LOCUS       NM_001357500            4393 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus casein kinase 1, alpha 1 (Csnk1a1), transcript variant
            4, mRNA.
ACCESSION   NM_001357500 XM_006526388
VERSION     NM_001357500.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4393)
  AUTHORS   Melendez,R.A., Wynn,D.T., Merugu,S.B., Singh,P., Kaplan,K.P. and
            Robbins,D.J.
  TITLE     Exploring the role of casein kinase 1alpha splice variants across
            cancer cell lines
  JOURNAL   Biochem Biophys Res Commun 723, 150189 (2024)
   PUBMED   38852281
  REMARK    GeneRIF: Exploring the role of casein kinase 1alpha splice variants
            across cancer cell lines.
REFERENCE   2  (bases 1 to 4393)
  AUTHORS   Luo,X., Zhang,D., Zheng,J., Liu,H., Sun,L., Guo,H., Wang,L. and
            Cui,S.
  TITLE     Casein kinase 1alpha mediates estradiol secretion via CYP19A1
            expression in mouse ovarian granulosa cells
  JOURNAL   BMC Biol 22 (1), 176 (2024)
   PUBMED   39183304
  REMARK    GeneRIF: Casein kinase 1alpha mediates estradiol secretion via
            CYP19A1 expression in mouse ovarian granulosa cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4393)
  AUTHORS   Fuchs,S.N.R., Stalmann,U.S.A., Snoeren,I.A.M., Bindels,E.,
            Schmitz,S., Banjanin,B., Hoogenboezem,R.M., van Herk,S., Saad,M.,
            Walter,W., Haferlach,T., Seillier,L., Saez-Rodriguez,J.,
            Dugourd,A.J.F., Lehmann,K.V., Ben-Neriah,Y., Gleitz,H.F.E. and
            Schneider,R.K.
  TITLE     Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53
            in Myc induction can promote leukemic transformation
  JOURNAL   Blood Adv 8 (3), 766-779 (2024)
   PUBMED   38147624
  REMARK    GeneRIF: Collaborative effect of Csnk1a1 haploinsufficiency and
            mutant p53 in Myc induction can promote leukemic transformation.
REFERENCE   4  (bases 1 to 4393)
  AUTHORS   Zhang,D., Lu,C., Zhou,Y., Luo,X., Guo,H., Zhang,J., Gao,Q., Liu,H.,
            Shang,C. and Cui,S.
  TITLE     CK1alpha deficiency impairs mouse uterine adenogenesis by inducing
            epithelial cell apoptosis through GSK3beta pathway and inhibiting
            Foxa2 expression through p53 pathwaydagger
  JOURNAL   Biol Reprod 110 (2), 246-260 (2024)
   PUBMED   37944068
  REMARK    GeneRIF: CK1alpha deficiency impairs mouse uterine adenogenesis by
            inducing epithelial cell apoptosis through GSK3beta pathway and
            inhibiting Foxa2 expression through p53 pathwaydagger.
REFERENCE   5  (bases 1 to 4393)
  AUTHORS   Pan,M., Hu,T., Lyu,J., Yin,Y., Sun,J., Wang,Q., Xu,L., Hu,H. and
            Wang,C.
  TITLE     CSNK1A1/CK1alpha suppresses autoimmunity by restraining the
            CGAS-STING1 signaling
  JOURNAL   Autophagy 20 (2), 311-328 (2024)
   PUBMED   37723657
  REMARK    GeneRIF: CSNK1A1/CK1alpha suppresses autoimmunity by restraining
            the CGAS-STING1 signaling.
REFERENCE   6  (bases 1 to 4393)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4393)
  AUTHORS   Zhang,Y., Qiu,W.J., Chan,S.C., Han,J., He,X. and Lin,S.C.
  TITLE     Casein kinase I and casein kinase II differentially regulate axin
            function in Wnt and JNK pathways
  JOURNAL   J Biol Chem 277 (20), 17706-17712 (2002)
   PUBMED   11884395
  REMARK    GeneRIF: Casein kinase I and casein kinase II differentially
            regulate axin function
REFERENCE   8  (bases 1 to 4393)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   9  (bases 1 to 4393)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
REFERENCE   10 (bases 1 to 4393)
  AUTHORS   McInnes,C. and Leader,D.P.
  TITLE     Tissue-specific distribution of mouse casein kinase I alpha mRNA
  JOURNAL   DNA Seq 8 (1-2), 55-57 (1997)
   PUBMED   9522121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153155.6 and AI853067.1.
            
            On Oct 28, 2017 this sequence version replaced XM_006526388.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.592029.1, AK078398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               AC153155.6         167476-168076
            602-708             AC153155.6         168706-168812
            709-835             AC153155.6         180467-180593
            836-934             AC153155.6         181667-181765
            935-1074            AC153155.6         187613-187752
            1075-1153           AC153155.6         188710-188788
            1154-1228           AC153155.6         189381-189455
            1229-1335           AC153155.6         190870-190976
            1336-1484           AC153155.6         192542-192690
            1485-4369           AC153155.6         199629-202513
            4370-4393           AI853067.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..4393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.62 cM"
     gene            1..4393
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /note="casein kinase 1, alpha 1"
                     /db_xref="GeneID:93687"
                     /db_xref="MGI:MGI:1934950"
     exon            1..601
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..1492
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /EC_number="2.7.11.1"
                     /note="isoform 4 is encoded by transcript variant 4; CK1;
                     CKI-alpha; casein kinase I-alpha"
                     /codon_start=1
                     /product="casein kinase I isoform alpha isoform 4"
                     /protein_id="NP_001344429.1"
                     /db_xref="CCDS:CCDS89254.1"
                     /db_xref="GeneID:93687"
                     /db_xref="MGI:MGI:1934950"
                     /translation="MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA
                     VKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFN
                     FCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGL
                     AKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTS
                     LPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMY
                     LRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNM
                     KGF"
     exon            602..708
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            709..835
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            836..934
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1074
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1153
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1228
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1335
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1484
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..4379
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2339..2344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /note="hexamer: ATTAAA"
     regulatory      2346..2351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /note="hexamer: ACTAAA"
     polyA_site      2356
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /note="major polyA site"
     polyA_site      2365
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /note="major polyA site"
     regulatory      4100..4105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /note="hexamer: AATAAA"
     polyA_site      4122
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
     regulatory      4353..4358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
                     /note="hexamer: AATAAA"
     polyA_site      4379
                     /gene="Csnk1a1"
                     /gene_synonym="2610208K14Rik; 4632404G05Rik;
                     5430427P18Rik; CK1a; Csnk1a"
ORIGIN      
        1 agagtgctcc gcgccgtgaa gaagcggctc ccggggactg ggggcatttt gtgttggctg
       61 gagctagagt aacaagatgg cggcctcggc ggagtgacgg cttccctccg ggccggagcc
      121 ggcggcagtg gtggcagcgg taccgcccgc cctcgttcac cgcgcccctt tcccagcccg
      181 cgacgtcgcc gcgaccacga aaaaaaatca gcggcggccg cccgagaaca acaagcggcc
      241 gagcttcagc agccgcgacc acccttcacg aaccgcggcc tggcccttca gcgagcggcg
      301 gcggcggcga tccggcttct ctctgccgcc tgtgcgcccc gtgacgccga cagagccttg
      361 ggtttaggtt gcccgccgcg cttctcactt ctgccgcggg tggaacagcc ccggaggctt
      421 ccatcctctt cctgaggtgt cggggctcgg ccccccgcct ccatcttcgc gtctcaggat
      481 ggcgagcagc agcggctcca aggccgaatt tatcgtcggt ggaaaataca aactggtgcg
      541 gaagatcgga tctggctctt tcggggacat ttatctagcg atcaacatca ccaatggcga
      601 ggaagtggca gtgaaactag aatcccagaa ggccaggcat ccccagttgc tgtacgagag
      661 caaactgtat aagattcttc aaggtggggt tggcatccct cacatacggt ggtatgggca
      721 agaaaaagac tataatgtac tagtcatgga tctcctggga cccagccttg aagacctctt
      781 caacttctgt tcaaggaggt tcactatgaa gaccgtactt atgttagctg accagatgat
      841 cagtagaatt gaatatgtgc atacaaagaa ttttatacac agagacatta aaccagataa
      901 cttcctaatg ggtattgggc gtcactgtaa taagttattc cttattgatt ttggtttggc
      961 caaaaagtac agagacaaca ggacaaggca acacatacca tacagagaag ataaaaacct
     1021 cactggcact gcccgatacg ccagcatcaa tgcacatctt ggtattgagc agagtcgccg
     1081 agatgacatg gaatctttag gatatgtttt gatgtatttt aatagaacca gtctgccgtg
     1141 gcaaggactg aaggctgcaa caaagaaaca aaaatatgaa aagattagtg aaaagaagat
     1201 gtccactcct gttgaggtgt tgtgtaaggg gtttcctgca gaatttgcca tgtacttaaa
     1261 ttactgtcgt gggctgcgct ttgaggaagc tccggattac atgtatctga ggcagctatt
     1321 ccgcatcctt ttcaggaccc tgaaccacca atatgactac acatttgatt ggacgatgtt
     1381 aaagcagaaa gcagcccagc aggcagcctc ttccagtggg cagggtcagc aggcccaaac
     1441 ccccacaggc aagcaaactg acaaaaccaa gagtaacatg aaaggtttct aagcatgaat
     1501 tgtggaagag aagcagcaga gcagacgatt ggagcagcgt ttgtttctcc ccaaacctag
     1561 acattttagt tcatatgtac actagccagt ggttgtggac aaccatttac ttggtgtaaa
     1621 gaacttcatt tcggtataaa ctggctctgg gtagcactgc ggatcctgag ctgtagccac
     1681 tgtccttgtg aatattaact gaggtagtga aacatggtgt ccggttttct attgcatttt
     1741 ttttcaagtg gaaaagttaa ctaaatggtt gacacacaaa ttggtggaga aattgtgcat
     1801 atgccaattt ttattttatt tttttgttaa aatcttttat tttgaactat actgctttga
     1861 gatctcattt cagaagaacg gcatgaacag tcttcagcca cagttgtgat ggttgtaaat
     1921 gttcacaatt gtgtgttctt agggttttcc atccctgggg tttgcaagtt gttaacttaa
     1981 aacattcttt aaatggctgg cttcttgttt gcaagccagc tgatatggta gcaaccaaag
     2041 attccagtgt ttgagcattt gaaagactct gcctgcttac ctgtgctaga aataacagca
     2101 tctaaagtga agacttaaga aaaaaaacat agcgactact agattctctt taggactctg
     2161 cattaactct ataatgttct tgctattaaa aaaaagcata tttgtcacgg aaatttagtt
     2221 accgtcttac aactgaacat gtatgtgtgt tgcttagata aatgtaatca ctgtaaacat
     2281 ctatacgatc tgggattttg tttttatttt gaaatgggag ctttttgttt acaagttcat
     2341 taaaaactaa aaactgtttc tgtaaggaag tgaaattttt ttaaacaaca aaatgccttg
     2401 gctgactcac tatgaagtgt gtgtgtgtgt gtgtgtacat atatatacat atatatgcac
     2461 acatatatat accatcccca gttttttgtt ttgttttata ttttgagaca gagtctcatt
     2521 ttgtagctct agctggcctg gaactttata gatcaggctg gcctagaact ctcagatcct
     2581 cctgactctg cctctctaaa gagctgggac tgaaaaaaat gagccaccat gtccagcttt
     2641 ccctaatttt ttgatagact acttcaagcc atttgttata tgatattcct ttgctgcaaa
     2701 aggtttggtt ttgggttttt gggggggggg ggctgttctt gatctgaaga gaaaggtatt
     2761 ctttggcttt ctgtttgtag ctcacaggca cactaccccg tgctacagct gtgggagctt
     2821 tggcattgac ttctgccgcc actgactagc agatgaactg atgacagtga aagtgttaaa
     2881 gggtttaact atattacaaa atatgtttct tcaaaatccc tgtgaaatgg ctgtaaggtt
     2941 gtcatacagt gtgaagttag tgattgttga tcctcaagcc ccacctctct aagtacctgt
     3001 gcacgcttcc cccagtcttt cttggttgct cttcagttgt ttctctgatc caagagaagg
     3061 aaaaacttac agtaattctt taaatggtgt aatttattca tttacagcat gtcaagataa
     3121 attaaaaaga aaatttgtct gaaaatgctg ccaggagcct attgtgtaac taggtgttgt
     3181 gtataatctt gaattgtaaa ttgacccatg tttggtaaga ttgtatcaga attgatttgt
     3241 agtagttttc cttttcttct cccccccccc cttttttttg aaacagcaat aattaactcc
     3301 atgattgcca cattctgtca ccaagagatg tgttattacc gtaaagctga aataatcttc
     3361 tgaggtggat ctgatggtgg ggtggcagct tcatgcttgt cagtttcttg actaataaac
     3421 cctttgatac ttttagcggg aaatcagtct cataaagcta ttttgagtat agtttgtgta
     3481 aaataaaact gttcagcttt ggcaatagct ttccaagttg aactccctct ctctatctag
     3541 caggatattt tttcagtgct tttatttact atgcacttag actatgcact ttttctgaaa
     3601 tatttttgta acactttttt gtatttttgc catttgaaaa ggttgtggtg ttgttggtat
     3661 gtcattaagt tgcaggtttg aaactgctgt tagctttgtg actcagaatc tagaaatgtt
     3721 ctgtcctggt attttgtcgt cccatctaca gctggagctg gaatccgttg atcttctagc
     3781 taccattcat tttcttcaca gttcacaaag aagagcgtga aattcagtga atgcagttac
     3841 taatcctgtc tggaaatgaa tctcatttca ccaaatcaat tgtgtttttc cactaaaatg
     3901 atggtgtatg ttgaagacat cactctgaga ttggaagacc tcaccactaa aggctccatc
     3961 cacagtggct ggctcagctg aactttaggt tgccattctt ttctttgttc accattgggt
     4021 gatgcagctt tttaactgtt gggagatggc cattctaact actgttgaat gtctctgttt
     4081 tgggaaggta aaataagaaa ataaaaaaag aatatatatg aagggagagg ctggttgtct
     4141 ctcccatgtg gttgtgaata tgctcttatg acccacaagt ggacatacaa ggcttatctt
     4201 tgctgtgatt tcctctctgc tttaagtcta tcatactgta aatatttcag agtgtactgt
     4261 aacacgagct gaattgtgat aaatcatgaa ctgcagagac agacggtgta gtctaagcca
     4321 gtaggctgtt ctccctggag attgctggga ataataaaga atagtttatt gtaactcaaa
     4381 aaaaaaaaaa aaa
//
