LOCUS       NM_139059               3399 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus casein kinase 1, delta (Csnk1d), transcript variant 1,
            mRNA.
ACCESSION   NM_139059
VERSION     NM_139059.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3399)
  AUTHORS   Torii,S., Arakawa,S., Sato,S., Ishikawa,K.I., Taniguchi,D.,
            Sakurai,H.T., Honda,S., Hiraoka,Y., Ono,M., Akamatsu,W., Hattori,N.
            and Shimizu,S.
  TITLE     Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the
            pathogenesis of familial Parkinson's disease caused by CHCHD2
  JOURNAL   EMBO Mol Med 15 (9), e17451 (2023)
   PUBMED   37578019
  REMARK    GeneRIF: Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in
            the pathogenesis of familial Parkinson's disease caused by CHCHD2.
REFERENCE   2  (bases 1 to 3399)
  AUTHORS   Tsuno,Y., Peng,Y., Horike,S.I., Wang,M., Matsui,A., Yamagata,K.,
            Sugiyama,M., Nakamura,T.J., Daikoku,T., Maejima,T. and Mieda,M.
  TITLE     In vivo recording of suprachiasmatic nucleus dynamics reveals a
            dominant role of arginine vasopressin neurons in circadian
            pacesetting
  JOURNAL   PLoS Biol 21 (8), e3002281 (2023)
   PUBMED   37643163
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3399)
  AUTHORS   Maejima,T., Tsuno,Y., Miyazaki,S., Tsuneoka,Y., Hasegawa,E.,
            Islam,M.T., Enoki,R., Nakamura,T.J. and Mieda,M.
  TITLE     GABA from vasopressin neurons regulates the time at which
            suprachiasmatic nucleus molecular clocks enable circadian behavior
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33526663
REFERENCE   4  (bases 1 to 3399)
  AUTHORS   Masuda,S., Narasimamurthy,R., Yoshitane,H., Kim,J.K., Fukada,Y. and
            Virshup,D.M.
  TITLE     Mutation of a PER2 phosphodegron perturbs the circadian
            phosphoswitch
  JOURNAL   Proc Natl Acad Sci U S A 117 (20), 10888-10896 (2020)
   PUBMED   32354999
REFERENCE   5  (bases 1 to 3399)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3399)
  AUTHORS   Yu,S. and Roth,M.G.
  TITLE     Casein kinase I regulates membrane binding by ARF GAP1
  JOURNAL   Mol Biol Cell 13 (8), 2559-2570 (2002)
   PUBMED   12181329
REFERENCE   7  (bases 1 to 3399)
  AUTHORS   Akashi,M., Tsuchiya,Y., Yoshino,T. and Nishida,E.
  TITLE     Control of intracellular dynamics of mammalian period proteins by
            casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells
  JOURNAL   Mol Cell Biol 22 (6), 1693-1703 (2002)
   PUBMED   11865049
REFERENCE   8  (bases 1 to 3399)
  AUTHORS   Ishida,Y., Yagita,K., Fukuyama,T., Nishimura,M., Nagano,M.,
            Shigeyoshi,Y., Yamaguchi,S., Komori,T. and Okamura,H.
  TITLE     Constitutive expression and delayed light response of casein kinase
            Iepsilon and Idelta mRNAs in the mouse suprachiasmatic nucleus
  JOURNAL   J Neurosci Res 64 (6), 612-616 (2001)
   PUBMED   11398185
REFERENCE   9  (bases 1 to 3399)
  AUTHORS   Vielhaber,E., Eide,E., Rivers,A., Gao,Z.H. and Virshup,D.M.
  TITLE     Nuclear entry of the circadian regulator mPER1 is controlled by
            mammalian casein kinase I epsilon
  JOURNAL   Mol Cell Biol 20 (13), 4888-4899 (2000)
   PUBMED   10848614
REFERENCE   10 (bases 1 to 3399)
  AUTHORS   Leimeister,C., Bach,A., Woolf,A.S. and Gessler,M.
  TITLE     Screen for genes regulated during early kidney morphogenesis
  JOURNAL   Dev Genet 24 (3-4), 273-283 (1999)
   PUBMED   10322635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662887.13 and AL662901.18.
            
            On Nov 15, 2022 this sequence version replaced NM_139059.2.
            
            Summary: This gene encodes a member of the casein kinase I (CKI)
            family of serine/threonine protein kinases. A highly similar human
            protein regulates an array of cellular processes by influencing the
            Wnt and hedgehog signaling pathways. The encoded protein may also
            be involved in the regulation of apoptosis, circadian rhythm,
            microtubule dynamics, chromosome segregation, and p53-mediated
            effects on growth. Alternatively spliced transcript variants
            encoding different isoforms have been described. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088642.1, AK152721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AL662887.13        24076-24200         c
            126-236             AL662887.13        16374-16484         c
            237-385             AL662887.13        6962-7110           c
            386-614             AL662887.13        6107-6335           c
            615-785             AL662887.13        5518-5688           c
            786-934             AL662887.13        4708-4856           c
            935-1106            AL662887.13        2164-2335           c
            1107-1246           AL662901.18        49900-50039         c
            1247-3399           AL662901.18        43659-45811         c
FEATURES             Location/Qualifiers
     source          1..3399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.75 cM"
     gene            1..3399
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /note="casein kinase 1, delta"
                     /db_xref="GeneID:104318"
                     /db_xref="MGI:MGI:1355272"
     exon            1..125
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1297
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 1 is encoded by transcript variant 1; CKId;
                     CKI-delta; tau-protein kinase CSNK1D"
                     /codon_start=1
                     /product="casein kinase I isoform delta isoform 1"
                     /protein_id="NP_620690.1"
                     /db_xref="CCDS:CCDS25762.1"
                     /db_xref="GeneID:104318"
                     /db_xref="MGI:MGI:1355272"
                     /translation="MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKT
                     KHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
                     KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
                     THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKA
                     ATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNL
                     FHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRL
                     RGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDT
                     SRMSTSQIPGRVASSGLQSVVHR"
     exon            126..236
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            237..385
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            386..614
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            615..785
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            786..934
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1106
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1246
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..3399
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3378..3383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3399
                     /gene="Csnk1d"
                     /gene_synonym="1200006A05Rik; D930010H05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcagacccag gaagcggccg ggcgggcagt agcgagccgc accgctgcca tggagctgag
       61 ggtcgggaac aggtaccgac tgggccgcaa gatcggcagc ggctccttcg gagacatcta
      121 tctcggtacg gacattgctg cgggagaaga agttgccatc aagcttgaat gtgtcaaaac
      181 caaacatcct cagctccaca ttgagagcaa gatctacaaa atgatgcagg gaggagtggg
      241 catccctacc atcagatggt gtggggctga gggggactac aatgtcatgg tgatggagct
      301 actgggaccc agcctggaag acctgttcaa cttctgttca aggaagttta gtctcaaaac
      361 tgttctgttg cttgctgacc aaatgataag tcgtattgag tacattcatt cgaagaattt
      421 tatccaccga gatgtgaagc cagataactt cctcatgggg ctgggaaaga aaggcaacct
      481 ggtctacatc attgactttg ggctggccaa gaagtatcgg gatgcacgca cccaccagca
      541 tatcccctat cgagagaaca agaacctcac agggacagca cgctatgcct ccatcaacac
      601 gcaccttggc attgaacaat ctcgaaggga tgacttggag tctctggggt acgtgctgat
      661 gtacttcaac ctgggctctc tcccctggca ggggctgaag gccgccacca agaggcagaa
      721 gtatgagagg atcagtgaga agaagatgtc cactcccatt gaagtgctgt gcaagggcta
      781 tccttctgaa tttgccacat acctgaattt ctgccgttcc ttacgttttg atgacaaacc
      841 tgactactcc tacctgagac agctcttcag aaatctgttc catcgccaag gcttctccta
      901 cgactatgtg ttcgactgga acatgctcaa atttggtgcc agccgggctg cagatgatgc
      961 tgagcgggaa cgccgggatc gagaagaacg attaagacac tcccggaatc cagccactcg
     1021 tggcctccct tctacagctt ccggccgtct gcggggaacc caggaagtgg ctcccccaac
     1081 gccccttacc cctacctcac acacggccaa cacctctccg aggcctgtct ctggcatgga
     1141 acgagaacgg aaagtgagta tgcggctgca ccgtggggcc ccagtcaacg tctcctcatc
     1201 tgatctcacg ggccgacaag atacctctcg catgtccacc tcacagattc ccggtcgggt
     1261 ggcttccagt ggtcttcagt ctgtcgtgca ccgatgagaa ctctcctttt tgctgtgaag
     1321 ggcagacaat gcatggctga tctactctgt taccaatggc tttactagtg acacgccccc
     1381 cggtctaaac ctgaaatgtt aacgccggga gctctccagg ccactcaccc agcgatgcac
     1441 atggggaatc aaaacacaaa ctaaatggac aggctccaag agctgccatc gccaggggct
     1501 gccaccgtgg ccccgtgtga gctcagttat catggggctg ggacgaagag cagaggctgg
     1561 gagaccattg cagagagaac ccgactccct gtgaagagcc tctcagctcc caccagtggt
     1621 ggcggacctg cgctccctga tgatcccacc gcagctacca gtcttctact tggttaagac
     1681 agttttgtat cattttgcta aaaattactg gcttaaatct gtgtaaagaa atctgtcttt
     1741 ttattgtttc tttcttgtct gtttttgcgg tcttaaacaa agaaggatgt tgaccttaaa
     1801 gaatcctaag acacgctggc ttggagcttc tatgtaaaat ggaggcaggc aagagagggg
     1861 cacatgtgag tgttgaggat gtgtgtggtg ttctgttttg ttttctcatg ttgtgctgtt
     1921 cactttggaa aggaacttct catcagttgt gtatgtgtgt gcgtgtgcgc gtgtgcgtgt
     1981 gtgtcttgtg gctcccatca gcctaatttg ggcatcttgc ttactctttc ccactgtaaa
     2041 ctgatagcct gcagtcatca gagcaggtac aactgccatg gcgtgagggc tcacagttac
     2101 agcctcagca aagcaccacg gcctggcagt cctcccaaag gaggcagaag gaagtcagag
     2161 ctgaagaacc cacatgctgg gacggggggc ccctctaggc tgctggagag ctccaagatt
     2221 caaagctgag cttgtgtttg tggtttctag ggagaggatt gctgttggta ggattggttt
     2281 cctctatgcc tttgaacttg ggaagttgca gaatagactg aatagtctca tgcagatgcc
     2341 atttgggttt gtcatgggct ctctgctcag agccagggag ctggctgtcc tagaaacaca
     2401 ccatggtttg cccagaggga ccagtggcca aagggaatca accctgaagt gccaagaagc
     2461 aggtaactgc ctatctgact ctaaaacaaa ccttcacctc cacatgctgc gtgacctcca
     2521 gaaaggtgtg gtgccacaca ctgcgtggtc ttcagctgga cacactgcgg gctgggctgc
     2581 tctgccgctg gcggttagga tgccaccatg ctcttcccca ccatgtgcac cggatatgaa
     2641 gagacggcag gacctgagct ccccatctga gaagtgggtg cagtacatgt gtgtgggtcc
     2701 atctctgatt ttccctgtca gcctatggag agttatgctg gttacctcgc tcccttggag
     2761 gtttggctct aatggtgcca ccatggcttc tcccttcttc ccagagttcc ctggctctga
     2821 gcactggccc ggggttggga gggacacact gctgatgtgt gatatagcac ctcagaatgt
     2881 ggctgttaat tgtgcctgcc agccatctga gcctgtgggt gctgatttct gaatcctgaa
     2941 ctggttactc tgcaagcatt ttagggtgca gagacttgac tccgtgggac tgtgtgtcta
     3001 ggagtgcaga gggaggttgg gagggtcggg cgagtttgag atttttgttg caaatccttt
     3061 atcagagttg gtcctcccct ctccagtggc aggcctgccc ggcaagtgtt cttgttgata
     3121 cctgtggttc tggaggggta tggggtggcc ttgagactaa tccaggttca gcctggccct
     3181 gctgggttgt gccgagacta ggaccattgg aagtcctcca gggtgtgttc tgacggttct
     3241 tgcccgatat gtaatcccat cgtcactcgc aggaagcgta gttagaatgt gtgtatcaac
     3301 ctgtgtcttg gtgaccagtc tctgagctgt gcgtttgtac taccactgta tttgtgtact
     3361 ttaacaattg tgtaaataat aaattcataa tgacttcta
//
