta ttgttaaatg cccttttttt ctacttttta aaagatatgt
     6841 aatatttcat aatccctggc actggtcaaa aaaaaaacac agctgtgaaa agtaaaattg
     6901 tagtattttt taaatgaatg tcaatttcaa gtgtatttga aatgtttcct ccagtagaca
     6961 gatttgaaca ccgttggaaa agactccttt gcagaggaac tagcctttgg agaaaatgga
     7021 ctgtgggtct ggatatgtta tctcagagta gcccatttca tagggcaccg tgacaacaca
     7081 aatgtgatct ttaagtatac ctcttccccc tggggaggga aggacttagt ttgcaccctt
     7141 tttgtatgta aaataaaatg tcctaccttt cttggctact ttt
//
