LOCUS       NM_001411881            2846 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus casein kinase 1, epsilon (Csnk1e), transcript variant
            13, mRNA.
ACCESSION   NM_001411881 XM_011245649
VERSION     NM_001411881.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2846)
  AUTHORS   Ko,V.I., Ong,K., Kwon,D.Y., Li,X., Pietrasiewicz,A., Harvey,J.S.,
            Lulla,M., Bhat,G., Cleveland,D.W. and Ravits,J.M.
  TITLE     CK1delta/epsilon-mediated TDP-43 phosphorylation contributes to
            early motor neuron disease toxicity in amyotrophic lateral
            sclerosis
  JOURNAL   Acta Neuropathol Commun 12 (1), 187 (2024)
   PUBMED   39633494
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2846)
  AUTHORS   Ogasawara,J., Matsumoto,N., Takeuchi,Y., Yamashiro,K., Yasui,M. and
            Ikegaya,Y.
  TITLE     Lengthened circadian rhythms in mice with self-controlled ambient
            light intensity
  JOURNAL   Sci Rep 14 (1), 7778 (2024)
   PUBMED   38565587
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2846)
  AUTHORS   Torii,S., Arakawa,S., Sato,S., Ishikawa,K.I., Taniguchi,D.,
            Sakurai,H.T., Honda,S., Hiraoka,Y., Ono,M., Akamatsu,W., Hattori,N.
            and Shimizu,S.
  TITLE     Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the
            pathogenesis of familial Parkinson's disease caused by CHCHD2
  JOURNAL   EMBO Mol Med 15 (9), e17451 (2023)
   PUBMED   37578019
  REMARK    GeneRIF: Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in
            the pathogenesis of familial Parkinson's disease caused by CHCHD2.
REFERENCE   4  (bases 1 to 2846)
  AUTHORS   Zhou,L., Fitzpatrick,K., Olker,C., Vitaterna,M.H. and Turek,F.W.
  TITLE     Casein kinase 1 epsilon and circadian misalignment impact affective
            behaviours in mice
  JOURNAL   Eur J Neurosci 55 (9-10), 2939-2954 (2022)
   PUBMED   34514665
  REMARK    GeneRIF: Casein kinase 1 epsilon and circadian misalignment impact
            affective behaviours in mice.
REFERENCE   5  (bases 1 to 2846)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2846)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   7  (bases 1 to 2846)
  AUTHORS   Vielhaber,E., Eide,E., Rivers,A., Gao,Z.H. and Virshup,D.M.
  TITLE     Nuclear entry of the circadian regulator mPER1 is controlled by
            mammalian casein kinase I epsilon
  JOURNAL   Mol Cell Biol 20 (13), 4888-4899 (2000)
   PUBMED   10848614
REFERENCE   8  (bases 1 to 2846)
  AUTHORS   Lowrey,P.L., Shimomura,K., Antoch,M.P., Yamazaki,S.,
            Zemenides,P.D., Ralph,M.R., Menaker,M. and Takahashi,J.S.
  TITLE     Positional syntenic cloning and functional characterization of the
            mammalian circadian mutation tau
  JOURNAL   Science 288 (5465), 483-492 (2000)
   PUBMED   10775102
REFERENCE   9  (bases 1 to 2846)
  AUTHORS   Kusuda,J., Hirai,M., Tanuma,R. and Hashimoto,K.
  TITLE     cDNA cloning and chromosome mapping of the mouse casein kinase I
            epsilon gene (Csnk1e)
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 99-101 (1999)
   PUBMED   10640823
REFERENCE   10 (bases 1 to 2846)
  AUTHORS   Kusuda,J., Hidari,N., Hirai,M. and Hashimoto,K.
  TITLE     Sequence analysis of the cDNA for the human casein kinase I delta
            (CSNK1D) gene and its chromosomal localization
  JOURNAL   Genomics 32 (1), 140-143 (1996)
   PUBMED   8786104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165278.4.
            
            On Sep 8, 2022 this sequence version replaced XM_011245649.3.
            
            Summary: The protein encoded by this gene is a serine/threonine
            protein kinase and a member of the casein kinase I protein family,
            whose members have been implicated in the control of cytoplasmic
            and nuclear processes, including DNA replication and repair. The
            encoded protein is found in the cytoplasm as a monomer and can
            phosphorylate a variety of proteins, including itself. This protein
            has been shown to phosphorylate period, a circadian rhythm protein.
            Three transcript variants encoding two different isoforms have been
            found for this gene. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.14973940.1,
                                           SRR13422598.767068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AC165278.4         115083-115245       c
            164-251             AC165278.4         111927-112014       c
            252-362             AC165278.4         103210-103320       c
            363-511             AC165278.4         102867-103015       c
            512-740             AC165278.4         99414-99642         c
            741-911             AC165278.4         98655-98825         c
            912-1060            AC165278.4         97995-98143         c
            1061-1121           AC165278.4         94872-94932         c
            1122-1314           AC165278.4         93973-94165         c
            1315-1454           AC165278.4         93739-93878         c
            1455-1518           AC165278.4         93060-93123         c
            1519-2846           AC165278.4         91015-92342         c
FEATURES             Location/Qualifiers
     source          1..2846
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.71 cM"
     gene            1..2846
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /note="casein kinase 1, epsilon"
                     /db_xref="GeneID:27373"
                     /db_xref="MGI:MGI:1351660"
     exon            1..163
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            164..251
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1471
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /EC_number="2.7.11.1"
                     /note="isoform c is encoded by transcript variant 13; KC1
                     epsilon; CKI-epsilon"
                     /codon_start=1
                     /product="casein kinase I isoform epsilon isoform c"
                     /protein_id="NP_001398810.1"
                     /db_xref="GeneID:27373"
                     /db_xref="MGI:MGI:1351660"
                     /translation="MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKT
                     KHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
                     KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
                     THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKA
                     ATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNL
                     FHRQGFSYDYVFDWNMLKFMRPPFHQPPALPCGRPQDQLGCSPESRGCRPGKTGARTG
                     REDGAVARVRDQSPAPWPTYRGYRQPTPKCSRACGFHSSLPHPTNWQYFSQSDLTGRP
                     REEGEHETPQRCPCQCLLLRPHWAARGLPACSLTDKRAI"
     exon            252..362
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            363..511
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            512..740
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            741..911
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1060
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1121
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1314
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1454
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1518
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..2846
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /note="hexamer: AATAAA"
     polyA_site      2846
                     /gene="Csnk1e"
                     /gene_synonym="CK1epsilon; CKIe; KC1epsilon; tau"
                     /note="major polyA site"
ORIGIN      
        1 agggagcgcg cgagccggcg gcgggggcgg gcggcgggag gcggcggagc gcggagcctg
       61 agcccggccg ggccgagcgc agcgcagcgg gccggggaga ggctggcgcg cccgcggccc
      121 ggcgaatcct ctggcatccg ccccggcggg ccgccccggc gcgcaaggtt gaagcatgga
      181 gttgcgtgtg ggaaataagt atcgcctggg ccgaaagatc ggcagtggct cctttggaga
      241 catctacctg ggtgccaaca ttgcctctgg tgaggaagta gccatcaagc tcgaatgtgt
      301 gaagacgaaa catccccagc tccacatcga gagcaagttc tacaagatga tgcagggcgg
      361 agtggggatc ccgtccatca agtggtgcgg ggctgaggga gactataacg tgatggtcat
      421 ggagctgctg gggcccagcc tggaggacct cttcaacttc tgttcccgga agttcagcct
      481 caagacggtg ctgttgctgg ccgaccagat gatcagccgc atcgagtaca tacactccaa
      541 gaacttcatc caccgggatg tgaagcccga caacttcctc atgggcctgg ggaagaaagg
      601 caacctggtg tacatcattg acttcggcct ggccaagaag taccgcgatg cccgcacaca
      661 ccagcatatt ccctaccggg aaaacaagaa cctgaccggc actgcccgct atgcctctat
      721 caacacccac ctgggcattg agcaaagccg tcgagatgac ctagagagct tgggctatgt
      781 gctcatgtac ttcaacctgg gctccctgcc ctggcagggc ctcaaagcag ccaccaagcg
      841 tcagaagtac gagcggatta gcgagaagaa gatgtcaacg ccaatcgagg tcctctgcaa
      901 aggctacccc tccgagttct caacatacct caacttctgc cgctccctgc ggttcgatga
      961 taagcctgac tactcctacc tgcgccagct cttccgaaat ctctttcacc ggcagggttt
     1021 ctcctacgac tacgtcttcg actggaacat gctcaaattc atgcggcccc ccttccacca
     1081 gccccctgcc cttccctgtg gacggcccca ggaccagcta gggtgcagcc cggaatcccg
     1141 aggatgtaga ccgggaaaga cgggagcacg aacgggaaga gaggatgggg cagttgcgag
     1201 ggtccgcgac cagagccctg ccccctggcc cacctacagg ggctaccgcc aaccgactcc
     1261 gaagtgcagc cgagcctgtg gcttccactc cagcctcccg catccaacaa actggcaata
     1321 cttctcccag agcgatctca cgggccgacc gagagaggaa ggtgagcatg agactccaca
     1381 gaggtgcccc tgccaatgtc tcctcctcag acctcactgg gcggcaagag gtctcccggc
     1441 ttgcagcctc acagacaagc gtgccatttg accatcttgg gaaatgagga gagcgaccac
     1501 agaccagtgt ttgcttagtg tcttcactgc attttcttta aaaaaaaaaa aattaaatac
     1561 aaataagaga aaggacagaa agaaagaaca gttcacatga acaaaaaaga gaaaaacaaa
     1621 caaaccacaa aacccacaac ccagcacaaa gtcgacaatg gattttgttt ctttgattta
     1681 ttttgccaat ggcaaaaaga caagacctcg ttagcactga ggattcttgt tcccttgcct
     1741 tgcccactgc tcccgacctg aaggctgcca acactcctct aaggacactg ggtcacatgc
     1801 cagccacctg ttctcgccac cggccaccac gtgccgggcc gccatcggag gtgcctgaag
     1861 agcttgtgtc agggagcggt ttggccagtc agagacaagt cccaagagat ttcatggagc
     1921 cttggatgac acacacgcca tcagcccttg ggtgatgaca gtgaccagtg ttgtatgggg
     1981 ctttcccaga atccccttcc ctgagcatcc tggtctcccc cacacacacc tgtcacctct
     2041 ctacagagac cctgagggtg cggtgagatg gaggccatga tgccttgtgt gactgtgagt
     2101 gtgtgtgtgt atgcatgaga gagagagaga gagagagaga gagagagaga gagagactga
     2161 gagagagaga gagactgaga gactgactga gagactgact gagagactgc tgacttgtat
     2221 ttttcagagc tgcaggtggc ctgccacgcc tgcctggcca agtttctgtt cccctcctcc
     2281 taaagtcaag gtggggtgga caatgacttc cacatccctc agggcataga gtccttgcca
     2341 ccacctgtcc ccagatgcca gtgtgtggca cccctccccc cccaacttcc attcctgatc
     2401 ttaggcaagt tcttggagtc tgctcccaga tggcatcggc tctgagatac cggttacttc
     2461 cctggtcctg agagtcacct gtggtcaccc ctcttcccag gcctgacttc tgagtaggac
     2521 cctgggtcag ggctaagtgt tgaatttacc cttcctggtt aacacctgtt ttgttggttt
     2581 ttttattatt attattatta ttatttttgt ttgttttctc agtgtgtgta tttcctaatt
     2641 tatttacctc tttttttccc ctttctttct tttttttaat taaagagcaa aactttttat
     2701 tactttgtaa tttaaaaaac tgaaaaaaaa attactgaag aactttgggg ggaattttgt
     2761 acttttttcc tgtgtaaata ttggactttt ttgagcttta ttgtggttgt taatttgaag
     2821 taataaagta gaaaaggaca aagtga
//
